EKS-GAG-00208

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00208

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	321.7	3.1E-96	13	265	253

Status

Unreviewed

Ensembl Protein

ENSGALP00000026466

UniProt Accession

F1NKU2;

Protein Name

Protein Synonyms/Alias

Gene Name

MELK

Gene Synonyms/Alias

MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000016438	ENSGALP00000026466	ENSGALT00000026517

Organism

Gallus gallus

Functional Description

Protein Length

657

Protein Sequence
(FASTA)

MSVSDYEEIL KYYELHETIG TGGFAKVKLG RHLLTGEKVA IKIMDKVALG DDLPRVKTEI 60

DAMKNLSHQH VCRLYHVIET SKKIFMVLEY CPGGELFDYI VSKDRLSEEE ARVFFRQIVS 120

AIAYVHSQGY AHRDLKPENL LIDEEHNLKL IDFGLCAKPK GGLDYRLNTC CGSPAYAAPE 180

LIQGKAYIGS EADIWSMGVL LYALLCGFLP FDDDNVMALY RRITRGKYAV PKWLSPSSTL 240

LLNQLLQVDP KKRITVKHLL SHPWLMQGYS DAVQWQSKYP LGHLDEDCVT ELSVFHNKSR 300

ENISALISKW NYDQMSATYL LLQSKKFRGK RIHLRIPSQT GHASTTQSAS LGSEKAMTYE 360

DVPDCSDVPD AFGSMEFSDA ASLFEESPLE EFSLNTHRTK QHSRHDTQLG DMEFTLSTPV 420

TRKVASKKHA NKENVDAESA LRNELPFALP APKASFSKSQ TEKQVQGIPF QAPTSKESQF 480

TTVTPVKKPK TPTNTCELTA TEVLTEKRCH SVDLDLNRGH VDSSQKKRKA KLFGSLERGL 540

DKVITMLTPG KKKRFSRPGP RKLKAHYNVT MTQLLNPDQL LNEIISILSK KQVEYVKKGY 600

TLKCQTKPDF GRESMKFELE VCRLSKNGAV GIRRQRLRGD AWVYKRLVED ILSSCQV 657

Nucleotide Sequence
(FASTA)

ATGTCTGTCA GTGACTACGA GGAAATTCTC AAGTACTATG AATTACATGA AACAATTGGA 60

ACGGGTGGTT TTGCAAAGGT AAAACTCGGA CGGCATCTTC TTACTGGTGA AAAAGTTGCA 120

ATAAAAATCA TGGACAAAGT TGCTTTAGGG GATGACTTGC CTCGAGTTAA AACAGAAATT 180

GATGCCATGA AGAACTTAAG TCATCAACAT GTTTGCCGAT TGTACCATGT AATAGAGACA 240

TCAAAGAAAA TATTCATGGT CTTAGAGTAT TGTCCCGGAG GAGAGCTGTT TGATTACATT 300

GTTTCTAAGG ACCGCCTTTC GGAAGAGGAA GCTCGTGTCT TTTTTCGACA GATTGTTTCA 360

GCAATTGCTT ATGTTCACAG TCAGGGTTAT GCCCACAGAG ACCTCAAACC AGAAAATCTG 420

CTGATTGATG AGGAACATAA TTTGAAGCTG ATAGACTTCG GACTCTGTGC AAAGCCAAAG 480

GGAGGCCTCG ATTACCGCCT GAACACATGC TGTGGAAGCC CAGCATACGC AGCACCAGAG 540

CTAATCCAGG GCAAAGCGTA TATTGGCTCA GAGGCAGATA TTTGGAGCAT GGGTGTACTG 600

CTGTATGCTC TGCTGTGTGG GTTTCTTCCT TTTGATGATG ACAATGTGAT GGCACTCTAC 660

AGGAGGATAA CAAGAGGAAA ATACGCTGTT CCAAAATGGC TTTCACCTAG CAGTACGCTG 720

CTGCTTAACC AACTGCTACA GGTAGACCCA AAGAAGCGGA TTACAGTTAA ACACCTGTTA 780

AGTCACCCTT GGCTCATGCA AGGTTATTCT GATGCTGTTC AGTGGCAAAG TAAATACCCA 840

CTGGGACATC TTGATGAAGA CTGTGTAACA GAGCTTTCTG TGTTTCACAA CAAGAGCAGA 900

GAGAATATAT CAGCATTAAT ATCAAAGTGG AATTACGACC AGATGTCAGC AACCTATCTC 960

TTGCTTCAAT CCAAGAAGTT TCGTGGCAAG CGCATTCACT TAAGAATTCC ATCACAAACA 1020

GGACATGCCA GTACAACACA GTCAGCAAGC CTGGGGTCTG AAAAGGCTAT GACATATGAA 1080

GATGTGCCAG ACTGCAGCGA TGTGCCAGAT GCGTTTGGAT CTATGGAATT CTCTGATGCA 1140

GCTTCACTGT TTGAGGAATC TCCACTAGAA GAGTTTAGTC TAAATACTCA CAGAACAAAG 1200

CAGCATTCGA GGCATGATAC TCAACTGGGT GATATGGAAT TCACACTGTC AACTCCAGTG 1260

ACAAGAAAAG TGGCATCGAA GAAGCATGCA AACAAAGAGA ATGTTGATGC AGAGTCAGCA 1320

TTAAGAAATG AGCTGCCCTT TGCACTTCCT GCTCCAAAGG CCTCCTTTTC AAAGAGTCAG 1380

ACAGAGAAGC AAGTACAAGG CATACCCTTT CAGGCACCTA CTTCCAAAGA GAGCCAGTTC 1440

ACGACAGTCA CCCCAGTTAA GAAGCCCAAA ACACCAACAA ATACATGTGA ACTGACAGCA 1500

ACTGAGGTTC TTACTGAGAA AAGGTGTCAT TCTGTGGATT TAGATCTCAA CCGAGGTCAT 1560

GTGGATAGCA GCCAAAAGAA GAGAAAGGCC AAACTATTTG GAAGTCTCGA AAGAGGCCTA 1620

GATAAAGTGA TTACAATGCT TACACCAGGC AAAAAGAAGC GATTCAGTAG ACCTGGGCCA 1680

AGAAAACTTA AGGCGCACTA TAATGTTACC ATGACTCAAC TACTGAATCC AGACCAACTG 1740

CTGAATGAAA TAATCTCTAT CCTTTCAAAG AAGCAAGTGG AATACGTTAA GAAGGGCTAC 1800

ACCCTGAAAT GCCAAACAAA GCCAGATTTT GGCAGAGAAT CTATGAAGTT TGAGTTAGAA 1860

GTGTGTCGGC TCAGTAAGAA TGGAGCGGTT GGTATCAGGA GGCAGAGGCT TAGAGGGGAT 1920

GCTTGGGTCT ACAAGAGGCT GGTGGAAGAC ATTTTATCCA GCTGCCAAGT GTGA 1974

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l++t+G+g f+kVkl +h +t+ekva+Ki++k +l +  l ++k+Ei+++k+l+h+++

Q: 13    YELHETIGTGGFAKVKLGRHLLTGEKVAIKIMDKVALGD-DLPRVKTEIDAMKNLSHQHV  71

         99********************************88865.589*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++viet+kk+++vley+ ggeLfdyi++k rl+e+ear +f+q+vsa+ Y+hs+g +

Q: 72    CRLYHVIETSKKIFMVLEYCPGGELFDYIVSKDRLSEEEARVFFRQIVSAIAYVHSQGYA  131

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+++n+k++DFGl+++ k g    l+t+cGsp+YaaPel++gk Y g++

Q: 132   HRDLKPENLLIDEEHNLKLIDFGLCAKPKGGldYRLNTCCGSPAYAAPELIQGKAYIGSE  191

         **************************999887799*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +D+Ws+Gv+Lyal++g lPfd++n+ +l+++i++gk+ +pk+ls++ + Ll++lL+vdp+

Q: 192   ADIWSMGVLLYALLCGFLPFDDDNVMALYRRITRGKYAVPKWLSPSSTLLLNQLLQVDPK  251

         ************************************************************

S: 239   kRatieeilkhewl  252

         kR+t++++l+h+wl

Q: 252   KRITVKHLLSHPWL  265

         *************7

Domain Sequence
(FASTA)

YELHETIGTG GFAKVKLGRH LLTGEKVAIK IMDKVALGDD LPRVKTEIDA MKNLSHQHVC 60

RLYHVIETSK KIFMVLEYCP GGELFDYIVS KDRLSEEEAR VFFRQIVSAI AYVHSQGYAH 120

RDLKPENLLI DEEHNLKLID FGLCAKPKGG LDYRLNTCCG SPAYAAPELI QGKAYIGSEA 180

DIWSMGVLLY ALLCGFLPFD DDNVMALYRR ITRGKYAVPK WLSPSSTLLL NQLLQVDPKK 240

RITVKHLLSH PWL 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005509	; F:calcium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0061351	; P:neural precursor cell proliferation
GO:0043065	; P:positive regulation of apoptotic process
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013