EPS-GAG-00044

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GAG-00044

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	462.5	6.7E-139	128	458	331

Status

Unreviewed

Ensembl Protein

ENSGALP00000026611

UniProt Accession

E1BTX9;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF1

Gene Synonyms/Alias

PPEF1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000016522	ENSGALP00000026611	ENSGALT00000026662

Organism

Gallus gallus

Functional Description

Protein Length

647

Protein Sequence
(FASTA)

MGCNASAHYS KHKYNETAIK ATVLIQRWYR CKRAQLEVRR RYSLTIFQSI EYADEQEQTQ 60

LSNFFTFMLE HCVHRGEGKE KVARTSTGSD VSPGTDSYVI KYEKIDVPDS YRGPRLSFPL 120

DISHAKTLLN ALKDRQLLHA RYVLQLLCET RRVLKEKPNI THVSVSYFKE ITICGDLHGN 180

LDDLLLVFHK NGLPSENNPY VFNGDFVDRG KNSMEILIIL FVFLLIYPND FHLNRGNHED 240

YILNMKYGFA KEVLKKYKDH GKTILHHLQD IFSWLPLATI VNNKVLIVHG GISDTTDLDS 300

LNLLERNKMQ STMSAAEDID EDTKVRDRQK EPGRTFRAHR EGTETSMPKL SLVLLCFFQV 360

LDILWSDPNK QHGCTPNQRR GGGCYFGPDT TDQLLKRYNL KMLIRSHEFK PDGYDLTHNG 420

KVITIFSASN YYEAGSNRGA YIRMNPDLVP HFIQYQVCAC TDKKKNWERV KTIEQSALQN 480

LQERIFVHKR KLMDTFAKCD CKNTGRISIS DWAAVMESVL QLKLPWRMLR SRLVKTDPDG 540

KVDYMSCFCY MDTARPMHQV QPTLVETLCK YRRDLQMIFN VLDEDRSGLI SPNEFRKMWK 600

IFSSYLGIHS HDEAVDKLAQ SIDFNKDGNI DFSEFLEAFH VVHQLEN 647

Nucleotide Sequence
(FASTA)

ATGGGGTGCA ACGCTTCCGC GCATTACAGT AAACACAAAT ATAACGAAAC AGCCATAAAA 60

GCTACTGTGT TAATCCAGAG GTGGTACCGT TGTAAAAGAG CCCAGCTGGA GGTCCGTCGC 120

CGCTATTCTC TGACTATCTT TCAGTCAATC GAATATGCTG ATGAGCAAGA GCAAACACAG 180

CTGTCCAACT TTTTCACGTT CATGCTGGAG CACTGTGTTC ATCGTGGTGA AGGTAAGGAG 240

AAAGTTGCTC GTACTTCCAC CGGCTCCGAT GTTTCTCCTG GTACGGACTC ATATGTAATT 300

AAATATGAAA AGATTGATGT TCCAGACTCC TATCGTGGAC CACGACTCTC ATTTCCCCTT 360

GATATTTCAC ATGCTAAGAC TCTTCTTAAC GCGCTCAAGG ATAGACAGCT GCTTCATGCC 420

CGCTATGTCC TGCAGCTGTT ATGTGAGACC AGGAGGGTTC TCAAGGAGAA GCCAAATATC 480

ACCCATGTTT CAGTTTCCTA CTTCAAGGAG ATAACCATCT GTGGAGACTT GCATGGAAAT 540

CTGGATGATC TTTTACTGGT ATTCCACAAG AACGGTCTGC CTTCAGAAAA CAACCCTTAT 600

GTCTTTAATG GCGATTTTGT TGACAGAGGA AAAAATTCTA TGGAAATACT TATAATCCTA 660

TTTGTGTTTC TTCTTATCTA CCCGAATGAT TTTCACTTGA ACAGAGGAAA CCATGAAGAC 720

TACATCTTAA ACATGAAATA CGGCTTCGCT AAAGAAGTTT TGAAGAAGTA TAAGGACCAT 780

GGCAAGACAA TTTTGCATCA TCTGCAAGAC ATTTTCAGCT GGCTTCCCCT TGCCACTATA 840

GTTAATAACA AAGTGCTTAT TGTCCATGGA GGAATTTCAG ACACCACAGA TTTGGATTCC 900

CTGAATTTAC TTGAGAGAAA TAAGATGCAA AGCACGATGT CTGCAGCTGA AGACATTGAT 960

GAAGACACGA AAGTTAGAGA CAGACAAAAA GAACCAGGAA GAACATTCAG AGCTCACCGA 1020

GAAGGAACGG AAACAAGTAT GCCCAAGCTT AGTTTAGTCC TCCTTTGCTT TTTCCAGGTC 1080

CTGGACATTC TCTGGAGTGA TCCAAATAAA CAACATGGCT GCACTCCGAA CCAGCGTCGA 1140

GGAGGAGGTT GTTACTTTGG CCCTGACACT ACTGACCAGC TGCTTAAAAG GTATAATCTG 1200

AAGATGCTAA TCAGGTCTCA TGAATTTAAG CCGGACGGCT ACGACCTCAC TCATAATGGG 1260

AAGGTTATCA CTATATTTTC TGCTTCTAAC TATTACGAAG CGGGGAGCAA CCGAGGAGCA 1320

TACATCCGAA TGAATCCTGA TCTGGTTCCT CATTTTATAC AGTACCAAGT CTGCGCGTGC 1380

ACAGACAAGA AGAAAAATTG GGAGAGGGTG AAAACAATTG AACAGTCTGC TTTACAAAAC 1440

TTACAAGAGA GGATTTTTGT TCACAAGCGT AAACTCATGG ACACCTTTGC AAAGTGTGAC 1500

TGCAAAAACA CAGGCAGGAT TTCTATCAGT GACTGGGCAG CAGTGATGGA GTCAGTCCTA 1560

CAACTCAAAC TGCCCTGGAG GATGCTGAGG TCTCGGTTAG TGAAGACAGA TCCAGATGGA 1620

AAAGTTGACT ACATGTCATG TTTTTGCTAT ATGGACACAG CTCGTCCTAT GCATCAGGTT 1680

CAGCCAACTT TGGTGGAAAC GCTGTGCAAA TACAGAAGAG ATCTGCAGAT GATCTTTAAC 1740

GTCTTGGATG AAGATCGGTC AGGTCTGATT TCTCCCAATG AGTTCCGCAA GATGTGGAAG 1800

ATCTTCAGTT CTTACCTGGG AATTCATTCA CACGATGAAG CTGTTGACAA GTTAGCCCAG 1860

AGCATAGACT TCAACAAAGA TGGCAACATT GACTTCAGTG AATTTTTAGA GGCCTTTCAT 1920

GTGGTTCACC AACTAGAGAA C 1941

Domain Profile

S: 4     llevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlllv  63

         ll+++k+++ lha+yvl++l e+++vlk+ pni+hvs +  ke+t++GdlhG+lddlllv

Q: 128   LLNALKDRQLLHARYVLQLLCETRRVLKEKPNITHVSVSYFKEITICGDLHGNLDDLLLV  187

         89**********************************************************

S: 64    lkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnary  123

         ++knGlPse+npyvfnGdfvdrGk+++e+l++l ++ l++Pn+ +lnrGnhed ++n++y

Q: 188   FHKNGLPSENNPYVFNGDFVDRGKNSMEILIILFVFLLIYPNDFHLNRGNHEDYILNMKY  247

         ************************************************************

S: 124   GfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksverk  183

         Gf kevl+kyk++gk il+ l++++ wlPl++iv+++vl+vhGG+s++t+ld l+ +er+

Q: 248   GFAKEVLKKYKDHGKTILHHLQDIFSWLPLATIVNNKVLIVHGGISDTTDLDSLNLLERN  307

         ************************************************************

S: 184   krksvllpPeessrd................lgrldtdgepreslteteweqiidilwsd  227

         k++s +   e+ + d                +    +   p+ sl    + q++dilwsd

Q: 308   KMQSTMSAAEDIDEDtkvrdrqkepgrtfraHREGTETSMPKLSLVLLCFFQVLDILWSD  367

         *******999988889999******99999865556677788999999999*********

S: 228   PratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvtifs  287

         P+ ++G++Pn+ rG+G+yfGPd t+++lk+y+lk++irshe kp+gy+++h+gkv+tifs

Q: 368   PNKQHGCTPNQRRGGGCYFGPDTTDQLLKRYNLKMLIRSHEFKPDGYDLTHNGKVITIFS  427

         ************************************************************

S: 288   asnyyeegsnkgayiklnsqltprfvqyiva  318

         asnyye gsn+gayi++n +l+p+f+qy+v+

Q: 428   ASNYYEAGSNRGAYIRMNPDLVPHFIQYQVC  458

         *****************************96

Domain Sequence
(FASTA)

LLNALKDRQL LHARYVLQLL CETRRVLKEK PNITHVSVSY FKEITICGDL HGNLDDLLLV 60

FHKNGLPSEN NPYVFNGDFV DRGKNSMEIL IILFVFLLIY PNDFHLNRGN HEDYILNMKY 120

GFAKEVLKKY KDHGKTILHH LQDIFSWLPL ATIVNNKVLI VHGGISDTTD LDSLNLLERN 180

KMQSTMSAAE DIDEDTKVRD RQKEPGRTFR AHREGTETSM PKLSLVLLCF FQVLDILWSD 240

PNKQHGCTPN QRRGGGCYFG PDTTDQLLKR YNLKMLIRSH EFKPDGYDLT HNGKVITIFS 300

ASNYYEAGSN RGAYIRMNPD LVPHFIQYQV C 331

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0004721	; F:phosphoprotein phosphatase activity

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 3.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013