EKS-GAG-00178

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00178

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	459.8	2.8E-138	13	297	285

Status

Unreviewed

Ensembl Protein

ENSGALP00000026624

UniProt Accession

E1BTX0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000016529	ENSGALP00000026624	ENSGALT00000026675

Organism

Gallus gallus

Functional Description

Protein Length

904

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGSNANYTE YVATRWYRSP 180

ELLLGAPYGK AVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PAEQMKLFYS 240

NPRFHGLRFP AVNHPQSLER RYLGILSGVL LDLMKNLLKL DPADRYLTEQ CLNHPSFQTQ 300

RLLDRCGSSP SRSAKRKPYH VDSNTLSNRN QASKSSALQS HHRSNSKDIQ TLGIGGPREE 360

GLPANESFLN GNLSGAAHSP MHAKKSSNQP GSGNKDLANN NMPHLLSPKE TKAKTEFDFN 420

VDPKSSDGPG TKYLKSNTRS QQNRHSFMET SQSKTGTLQP GDKHSRHSYI DTIPQSSKSP 480

SYRTKSKSHG VLTDSKSVGN LSEARAQAAE PNSSRYFPSS CMDLNSPTSP TAPRHSDNRT 540

LLSPSGRNNR SEGTLDTRRP STRHSKTMEE LKLPDHMDGS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVSRDRV RSKGSEGGLS VGQGMAARAN SLQLLSPQQS DQIPSETNLT 660

RPPVKDSSRD VTAAFHSRRK SEGGAYHDPH TEDGASTKEN RILYNEAVPR RVGSFYRVPS 720

PRPDSTYIEN NVSNRASVLP ADSSTVANHS KRQTTFDTWK SPENLNSHSE QLKEKEKQGF 780

FRAIKKKKKK SQTMPGTDGQ DLLALQKAIH SSNHQSSRQK DWHPEKMTEI QPHSQPLKSL 840

RKLLHLSSNH PIPAEPRFQP LPSQPAKPAF SEVRIHPMSQ SSSSGSSNAR QEPQPKSRPT 900

LQIP 904

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGTGTTGT ACTTAAATGC AGACACAAGG AGACACATGA AATTGTGGCT 120

ATCAAGAAAT TCAAAGACAG TGAAGAAAAT GAAGAAGTCA AAGAAACCAC TTTACGAGAA 180

CTTAAAATGC TTCGCACTTT AAAACAGGAG AACATAGTGG AGCTGAAGGA AGCCTTCAGA 240

AGAAGAGGAA AATTATACTT AGTTTTTGAA TATGTGGAAA AAAATATGCT TGAATTGCTA 300

GAAGAAATGC CAAATGGAGT TCCACCAGAA AAAGTGAAAA GTTATATCTA CCAGCTAATT 360

AAAGCAATTC ATTGGTGTCA TAAGAATGAT ATCGTTCATA GAGATATCAA ACCAGAGAAT 420

CTCTTAATAA GCCACAATGA TGTTCTGAAA TTGTGTGACT TTGGCTTTGC CCGTAATCTT 480

TCTGAAGGAA GCAATGCTAA CTATACAGAA TATGTGGCTA CCAGGTGGTA CCGCTCACCC 540

GAACTCTTGC TTGGAGCCCC ATATGGAAAG GCTGTGGATA TGTGGTCTGT GGGCTGTATT 600

CTGGGTGAGC TGAGTGACGG ACAGCCCTTG TTCCCAGGGG AGAGCGAGAT TGACCAGCTC 660

TTTACCATTC AGAAGGTGCT AGGCCCACTG CCAGCTGAGC AGATGAAGCT CTTCTACAGC 720

AACCCACGCT TCCATGGACT GAGGTTTCCT GCAGTCAATC ATCCACAATC TTTAGAGAGA 780

AGATACTTGG GAATTTTAAG TGGTGTTTTG CTTGATCTTA TGAAGAACTT ACTGAAGTTA 840

GATCCAGCAG ACAGATACTT GACAGAACAA TGTTTGAACC ATCCTTCATT TCAAACACAA 900

AGACTCTTGG ATCGCTGTGG AAGTTCACCT TCACGATCAG CTAAAAGAAA GCCTTACCAC 960

GTCGACAGCA ACACATTATC TAACAGAAAT CAAGCCAGCA AAAGTTCTGC TTTGCAGTCA 1020

CACCACAGAT CAAACAGCAA GGATATACAG ACACTAGGGA TTGGCGGGCC AAGAGAAGAG 1080

GGTCTTCCAG CAAATGAAAG CTTTTTAAAT GGAAACCTCT CTGGAGCTGC ACATAGCCCA 1140

ATGCACGCGA AGAAATCAAG CAACCAGCCT GGATCTGGCA ATAAAGATCT AGCCAACAAT 1200

AACATGCCAC ATCTTCTTAG TCCAAAGGAA ACAAAGGCAA AAACAGAATT TGATTTTAAT 1260

GTGGACCCAA AAAGTTCTGA TGGTCCAGGT ACGAAGTACC TGAAGTCTAA CACCAGATCT 1320

CAGCAGAACC GGCACTCATT TATGGAAACG TCTCAAAGCA AAACTGGGAC GCTGCAGCCC 1380

GGCGATAAGC ATAGTCGCCA CAGCTATATT GATACCATTC CACAGTCTTC TAAGAGTCCT 1440

TCGTATCGGA CAAAGTCAAA GAGCCATGGG GTTCTGACAG ACTCAAAATC CGTGGGCAAC 1500

CTATCTGAGG CCAGGGCTCA AGCTGCAGAA CCAAACAGCA GTCGCTATTT TCCATCCAGC 1560

TGTATGGACT TGAACTCTCC TACCAGTCCG ACCGCTCCCC GCCATAGCGA TAACAGAACT 1620

TTGCTCAGCC CGTCTGGGAG GAATAACCGC AGCGAGGGTA CCCTGGACAC CCGAAGACCT 1680

TCAACCAGAC ACTCCAAAAC AATGGAGGAG TTAAAACTGC CAGATCACAT GGATGGAAGC 1740

CATTCCCACT CGCTCTCTGC TCCACACGAA TCTTTTTCCT ATGGCCTAGG TTATACCAGT 1800

CCTTTCTCTT CACAGCAGCG CCCTCATAGA CACTCTATGT ATGTGAGCCG GGACAGAGTG 1860

AGGTCAAAGG GCTCAGAGGG TGGCTTAAGC GTAGGGCAAG GGATGGCAGC CAGAGCAAAC 1920

AGCCTGCAAC TGTTATCTCC ACAGCAGAGT GACCAGATTC CATCAGAAAC AAATTTAACA 1980

AGACCTCCAG TAAAAGATTC CTCCAGAGAT GTTACAGCTG CATTTCATTC ACGGCGAAAA 2040

TCTGAGGGTG GAGCATATCA TGATCCACAC ACAGAAGATG GAGCATCTAC TAAGGAAAAT 2100

AGAATTCTGT ATAATGAAGC TGTTCCAAGA AGAGTTGGCA GTTTTTACAG AGTTCCATCT 2160

CCGCGTCCAG ACAGCACATA CATAGAAAAC AATGTGTCAA ACAGAGCCTC TGTACTACCA 2220

GCAGACAGCA GCACGGTGGC AAACCACTCA AAGAGACAAA CCACCTTTGA TACCTGGAAA 2280

AGTCCTGAAA ATCTTAACAG TCACTCTGAG CAGCTTAAGG AGAAAGAAAA GCAAGGTTTT 2340

TTCAGGGCAA TAAAGAAGAA AAAGAAGAAA TCTCAAACCA TGCCTGGCAC TGATGGTCAG 2400

GATCTCCTGG CGTTACAGAA AGCCATTCAT TCTTCTAATC ACCAGAGCAG CAGGCAGAAG 2460

GATTGGCATC CTGAGAAGAT GACAGAAATC CAGCCTCATA GCCAGCCATT AAAATCTCTG 2520

CGAAAGCTAT TACACCTCTC TTCAAATCAT CCCATCCCTG CTGAGCCTCG CTTCCAACCC 2580

TTACCAAGTC AGCCGGCCAA ACCTGCTTTT TCTGAAGTGC GAATTCACCC CATGAGTCAA 2640

AGCTCCAGCA GCGGCAGCAG CAACGCACGG CAGGAGCCGC AGCCAAAGAG CCGGCCGACG 2700

CTGCAGATCC CG 2712

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGk+

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGSNANYTEYVATRWYRSPELLLG-APYGKA  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   l+ vlldl+k++lkldpa+r+++e++l+h+ f

Q: 252   VNHPQSLERRYLgILSGVLLDLMKNLLKLDPADRYLTEQCLNHPSF  297

         ***********98899***************************987

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GSNANYTEYV ATRWYRSPEL LLGAPYGKAV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPA EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILSGVLLD LMKNLLKLDP ADRYLTEQCL NHPSF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013