EKS-GAG-00314
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00314
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src429.34.6E-129238487250
StatusUnreviewed
Ensembl ProteinENSGALP00000026839
UniProt AccessionE1BYL7;
Protein Name
Protein Synonyms/Alias
Gene NameBLK
Gene Synonyms/Alias BLK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000016661ENSGALP00000026839ENSGALT00000026890
OrganismGallus gallus
Functional Description
Protein Length504
Protein Sequence
(FASTA)
MGLIGSKNQL MSNEKFTSGS NPKNRSRPPP APPKSKLTFN SALPKPSAHQ SPAEYDTIVI 60
ALYDFAASSD RDLELVKGEK LQILSNEGDW WLAKSLRSGK KGYIPSNFVA LVDSLEQEKW 120
FFKTLSRKDA ERLLLSSGNK VGSFLVRESE TSTGAYSLSV RDSDSAHGDI IKHYRIRSLD 180
GGGYYISPRM TFATLPELIH HYSQRGDGLC QRLMAPCTSL APQRPWAQDE WEIPRESLKL 240
VKKLGSGQFG EVWMGYYKNN FKVAVKTMKE GSMDPEAFLA EANLMKKLQH NKLVRLYAVV 300
TKQPIYIVTE YMANGCLLDY LKTEEGSQLN LPKLIDMSAQ VAEGMAYIER MNSIHRDLRA 360
ANILVSETLC CKIADFGLAR IIEDEYLAQE AGAKFPIKWT APEAINFGVF TIKSDVWSFG 420
ILLTEIITYG RIPYPGMTNP EVIRNLEQGY RMPCPDMCPA ELYSIILRCW RNKPEERPTF 480
EYLQSVLEDF YTATEKQYEA EPQP 504
Nucleotide Sequence
(FASTA)
ATGGGGTTGA TTGGGAGCAA AAACCAGCTG ATGTCCAATG AGAAATTTAC GTCAGGAAGC 60
AATCCGAAAA ACAGGAGTAG ACCTCCTCCT GCCCCACCCA AATCAAAACT TACCTTTAAT 120
TCTGCACTTC CAAAACCCTC AGCACATCAA AGTCCAGCTG AATATGACAC CATTGTGATT 180
GCACTGTACG ACTTTGCTGC TTCAAGTGAC CGTGATCTGG AGCTGGTCAA GGGAGAGAAA 240
CTCCAGATCC TCTCCAACGA GGGAGACTGG TGGCTGGCCA AATCCCTCCG AAGTGGGAAG 300
AAAGGCTATA TCCCCAGCAA CTTCGTTGCA CTAGTAGACA GCCTGGAGCA GGAAAAGTGG 360
TTTTTTAAAA CCCTGAGCAG AAAAGATGCT GAACGGCTGC TGTTGTCTTC TGGTAACAAA 420
GTCGGCTCCT TCCTTGTTCG AGAGAGTGAG ACCAGCACAG GTGCCTATTC CTTGTCCGTG 480
AGAGACAGCG ATTCTGCTCA TGGGGACATC ATCAAACACT ACAGGATCCG CTCCTTAGAT 540
GGCGGAGGTT ATTACATCTC CCCAAGGATG ACTTTTGCCA CCCTGCCAGA GCTAATCCAT 600
CATTACAGCC AGAGGGGAGA TGGTCTGTGC CAGAGGCTCA TGGCTCCCTG CACATCCCTG 660
GCTCCCCAGA GGCCCTGGGC ACAGGATGAG TGGGAGATCC CACGGGAGTC TCTGAAACTT 720
GTGAAGAAGC TTGGCAGTGG GCAGTTTGGG GAAGTGTGGA TGGGCTACTA CAAGAACAAC 780
TTCAAAGTGG CTGTGAAGAC CATGAAGGAG GGCAGCATGG ATCCTGAAGC CTTCTTGGCA 840
GAAGCAAACT TGATGAAGAA GCTCCAGCAT AATAAGCTGG TCCGGCTCTA TGCTGTAGTC 900
ACAAAGCAGC CAATTTACAT CGTGACAGAG TACATGGCCA ATGGATGCTT GCTGGATTAT 960
CTGAAGACAG AGGAAGGAAG CCAACTGAAT CTCCCCAAAC TCATTGATAT GTCTGCTCAG 1020
GTGGCAGAGG GAATGGCATA CATTGAGAGA ATGAACTCCA TCCACCGCGA CTTGAGAGCT 1080
GCCAACATCC TCGTCTCAGA GACACTCTGC TGCAAAATTG CTGATTTTGG CTTGGCCAGG 1140
ATCATTGAGG ATGAATACTT GGCACAAGAA GCAGGAGCCA AATTCCCAAT CAAATGGACG 1200
GCACCGGAAG CCATTAACTT TGGAGTTTTC ACCATCAAGT CTGACGTGTG GTCTTTTGGG 1260
ATCCTCTTGA CTGAAATCAT AACCTATGGC AGGATCCCTT ATCCAGGGAT GACCAACCCG 1320
GAGGTGATTC GCAACCTGGA GCAGGGTTAC CGCATGCCCT GCCCGGACAT GTGTCCAGCT 1380
GAGCTCTACA GCATCATCCT GAGATGCTGG CGAAACAAAC CCGAGGAGCG CCCGACCTTT 1440
GAGTACCTTC AGTCCGTCCT TGAGGACTTT TACACGGCCA CAGAGAAGCA GTATGAGGCA 1500
GAGCCTCAGC CATAA 1515
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklvkklG+GqfGevw+g++k++ kvavkt+keg+++peafl+ea+++kkl+h+klv+ly
Q: 238   LKLVKKLGSGQFGEVWMGYYKNNFKVAVKTMKEGSMDPEAFLAEANLMKKLQHNKLVRLY  297
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ +Piyivte+ma+G+lld+lk+eeg++l+lpkl+d++aqvaeGmay+e++n ihr
Q: 298   AVVTK-QPIYIVTEYMANGCLLDYLKTEEGSQLNLPKLIDMSAQVAEGMAYIERMNSIHR  356
         ****9.9*****************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+e+l++k+adfGlar+ied+   ++ gak+PikWtaPeai++g+ftiksdv
Q: 357   DLRAANILVSETLCCKIADFGLARIIEDEYLAQEAGAKFPIKWTAPEAINFGVFTIKSDV  416
         **************************999888999*************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGilltei+t+G++PypGmtn ev++++e+gyr+p+p+ cp+ely+++l+cw+++pee
Q: 417   WSFGILLTEIITYGRIPYPGMTNPEVIRNLEQGYRMPCPDMCPAELYSIILRCWRNKPEE  476
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq+vl
Q: 477   RPTFEYLQSVL  487
         ********986
Domain Sequence
(FASTA)
LKLVKKLGSG QFGEVWMGYY KNNFKVAVKT MKEGSMDPEA FLAEANLMKK LQHNKLVRLY 60
AVVTKQPIYI VTEYMANGCL LDYLKTEEGS QLNLPKLIDM SAQVAEGMAY IERMNSIHRD 120
LRAANILVSE TLCCKIADFG LARIIEDEYL AQEAGAKFPI KWTAPEAINF GVFTIKSDVW 180
SFGILLTEII TYGRIPYPGM TNPEVIRNLE QGYRMPCPDM CPAELYSIIL RCWRNKPEER 240
PTFEYLQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00345
EKS-ANC-00360
EKS-BOT-00372
EKS-CAJ-00377
EKS-CAF-00372
EKS-CAP-00405
EKS-DAR-00751
EKS-EQC-00363
EKS-FEC-00359
EKS-GAM-00225
EKS-GOG-00363
EKS-HOS-00379
EKS-ICT-00353
EKS-LAC-00386
EKS-LOA-00381
EKS-MAM-00373
EKS-MEG-00304
EKS-MOD-00360
EKS-MUM-00404
EKS-MUP-00366
EKS-NOL-00339
EKS-ORN-00479
EKS-ORC-00351
EKS-ORL-00443
EKS-OTG-00375
EKS-PAT-00352
EKS-PES-00329
EKS-POA-00361
EKS-PTV-00095
EKS-RAN-00386
EKS-SAH-00342
EKS-SUS-00325
EKS-TAG-00443
EKS-TAR-00476
EKS-TUT-00099
EKS-XIM-00469
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0032024; P:positive regulation of insulin secretion
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013