EKS-GAG-00343
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00343
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR527.91.4E-158624955332
StatusUnreviewed
Ensembl ProteinENSGALP00000027559
UniProt AccessionF1P380;
Protein Name
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000017093ENSGALP00000027559ENSGALT00000027611
OrganismGallus gallus
Functional Description
Protein Length1002
Protein Sequence
(FASTA)
KRKRKKRKER KKFCFIVLVM TAMTFTSAMN QSTSEITCVF IRQRDGASRT EETSVSSKIS 60
NVLEDLECHL NSQGAENIYE PIKKVEANVF EDIELRIIMN ISEIISCHCF FKEIQPCEPS 120
LDSDNQYVTS LYFSQIRETQ AGKYTFSVIS KNSNYTIIVP VLIRIDNKQM SKLRCKPGKP 180
YFRISEKLDV IECISESYPQ PSVKWAFCRT PEKRYEENGE IDGIQKVQYE LHQSELFETY 240
IWCCAANDLG RECTSLFTID LSERRAAPSA ELLLKVGEPL LIRCRAVYRN YKFRINLSFE 300
NKEVQQNRRF EGLEYQTDHS AIRTQYMFTP AARKGDSGRY TCSSTAHPNQ TALVTVLEKG 360
FINITDSRED FEIGDEEFCF EVNFTAYPPV KCMWLFSQKT FPCKQSYSVD GHSISSKFCN 420
HQHRSGIYMF YAENGDTAMT KKFTLYVRRK PEVTMQLLFK QISCIADSYP ASSWVWRHCP 480
DLNSTNCTEE IKEGIQNFLP ERRSLGSWIS SSILDVKETA TTFSVECCAS NLVGSNCRKS 540
FINIVAGTVS SLPDNAALCV FAGFIFLLIV FLCALICHKY KKQFRYESQL QMMQVIGPLD 600
NEYIYVDFRE YEYDLKWEFP RENLEFGQVL GSGAFGKVVN ATAYGISKAG DSVQVAVKML 660
KEKSDTSEKD ALMSELKMMT HIGSHENIVN LLGACTVSGP IYLIFEYCCY GDLLNYLRSK 720
REKFHWTLTD IFKQHNFSFY HNICSEQNSR EDELKSTQTS QNINMTSGPN GIALCSEEDE 780
IKCASRQMDE EEDFCVLTFE DLLCFAYQVA KGMEFLESKL CIHRDLAARN ILVTHGKVMK 840
ICDFGLARDV VNDSNYIVRG NVRLPVKWMA PESLFEGMYT MKSDVWSFGI LLWEIFSLGV 900
NPYPGIQVDA NFYKLIKSGF KMDRPYYATK HVYYVMQSCW ALDSRRRPSF SQLVSSLACQ 960
LVEAEGAVYQ NMKKNASPPK SNNKTNPRVS KAEESLLSPP LL 1002
Nucleotide Sequence
(FASTA)
AAAAGGAAAA GGAAAAAAAG AAAAGAAAGG AAAAAGTTCT GTTTTATAGT TCTTGTTATG 60
ACAGCCATGA CTTTCACTTC TGCAATGAAT CAAAGCACAT CTGAGATTAC GTGTGTGTTT 120
ATCAGACAGA GAGATGGAGC TTCAAGGACA GAAGAGACAT CAGTATCTTC CAAGATCTCT 180
AATGTTTTGG AAGATCTTGA GTGCCATTTG AATTCTCAGG GAGCCGAGAA CATCTATGAA 240
CCAATTAAAA AAGTGGAAGC TAATGTGTTT GAGGATATTG AATTAAGAAT AATAATGAAC 300
ATTTCAGAGA TAATTTCATG CCATTGTTTT TTTAAAGAAA TCCAACCTTG TGAACCTTCA 360
TTGGATTCAG ATAACCAGTA CGTTACTTCT TTGTATTTTT CTCAAATACG GGAAACACAA 420
GCTGGAAAAT ACACTTTCTC AGTCATCAGT AAAAACAGCA ATTACACCAT CATTGTTCCT 480
GTTCTCATCC GAATTGATAA CAAGCAAATG AGCAAATTAA GATGTAAACC AGGCAAACCC 540
TATTTCAGGA TATCTGAAAA ACTGGATGTT ATAGAGTGCA TATCAGAGAG CTACCCCCAG 600
CCCTCTGTGA AGTGGGCATT TTGCAGAACA CCTGAAAAGA GGTATGAAGA AAACGGAGAA 660
ATAGATGGCA TACAGAAGGT ACAATATGAA TTACACCAGA GTGAGTTGTT TGAAACTTAC 720
ATATGGTGCT GTGCAGCTAA TGACCTGGGC AGAGAATGCA CCAGCCTCTT TACTATAGAT 780
TTAAGTGAAA GACGAGCAGC ACCTTCAGCT GAGTTACTTC TCAAAGTTGG GGAACCGTTG 840
CTGATCAGAT GCAGAGCTGT TTATCGTAAT TACAAATTCA GGATAAATTT ATCTTTTGAA 900
AACAAAGAAG TGCAGCAGAA TCGCCGATTT GAGGGGTTGG AGTACCAAAC AGACCACTCA 960
GCCATTCGGA CCCAGTACAT GTTTACCCCA GCAGCAAGAA AAGGCGACAG CGGACGTTAT 1020
ACCTGCTCTT CTACGGCTCA TCCAAATCAA ACTGCTTTGG TTACTGTTTT AGAAAAGGGA 1080
TTTATAAATA TAACTGACTC TAGAGAAGAT TTTGAAATTG GTGACGAAGA GTTTTGCTTT 1140
GAAGTCAACT TTACAGCATA TCCACCAGTT AAATGCATGT GGCTATTTTC CCAGAAAACA 1200
TTTCCATGTA AGCAAAGTTA CAGTGTGGAT GGACACAGCA TTTCATCAAA GTTCTGCAAT 1260
CATCAGCACC GTTCTGGGAT ATATATGTTT TATGCTGAAA ATGGTGATAC GGCCATGACA 1320
AAAAAATTCA CTTTGTACGT GAGAAGAAAA CCTGAAGTAA CAATGCAGTT ATTGTTCAAG 1380
CAGATCTCCT GCATCGCTGA CAGCTATCCA GCCTCATCCT GGGTTTGGAG GCACTGTCCT 1440
GACCTGAACT CAACCAACTG TACTGAAGAA ATCAAGGAAG GGATCCAGAA CTTCTTGCCA 1500
GAAAGGAGAT CTCTGGGGTC GTGGATTTCA AGCAGTATTT TAGATGTAAA GGAGACAGCA 1560
ACAACATTCT CTGTTGAATG CTGTGCAAGC AATCTGGTCG GCTCCAACTG CAGAAAGAGC 1620
TTCATTAACA TAGTTGCAGG AACTGTTTCT TCTCTGCCAG ACAATGCTGC ACTCTGTGTC 1680
TTTGCTGGAT TTATCTTCCT GTTGATCGTT TTTTTGTGTG CACTCATTTG TCATAAATAC 1740
AAAAAGCAAT TTAGATACGA AAGCCAGTTG CAAATGATGC AGGTGATTGG ACCACTGGAT 1800
AACGAGTACA TCTACGTTGA CTTCCGTGAA TATGAATATG ATCTCAAATG GGAATTTCCC 1860
AGGGAAAATC TGGAATTTGG ACAGGTTCTC GGCTCTGGGG CTTTTGGGAA AGTGGTGAAT 1920
GCTACAGCTT ATGGAATTAG CAAGGCGGGA GACTCAGTGC AGGTGGCAGT CAAAATGCTA 1980
AAAGAAAAGT CTGACACTTC AGAAAAAGAT GCTCTGATGT CTGAACTGAA AATGATGACT 2040
CACATTGGAA GCCATGAAAA TATTGTGAAC CTGCTAGGAG CTTGCACTGT GTCAGGACCA 2100
ATCTACTTGA TTTTTGAATA CTGTTGCTAT GGTGACCTTC TGAACTACTT AAGGAGCAAG 2160
AGAGAAAAAT TTCACTGGAC GCTGACTGAT ATTTTTAAAC AGCACAACTT CAGTTTCTAT 2220
CACAATATCT GTTCGGAGCA AAATTCCAGA GAGGATGAAC TTAAATCCAC ACAAACAAGC 2280
CAAAACATAA ATATGACCTC TGGGCCAAAT GGGATTGCAC TCTGTTCTGA GGAAGATGAA 2340
ATTAAGTGTG CAAGCAGACA GATGGATGAA GAAGAGGATT TTTGTGTGCT CACTTTTGAA 2400
GACCTTCTAT GCTTCGCTTA TCAAGTTGCC AAAGGAATGG AGTTTCTTGA GTCCAAATTG 2460
TGCATTCACA GAGACCTCGC TGCCCGCAAT ATACTGGTGA CCCATGGGAA AGTCATGAAA 2520
ATCTGTGACT TTGGCCTTGC CAGAGATGTC GTGAATGACT CCAACTACAT CGTCCGGGGC 2580
AATGTTCGCT TACCCGTTAA ATGGATGGCT CCTGAAAGCT TATTTGAGGG GATGTACACC 2640
ATGAAGAGTG ACGTTTGGTC TTTCGGAATA CTGCTGTGGG AAATATTCTC TTTGGGTGTA 2700
AATCCCTACC CTGGCATTCA AGTTGATGCG AACTTCTACA AATTGATTAA AAGTGGATTT 2760
AAAATGGACC GACCTTATTA TGCTACAAAA CACGTCTATT ATGTGATGCA GTCCTGCTGG 2820
GCACTGGACT CCAGAAGAAG ACCCTCATTT TCCCAGCTGG TTTCCTCTCT TGCCTGTCAG 2880
CTGGTGGAGG CAGAGGGAGC AGTTTACCAG AACATGAAGA AAAATGCTTC TCCACCCAAA 2940
TCCAACAACA AAACTAACCC ACGTGTAAGT AAGGCTGAGG AATCTCTTCT GTCCCCACCT 3000
CTGCTCTAA 3009
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+G+vlGsGafGkvv+atayG+sk++ +++vavkmlk+++++sek+almselk+++h+G
Q: 624   LEFGQVLGSGAFGKVVNATAYGISKAGDSVQVAVKMLKEKSDTSEKDALMSELKMMTHIG  683
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact++Gpiy+i+eyccyGdllnylr+kre+f+ + ++++k+++++++++ 
Q: 684   SHENIVNLLGACTVSGPIYLIFEYCCYGDLLNYLRSKREKFHWTLTDIFKQHNFSFYHN-  742
         *******************************************************9887.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         + ++++ r ++  s+++s++ +++  + + +   +++        +      +++ eeed
Q: 743   ICSEQNSREDELKSTQTSQN-INMTSGPNGIALCSEEDEI-----KCA---SRQMDEEED  793
         76777777777777777766.8998877766655443333.....333...344557899
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
           vl++edll+f+yqvakGmefl+sk c+hrdlaarn+l+t+Gkv+kicdfGlard+++d
Q: 794   FCVLTFEDLLCFAYQVAKGMEFLESKLCIHRDLAARNILVTHGKVMKICDFGLARDVVND  853
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         sny+v+Gn rlpvkwmapes+f+++yt+ksdvws+GillweifslG++pypg+ vd++fy
Q: 854   SNYIVRGNVRLPVKWMAPESLFEGMYTMKSDVWSFGILLWEIFSLGVNPYPGIQVDANFY  913
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         klik+G++m++p yat+++y +mq+cw+ ++++rpsf+qlv+
Q: 914   KLIKSGFKMDRPYYATKHVYYVMQSCWALDSRRRPSFSQLVS  955
         ***************************************996
Domain Sequence
(FASTA)
LEFGQVLGSG AFGKVVNATA YGISKAGDSV QVAVKMLKEK SDTSEKDALM SELKMMTHIG 60
SHENIVNLLG ACTVSGPIYL IFEYCCYGDL LNYLRSKREK FHWTLTDIFK QHNFSFYHNI 120
CSEQNSREDE LKSTQTSQNI NMTSGPNGIA LCSEEDEIKC ASRQMDEEED FCVLTFEDLL 180
CFAYQVAKGM EFLESKLCIH RDLAARNILV THGKVMKICD FGLARDVVND SNYIVRGNVR 240
LPVKWMAPES LFEGMYTMKS DVWSFGILLW EIFSLGVNPY PGIQVDANFY KLIKSGFKMD 300
RPYYATKHVY YVMQSCWALD SRRRPSFSQL VS 332
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TAR-00506
EKS-TEN-00504
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013