EKS-GAG-00323

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00323

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	259.9	2.7E-77	165	415	251

Status

Unreviewed

Ensembl Protein

ENSGALP00000027964

UniProt Accession

Q9DF58;

Protein Name

Protein Synonyms/Alias

Integrin-linked kinase;

Gene Name

ILK

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000017335	ENSGALP00000027964	ENSGALT00000028017

Organism

Gallus gallus

Functional Description

Protein Length

422

Protein Sequence
(FASTA)

DDHGFSPLHW ACREGRSNVV DMLIMRGARI NVMNRGDDTP LHLAASHGHR DIVQKLIQFK 60

ADINAVNEHG NTPLHYACFW GHDTVAEDLV GNGALVSIAN KYSETPIDKA KMPLREILKE 120

RAEKLGQNLT KIPYKDTFWK GTTRTRPRNG TLNKLAGIDF KQLSLSQKLN ENQSGELWKG 180

RWQGNDIVIK MLKIRDWTTR KSRDFNEEYP KLRIFSHPNV LPVLGACQSP PAPHPIVISH 240

WMPYGSLYNV LHEGTNFVVD QMQAVKFAFD IARGMAFLHT LEPLIPRHHL NSRSIMIDED 300

MTARISMADV KFSFQCPGRM YAPAWVAPEA LQKKPEEINR RSADMWSFAV LLWELVTREV 360

PFADLSNMEI GMKVALEGLR PTIPPGISPH ICKLMKICMN EDPAKRPKFD MIVPILEKMQ 420

DK 422

Nucleotide Sequence
(FASTA)

GATGACCATG GCTTCAGCCC CCTGCACTGG GCCTGCCGCG AGGGCCGCTC CAACGTGGTG 60

GACATGCTGA TCATGCGGGG AGCGCGCATC AATGTCATGA ACCGCGGTGA TGACACCCCG 120

CTGCACCTGG CAGCCAGCCA CGGCCACCGC GACATCGTGC AGAAGCTGAT CCAGTTCAAA 180

GCGGACATCA ATGCGGTGAA CGAACACGGG AACACCCCCC TACATTATGC CTGCTTCTGG 240

GGACACGACA CGGTGGCAGA GGACCTTGTG GGTAACGGGG CCTTGGTCAG CATTGCCAAC 300

AAGTACAGCG AGACGCCCAT TGACAAAGCC AAGATGCCGC TGCGGGAGAT ACTGAAAGAG 360

CGTGCAGAGA AGCTGGGCCA GAACCTGACC AAGATCCCCT ACAAGGACAC CTTCTGGAAG 420

GGCACGACCC GCACACGGCC CCGAAATGGG ACCCTCAACA AACTTGCTGG AATAGACTTC 480

AAACAGCTGA GCTTGAGCCA AAAACTCAAT GAGAACCAAT CAGGAGAGCT GTGGAAAGGG 540

CGCTGGCAAG GCAATGACAT TGTCATCAAA ATGCTGAAAA TTCGGGACTG GACAACTCGG 600

AAGAGCCGAG ACTTCAACGA GGAGTACCCA AAGCTGCGGA TCTTCTCTCA CCCCAACGTG 660

CTGCCAGTGC TGGGCGCCTG CCAGTCCCCC CCGGCCCCCC ATCCCATTGT CATCAGCCAC 720

TGGATGCCCT ACGGCTCCCT CTACAATGTG TTACATGAGG GGACAAACTT CGTGGTGGAC 780

CAGATGCAGG CGGTGAAATT CGCTTTTGAC ATTGCGCGGG GCATGGCCTT CCTGCACACG 840

CTGGAGCCCC TCATCCCACG GCACCACCTG AACAGCCGCA GCATCATGAT TGACGAGGAC 900

ATGACTGCAA GGATCAGCAT GGCCGACGTG AAGTTCTCCT TCCAGTGCCC TGGGAGGATG 960

TATGCGCCTG CCTGGGTGGC ACCAGAAGCC CTGCAGAAGA AGCCAGAGGA AATTAACAGG 1020

CGCTCGGCGG ACATGTGGAG CTTTGCGGTG CTGCTATGGG AGCTGGTGAC CCGCGAGGTG 1080

CCGTTTGCAG ACTTGTCCAA CATGGAGATA GGCATGAAGG TGGCACTGGA AGGGCTCCGT 1140

CCAACCATCC CCCCTGGCAT CTCCCCACAC ATCTGCAAGC TGATGAAGAT CTGCATGAAT 1200

GAGGACCCGG CCAAGCGCCC AAAGTTCGAC ATGATCGTGC CCATCCTAGA GAAGATGCAG 1260

GACAAGTAG 1269

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         l+++++++++g+++k++w+++++++K l+ ++++++k++++++e  +l+ +shpn++ +l

Q: 165   LSQKLNENQSGELWKGRWQGNDIVIKMLKIRDWTTRKSRDFNEEYPKLRIFSHPNVLPVL  224

         67899*******************************************************

S: 63    Gvcleepn..lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         G+c+++p+   +++ +++++gsL+nvlhe ++ ++d+ ++v++a++iArGma+Lh+ +p

Q: 225   GACQSPPAphPIVISHWMPYGSLYNVLHEGTNFVVDQMQAVKFAFDIARGMAFLHTLEPL  284

         ******997458999******************************************997

S: 121   kiihrdLksknvLlseekktlkicdFGtarelskstkmsaa.gtlawmaPEvlkeekvs.  178

          i +++L+s+++++ +e++t++i++ +++++   s+++  + +++aw+aPE+l++++ +

Q: 285   -IPRHHLNSRSIMI-DEDMTARISM-ADVKF---SFQCPGRmYAPAWVAPEALQKKPEEi  338

         .*************.**********.88888...78999998************999887

S: 179   ..eksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkec  236

           +++D+wS++v+LWel+trevP++dls+++i +kval+glr++ip+ ++++++kLmk c

Q: 339   nrRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHICKLMKIC  398

         7899********************************************************

S: 237   wnedpekRpsfseivks  253

         +nedp+kRp+f++iv +

Q: 399   MNEDPAKRPKFDMIVPI  415

         **************986

Domain Sequence
(FASTA)

LSQKLNENQS GELWKGRWQG NDIVIKMLKI RDWTTRKSRD FNEEYPKLRI FSHPNVLPVL 60

GACQSPPAPH PIVISHWMPY GSLYNVLHEG TNFVVDQMQA VKFAFDIARG MAFLHTLEPL 120

IPRHHLNSRS IMIDEDMTAR ISMADVKFSF QCPGRMYAPA WVAPEALQKK PEEINRRSAD 180

MWSFAVLLWE LVTREVPFAD LSNMEIGMKV ALEGLRPTIP PGISPHICKL MKICMNEDPA 240

KRPKFDMIVP I 251

Keyword

ANK repeat; Integrin; Kinase; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045197	; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0007229	; P:integrin-mediated signaling pathway
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0008284	; P:positive regulation of cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0042327	; P:positive regulation of phosphorylation
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

gga:374018

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR016253	; Integrin-linked_kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 3.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 3.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013