EKS-GAG-00252
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00252
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR462.34.4E-139281526246
StatusUnreviewed
Ensembl ProteinENSGALP00000029065
UniProt AccessionH9L2E8;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000018828ENSGALP00000035095ENSGALT00000035866
ENSGALG00000018828ENSGALP00000029065ENSGALT00000029714
OrganismGallus gallus
Functional Description
Protein Length755
Protein Sequence
(FASTA)
GAYSLTLDLA VRALGLRALQ EISSGMVLIH HNPQLCFLQK VPWDSIFRHP RQHLFQTHNK 60
APEQCESDGL VCFHLCAHGH CWGPGPTQCV SCERFLRGQE CVASCNLLDG ATREHANGTR 120
CLPCHPECQP QNGTETCFGS DADQCVACAH YKDGQQCVRR CPSGVKVDAS FVPIWKYPDE 180
EGVCQLCPTN CTHSCTIRDE DGCPVDQKPS QVTSIIAGVV GALLVVVLLL ITVVCVKRRR 240
QQERKHTMRR LLQETELVEP LTPSGALPNQ AQMRILKETE LKKVKVLGSG AFGTVYKGIW 300
IPDGESVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS PYVSRLLGIC LTSTVQLVTQ 360
LMPYGCLLDY VRENKDRIGS QDLLNWCVQI AKGMSYLEEV RLVHRDLAAR NVLVKSPNHV 420
KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF THQSDVWSYG VTVWELMTFG 480
AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCE WGDVGTRGRD PTGALNGASA 540
SASGWDESDF RSARSPKCAA AGSVGRKVLN ATRRPRGPRA APRHRARLCA LLPPQSTAET 600
PADTTEGEES AAFPFPPQSL VEGPECPVPE ALEVDGGAKG ALPSPPATRY SEDPTALPGD 660
ESEGLDPEGF ATPGAHATMP EYVNQAGERP SPPRHPCAPP SPPDKPKGHQ GKNGLIKDTK 720
HPFLGPFGRA VENPEYLAPP GLPAPTAFSQ AFDNP 755
Nucleotide Sequence
(FASTA)
GGTGCCTACT CACTGACGCT GGACCTGGCG GTGCGGGCGC TGGGGCTGCG CGCCCTGCAG 60
GAGATCAGCA GCGGGATGGT GCTCATCCAC CACAACCCCC AGCTCTGCTT CCTCCAGAAG 120
GTGCCCTGGG ACAGCATCTT CCGCCACCCC CGCCAGCACC TCTTCCAGAC CCACAACAAA 180
GCCCCCGAGC AGTGCGAGAG CGATGGCCTG GTGTGCTTCC ACCTCTGCGC CCACGGGCAC 240
TGCTGGGGGC CCGGCCCCAC ACAGTGCGTC TCCTGTGAGC GCTTCCTGCG GGGCCAGGAG 300
TGCGTGGCCT CCTGCAACCT GCTGGATGGT GCCACCCGGG AGCACGCCAA CGGCACGCGC 360
TGCCTGCCCT GCCACCCCGA GTGCCAGCCA CAGAACGGCA CCGAGACCTG CTTTGGATCG 420
GATGCGGATC AGTGCGTGGC ATGCGCGCAC TACAAGGATG GGCAGCAGTG CGTGCGGCGC 480
TGCCCCAGCG GGGTGAAAGT GGATGCCTCT TTTGTGCCCA TCTGGAAGTA CCCGGACGAG 540
GAGGGGGTCT GCCAGCTCTG CCCCACCAAC TGCACCCACT CGTGCACCAT CCGGGATGAG 600
GACGGCTGCC CCGTGGACCA GAAGCCAAGC CAGGTGACGT CCATCATTGC TGGAGTGGTG 660
GGGGCTCTGC TGGTTGTCGT CCTTCTGCTC ATCACCGTGG TCTGCGTCAA GCGCCGGCGG 720
CAGCAGGAGA GGAAGCACAC CATGCGGCGG CTGCTGCAGG AGACCGAGCT GGTGGAGCCG 780
CTGACACCCA GCGGGGCCCT CCCCAACCAA GCGCAGATGC GCATCCTCAA GGAGACGGAG 840
CTGAAGAAAG TGAAGGTTTT GGGCTCCGGC GCTTTCGGCA CTGTCTATAA GGGCATCTGG 900
ATCCCTGACG GGGAGAGCGT GAAGATCCCG GTGGCCATCA AGGTGTTGCG GGAGAACACC 960
TCGCCCAAAG CCAACAAGGA GATCCTGGAT GAAGCCTACG TGATGGCCGG GGTGGGCAGC 1020
CCCTACGTGT CGCGGCTGCT GGGCATCTGC CTGACCTCCA CGGTGCAGCT GGTGACGCAG 1080
CTGATGCCCT ACGGCTGCTT GCTGGACTAC GTGCGGGAGA ACAAGGACCG CATCGGCTCC 1140
CAGGACCTGC TCAACTGGTG TGTGCAGATC GCCAAGGGGA TGAGCTACCT GGAGGAGGTG 1200
CGGCTGGTGC ACCGTGATTT GGCTGCTCGC AACGTCCTGG TCAAGAGCCC CAACCACGTC 1260
AAAATCACCG ACTTCGGGCT GGCACGGCTG CTTGATATCG ACGAGACCGA GTACCACGCC 1320
GACGGGGGCA AGGTCCCCAT CAAGTGGATG GCGCTGGAGT CCATTCTGCG CCGGCGCTTC 1380
ACCCACCAGA GCGACGTCTG GAGCTACGGC GTCACCGTGT GGGAGCTGAT GACCTTTGGG 1440
GCGAAACCAT ACGATGGGAT CCCGGCGCGG GAGATCCCCG ACCTGCTGGA GAAAGGCGAG 1500
CGGCTGCCGC AGCCGCCCAT CTGCACCATC GACGTCTACA TGATCATGGT GAAATGTGAG 1560
TGGGGGGACG TGGGGACACG GGGCCGGGAC CCCACCGGCG CCCTGAACGG CGCCTCGGCT 1620
TCTGCCTCAG GCTGGGATGA ATCGGACTTC CGGAGTGCCC GGAGCCCCAA ATGTGCTGCT 1680
GCGGGGTCTG TGGGGCGCAA AGTCCTTAAC GCTACCCGGA GACCCCGTGG ACCCCGTGCA 1740
GCCCCACGGC ACCGTGCTCG ACTCTGTGCC CTTTTGCCTC CTCAGAGCAC AGCAGAGACC 1800
CCAGCCGACA CGACAGAGGG CGAGGAATCA GCCGCCTTCC CCTTCCCACC GCAGAGCCTG 1860
GTGGAGGGCC CAGAGTGCCC CGTGCCGGAG GCTCTGGAGG TGGATGGTGG GGCCAAGGGA 1920
GCCCTGCCAA GCCCCCCAGC CACACGGTAC AGCGAGGACC CCACTGCGCT GCCAGGCGAT 1980
GAGAGCGAGG GTCTGGACCC TGAGGGCTTC GCCACCCCAG GTGCCCATGC CACTATGCCA 2040
GAGTACGTGA ATCAGGCTGG GGAGCGGCCG TCGCCCCCCC GGCACCCCTG TGCACCACCA 2100
TCCCCACCAG ACAAGCCCAA GGGCCACCAA GGCAAGAATG GGCTCATCAA GGACACCAAG 2160
CACCCCTTCC TGGGGCCCTT TGGCCGCGCC GTGGAGAACC CTGAGTACCT GGCACCCCCG 2220
GGGCTGCCGG CCCCCACCGC CTTCAGCCAG GCCTTCGACA ACCCC 2265
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkk+kvlGsGafGtvykGiwip+ge+vkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 281   LKKVKVLGSGAFGTVYKGIWIPDGESVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  340
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclldyvre+kd++Gsq+llnwcvqiakGmsylee 
Q: 341   PYVSRLLGICLTSTVQLVTQLMPYGCLLDYVRENKDRIGSQDLLNWCVQIAKGMSYLEEV  400
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 401   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  460
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkc 
Q: 461   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCE  520
         ***********************************************************7
S: 241   midaes  246
           d  +
Q: 521   WGDVGT  526
         766655
Domain Sequence
(FASTA)
LKKVKVLGSG AFGTVYKGIW IPDGESVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDY VRENKDRIGS QDLLNWCVQI AKGMSYLEEV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCE 240
WGDVGT 246
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Homo sapiens"; ?>Meleagris gallopavo"; ?>Ornithorhynchus anatinus"; ?>Pelodiscus sinensis"; ?>
EKS-CAJ-00305
EKS-HOS-00305
EKS-MEG-00240
EKS-ORA-00264
EKS-PES-00267
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 2.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013