EKS-GAG-00312
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00312
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src441.77.6E-133227477251
StatusUnreviewed
Ensembl ProteinENSGALP00000029288
UniProt AccessionF1NUU2;
Protein Name
Protein Synonyms/Alias
Gene NameLYN
Gene Synonyms/Alias LYN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000018967ENSGALP00000024733ENSGALT00000024779
ENSGALG00000018967ENSGALP00000029288ENSGALT00000029932
OrganismGallus gallus
Functional Description
Protein Length492
Protein Sequence
(FASTA)
MGCIKSKRKA NLHGDGLDLK NQPANTDAHL LPGQIFANEE TEEHGVIVVA LYPYDGLHED 60
DLSFKKGEKL KVIEELGEWW KARSLTTKKE GFIPSNYVAK VNTLETEEWF FKDITRKDAE 120
RQLLAPGNGP GAFLIRESET LKGSYSLSIR DYDPQHGDVI KHYKIRSLDN GGFYISPRIT 180
FPSINDMIKH YQKQSDGLCR KLEKACISPK PQKPWDKDAW EIPRESIKLV KKLGAGQFGE 240
VWMGYYHNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD KLVRLYAVVT KEEPIYIITE 300
FMAKGSLLDF LKSDEGSRLM LPKLIDFSAQ IAEGMAYIER KNYIHRDLRA ANVLVSDLLM 360
CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINYGSF TIKSDVWSFG ILLYEIVTYG 420
KIPYPGMSNS DVMVALQRGY RMPRMETCPA ELYDIMKTCW KDKAKERPTF DYLQSVLDDF 480
YTATEGQYQQ QP 492
Nucleotide Sequence
(FASTA)
ATGGGATGTA TAAAATCAAA AAGGAAAGCG AATCTGCATG GAGATGGGCT AGATTTGAAG 60
AATCAACCAG CAAATACAGA TGCACACCTT CTACCCGGAC AGATATTTGC CAATGAAGAA 120
ACAGAAGAGC ATGGAGTCAT TGTAGTAGCT CTGTATCCTT ATGATGGCCT TCATGAAGAT 180
GACTTGTCCT TCAAAAAAGG AGAAAAATTG AAAGTTATTG AGGAGCTGGG AGAATGGTGG 240
AAAGCTAGAT CTCTCACAAC AAAGAAAGAA GGTTTCATTC CCAGCAATTA CGTAGCAAAA 300
GTAAACACCT TGGAAACAGA AGAGTGGTTC TTCAAAGACA TAACTCGAAA AGATGCTGAA 360
AGGCAACTCC TGGCTCCTGG AAATGGCCCT GGAGCATTCC TTATCAGAGA AAGTGAAACA 420
TTAAAAGGCA GTTATTCTCT GTCCATAAGA GACTATGATC CCCAACATGG TGATGTCATT 480
AAGCACTACA AAATTAGGAG TCTAGACAAT GGAGGATTTT ACATCTCTCC AAGAATAACT 540
TTTCCCAGCA TCAATGATAT GATCAAGCAT TATCAAAAAC AATCAGATGG CTTATGCAGA 600
AAATTGGAAA AAGCTTGTAT TAGTCCAAAG CCTCAAAAAC CGTGGGATAA AGATGCATGG 660
GAAATTCCAC GAGAGTCAAT TAAATTAGTG AAGAAGCTCG GAGCTGGTCA GTTTGGAGAA 720
GTCTGGATGG GTTACTATCA TAATAGTACA AAAGTGGCTG TGAAGACTTT GAAGCCTGGA 780
ACGATGTCTG TGCAAGCCTT TCTGGAGGAA GCCAACCTCA TGAAGACGCT TCAGCATGAC 840
AAGCTAGTTA GGCTTTATGC TGTAGTGACC AAAGAAGAAC CTATTTATAT AATAACAGAA 900
TTCATGGCAA AAGGAAGCTT GCTGGATTTT CTGAAGAGTG ATGAAGGAAG TAGATTGATG 960
CTTCCAAAGC TAATTGACTT CTCTGCTCAG ATTGCAGAAG GGATGGCATA CATAGAAAGA 1020
AAAAATTACA TCCATCGAGA TTTGAGAGCA GCTAATGTTC TGGTTTCAGA CTTACTGATG 1080
TGCAAAATTG CTGATTTTGG ACTAGCTAGA GTCATTGAAG ACAACGAATA TACAGCAAGA 1140
GAAGGTGCAA AGTTCCCTAT TAAATGGACA GCACCGGAGG CGATCAACTA TGGATCTTTC 1200
ACTATTAAAT CTGATGTATG GTCATTTGGG ATTCTCCTGT ATGAAATCGT TACATATGGA 1260
AAGATTCCTT ATCCAGGTAT GAGCAATTCA GATGTGATGG TTGCTCTTCA GCGGGGGTAC 1320
CGAATGCCAC GTATGGAAAC CTGTCCAGCT GAGCTTTATG ATATCATGAA AACATGCTGG 1380
AAAGACAAAG CAAAAGAAAG GCCGACCTTT GATTACCTAC AGAGCGTACT TGATGATTTC 1440
TACACAGCAA CAGAAGGGCA ATATCAACAG CAGCCATAG 1479
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         +klvkklG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly
Q: 227   IKLVKKLGAGQFGEVWMGYYHNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  286
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++eePiyi+te+makGslldflk++eg++l lpkl+d++aq+aeGmay+e+kn+ihr
Q: 287   AVVTKEEPIYIITEFMAKGSLLDFLKSDEGSRLMLPKLIDFSAQIAEGMAYIERKNYIHR  346
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+nvlv++ l++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 347   DLRAANVLVSDLLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDV  406
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+Gk+PypGm+n++v+ +++rgyr+pr+e+cp+ely+++++cwk +++e
Q: 407   WSFGILLYEIVTYGKIPYPGMSNSDVMVALQRGYRMPRMETCPAELYDIMKTCWKDKAKE  466
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++lq+vl
Q: 467   RPTFDYLQSVL  477
         ********986
Domain Sequence
(FASTA)
IKLVKKLGAG QFGEVWMGYY HNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60
AVVTKEEPIY IITEFMAKGS LLDFLKSDEG SRLMLPKLID FSAQIAEGMA YIERKNYIHR 120
DLRAANVLVS DLLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN YGSFTIKSDV 180
WSFGILLYEI VTYGKIPYPG MSNSDVMVAL QRGYRMPRME TCPAELYDIM KTCWKDKAKE 240
RPTFDYLQSV L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00342
EKS-ANC-00358
EKS-BOT-00368
EKS-CAJ-00372
EKS-CAF-00369
EKS-CAP-00401
EKS-DAR-00748
EKS-EQC-00359
EKS-ERE-00004
EKS-GAM-00222
EKS-GAA-00452
EKS-GOG-00359
EKS-HOS-00374
EKS-ICT-00348
EKS-LAC-00384
EKS-LOA-00377
EKS-MAM-00368
EKS-MOD-00359
EKS-MUM-00400
EKS-MUP-00362
EKS-MYL-00366
EKS-NOL-00336
EKS-ORN-00477
EKS-ORA-00322
EKS-ORC-00346
EKS-ORL-00439
EKS-OTG-00372
EKS-PAT-00348
EKS-PES-00327
EKS-POA-00358
EKS-RAN-00382
EKS-SAH-00338
EKS-SUS-00327
EKS-TAG-00441
EKS-TAS-00040
EKS-TEN-00466
EKS-XET-00488
EKS-XIM-00465
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001782; P:B cell homeostasis
GO:0050853; P:B cell receptor signaling pathway
GO:0071300; P:cellular response to retinoic acid
GO:0002774; P:Fc receptor mediated inhibitory signaling pathway
GO:0002431; P:Fc receptor mediated stimulatory signaling pathway
GO:0035556; P:intracellular signal transduction
GO:0030889; P:negative regulation of B cell proliferation
GO:0070373; P:negative regulation of ERK1 and ERK2 cascade
GO:0043407; P:negative regulation of MAP kinase activity
GO:0070667; P:negative regulation of mast cell proliferation
GO:0002762; P:negative regulation of myeloid leukocyte differentiation
GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0002576; P:platelet degranulation
GO:0030335; P:positive regulation of cell migration
GO:2000670; P:positive regulation of dendritic cell apoptotic process
GO:0070668; P:positive regulation of mast cell proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0002902; P:regulation of B cell apoptotic process
GO:0050855; P:regulation of B cell receptor signaling pathway
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0050707; P:regulation of cytokine secretion
GO:0045646; P:regulation of erythrocyte differentiation
GO:0050727; P:regulation of inflammatory response
GO:0043304; P:regulation of mast cell degranulation
GO:0090025; P:regulation of monocyte chemotaxis
GO:0090330; P:regulation of platelet aggregation
GO:0006974; P:response to DNA damage stimulus
GO:0009725; P:response to hormone stimulus
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013