EKS-GAG-00330

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00330

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	348.9	2.4E-104	1300	1558	259

Status

Unreviewed

Ensembl Protein

ENSGALP00000018870

UniProt Accession

E1BXN6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000020003	ENSGALP00000018870	ENSGALT00000018893

Organism

Gallus gallus

Functional Description

Protein Length

1565

Protein Sequence
(FASTA)

MEEPPPPPPG RKECKSEDAT CKISESEPEE LSDEASADTF YGTSPPSTPR QMKRMSTKHQ 60

KNNVGRPASR STLKEKMSIP PQSVHKDNGK TIENVEEHSY KQGKKMRDTL RTTERDHKKN 120

VQCSFMLDSV GGSLPKKTIP DVDLNKPYLS LGCSNAKLPV SVPMPISRTA RQTSRTDCPA 180

DRLKFFETLR LLLKLTSVSK KKDREQRGQE STSSVWLNRS NELIWLELQA WHAGRSINDQ 240

DLYLYAARQA IPDIINEILT FKVNYGSFSY VKNGASLNGT SGEGVCKATH GTSALGYSSY 300

HEHLHRQRIS FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT 360

KDLNQKLRIM GTVLGIKNLS DIGWPVFEIP SPRPSKDDDP EDEGVDRETE VKESSGTCTE 420

ESDGEEQISE ENVEELRQAI KNNFTNQPNF DFQDHFSRKL DRLESGDDSA SWIIPECSAE 480

AGCSKHCLTS IYRPFVDKAL KQMGLRKLIL RLHKLMHGSL QRARMALVRS DCPLEFSECP 540

DPMLCSDYVQ LLNSPPCCEQ KCSTVSWEEL KSMDLPSFEP AFLVLCRVLL NVIHECLKLR 600

LEQRPAGEPS LLSIKQLVRE CKEVLKGGLL MKQYYQFMLR EVLDDLQKID CNIDAFEEDL 660

HKMLMVYFDY MRSWIQMLQQ LPQASHSLKN LLEEEWNFTK EITPYIRGGE AQAGKLFCDI 720

AGMLLKSTGI FLDSGLQDSC DEFWASADDS TASDEIRRSV IETSRALKEL FHEARERASK 780

ALGFAKMLRK DLEIAAEFAL SAPVRDLLNA LKTKEYVKVQ IPGLENLQVF VPNSIAGEKS 840

VILQLLNAAA GKDCSKDSDE VAYEAYLIMT KHSDKDHELG DMWSAWEGQP VKVVPQVETV 900

DTLRSMQVDN LLLVVIQSAH LVSQRKAFQQ SIEGLISLHQ EQTSSQPVIA KALQQLKNDA 960

LQLCNKISSA IDRVDHMFTS EFDAEVDESE SATLQQYYRE AMIQAYNFGF EYHKEVVRLM 1020

SGEFRQKIGD KYISFARKWM NYVLTKCESG RGTRPRWATQ GFDFLQAIEP AFISALPEDD 1080

FLSLQALMNE CIGHVIGKPH SPVTGLYLAI HRNSPRPVKV PRCHSDPPNP HLIIPTPEGF 1140

SHSTRSVPCD ARNPCNVTVS RPAPIGSDST QPKSVSSAND TRGSSVPEND RLASIAAELQ 1200

FRSLSRHSSP TEEREEPSYP KGDSSGSSRR SWELRTLINQ TKDTVSKQAP IEAVQKSVQL 1260

FEERRYREMR RKNIIGQVCD TPKSYDNVMH VGLRKVTFKW QRGNKIGEGQ YGKVYTCISV 1320

DTGELMAMKE IRFQPNDHKT IKETADELKI FEGIKHPNLV RYFGVELHRE EMYIFMEYCD 1380

EGTLEEVSKL GLQEHVIRLY TKQITIAINV LHEHGIVHRD IKGANIFLTS SGLIKLGDFG 1440

CSVKLKNNTQ TMPGEVNSTL GTAAYMAPEV ITRAKGEGHG RAADIWSLGC VVIEMVTGKR 1500

PWHEYEHNFQ IMYRVGMGHK PPIPDKVSPE GKDFLCHCLE SDPKMRWTAS QLLDHPFVKV 1560

CTDEE 1565

Nucleotide Sequence
(FASTA)

ATGGAGGAGC CGCCGCCGCC GCCGCCGGGG AGGAAAGAGT GCAAATCAGA AGATGCTACT 60

TGCAAGATCT CTGAATCTGA ACCTGAGGAG TTATCAGATG AAGCAAGTGC TGACACCTTC 120

TATGGAACTT CTCCTCCTAG TACACCCCGC CAGATGAAGC GTATGTCAAC AAAGCATCAG 180

AAAAACAACG TCGGGAGACC TGCTAGCCGC TCTACTTTGA AAGAAAAGAT GAGTATACCA 240

CCTCAATCCG TGCATAAAGA CAATGGGAAA ACCATTGAGA ACGTGGAGGA GCACAGCTAT 300

AAGCAAGGGA AAAAAATGCG TGACACCCTA AGGACGACAG AACGAGATCA CAAGAAAAAT 360

GTGCAGTGCT CGTTTATGTT AGACTCAGTT GGCGGGTCTC TGCCAAAAAA AACAATTCCA 420

GATGTTGATC TCAATAAGCC TTACCTCAGC CTTGGCTGTA GCAATGCTAA GCTTCCAGTC 480

TCTGTGCCCA TGCCAATCTC CAGAACTGCA CGCCAGACTT CTAGGACTGA TTGCCCAGCG 540

GACCGCTTAA AATTCTTTGA AACCCTGCGG CTTTTGTTAA AACTTACCTC AGTCTCGAAA 600

AAAAAGGACA GGGAGCAAAG AGGACAGGAA AGCACCTCTT CTGTCTGGCT GAACCGATCC 660

AATGAACTGA TCTGGCTAGA GCTGCAAGCT TGGCATGCTG GCCGGAGTAT TAATGACCAA 720

GACCTTTATC TCTATGCAGC CCGTCAAGCT ATCCCTGATA TTATCAATGA AATCCTTACA 780

TTCAAAGTGA ACTATGGAAG CTTCTCCTAT GTAAAAAATG GAGCCAGTCT CAATGGTACG 840

TCAGGAGAAG GAGTTTGCAA AGCAACACAT GGAACCAGTG CTTTGGGTTA CTCAAGTTAC 900

CACGAACACC TCCATCGCCA GCGAATCTCA TTTGAGCAAG TAAAGCGAAT AATGGAACTG 960

CTAGAGTATA TAGAAGCACT TTATCCATCT CTGCAGGCTC TTCAAAAGGA CTATGAAAAG 1020

TATGCTGCAA AAGACTTCCA GGACAGAGTG CAGGCACTCT GTCTGTGGTT GAACATTACA 1080

AAAGACTTAA ATCAAAAGCT AAGGATTATG GGGACTGTTT TGGGCATCAA AAATCTCTCT 1140

GACATTGGCT GGCCAGTGTT TGAAATTCCT TCTCCTCGAC CGTCTAAGGA CGATGATCCA 1200

GAGGATGAAG GAGTTGATAG GGAAACTGAA GTAAAGGAAT CCTCAGGAAC ATGCACAGAG 1260

GAGAGCGATG GCGAAGAACA AATCTCTGAG GAGAATGTTG AGGAACTTAG ACAAGCCATC 1320

AAGAACAATT TTACTAATCA GCCAAATTTC GACTTTCAGG ACCATTTTTC AAGGAAGCTT 1380

GATAGGCTTG AATCTGGGGA TGACTCTGCC TCTTGGATTA TTCCAGAATG CAGTGCTGAG 1440

GCAGGCTGCA GCAAACACTG TTTGACTTCT ATTTACAGGC CGTTTGTAGA CAAAGCACTG 1500

AAGCAAATGG GGTTGAGGAA GCTAATTTTA AGACTACACA AGCTAATGCA TGGTTCATTG 1560

CAAAGGGCTC GTATGGCGTT GGTAAGGAGT GATTGCCCGC TGGAGTTTTC AGAATGTCCA 1620

GATCCCATGT TGTGTTCAGA TTACGTGCAG TTATTAAATT CCCCACCTTG CTGTGAGCAA 1680

AAATGCAGCA CTGTATCATG GGAAGAGCTC AAATCCATGG ATTTGCCATC TTTTGAACCT 1740

GCATTCTTGG TCCTTTGCCG AGTCCTGCTC AATGTTATCC ATGAATGTCT CAAGCTAAGG 1800

TTGGAACAAA GGCCTGCTGG GGAGCCATCT CTTTTGAGTA TTAAACAGCT AGTGAGGGAG 1860

TGTAAGGAGG TTCTGAAGGG TGGCCTGTTA ATGAAGCAAT ATTACCAATT TATGTTGCGT 1920

GAGGTGTTAG ATGACTTGCA AAAGATTGAT TGCAACATTG ATGCTTTTGA AGAGGACCTG 1980

CATAAAATGT TGATGGTTTA CTTTGATTAC ATGCGAAGCT GGATCCAAAT GCTACAGCAG 2040

TTACCTCAAG CATCTCATAG TTTAAAAAAT CTCCTAGAGG AAGAATGGAA TTTCACCAAA 2100

GAAATAACTC CATATATAAG AGGAGGAGAA GCTCAAGCTG GAAAACTATT TTGTGATATT 2160

GCAGGAATGC TGCTGAAATC TACAGGAATA TTTTTAGATT CTGGACTACA AGACAGTTGT 2220

GATGAATTTT GGGCCAGTGC CGATGACAGT ACTGCATCAG ATGAAATAAG GAGGTCTGTC 2280

ATAGAGACCA GCCGAGCACT CAAGGAACTG TTTCATGAAG CTAGAGAAAG GGCCTCCAAG 2340

GCTCTTGGAT TTGCTAAAAT GCTGAGGAAG GACCTTGAAA TAGCAGCAGA GTTTGCATTG 2400

TCAGCCCCTG TCCGAGATCT TCTGAATGCT CTGAAAACGA AAGAGTATGT GAAGGTACAA 2460

ATCCCTGGAC TCGAGAATTT ACAAGTATTT GTCCCAAATA GTATTGCAGG TGAAAAGTCT 2520

GTGATTTTGC AGCTCCTAAA TGCGGCTGCT GGGAAAGATT GCTCAAAAGA TTCAGATGAG 2580

GTTGCATATG AGGCCTATTT AATAATGACC AAACACAGTG ACAAAGACCA TGAATTAGGT 2640

GACATGTGGA GTGCATGGGA GGGCCAACCA GTCAAAGTGG TGCCACAAGT GGAAACTGTT 2700

GATACGCTAC GAAGCATGCA GGTTGACAAC CTCCTTCTCG TAGTCATTCA GTCTGCCCAC 2760

CTTGTGAGTC AGCGAAAAGC TTTCCAACAG TCTATAGAAG GGCTCATATC ACTCCACCAG 2820

GAACAGACAT CCAGCCAACC AGTCATTGCC AAAGCTCTGC AGCAACTAAA GAATGATGCA 2880

TTGCAGCTAT GCAATAAGAT AAGCAGTGCC ATTGACAGAG TTGATCATAT GTTCACATCT 2940

GAGTTTGATG CTGAAGTTGA TGAATCTGAA TCTGCGACTT TGCAGCAATA CTACCGGGAA 3000

GCCATGATTC AGGCTTACAA TTTTGGGTTT GAGTACCACA AAGAAGTTGT TCGTCTGATG 3060

TCTGGAGAAT TCAGGCAGAA AATTGGAGAC AAATATATCA GCTTTGCCAG AAAGTGGATG 3120

AACTACGTGC TAACAAAATG TGAGAGTGGC CGAGGCACTC GACCCAGGTG GGCAACTCAA 3180

GGTTTTGATT TTCTTCAAGC CATTGAACCA GCATTTATTT CGGCTCTCCC AGAAGATGAT 3240

TTCTTGAGTT TGCAAGCTCT GATGAATGAG TGCATTGGCC ACGTTATTGG AAAACCTCAC 3300

AGTCCTGTTA CAGGTCTGTA CCTTGCTATT CATCGGAACA GTCCCCGTCC CGTGAAAGTA 3360

CCTCGATGCC ATAGTGATCC ACCGAATCCT CATCTTATCA TCCCCACTCC TGAAGGCTTC 3420

AGCCACAGCA CACGGAGCGT CCCTTGCGAT GCACGGAACC CTTGCAACGT TACTGTCAGT 3480

CGCCCCGCTC CCATTGGTAG TGACTCAACT CAACCTAAAT CTGTCAGCAG TGCAAATGAT 3540

ACCAGGGGTT CCAGTGTCCC CGAAAATGAT CGACTGGCTT CAATAGCAGC CGAGTTGCAG 3600

TTCAGATCCC TTAGTCGTCA CTCCAGTCCC ACTGAGGAGC GAGAAGAACC ATCATATCCA 3660

AAAGGAGATT CAAGTGGCTC ATCCCGGCGG AGTTGGGAGC TCAGAACCTT AATCAACCAG 3720

ACCAAAGACA CTGTTTCCAA ACAAGCACCA ATAGAAGCTG TTCAGAAGTC TGTTCAGTTG 3780

TTTGAAGAAA GGAGATACAG AGAGATGAGG AGGAAGAATA TCATTGGCCA AGTTTGCGAC 3840

ACACCAAAAT CCTACGATAA TGTCATGCAT GTAGGGTTGA GAAAAGTGAC TTTCAAGTGG 3900

CAGAGAGGAA ACAAAATTGG TGAAGGCCAA TATGGGAAAG TATATACCTG CATTAGTGTT 3960

GACACTGGAG AGCTGATGGC TATGAAAGAA ATAAGATTTC AACCTAATGA TCACAAAACC 4020

ATCAAAGAAA CAGCTGATGA ACTGAAGATT TTTGAAGGCA TCAAACACCC TAATCTTGTT 4080

CGGTATTTTG GTGTGGAGCT CCATAGGGAA GAGATGTACA TCTTCATGGA GTACTGTGAT 4140

GAGGGCACGC TGGAGGAGGT GTCAAAACTG GGCCTTCAGG AGCATGTCAT TAGGCTCTAC 4200

ACAAAGCAGA TCACCATTGC TATCAATGTA CTACATGAAC ACGGTATTGT TCATCGAGAC 4260

ATTAAAGGAG CCAACATCTT TCTTACCTCA TCCGGACTGA TTAAACTGGG TGACTTTGGC 4320

TGCTCAGTAA AACTAAAGAA CAACACTCAA ACAATGCCTG GAGAAGTGAA CAGTACATTG 4380

GGTACTGCAG CGTACATGGC TCCAGAAGTA ATTACTAGAG CAAAAGGAGA AGGGCATGGA 4440

CGTGCAGCAG ACATCTGGAG CCTGGGCTGT GTTGTTATAG AGATGGTCAC TGGCAAGAGG 4500

CCTTGGCACG AATATGAGCA CAACTTCCAG ATCATGTATA GAGTGGGGAT GGGTCATAAA 4560

CCTCCTATTC CTGACAAAGT GAGTCCGGAG GGGAAAGACT TCCTTTGCCA CTGCCTGGAA 4620

AGTGACCCAA AGATGAGGTG GACAGCCAGC CAGCTCCTCG ACCATCCTTT TGTCAAGGTT 4680

TGCACAGATG AAGAATGA 4698

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1300  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1356

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ ytkqi  ++++LHe+

Q: 1357  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSKL--GLQEHVIRLYTKQITIAINVLHEH  1414

         *******************************774..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1415  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNTQTMpGEVNSTLGTAAYMAPEVITRa  1474

         ********************************9987762569****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im++vg+ + kP+ip+k+s+egkd

Q: 1475  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYRVGMGH-KPPIPDKVSPEGKD  1533

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl +cle+dpk r++a++LL+h+f+

Q: 1534  FLCHCLESDPKMRWTASQLLDHPFV  1558

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSK LGLQEHVIRL YTKQITIAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNT QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYRVGMGH KPPIPDKVSP EGKDFLCHCL 240

ESDPKMRWTA SQLLDHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043507	; P:positive regulation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013