EKS-GAG-00340
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00340
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR576.32.7E-173567924358
StatusUnreviewed
Ensembl ProteinENSGALP00000009178
UniProt AccessionF1N868;
Protein Name
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000021313ENSGALP00000009178ENSGALT00000009192
OrganismGallus gallus
Functional Description
Protein Length956
Protein Sequence
(FASTA)
IEPEDAELVL RLHSTFSLVC YGDGTLVWER DGQPLTAVLE HRDGVFISNL TLRNVTGRHT 60
GEYACFYSPD QAPERAERKA LYIYVPDPSL VFLPAITSEE FFIFITGYTE ATIPCRVTNP 120
ELQVTLYEKK VENPIPATYD PQQGFKGFFE DKTYYCQAIV DDQEVDSDTF YVYRIQVSSV 180
NVSISAVQTV VRQGENVTLM CTVSGNELVN FNWDYPRKQA GKAVEPVTDF LPGSTHDIRS 240
ILIIQNAELE DSGTYVCNVS EGYHEKTDRK DITVQVIERG FVRFHTHLAS TVYAEVHKSH 300
IIQVDVEAYP QPNIVWLKNN KTLTMESSSE FTITNRNLSE TRYQTSLVLV RVKQEEGGYY 360
TIRASNEDDA QELSFHLQIN VPAKVVDLKE NSSASSGEQT VTCSAEGMPQ PEISWSTCSN 420
IKWCGSQGQP TQLLGNNSAE IGLHTNATYH AELQVYRVNS TLQLHRVDEP LLLRCTVQNF 480
LGSNSQDITL VPNALPFKVV IISVILALLV LTVISLIILI ILWQKKPRYE IRWKVIESVS 540
SDGHEYIYVD PMQLPYDSSW EVPRDKLVLG RTLGSGAFGR VVEATAHGLS HSQSTMKVAV 600
KMLKSTARSS EKQALMSELK IMSHLGPHLN IVNLLGACTK GGPIYIITEY CRYGDLVDYL 660
HRNKHTFLQS YGEKARREAE LYGNTIKEDH VQSHLSLSVE SDGGYMDMSK DESLDYVPMS 720
DMKGEVKYAD IESSNYGTPY ELDSYSPSAP ERTDRVTLIN ESPLLSYMDL VGFSFQVANG 780
MEFLASKNCV HRDLAARNVL ICEGKLVKIC DFGLARDIMR DSNYISKGST FLPLKWMAPE 840
SIFNNLYTTL SDVWSFGILL WEIFTLGGTP YPELPMNEQF YNAIKRGYRM SKPTHASDEI 900
YDIMQKCWEE KFEIRPSFSQ LVVLMGNLLV DCYRKRYQQV DEEFMKSDHP AVVRTR 956
Nucleotide Sequence
(FASTA)
ATCGAACCTG AAGATGCTGA GCTCGTCCTT AGGCTCCACA GCACTTTCTC CCTCGTGTGC 60
TATGGGGACG GCACGCTGGT CTGGGAGCGG GATGGTCAGC CTCTCACTGC CGTGCTGGAG 120
CACAGGGACG GGGTCTTCAT CAGCAACCTC ACCCTCAGGA ACGTGACAGG CCGTCACACG 180
GGGGAGTATG CGTGCTTCTA CAGCCCCGAC CAGGCTCCAG AGCGAGCAGA GAGGAAAGCC 240
CTTTACATCT ACGTTCCAGA TCCCTCCTTA GTTTTTCTCC CCGCAATCAC TTCTGAAGAG 300
TTCTTCATCT TCATCACGGG CTACACAGAG GCCACCATCC CATGCCGTGT GACCAACCCA 360
GAGCTGCAGG TGACCCTCTA TGAAAAGAAA GTGGAGAATC CCATTCCAGC TACTTATGAC 420
CCACAACAGG GCTTCAAAGG CTTCTTTGAG GACAAGACCT ACTACTGCCA GGCAATCGTG 480
GATGACCAAG AGGTGGATTC AGACACCTTC TATGTCTACC GGATCCAGGT CTCATCTGTG 540
AACGTCTCCA TCAGCGCAGT GCAGACCGTA GTGCGGCAGG GAGAAAATGT TACCCTGATG 600
TGCACTGTCA GTGGCAATGA GCTGGTCAAC TTCAACTGGG ATTATCCCCG CAAGCAGGCA 660
GGGAAGGCTG TGGAGCCAGT GACCGATTTC CTACCTGGAT CCACCCATGA CATCCGTTCC 720
ATCCTCATCA TCCAGAATGC AGAGCTAGAG GACAGTGGGA CCTACGTCTG CAATGTCTCT 780
GAGGGCTACC ATGAGAAGAC AGACCGGAAA GACATCACGG TCCAAGTGAT CGAGCGTGGC 840
TTTGTACGCT TCCACACCCA CCTGGCCAGC ACGGTGTATG CTGAGGTCCA CAAGAGCCAC 900
ATCATCCAGG TGGATGTGGA GGCCTACCCA CAGCCAAACA TTGTGTGGCT GAAGAACAAC 960
AAGACATTGA CCATGGAGAG CAGCAGCGAG TTCACCATCA CCAACAGGAA CCTGTCAGAA 1020
ACCAGGTATC AGACGTCTCT GGTCCTGGTG CGTGTGAAGC AGGAGGAAGG AGGATATTAC 1080
ACCATCCGAG CTTCCAATGA GGATGATGCA CAAGAGCTGT CCTTCCATCT GCAGATAAAT 1140
GTGCCAGCCA AAGTGGTGGA TCTCAAGGAA AACAGCAGTG CCAGCAGCGG GGAGCAGACT 1200
GTAACGTGCT CTGCTGAAGG GATGCCCCAG CCAGAGATCA GTTGGTCCAC TTGCAGCAAC 1260
ATCAAATGGT GTGGCAGCCA GGGGCAACCC ACCCAGCTGC TGGGGAACAA CTCTGCAGAG 1320
ATTGGCCTGC ACACTAATGC TACGTACCAT GCAGAGCTGC AGGTGTACCG TGTGAACAGC 1380
ACCCTGCAGC TGCACAGGGT GGATGAACCC CTGCTTCTGA GATGCACCGT GCAAAACTTC 1440
CTGGGCTCCA ACTCCCAAGA CATCACTCTG GTCCCAAATG CCTTGCCATT CAAAGTGGTC 1500
ATCATCTCCG TCATCCTGGC TCTGCTGGTC CTCACCGTCA TCTCCCTGAT CATCCTGATC 1560
ATCCTGTGGC AGAAGAAACC TCGCTATGAG ATCCGCTGGA AGGTGATCGA GTCAGTGAGC 1620
TCCGATGGGC ACGAGTACAT CTACGTGGAT CCCATGCAGC TCCCTTATGA CTCCAGCTGG 1680
GAGGTGCCCA GGGACAAGCT GGTGTTAGGA CGCACTCTTG GCTCTGGTGC CTTTGGACGC 1740
GTGGTGGAGG CAACAGCGCA TGGCCTGAGC CATTCACAGT CCACCATGAA AGTGGCAGTC 1800
AAGATGCTCA AGTCCACTGC ACGGAGCAGT GAGAAGCAAG CCCTCATGTC TGAGCTGAAG 1860
ATCATGAGCC ACCTGGGACC TCACCTCAAC ATCGTCAACT TGCTGGGGGC CTGCACCAAA 1920
GGAGGGCCCA TCTATATCAT CACCGAGTAC TGCCGTTATG GGGACCTGGT GGACTACCTG 1980
CACCGCAACA AGCACACCTT CCTGCAGTCC TATGGCGAGA AGGCCCGCCG GGAGGCAGAG 2040
CTGTATGGGA ATACCATCAA GGAGGACCAC GTGCAGAGTC ACCTCTCCTT GTCTGTCGAG 2100
AGCGATGGGG GCTACATGGA CATGAGCAAG GATGAGTCTC TGGATTATGT GCCCATGTCT 2160
GACATGAAGG GTGAAGTCAA GTACGCTGAC ATCGAGTCTT CTAACTATGG CACCCCATAC 2220
GAGCTGGACA GCTATTCCCC ATCAGCTCCG GAAAGAACAG ACCGGGTGAC ACTGATAAAT 2280
GAATCTCCAC TCCTCAGCTA CATGGACTTG GTGGGCTTCA GCTTCCAGGT GGCCAATGGG 2340
ATGGAGTTCC TGGCTTCCAA AAATTGTGTG CATCGTGACC TGGCTGCCAG GAACGTCCTC 2400
ATCTGCGAGG GGAAGCTGGT GAAGATCTGT GACTTTGGTC TGGCAAGAGA CATCATGAGG 2460
GATTCCAACT ACATCTCCAA AGGCAGTACC TTCTTGCCCC TTAAGTGGAT GGCCCCAGAG 2520
AGCATCTTCA ACAACCTCTA CACCACCCTA AGTGATGTGT GGTCCTTTGG GATTCTTCTC 2580
TGGGAGATAT TCACTCTAGG AGGGACTCCC TACCCTGAAC TGCCTATGAA CGAACAGTTC 2640
TACAATGCCA TCAAACGTGG CTATCGGATG TCCAAACCTA CCCATGCTTC TGATGAAATC 2700
TACGATATCA TGCAGAAGTG CTGGGAGGAG AAGTTTGAGA TCAGACCGTC CTTCTCACAG 2760
CTGGTGGTGC TTATGGGAAA CCTCTTGGTG GACTGCTACA GAAAGAGGTA CCAGCAGGTA 2820
GATGAAGAGT TCATGAAGAG CGACCACCCC GCTGTTGTTC GCACAAGA 2868
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s++++kvavkmlkstarssek+almselki+shlG
Q: 567   LVLGRTLGSGAFGRVVEATAHGLSHSQSTMKVAVKMLKSTARSSEKQALMSELKIMSHLG  626
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+++ ek   +e+el+ ++
Q: 627   PHLNIVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQSYGEK-ARREAELYGNT  685
         ******************************************999999.55677888887
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklas..e  162
         + ++ +++s+ sls+es++ y+d++kd                ++d++ss++ ++++  +
Q: 686   I-KEDHVQSHLSLSVESDGGYMDMSKDesldyvpmsdmkgevkYADIESSNYGTPYEldS  744
         7.77889*********************************************99986115
S: 163   kkksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllte  222
         +  sa er+ + +l++e s  l+++dl+ fs+qva+Gmeflaskncvhrdlaarnvl++e
Q: 745   YSPSAPERTDRVTLINE-SPLLSYMDLVGFSFQVANGMEFLASKNCVHRDLAARNVLICE  803
         5678999**9*999999.99****************************************
S: 223   GkvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillwei  282
         Gk+vkicdfGlardim+dsny++kG+++lp+kwmapesif++lyt+ sdvws+Gillwei
Q: 804   GKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNNLYTTLSDVWSFGILLWEI  863
         ************************************************************
S: 283   fslGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         f+lG+tpyp+l+++++fy++ik+Gyrm++p++a++eiy+imqkcwe+++e rpsf+qlv 
Q: 864   FTLGGTPYPELPMNEQFYNAIKRGYRMSKPTHASDEIYDIMQKCWEEKFEIRPSFSQLVV  923
         **********************************************************98
S: 343   l  343
         l
Q: 924   L  924
         7
Domain Sequence
(FASTA)
LVLGRTLGSG AFGRVVEATA HGLSHSQSTM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNIVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQSYGEKAR REAELYGNTI 120
KEDHVQSHLS LSVESDGGYM DMSKDESLDY VPMSDMKGEV KYADIESSNY GTPYELDSYS 180
PSAPERTDRV TLINESPLLS YMDLVGFSFQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240
VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNNL YTTLSDVWSF GILLWEIFTL 300
GGTPYPELPM NEQFYNAIKR GYRMSKPTHA SDEIYDIMQK CWEEKFEIRP SFSQLVVL 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005019; F:platelet-derived growth factor beta-receptor activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0060326; P:cell chemotaxis
GO:0006807; P:nitrogen compound metabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777; P:protein autophosphorylation
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013