EKS-GOG-00432

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00432

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	479.2	4.5E-144	71	337	267

Status

Unreviewed

Ensembl Protein

ENSGGOP00000000346

UniProt Accession

G3S831;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPG

Gene Synonyms/Alias

CDC42BPG;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000000352	ENSGGOP00000024243	ENSGGOT00000022251
ENSGGOG00000000352	ENSGGOP00000000346	ENSGGOT00000000355

Organism

Gorilla gorilla

Functional Description

Protein Length

1510

Protein Sequence
(FASTA)

MERRLRALEQ LARGEAGGCP GLDGLLDLLL ALHHELSSGP LRRERSVAQF LSWASPFVSK 60

VKELRLQRDD FEILKVIGRG AFGEVAVVRQ RDTGQIFAMK MLHKWEMLKR AETACFREER 120

DVLVKGDSRW VTTLHYAFQD EEYLYLVMDY YAGGDLLTLL SRFEDRLPPE LAQFYLAEMV 180

LAIHSLHKLG YVHRDVKPDN VLLDVNGHIR LADFGSCLRL NTNGMVDSSV AVGTPDYISP 240

EILQAMEEGK GHYGPQCDWW SLGVCAYELL FGETPFYAES LVETYGKIMN HEDHLQFPPD 300

VPDVPASAQD LIRQLLCRQE ERLGRGGLDD FRNHPFFEGV DWEQLASSTA PYIPELRGPM 360

DTSNFDVDDD TLNHPGTLPP PSHGAFSGHH LPFVGFTYTS GSHSPESSSE ACAALEQKLR 420

CLEQEKVELS RKHQEALHAP TDHRELEQLQ KEVQTLRDRL PEMLRDKASL SQTDGPPAGS 480

PGQDSDLRQE LDRLHQELAE GRAGLQAQEQ ELCRAQGQQE ELLQRLQEAQ EREAATASQT 540

RALSSQLEEA RDAQRELEAQ VSSLSRQVTQ LQGQWEQRLE ESSQAKTIHT ASETNGMGSP 600

EGGPLEAQLR KEVAALREQL EQAHSHRPSG KEEALCQLQE ENRRLSQEQE RLEAELAQEQ 660

ESKQRLEGER RETESNWEAQ LADILSWVND EKVSRGYLQA LATKMAEELE SLRNVGTQTL 720

PARPLDHQWK ARRLQKMEAS ARLELQSALE AEIRAKQGLQ ERLTQVQEAQ LQAERRLQEA 780

EKQSQALQQE LAMLREELRA RGPVDTKPLN SLIPFLSFRS SEKDSAKDPG ISGEATRHGG 840

EPELRPEGRR SLRMGAVFPR APTSNTASTE GLPAKPGSHT LRPRSFPSPT KCLRCTSLML 900

GLGRQGLGCD ACGYFCHTTC APQAPPCPVP PDLLRTALGV HPETGTGTAY EGFLSVPRPS 960

GVRRGWQRVF AALSDSRLLL FDAPDPRLSP PSGALLQVLD LRDPQFSATP VLASDVIHAQ 1020

SRDLPRIFRV TTSQLAVPPT TCTVLLLAES KGERERWLQV LGELQRLLLD ARPRPRPVYT 1080

LKEAYDNGLP LLPHTLCAAI LDQDRLALGT EEGLFVIHLR SNDIFQVGEC RRVQQLTLSP 1140

SAGLLVVLCG RGPSVRLFAL AELENIEVAG AKIPESRGCQ ALAAGSILQA RTPVLCVAVK 1200

RQVLCYQLGP GPGPWQRRIR ELQAPEELPP SRGGLGEALG AMELSLSEFL LLFTTAGIYV 1260

DGAGRKSRGH ELLWPAAPMG WGYAAPYLTV FSENSIDVFD VRRAEWVQTV PLKKVRPLNP 1320

EGSLFLYGTE KVRLTYLRNQ LAEKDEFDIP DLTDNSRRQL FRTKSKRRFF FRVSEEQQKQ 1380

QRREMLKDPF VRSKLISPPT NFNHLVHVGP ANGRPGARDK SPAPEEKGRI ARGSGPQRPH 1440

SFSEALRRPA SMGSEGLGGD ADPMKRKPWT SLSSESVSCP QGSLSPATSL MQVSERPRSL 1500

PLSPELESSP 1510

Nucleotide Sequence
(FASTA)

ATGGAGCGGC GGCTGCGCGC GCTGGAGCAG CTGGCGCGGG GCGAGGCCGG CGGCTGCCCG 60

GGGCTCGACG GCCTCCTAGA TCTGCTGCTG GCGCTGCACC ACGAGCTCAG CAGCGGCCCC 120

CTACGGCGGG AGCGCAGCGT GGCGCAGTTC CTGAGCTGGG CCAGCCCCTT CGTATCAAAG 180

GTGAAAGAAC TGCGTCTGCA AAGAGATGAC TTTGAGATCT TGAAGGTGAT CGGCCGAGGA 240

GCCTTTGGGG AGGTCGCCGT GGTGAGGCAG AGGGACACTG GGCAGATTTT TGCCATGAAA 300

ATGCTGCACA AGTGGGAGAT GCTGAAGAGG GCTGAGACAG CCTGTTTCCG GGAGGAGCGG 360

GATGTGCTCG TGAAAGGGGA CAGCCGTTGG GTGACCACTC TGCACTATGC CTTCCAAGAC 420

GAGGAGTACC TGTACCTTGT GATGGACTAC TATGCCGGTG GGGACCTCCT GACGCTGCTG 480

AGCCGCTTCG AGGACCGTCT CCCGCCCGAG CTGGCCCAGT TCTACCTGGC TGAGATGGTG 540

CTGGCCATCC ACTCGCTGCA CAAGCTGGGT TATGTCCACA GGGATGTCAA GCCAGACAAC 600

GTCCTGCTGG ATGTGAACGG GCACATTCGC CTGGCTGACT TCGGCTCCTG CCTGCGTCTC 660

AACACCAACG GCATGGTGGA TTCATCAGTG GCAGTAGGGA CGCCGGACTA TATCTCCCCT 720

GAGATCCTGC AGGCCATGGA GGAGGGCAAG GGCCACTACG GCCCACAGTG TGACTGGTGG 780

TCGCTTGGAG TCTGCGCCTA TGAGCTGCTC TTTGGGGAGA CGCCCTTCTA TGCTGAGTCC 840

TTGGTGGAAA CCTATGGCAA GATCATGAAC CACGAGGACC ACCTGCAGTT CCCCCCGGAC 900

GTGCCTGACG TGCCAGCCAG CGCCCAAGAC CTGATCCGCC AGCTGCTGTG TCGCCAGGAA 960

GAGCGGCTAG GCCGTGGTGG GCTGGACGAC TTCCGGAACC ATCCTTTCTT CGAAGGCGTG 1020

GACTGGGAGC AGCTGGCGAG CAGCACGGCC CCCTATATTC CTGAGCTGCG GGGGCCCATG 1080

GACACCTCCA ACTTTGATGT GGATGACGAC ACCCTCAACC ATCCAGGGAC CCTGCCACCG 1140

CCCTCCCACG GGGCCTTCTC CGGCCACCAC CTGCCATTTG TGGGCTTCAC CTACACCTCA 1200

GGCAGTCACA GTCCTGAGAG CAGCTCTGAG GCCTGCGCTG CCCTGGAGCA GAAGCTCCGG 1260

TGTCTGGAGC AGGAGAAGGT GGAGCTGAGC AGGAAGCACC AAGAGGCCCT GCACGCCCCC 1320

ACAGACCATC GGGAGCTGGA GCAGCTACAG AAAGAAGTGC AGACTCTGCG GGACAGGCTG 1380

CCAGAGATGC TGAGGGACAA GGCCTCATTG TCCCAGACGG ATGGGCCCCC AGCTGGTAGC 1440

CCAGGTCAGG ACAGTGACCT ACGGCAGGAG CTTGACCGAC TTCACCAGGA GCTGGCCGAG 1500

GGTCGGGCAG GGCTGCAGGC TCAGGAGCAG GAGCTCTGCA GGGCCCAGGG GCAGCAGGAG 1560

GAGCTGCTTC AGAGGCTACA GGAGGCCCAG GAGAGAGAGG CGGCTACAGC TAGCCAGACC 1620

CGGGCCCTGA GCTCCCAGCT GGAGGAAGCC CGGGATGCCC AGAGGGAGCT GGAGGCCCAG 1680

GTGTCCTCCC TGAGCCGGCA GGTGACGCAG CTGCAGGGAC AGTGGGAGCA ACGCCTTGAG 1740

GAGTCTTCCC AGGCCAAGAC CATCCACACA GCCTCTGAGA CCAACGGGAT GGGATCCCCC 1800

GAGGGTGGGC CTCTGGAGGC CCAACTGAGG AAGGAGGTGG CCGCCCTGCG AGAGCAGTTG 1860

GAGCAGGCCC ACAGCCACAG GCCGAGTGGT AAGGAGGAGG CTCTGTGCCA GCTGCAGGAG 1920

GAAAACCGGA GGCTGAGCCA GGAGCAGGAG CGGCTAGAAG CAGAGCTGGC CCAGGAGCAG 1980

GAGAGCAAGC AGCGGCTGGA GGGTGAGCGG CGGGAGACGG AGAGCAACTG GGAGGCCCAG 2040

CTCGCCGACA TCCTCAGCTG GGTGAACGAT GAGAAGGTCT CAAGAGGCTA CCTGCAGGCC 2100

CTGGCCACCA AGATGGCAGA GGAGCTGGAG TCCTTGAGGA ACGTAGGCAC CCAGACGCTC 2160

CCTGCCCGGC CACTGGACCA CCAGTGGAAG GCGCGGCGAC TGCAGAAGAT GGAGGCCTCA 2220

GCCAGGCTGG AGCTGCAGTC AGCGCTGGAG GCCGAGATCC GCGCCAAGCA GGGCCTGCAG 2280

GAGCGGCTGA CGCAGGTGCA GGAGGCCCAG CTGCAGGCTG AGCGCCGTCT GCAGGAGGCC 2340

GAGAAGCAGA GCCAGGCCCT GCAACAGGAG CTCGCCATGC TGCGGGAGGA GCTGCGGGCC 2400

CGAGGGCCAG TGGACACCAA GCCCTTAAAC TCCCTGATTC CCTTCCTGTC CTTCCGGAGC 2460

TCAGAGAAGG ATTCTGCCAA GGACCCTGGC ATCTCAGGAG AGGCCACAAG GCATGGAGGG 2520

GAACCAGAGC TGAGGCCGGA GGGCCGACGC AGCCTGCGCA TGGGGGCTGT GTTCCCCAGA 2580

GCACCCACTT CCAACACAGC CTCTACAGAA GGTCTTCCTG CTAAGCCCGG CTCACACACG 2640

CTGCGCCCCC GGAGCTTCCC ATCCCCGACC AAGTGTCTCC GCTGCACCTC GCTGATGCTG 2700

GGCCTGGGCC GCCAGGGCCT GGGTTGTGAT GCCTGCGGCT ATTTTTGTCA CACAACCTGT 2760

GCCCCACAGG CCCCACCCTG CCCCGTGCCC CCTGACCTCC TCCGCACAGC CCTGGGAGTA 2820

CACCCCGAAA CAGGCACAGG CACTGCCTAT GAGGGCTTTC TGTCGGTGCC GCGGCCCTCA 2880

GGCGTCCGGC GGGGCTGGCA GCGCGTGTTT GCTGCCCTGA GTGACTCACG CCTGCTGCTG 2940

TTTGACGCCC CTGACCCGAG GCTCAGCCCA CCCAGCGGGG CCCTCCTGCA GGTCCTAGAT 3000

CTGAGGGACC CCCAGTTCTC GGCTACCCCC GTCCTGGCCT CTGATGTCAT CCATGCCCAA 3060

TCCAGGGACC TGCCACGCAT CTTTAGGGTG ACGACCTCCC AGCTGGCAGT GCCGCCCACC 3120

ACGTGCACTG TGCTGCTGCT GGCGGAGAGC AAGGGGGAGC GGGAACGCTG GCTGCAGGTG 3180

CTGGGTGAGC TGCAGCGGCT GCTGCTGGAC GCGCGGCCAA GACCCCGGCC CGTGTACACA 3240

CTCAAGGAGG CCTACGACAA CGGGCTGCCA CTGCTGCCTC ACACGCTCTG CGCTGCCATC 3300

CTCGACCAGG ATCGACTTGC GCTTGGCACC GAGGAGGGGC TCTTTGTCAT CCATCTGCGC 3360

AGCAACGACA TCTTCCAGGT GGGGGAGTGC CGGCGTGTGC AGCAGCTGAC CTTGAGCCCC 3420

AGTGCAGGCC TGCTGGTCGT GCTGTGTGGC CGCGGCCCCA GCGTGCGTCT CTTTGCCCTG 3480

GCGGAGCTGG AGAACATAGA GGTAGCAGGT GCCAAGATCC CCGAGTCTCG AGGCTGCCAG 3540

GCGCTGGCAG CTGGAAGCAT CCTGCAGGCC CGCACCCCGG TGCTCTGTGT AGCCGTCAAG 3600

CGCCAGGTGC TCTGCTACCA GCTGGGCCCG GGCCCTGGGC CCTGGCAGCG CCGCATCCGT 3660

GAGCTGCAGG CACCTGAGGA GCTGCCACCA TCCCGTGGGG GCCTGGGTGA GGCACTGGGT 3720

GCCATGGAGC TTAGCCTCAG CGAGTTCCTG CTACTCTTCA CCACTGCTGG CATCTATGTG 3780

GATGGTGCAG GCCGCAAGTC TCGTGGCCAC GAGCTGTTGT GGCCAGCAGC GCCCATGGGC 3840

TGGGGGTATG CGGCCCCCTA CCTGACAGTG TTCAGCGAGA ACTCCATCGA TGTGTTTGAC 3900

GTGAGGAGGG CAGAATGGGT GCAGACCGTG CCGCTCAAGA AGGTGCGGCC CCTCAATCCA 3960

GAGGGCTCCC TGTTCCTCTA CGGCACCGAG AAGGTCCGCC TGACCTACCT CAGGAACCAG 4020

CTGGCAGAGA AGGACGAGTT CGACATCCCG GACCTCACCG ACAACAGCCG GCGCCAGCTG 4080

TTCCGCACCA AGAGCAAGCG CCGCTTCTTT TTCCGCGTGT CGGAGGAGCA GCAGAAGCAG 4140

CAGCGCAGGG AGATGCTGAA GGACCCTTTT GTGCGCTCCA AGCTCATCTC GCCGCCTACC 4200

AACTTCAACC ACCTAGTACA CGTGGGCCCT GCCAACGGGC GGCCCGGCGC CAGGGACAAG 4260

TCCCCGGCTC CCGAAGAGAA GGGCCGAATT GCCCGCGGCT CCGGCCCACA GCGGCCCCAC 4320

AGCTTCTCCG AGGCGTTGCG GCGCCCAGCC TCCATGGGCA GCGAAGGCCT CGGTGGAGAC 4380

GCAGACCCCA TGAAGAGGAA ACCCTGGACA TCCCTGTCCA GCGAGTCTGT GTCCTGCCCC 4440

CAGGGATCGC TGAGCCCTGC AACCTCCCTA ATGCAGGTCT CAGAACGGCC CCGAAGCCTC 4500

CCCCTATCCC CTGAATTGGA GAGCTCTCCT TGA 4533

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavvr+++t++++amk+l+k+e+lkrae+a+freerdvlvk+ds+w

Q: 71    FEILKVIGRGAFGEVAVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRW  130

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +++l+yafqde+ylylvm+y++GGdlltlls++ed+lp ela+fylae+vla++s+h+lg

Q: 131   VTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHKLG  190

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrd+kpdn+lld++Ghi+ladfGscl+ln++g+v+ssvavGtpdyispe+l+a+eegk

Q: 191   YVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGK  250

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg++cdwwslGv++yell+getpfyaeslvety+ki+nh+++l+fp d+ +v+++a+d

Q: 251   GHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVpDVPASAQD  310

         ************************************************9999********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++ll+++eerlgr g++d+++hpff

Q: 311   LIRQLLCRQEERLGRGGLDDFRNHPFF  337

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVRQ RDTGQIFAMK MLHKWEMLKR AETACFREER DVLVKGDSRW 60

VTTLHYAFQD EEYLYLVMDY YAGGDLLTLL SRFEDRLPPE LAQFYLAEMV LAIHSLHKLG 120

YVHRDVKPDN VLLDVNGHIR LADFGSCLRL NTNGMVDSSV AVGTPDYISP EILQAMEEGK 180

GHYGPQCDWW SLGVCAYELL FGETPFYAES LVETYGKIMN HEDHLQFPPD VPDVPASAQD 240

LIRQLLCRQE ERLGRGGLDD FRNHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 2.
PF08826	; DMPK_coil; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013