EKS-GOG-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	507.8	1.1E-152	707	1012	306

Status

Unreviewed

Ensembl Protein

ENSGGOP00000000536

UniProt Accession

G3QE50;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS1

Gene Synonyms/Alias

LATS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000000545	ENSGGOP00000000536	ENSGGOT00000000549

Organism

Gorilla gorilla

Functional Description

Protein Length

1132

Protein Sequence
(FASTA)

MKRSEKPEGY RQMRPKTFPA SNYTGSSRQM LQEIRESLRN LSKPSDAAKA EHNMSKMSTE 60

DPRQVRNPPK FGTHHKALQE IRNSLLPFAN ETNSSRSTSE VNPQMLQDLQ AAGFDEDMVI 120

QALQKTNNRS IEAAIEFISK MSYQDPRREQ MAAAAARPIN ASMKPAIGNV QQSVNRKQSW 180

KGSKESLVPQ RHGPPLGESV AYHSESPNSQ TDVGRPLSGS GISAFVQAHP SNGQRVNPPP 240

PPQVRSVTPP PPPRGQTPPP RGTTPPPPSW EPNSQTKRYS GNMEYVISRI SPVPPGAWQE 300

GYPPPPLNTS PMNPPNQGQR GISSVPVGRQ PIIMQSSSKF NFPSGRPGMQ NGTGQTDFMI 360

HQNVVPAGTV NRQPPPPYPL TAANGQSPSA LQTGGSAAPS SYTNGNIPQS MMVPNRNSHN 420

MELYNISVPG LQTNWPQSSS APAQSSPSSG HEIPTWQPNI PVRSNSFNNP LGNRASHSAN 480

SQPSATTVTA ITPAPIQQPV KSMRVLKPEL QTALAPTHPS WIPQPIQTVQ PSPFPEGTAS 540

NVTVMPPVAE APNYQGPPPP YPKHLLHQNP SVPPYESISK PSKEDQPSLP KEDESEKSYE 600

NVDSGDKEKK QITTSPITVR KNKKDEERRE SRIQSYSPQA FKFFMEQHVE NVLKSHQQRL 660

HRKKQLENEM MRVGLSQDAQ DQMRKMLCQK ESNYIRLKRA KMDKSMFVKI KTLGIGAFGE 720

VCLARKVDTK ALYATKTLRK KDVLLRNQVA HVKAERDILA EADNEWVVRL YYSFQDKDNL 780

YFVMDYIPGG DMMSLLIRMG IFPENLARFY IAELTCAVES VHKMGFIHRD IKPDNILIDR 840

DGHIKLTDFG LCTGFRWTHD SKYYQSGDHP RQDSMDFSNE WGDPSSCRCG DRLKPLERRA 900

ARQHQRCLAH SLVGTPNYIA PEVLLRTGYT QLCDWWSVGV ILFEMLVGQP PFLAQTPLET 960

QMKVINWQTS LHIPPQAKLS PEASDLIIKL CRGPEDRLGK NGADEIKAHP FFKTIDFSSD 1020

LRQQSASYIP KITHPTDTSN FDPVDPDKLW SDDNEEENVN DTLNGWYKNG KHPEHAFYEF 1080

TFRRFFDDNG YPYNYPKPIE YEYINSQGSE QQSDEDDQNT GSEIKNRDLV YV 1132

Nucleotide Sequence
(FASTA)

ATGAAGAGGA GTGAAAAGCC AGAAGGTTAT AGACAAATGA GGCCTAAGAC CTTTCCTGCC 60

AGTAACTATA CTGGCAGTAG CCGGCAAATG TTACAAGAAA TTCGGGAATC CCTTAGGAAT 120

TTATCTAAAC CATCTGATGC TGCTAAGGCT GAGCATAACA TGAGTAAAAT GTCAACCGAA 180

GATCCTCGAC AAGTCAGAAA TCCACCCAAA TTTGGGACGC ATCATAAAGC CTTGCAGGAA 240

ATTCGAAACT CTCTGCTTCC ATTTGCAAAT GAAACAAATT CTTCTCGGAG TACTTCAGAA 300

GTTAATCCAC AAATGCTTCA AGACTTGCAA GCTGCTGGAT TTGATGAGGA TATGGTTATA 360

CAAGCTCTTC AGAAAACTAA CAACAGAAGT ATAGAAGCAG CAATTGAATT CATTAGTAAA 420

ATGAGTTACC AAGATCCTCG ACGAGAGCAG ATGGCTGCAG CAGCTGCCAG ACCTATTAAT 480

GCCAGCATGA AACCAGCCAT AGGGAATGTG CAACAATCAG TTAACCGCAA ACAGAGCTGG 540

AAAGGTTCTA AAGAATCCTT AGTTCCTCAG AGGCATGGCC CGCCACTAGG AGAAAGTGTG 600

GCCTATCATT CTGAGAGTCC CAACTCACAG ACAGATGTAG GAAGACCTTT GTCTGGATCT 660

GGTATATCAG CATTTGTTCA AGCTCACCCT AGCAACGGAC AGAGAGTGAA CCCCCCACCA 720

CCACCTCAAG TAAGGAGTGT TACTCCTCCA CCACCTCCAA GAGGCCAGAC TCCCCCTCCA 780

AGAGGTACAA CTCCACCTCC CCCTTCATGG GAACCAAACT CTCAAACAAA GCGCTATTCT 840

GGAAACATGG AATACGTAAT CTCCCGAATC TCTCCTGTCC CACCTGGGGC ATGGCAAGAG 900

GGCTATCCTC CACCACCTCT CAACACTTCC CCCATGAATC CTCCTAATCA GGGACAGAGA 960

GGCATTAGTT CTGTTCCTGT TGGCAGACAA CCAATCATCA TGCAGAGTTC TAGCAAATTT 1020

AACTTTCCAT CAGGGAGACC TGGAATGCAG AATGGTACTG GACAAACTGA TTTCATGATA 1080

CACCAAAATG TTGTCCCTGC TGGCACTGTG AATCGGCAGC CACCACCTCC ATATCCTCTG 1140

ACAGCAGCTA ATGGACAAAG CCCTTCTGCT TTACAAACAG GGGGATCTGC TGCTCCTTCG 1200

TCATATACAA ATGGAAATAT TCCTCAGTCT ATGATGGTGC CAAACAGAAA TAGTCATAAC 1260

ATGGAACTAT ATAACATTAG TGTACCTGGA CTGCAGACAA ATTGGCCTCA GTCATCTTCT 1320

GCTCCAGCCC AGTCATCCCC GAGCAGTGGG CATGAAATCC CTACATGGCA ACCTAACATA 1380

CCAGTGAGGT CAAATTCTTT TAATAACCCA TTAGGAAATA GAGCAAGTCA CTCTGCTAAT 1440

TCTCAGCCTT CTGCTACAAC AGTCACTGCA ATTACACCAG CTCCTATTCA ACAGCCTGTG 1500

AAAAGTATGC GTGTATTAAA ACCAGAGCTA CAGACTGCTT TAGCACCTAC ACACCCTTCT 1560

TGGATACCAC AGCCAATTCA AACTGTTCAA CCCAGTCCTT TTCCTGAGGG AACCGCTTCA 1620

AATGTGACTG TGATGCCACC TGTTGCTGAA GCTCCAAACT ATCAAGGACC ACCACCACCC 1680

TACCCAAAAC ATCTGCTGCA CCAAAACCCA TCTGTTCCTC CATACGAGTC AATCAGTAAG 1740

CCTAGCAAAG AGGATCAGCC AAGCTTGCCC AAGGAAGATG AGAGTGAAAA GAGTTATGAA 1800

AATGTTGATA GTGGGGATAA AGAAAAGAAA CAGATTACAA CTTCACCCAT TACTGTTAGG 1860

AAAAACAAGA AAGATGAAGA GCGAAGGGAA TCTCGTATTC AAAGTTATTC TCCTCAAGCA 1920

TTTAAATTCT TTATGGAGCA ACATGTAGAA AATGTACTCA AATCTCATCA GCAGCGTCTA 1980

CATCGTAAAA AACAATTAGA GAATGAAATG ATGCGGGTTG GATTATCTCA AGATGCCCAG 2040

GATCAAATGA GAAAGATGCT TTGCCAAAAA GAATCTAATT ACATCCGTCT TAAAAGGGCT 2100

AAAATGGACA AGTCTATGTT TGTGAAGATA AAGACACTAG GAATAGGAGC ATTTGGTGAA 2160

GTCTGTCTAG CAAGAAAAGT AGATACTAAG GCTTTGTATG CAACAAAAAC TCTTCGAAAG 2220

AAAGATGTTC TTCTTCGAAA TCAAGTCGCT CATGTTAAAG CTGAGAGAGA TATCCTGGCT 2280

GAAGCTGACA ATGAATGGGT AGTTCGTCTA TATTATTCAT TCCAAGATAA GGACAATTTA 2340

TACTTTGTAA TGGACTACAT TCCTGGGGGT GATATGATGA GCCTATTAAT TAGAATGGGC 2400

ATCTTTCCAG AAAATCTGGC ACGATTCTAC ATAGCAGAAC TTACCTGTGC AGTTGAAAGT 2460

GTTCATAAAA TGGGTTTTAT TCATAGAGAT ATTAAACCTG ATAATATTTT GATTGATCGT 2520

GATGGTCATA TTAAATTGAC TGACTTTGGC CTCTGCACTG GCTTCAGATG GACACACGAT 2580

TCTAAGTACT ATCAGAGTGG TGACCATCCA CGGCAAGATA GCATGGATTT CAGTAATGAA 2640

TGGGGGGATC CCTCAAGCTG TCGATGTGGA GACAGACTGA AGCCATTAGA GCGGAGAGCT 2700

GCACGTCAGC ACCAGCGATG TCTAGCACAT TCTTTGGTTG GGACTCCCAA TTATATTGCA 2760

CCTGAAGTGT TGCTACGAAC AGGATACACA CAGTTGTGTG ATTGGTGGAG TGTTGGTGTT 2820

ATTCTTTTTG AAATGTTGGT GGGACAACCT CCTTTCTTGG CACAGACACC ATTAGAAACA 2880

CAAATGAAGG TTATCAACTG GCAAACATCT CTTCACATTC CACCACAAGC TAAACTCAGT 2940

CCTGAAGCTT CTGATCTTAT TATTAAACTT TGCCGAGGAC CCGAAGATCG CTTAGGCAAG 3000

AATGGTGCTG ATGAAATAAA AGCTCATCCA TTTTTTAAAA CAATTGATTT CTCCAGTGAC 3060

CTGAGACAGC AATCTGCTTC ATACATTCCT AAAATCACAC ACCCAACAGA TACATCAAAT 3120

TTTGATCCTG TTGATCCTGA TAAATTATGG AGTGATGATA ATGAGGAAGA AAATGTAAAT 3180

GACACTCTCA ATGGATGGTA TAAAAATGGA AAGCATCCTG AACATGCATT CTATGAATTT 3240

ACCTTCCGAA GGTTTTTTGA TGACAATGGC TACCCATATA ATTATCCGAA GCCTATTGAA 3300

TATGAATACA TTAATTCACA AGGCTCAGAG CAGCAGTCGG ATGAAGATGA TCAAAACACA 3360

GGCTCAGAGA TTAAAAATCG CGATCTAGTA TATGTTTAA 3399

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f k+k++g+GafGev+l+rk dtk++ya+k+lrkkd+l +nqvahvkaerdilaead+ew

Q: 707   FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW  766

         889*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vv+lyysfqdk+nly+vm+y+PGGd+m+lli+++i++e+larfyiael++avesvhk+Gf

Q: 767   VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF  826

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ ++ ++d++++s+

Q: 827   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNewgdpss  886

         ***************************************************999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+lerr++++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvil+eml

Q: 887   crcgdRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML  946

         ************************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla+tp et++kvinw+++l++p++++ls+ea+dli +l+  +e+rlgk+G+dei

Q: 947   VGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEI  1006

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 1007  KAHPFF  1012

         *****9

Domain Sequence
(FASTA)

FVKIKTLGIG AFGEVCLARK VDTKALYATK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60

VVRLYYSFQD KDNLYFVMDY IPGGDMMSLL IRMGIFPENL ARFYIAELTC AVESVHKMGF 120

IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHPRQDSMD FSNEWGDPSS 180

CRCGDRLKPL ERRAARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILFEML 240

VGQPPFLAQT PLETQMKVIN WQTSLHIPPQ AKLSPEASDL IIKLCRGPED RLGKNGADEI 300

KAHPFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR009060	; UBA-like.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.
PF00627	; UBA; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013