EPS-GOG-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GOG-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	199.3	1.3E-58	157	411	255

Status

Unreviewed

Ensembl Protein

ENSGGOP00000000634

UniProt Accession

G3QEE2;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1F

Gene Synonyms/Alias

PPM1F;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000000644	ENSGGOP00000000634	ENSGGOT00000000650
ENSGGOG00000000644	ENSGGOP00000022572	ENSGGOT00000033446

Organism

Gorilla gorilla

Functional Description

Protein Length

454

Protein Sequence
(FASTA)

MSSGAPQKSS PMASGAEETP GFLDMLLQDF PALLNPEDPL PWKAPGTVLS QEEVEGELAE 60

LAMGFLGSRK APPPLAAALA HEAVSQLLQT DLSEFRKLPR EEEEEEEDDD EEEKAPVTLL 120

DAQSLARSFF NRLWEVAGQW QKQVPLAAWA SQRQWLVSIH AIRNTRRKME DRHVSLPSFN 180

QLFGLSDPVN RAYFAVFDGH GGVDAARYAA VHVHTNAARQ PELPTDPAGA LREAFRRTDQ 240

MFLRKAKRER LQSGTTGVCA LIAGATLHVA WLGDSQVILV QQGQVVKLME PHRPERQDEK 300

ARIEALGGFV SHMDCWRVNG TLAVSRAIGD VFQKPYVSGE ADAASRALTG SEDYLLLACD 360

GFFDVVPHQE VVGLVQSHLT RQQGSGLRVA EELVAAARER GSHDNITVMV VFLRDPQELL 420

EGGNQGEGDP QAEGRRQDLP SSLPEPETQA PPRS 454

Nucleotide Sequence
(FASTA)

ATGTCCTCTG GAGCCCCACA GAAGAGCAGC CCAATGGCCA GTGGAGCTGA GGAGACCCCA 60

GGCTTCCTGG ACATGCTCCT GCAAGACTTC CCAGCCCTGC TGAACCCAGA GGACCCTCTG 120

CCATGGAAGG CCCCAGGGAC GGTGCTCAGC CAGGAGGAGG TGGAGGGCGA GCTGGCTGAG 180

CTGGCCATGG GCTTTCTGGG CAGCAGGAAG GCCCCGCCAC CACTTGCTGC TGCTCTGGCC 240

CACGAAGCAG TTTCACAGCT GCTACAGACA GACCTTTCCG AATTCAGGAA GTTGCCCAGG 300

GAGGAGGAAG AAGAGGAGGA GGACGATGAT GAGGAGGAAA AGGCCCCTGT GACCTTGCTG 360

GATGCCCAAA GCCTGGCACG GAGTTTCTTT AACCGCCTTT GGGAAGTTGC CGGCCAGTGG 420

CAGAAGCAGG TGCCATTGGC TGCGTGGGCC TCACAGCGGC AGTGGCTGGT CTCCATCCAC 480

GCCATCCGGA ACACTCGCCG CAAGATGGAG GACCGGCACG TGTCCCTCCC TTCCTTCAAC 540

CAGCTCTTCG GCTTGTCTGA CCCTGTGAAC CGCGCCTACT TTGCCGTGTT TGATGGTCAC 600

GGAGGCGTGG ATGCTGCGAG GTACGCCGCT GTCCACGTGC ACACCAACGC TGCCCGCCAG 660

CCAGAGCTGC CCACAGACCC TGCGGGAGCC CTCAGAGAAG CCTTCCGGCG CACCGACCAG 720

ATGTTTCTCA GGAAAGCCAA GCGAGAGCGG CTGCAGAGCG GCACCACAGG TGTGTGTGCG 780

CTCATTGCAG GAGCGACCCT GCACGTCGCC TGGCTCGGGG ACTCCCAGGT CATTTTGGTA 840

CAGCAGGGAC AGGTGGTGAA GCTGATGGAG CCACACAGAC CAGAACGGCA GGATGAGAAG 900

GCGCGCATTG AAGCATTGGG TGGCTTTGTG TCTCACATGG ACTGCTGGAG AGTCAACGGG 960

ACCCTGGCCG TCTCCAGAGC CATCGGGGAT GTCTTCCAGA AGCCCTACGT GTCTGGGGAG 1020

GCCGATGCAG CTTCCCGGGC ACTGACGGGC TCCGAGGACT ACCTGCTGCT TGCCTGTGAT 1080

GGCTTCTTTG ACGTCGTACC CCACCAGGAA GTTGTTGGCC TGGTCCAGAG CCACCTGACC 1140

AGGCAGCAGG GCAGCGGGCT CCGTGTCGCC GAGGAGCTGG TGGCTGCGGC CCGGGAGCGG 1200

GGCTCCCACG ACAACATCAC GGTCATGGTG GTCTTCCTCA GGGACCCCCA AGAGCTGCTG 1260

GAGGGCGGGA ACCAGGGAGA AGGGGACCCC CAGGCAGAAG GGAGGAGGCA GGACTTGCCC 1320

TCCAGCCTTC CAGAACCTGA GACCCAGGCT CCACCAAGAA GCTAG 1365

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklhei  60

         v++ ++ + r++med++ s p+f +  + +d    a+f+v+DGhgg ++a++++ ++h+

Q: 157   VSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPvnRAYFAVFDGHGGVDAARYAAVHVHTN  216

         6678999******************99888887789************************

S: 61    laeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyva  120

          a++ e      ++   al++aF +td+ +  l +++ +  +sG+t v+ali + +l+va

Q: 217   AARQPE----LPTDPAGALREAFRRTDQMF--LRKAKRERLQSGTTGVCALIAGATLHVA  270

         ****77....7788889*************..8888889999******************

S: 121   nvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalGd  180

          +GdS+++L ++g++v+l + H+p+r+dE++Rie+ gg v   d+ Rv+G LavsRa+Gd

Q: 271   WLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGD  330

         ********************************************99**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

         ++ kpyv+ e +  s  lt ++++l La+DG +dvv+ +e+v lv+++l+ ++ +   +a

Q: 331   VFQKPYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTrQQGSGLRVA  390

         ************************************************996777899***

S: 240   kkLvklalargskdnvsaivv  260

         ++Lv+ a++rgs+dn++++vv

Q: 391   EELVAAARERGSHDNITVMVV  411

         *****************9997

Domain Sequence
(FASTA)

VSIHAIRNTR RKMEDRHVSL PSFNQLFGLS DPVNRAYFAV FDGHGGVDAA RYAAVHVHTN 60

AARQPELPTD PAGALREAFR RTDQMFLRKA KRERLQSGTT GVCALIAGAT LHVAWLGDSQ 120

VILVQQGQVV KLMEPHRPER QDEKARIEAL GGFVSHMDCW RVNGTLAVSR AIGDVFQKPY 180

VSGEADAASR ALTGSEDYLL LACDGFFDVV PHQEVVGLVQ SHLTRQQGSG LRVAEELVAA 240

ARERGSHDNI TVMVV 255

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043234	; C:protein complex
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0035690	; P:cellular response to drug
GO:0097193	; P:intrinsic apoptotic signaling pathway
GO:0033137	; P:negative regulation of peptidyl-serine phosphorylation
GO:0044387	; P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0050921	; P:positive regulation of chemotaxis
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0010628	; P:positive regulation of gene expression
GO:0045927	; P:positive regulation of growth

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013