EKS-GOG-00117

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00117

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	362.6	1.6E-108	41	313	273

Status

Unreviewed

Ensembl Protein

ENSGGOP00000000730

UniProt Accession

G3QEN3;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000000740	ENSGGOP00000000730	ENSGGOT00000000746

Organism

Gorilla gorilla

Functional Description

Protein Length

1311

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDV 60

GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120

LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 180

LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI 240

GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP 300

EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS ATLSRGPPPP VGPAGSGYSG 360

GLALAEYDQP YGGFLDILRG GTERLFTNLK DTSSKVIQSV ANYAKGDLDI SYITSRIAVM 420

SFPAEGVESA LKNNIEDVRL FLDSKHPGHY AVYNLSPRTY RPSRFHNRVS ECGWAARRAP 480

HLHTLYNICR NMHAWLRQDH KNVCVVHCMD GRAASAVAVC SFLCFCRLFS TAEAAVYMFS 540

MKRCPPGIWP SHKRYIEYMC DMVAEEPITP HSKPILVRAV VMTPVPLFSK QRSGCRPFCE 600

VYVGDERVAS TSQEYDKMRD FKIEDGKAVI PLGVTVQGDV LIVIYHARST LGGRLQAKMA 660

SMKMFQIQFH TGFVPRNATT VKFAKYDLDA CDIQEKYPDL FQVNLEVEVE PRDRPSREAP 720

PWENSSMRGL NPKILFSSRE EQQDILSKFG KPELPRQPGS TAQYDAGAGS PEAEPTDSDS 780

PPSSSADASR FLHTLDWQEE KEAETGAENA SPKESESALM EDRDESEVSD EGGSPISSEG 840

QEPRADPEPP GLAAGLVQQD LVFEVETPAV LPEPVPQEDG VDLLGLHSEV GAGPAVPPQA 900

RRAPSSNTDL LSCLLGPPEA ASQGSPEDLL SEAPLLLASP APPLSVQSTP RGGPPAAADP 960

FGPLLPSSGN DSQPCSNPDL FGEFLSSDSV TGPPSLPSAH SAPPPSCSAD FLHLGDLPGE 1020

PSKMTASSSN PDLLGGWVAW TESAASAVAP TPATEGLLFS PGGQPAPCGS QASWTKSQNP 1080

DPFADLGDLS SGLQGSPAGF PPGGFIPKTA TTPKGSSSWQ TSRPPAQGAP WPPQAKPPPK 1140

ACTQPRPNYA SNLSVIGARE ERGVRAPSFA QKPKVSENDF EDLLSNQGFS SRSDKKGPKT 1200

IAEMRKQDLA KDTDPLKLKL LDWIEGKERN IRALLSTLHT VLWDGESRWT PVGMADLVAP 1260

EQVKKHYRRA VLAVHPDKAA GQPYEQHAKM IFMELNDAWS EFENQGSRPL F 1311

Nucleotide Sequence
(FASTA)

ATGTCGCTGC TGCAGTCGGC GCTCGACTTC TTGGCGGGTC CAGGCTCCCT GGGCGGTGCT 60

TCCGGCCGCG ACCAGAGTGA CTTCGTGGGG CAGACGGTGG AACTGGGCGA GCTGCGGCTG 120

CGGGTGCGGC GGGTCCTGGC CGAAGGAGGG TTTGCATTTG TGTATGAAGC TCAAGATGTG 180

GGGAGTGGCA GAGAGTATGC ATTAAAGAGG CTATTATCCA ATGAAGAGGA AAAGAACAGA 240

GCCATCATTC AAGAAGTTTG CTTCATGAAA AAGCTTTCCG GCCACCCGAA CATTGTCCAG 300

TTTTGTTCTG CAGCATCTAT AGGAAAAGAG GAGTCAGACA CGGGACAGGC TGAGTTCCTC 360

TTGCTCACAG AGCTCTGTAA AGGGCAGCTG GTGGAATTTT TGAAGAAAAT GGAATCTCGA 420

GGTCCCCTGT CGTGCGACAC GGTTCTGAAG ATCTTCTACC AGACATGCCG CGCCGTGCAG 480

CACATGCACC GGCAGAAGCC GCCCATCATC CACAGGGACC TCAAGGTTGA GAACTTGCTG 540

CTTAGTAACC AAGGGACCAT TAAGCTGTGT GACTTTGGCA GTGCCACGAC CATCTCGCAC 600

TACCCTGACT ACAGCTGGAG CGCCCAGAGG CGAGCCCTGG TGGAGGAAGA GATCACGAGG 660

AATACAACAC CAATGTATAG AACGCCAGAA ATCATAGACT TGTATTCCAA CTTCCCGATC 720

GGCGAGAAGC AGGATATCTG GGCCCTGGGC TGCATCTTGT ACCTGCTGTG CTTCCGGCAG 780

CACCCTTTTG AGGATGGAGC GAAACTTCGA ATAGTCAATG GGAAGTACTC GATCCCCCCG 840

CACGACACGC AGTACACGGT CTTCCACAGC CTCATCCGCG CCATGCTGCA GGTGAACCCG 900

GAGGAGCGGC TGTCCATCGC CGAGGTGGTG CACCAGCTGC AGGAGATCGC GGCCGCCCGC 960

AACGTGAACC CCAAGTCTCC CATCACAGAG CTCCTGGAGC AGAATGGAGG CTACGGGAGC 1020

GCCACACTGT CCCGAGGGCC ACCCCCTCCC GTGGGCCCCG CTGGCAGTGG CTACAGTGGA 1080

GGCCTGGCCC TGGCGGAGTA CGACCAGCCC TATGGCGGCT TCCTGGACAT TCTGCGGGGT 1140

GGGACAGAGC GGCTCTTCAC CAACCTCAAG GACACCTCCT CCAAGGTCAT CCAGTCCGTC 1200

GCTAATTATG CAAAGGGTGA CCTGGACATA TCTTACATCA CATCCAGAAT TGCGGTGATG 1260

TCATTCCCAG CAGAAGGTGT GGAGTCAGCG CTCAAAAACA ACATCGAAGA TGTGCGGTTG 1320

TTCCTGGACT CCAAGCACCC AGGGCACTAT GCCGTCTACA ACCTGTCCCC GAGGACCTAC 1380

CGGCCCTCCA GGTTCCACAA CCGGGTCTCT GAGTGTGGCT GGGCAGCGCG GCGGGCCCCG 1440

CACCTGCACA CCCTGTACAA CATCTGCAGG AACATGCACG CCTGGCTGCG GCAGGACCAT 1500

AAGAACGTCT GCGTCGTGCA CTGCATGGAC GGGAGAGCCG CGTCTGCTGT GGCCGTCTGC 1560

TCCTTCCTGT GCTTCTGCCG TCTCTTCAGC ACCGCGGAGG CCGCCGTGTA CATGTTCAGC 1620

ATGAAGCGCT GCCCACCAGG CATCTGGCCA TCCCACAAAA GGTACATCGA GTACATGTGT 1680

GACATGGTGG CAGAGGAGCC CATCACACCC CACAGCAAGC CCATCCTGGT GAGGGCCGTG 1740

GTCATGACAC CCGTGCCGCT GTTCAGCAAG CAGAGGAGCG GCTGCAGGCC CTTCTGCGAG 1800

GTCTACGTGG GGGACGAGCG TGTGGCCAGC ACCTCCCAGG AGTACGACAA GATGCGGGAC 1860

TTTAAGATTG AGGATGGCAA AGCGGTGATT CCCCTGGGCG TCACGGTGCA AGGAGACGTG 1920

CTCATCGTCA TCTATCACGC CCGGTCCACT CTGGGCGGCC GGCTGCAGGC CAAGATGGCA 1980

TCCATGAAGA TGTTCCAGAT TCAGTTCCAC ACAGGGTTTG TGCCTCGGAA CGCCACCACT 2040

GTGAAATTTG CCAAGTATGA CCTGGACGCG TGTGACATTC AAGAGAAATA CCCGGATTTA 2100

TTTCAAGTGA ACCTGGAAGT GGAGGTGGAG CCCAGGGACA GGCCGAGCCG GGAAGCCCCA 2160

CCATGGGAGA ACTCGAGCAT GAGGGGGCTG AACCCGAAAA TCCTGTTTTC CAGCCGGGAG 2220

GAGCAGCAAG ATATTCTGTC TAAGTTTGGG AAGCCGGAGC TTCCCCGGCA GCCCGGCTCC 2280

ACGGCTCAGT ATGATGCTGG GGCAGGGTCC CCGGAAGCCG AACCCACAGA CTCTGACTCA 2340

CCGCCAAGCA GCAGCGCGGA CGCCAGTCGC TTCCTGCACA CGCTGGACTG GCAGGAAGAG 2400

AAGGAGGCAG AGACTGGTGC AGAAAATGCG TCTCCCAAGG AGAGCGAGTC TGCCCTGATG 2460

GAGGACAGAG ACGAGAGTGA GGTGTCGGAC GAAGGGGGGT CCCCGATCTC CAGCGAGGGC 2520

CAGGAGCCCA GGGCCGACCC AGAGCCCCCC GGCCTGGCAG CAGGGCTGGT GCAGCAGGAC 2580

TTGGTTTTTG AGGTGGAGAC ACCGGCTGTG CTGCCGGAGC CTGTGCCACA GGAAGACGGG 2640

GTCGACCTCC TGGGCCTGCA CTCCGAGGTG GGCGCAGGGC CAGCTGTACC CCCGCAGGCC 2700

CGCAGGGCCC CCTCCAGCAA CACCGACCTG CTCAGCTGCC TCCTTGGGCC CCCTGAGGCC 2760

GCCTCGCAGG GGTCCCCGGA GGATCTGCTC AGCGAGGCCC CCCTGCTCCT GGCAAGCCCG 2820

GCCCCTCCCC TGAGCGTGCA GAGCACCCCA AGAGGAGGGC CCCCTGCCGC TGCTGACCCC 2880

TTTGGCCCGC TTCTGCCGTC TTCAGGCAAC GACTCCCAGC CCTGCTCCAA TCCTGATCTC 2940

TTCGGCGAAT TTCTCAGTTC GGACTCTGTG ACCGGCCCAC CATCCTTACC GTCTGCCCAC 3000

AGCGCTCCGC CCCCATCCTG CAGCGCCGAC TTCCTGCACC TGGGGGATCT GCCAGGAGAG 3060

CCCAGCAAGA TGACAGCCTC GTCCAGCAAC CCAGACCTGC TGGGAGGATG GGTTGCCTGG 3120

ACCGAGAGTG CAGCGTCAGC AGTGGCCCCC ACGCCAGCCA CGGAAGGCCT CCTCTTCTCT 3180

CCTGGAGGTC AGCCGGCCCC TTGTGGCTCT CAGGCCAGCT GGACCAAGTC TCAGAACCCG 3240

GACCCATTTG CTGACCTTGG CGACCTCAGC TCCGGCCTCC AAGGCTCACC AGCTGGATTC 3300

CCTCCTGGGG GCTTCATTCC CAAAACGGCC ACCACGCCCA AAGGCAGCAG CTCCTGGCAG 3360

ACAAGTCGGC CGCCAGCCCA GGGCGCCCCA TGGCCCCCTC AGGCCAAGCC GCCCCCCAAA 3420

GCCTGCACAC AGCCAAGGCC TAACTATGCC TCGAACTTGA GTGTGATCGG GGCGCGAGAG 3480

GAGCGGGGAG TCCGCGCACC CAGCTTCGCT CAAAAGCCAA AAGTCTCTGA GAACGACTTT 3540

GAAGATCTGT TGTCCAATCA AGGCTTCTCC TCCAGGTCTG ACAAGAAAGG GCCAAAGACC 3600

ATCGCAGAGA TGAGGAAGCA GGACCTGGCT AAAGACACGG ACCCACTCAA GCTGAAGCTC 3660

CTGGACTGGA TTGAGGGCAA GGAGCGGAAC ATCCGGGCCC TGCTGTCCAC GCTGCACACA 3720

GTGCTGTGGG ACGGGGAGAG CCGCTGGACG CCCGTGGGCA TGGCCGACCT GGTGGCTCCG 3780

GAGCAGGTGA AGAAGCACTA TCGCCGCGCG GTGCTGGCTG TGCACCCCGA CAAGGCCGCA 3840

GGGCAGCCGT ACGAGCAGCA CGCTAAGATG ATCTTCATGG AGCTGAATGA CGCCTGGTCG 3900

GAGTTTGAGA ACCAGGGCTC CCGGCCCCTC TTCTGA 3936

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         r+++vlaeGGfa+vy a+d+ +g++yalKr+l+neee++++i++E+++mkklsgh+niv+

Q: 41    RVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQ  100

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g++e+lll+e+ck g+lv++l+k++++g ls++++lki+++++rav

Q: 101   FCsaASIGKEESDTGQAEFLLLTELCK-GQLVEFLKKMESRGPLSCDTVLKIFYQTCRAV  159

         **877888999****************.8*******************************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeie  176

         +++H++++p+iHRDlkveN+lls++g+++lcD+GSatt+++ ++   s+q+++ ++eei+

Q: 160   QHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDyswSAQRRALVEEEIT  219

         *******************************************999999***********

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt++yr+PE+idlysn++i+ek+DiWaLGc+lY lcf+++Pfe+++kl+i+ngkysiP

Q: 220   RNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIP  279

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlell  270

         +++++++ ++sli++ml+v+peeR++ia+v+++l

Q: 280   PHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQL  313

         ******************************9986

Domain Sequence
(FASTA)

RVRRVLAEGG FAFVYEAQDV GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ 60

FCSAASIGKE ESDTGQAEFL LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ 120

HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR 180

NTTPMYRTPE IIDLYSNFPI GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP 240

HDTQYTVFHS LIRAMLQVNP EERLSIAEVV HQL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013