EKS-GOG-00387
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00387
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl548.72.7E-165510775266
StatusUnreviewed
Ensembl ProteinENSGGOP00000000792
UniProt AccessionG3QEU1;
Protein Name
Protein Synonyms/Alias
Gene NameTYRO3
Gene Synonyms/Alias TYRO3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000000802ENSGGOP00000000792ENSGGOT00000000808
OrganismGorilla gorilla
Functional Description
Protein Length882
Protein Sequence
(FASTA)
LAISASQGRP GEVPAPFETE SLSRLTHVPS HPSGLKLMGA PVKLTVSQGQ PVKLNCSVEG 60
MEEPDIQWVK DGAVVQNLDQ LYIPVSEQHW IGFLSLKSVE RSDAGRYWCQ VEDGGETEIS 120
QPVWLTVEGV PFFTVEPKDL AVPPNAPFQL SCEAVGPPEP VTIVWWRGTT KIGGPAPSPS 180
VLNVTGVTQS TMFSCEAHNP KGLASSRTAT VHLQALPAAP FNITVTKLSS SNASVAWMPG 240
ADGRALLQSC TVQVTQAPGG WEVLAVVVPV PPFTCLLRDL VPATNYSLRV RCANALGPSP 300
YADWVPFQTK GLAPASAPQN LHAIRTDAGL ILEWEEVIPE APLEGPLGPY KLSWVQDNGT 360
QDELTVEGTR ANLTGWDPQK DLIVRVCVSN AVGCGPWSQP LVVSSHDHAG QQGPPHSRTS 420
WVPVVLGVLT ALVTAAALAL ILLRKRRKET RFGQAFDSVM ARGEPAVHFR AARSFNRERP 480
ERIEATLDSL GISDELKEKL EDVLIPEQQF TLGRMLGKGE FGSVREAQLK QEDGSFVKVA 540
VKMLKADIIA SSDIEEFLRE AACMKEFDHP HVAKLVGVSL RSRAKGRLPI PMVILPFMKH 600
GDLHAFLLAS RIGENPFNLP LQTLIRFMVD IACGMEYLSS RNFIHRDLAA RNCMLAEDMT 660
VCVADFGLSR KIYSGDYYRQ GCASKLPVKW LALESLADNL YTVQSDVWAF GVTMWEIMTR 720
GQTPYAGIEN AEIYNYLIGG NRLKQPPECM EDVYDLMYQC WSADPKQRPS FTCLRMELES 780
ILGQLSVLSA SQDPLYINIQ RAEEPTAGGS VELPGGDQPY SGAGDGSGMG AVAGTPSDYR 840
YILTPGGLAE QPGQAEHQPE SPLNETQRLL LLQQGLLPHS SC 882
Nucleotide Sequence
(FASTA)
CTTGCCATAT CAGCTTCTCA GGGAAGGCCA GGAGAGGTCC CTGCTCCATT TGAGACAGAG 60
TCCCTCTCAA GGCTGACACA TGTTCCTTCC CACCCCTCAG GTCTGAAGCT CATGGGAGCC 120
CCGGTGAAGC TGACAGTGTC TCAGGGGCAG CCGGTGAAGC TCAACTGCAG TGTGGAGGGG 180
ATGGAGGAGC CTGACATCCA GTGGGTGAAG GATGGGGCTG TGGTCCAGAA CTTGGACCAG 240
TTGTACATCC CAGTCAGCGA GCAGCACTGG ATCGGCTTCC TCAGCCTGAA GTCAGTGGAG 300
CGCTCTGACG CCGGCCGGTA CTGGTGCCAG GTGGAGGATG GAGGCGAAAC CGAGATCTCC 360
CAGCCAGTGT GGCTTACGGT AGAAGGTGTG CCATTTTTCA CAGTGGAGCC AAAAGATCTG 420
GCAGTGCCAC CCAATGCCCC TTTCCAACTG TCTTGTGAGG CTGTGGGTCC CCCTGAACCT 480
GTTACCATTG TCTGGTGGAG AGGAACTACG AAGATCGGGG GACCCGCTCC CTCTCCATCT 540
GTTTTAAATG TAACAGGGGT GACCCAGAGC ACCATGTTTT CCTGTGAAGC TCACAACCCA 600
AAAGGCCTGG CCTCTTCTCG CACAGCCACT GTTCACCTTC AAGCACTGCC TGCAGCCCCC 660
TTCAACATCA CCGTGACAAA GCTTTCCAGC AGCAACGCTA GTGTGGCCTG GATGCCAGGT 720
GCTGATGGCC GAGCTCTGCT ACAGTCCTGT ACAGTTCAGG TGACACAGGC CCCAGGAGGC 780
TGGGAAGTCC TGGCTGTTGT GGTCCCTGTG CCCCCCTTTA CCTGCCTGCT CCGGGACCTG 840
GTGCCTGCCA CCAACTACAG CCTCAGGGTG CGCTGTGCCA ATGCCTTGGG GCCCTCTCCC 900
TATGCTGACT GGGTGCCCTT TCAGACCAAG GGTCTAGCCC CAGCCAGCGC TCCCCAAAAC 960
CTCCATGCCA TCCGCACAGA TGCAGGCCTC ATCTTGGAGT GGGAAGAAGT GATCCCCGAG 1020
GCCCCTCTGG AAGGCCCCTT GGGACCCTAC AAACTGTCCT GGGTTCAAGA CAATGGAACC 1080
CAGGATGAGC TGACAGTGGA GGGGACCAGG GCCAATTTGA CAGGCTGGGA TCCCCAAAAG 1140
GACCTGATCG TACGTGTGTG CGTCTCCAAT GCAGTTGGCT GTGGACCCTG GAGTCAGCCA 1200
CTGGTGGTCT CTTCTCATGA CCATGCAGGC CAGCAGGGCC CTCCTCACAG CCGCACATCC 1260
TGGGTACCTG TGGTCCTTGG TGTGCTAACG GCCCTGGTGA CGGCTGCTGC CCTGGCCCTC 1320
ATCCTGCTTC GAAAGAGACG GAAAGAGACG CGGTTTGGGC AAGCCTTTGA CAGTGTCATG 1380
GCCCGGGGAG AGCCAGCCGT TCACTTCCGG GCAGCCCGGT CCTTCAATCG AGAAAGGCCC 1440
GAGCGCATCG AGGCCACATT GGACAGCTTG GGCATCAGCG ATGAACTAAA GGAAAAACTG 1500
GAGGATGTGC TCATCCCAGA GCAGCAGTTC ACCCTGGGCC GGATGTTGGG CAAAGGAGAG 1560
TTTGGTTCAG TGCGGGAGGC CCAGCTGAAG CAAGAGGATG GCTCCTTTGT GAAAGTGGCT 1620
GTGAAGATGC TGAAAGCTGA CATCATTGCC TCAAGCGACA TTGAAGAGTT CCTCAGGGAA 1680
GCAGCTTGCA TGAAGGAGTT TGACCATCCA CACGTGGCCA AACTTGTTGG GGTAAGCCTC 1740
CGGAGCAGGG CTAAAGGCCG TCTCCCCATC CCCATGGTCA TCTTGCCCTT CATGAAGCAT 1800
GGGGACCTGC ATGCCTTCCT GCTCGCCTCC CGGATTGGGG AGAATCCTTT TAACCTACCC 1860
CTCCAGACCC TGATCCGGTT CATGGTGGAC ATTGCCTGCG GCATGGAGTA CCTGAGCTCT 1920
CGGAACTTCA TCCACCGAGA CCTGGCTGCT CGGAATTGCA TGCTGGCAGA GGACATGACA 1980
GTGTGTGTGG CTGACTTCGG ACTCTCCCGG AAGATCTACA GTGGGGACTA CTATCGTCAA 2040
GGCTGTGCCT CCAAACTGCC CGTCAAGTGG CTGGCCCTGG AGAGCCTGGC CGACAACCTG 2100
TATACTGTGC AGAGTGACGT GTGGGCGTTC GGGGTGACCA TGTGGGAGAT CATGACACGT 2160
GGGCAGACGC CATATGCTGG CATCGAAAAC GCTGAGATTT ACAACTACCT CATTGGCGGG 2220
AACCGCCTGA AACAGCCTCC GGAGTGTATG GAGGACGTGT ATGATCTCAT GTACCAGTGC 2280
TGGAGTGCTG ACCCCAAGCA GCGCCCGAGC TTTACTTGTC TGCGAATGGA ACTGGAGAGC 2340
ATCTTGGGCC AGCTGTCTGT GCTATCCGCC AGCCAGGACC CCTTATACAT CAACATCCAG 2400
AGAGCTGAGG AGCCCACTGC GGGAGGCAGC GTGGAGCTAC CTGGCGGGGA TCAGCCCTAC 2460
AGTGGGGCTG GGGATGGCAG TGGCATGGGG GCAGTGGCTG GCACTCCCAG TGACTATCGG 2520
TACATACTCA CCCCCGGAGG GCTGGCTGAG CAGCCAGGGC AGGCAGAGCA CCAGCCAGAG 2580
AGTCCCCTCA ATGAGACACA GAGGCTTTTG CTGCTGCAGC AAGGGCTACT GCCACACAGT 2640
AGCTGTTAG 2649
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh
Q: 510   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  569
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtl++fmv
Q: 570   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMV  629
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk
Q: 630   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  689
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp++c
Q: 690   WLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC  749
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ++++ydlmy+cw+adpk+rpsf+ lr
Q: 750   MEDVYDLMYQCWSADPKQRPSFTCLR  775
         ***********************998
Domain Sequence
(FASTA)
FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60
PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLIRFMV 120
DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180
WLALESLADN LYTVQSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPEC 240
MEDVYDLMYQ CWSADPKQRP SFTCLR 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00372
EKS-ANC-00384
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-CIS-00152
EKS-DAR-00777
EKS-EQC-00387
EKS-FEC-00382
EKS-GAG-00338
EKS-GAA-00488
EKS-HOS-00403
EKS-ICT-00375
EKS-LAC-00413
EKS-LOA-00403
EKS-MAM-00399
EKS-MEG-00329
EKS-MOD-00385
EKS-MUM-00432
EKS-MUP-00390
EKS-MYL-00393
EKS-NOL-00364
EKS-ORN-00511
EKS-ORA-00344
EKS-ORC-00374
EKS-ORL-00465
EKS-OTG-00402
EKS-PAT-00374
EKS-PES-00355
EKS-PTV-00110
EKS-RAN-00411
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00046
EKS-TEN-00498
EKS-XET-00511
EKS-XIM-00503
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0016021; C:integral to membrane
GO:0005635; C:nuclear envelope
GO:0005524; F:ATP binding
GO:0043548; F:phosphatidylinositol 3-kinase binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0021885; P:forebrain cell migration
GO:0050728; P:negative regulation of inflammatory response
GO:0045824; P:negative regulation of innate immune response
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0070050; P:neuron homeostasis
GO:0042698; P:ovulation cycle
GO:0070527; P:platelet aggregation
GO:0046777; P:protein autophosphorylation
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013