EKS-GOG-00282

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00282

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	408.6	1.9E-122	180	467	288

Status

Unreviewed

Ensembl Protein

ENSGGOP00000028195

UniProt Accession

G3QHH3;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000001827	ENSGGOP00000028195	ENSGGOT00000034733
ENSGGOG00000001827	ENSGGOP00000001802	ENSGGOT00000001840

Organism

Gorilla gorilla

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

FSFLWGTGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY ASWRNSSGTI 60

ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG GPEVTYEPPP 120

TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP PSPLVGLKPL 180

QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK HENLLQFIAA 240

EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY LHEDVPWCRG 300

EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG TRRYMAPEVL 360

EGAINFQRDA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ HPSLEELQEV 420

VVHKKMRPTI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL IRRSVNGTTS 480

DCLVSLVTSV TNVDLPPKES SI 502

Nucleotide Sequence
(FASTA)

TTCTCTTTTC TCTGGGGCAC AGGCTCTGGG CGTGGGGAGG CTGAGACACG GGAGTGCATC 60

TACTACAACG CCAACTGGGA GCTGGAGCGC ACCAACCAGA GCGGCCTGGA GCGCTGCGAA 120

GGCGAGCAGG ACAAGCGGCT GCACTGCTAC GCCTCCTGGC GCAACAGCTC TGGCACCATC 180

GAGCTCGTGA AGAAGGGCTG CTGGCTAGAT GACTTCAACT GCTACGATAG GCAGGAGTGC 240

GTGGCCACTG AGGAGAACCC CCAGGTGTAC TTCTGCTGCT GTGAAGGCAA CTTCTGCAAC 300

GAGCGCTTCA CTCATTTGCC AGAGGCTGGG GGCCCGGAAG TCACGTACGA GCCACCCCCG 360

ACAGCCCCCA CCCTGCTCAC GGTGCTGGCC TACTCACTGC TGCCCATCGG GGGCCTTTCC 420

CTCATCGTCC TGCTGGCCTT TTGGATGTAC CGGCATCGCA AGCCCCCCTA CGGTCATGTG 480

GACATCCATG AGGACCCTGG GCCTCCACCA CCATCCCCTC TGGTGGGCCT GAAGCCACTG 540

CAGCTGCTGG AGATCAAGGC TCGGGGGCGC TTTGGCTGTG TCTGGAAGGC CCAGCTCATG 600

AATGACTTTG TAGCTGTCAA GATCTTCCCA CTCCAGGACA AGCAGTCATG GCAGAGTGAA 660

CGGGAGATCT TCAGCACACC TGGCATGAAG CACGAGAACC TGCTACAGTT CATTGCTGCC 720

GAGAAGCGAG GCTCCAACCT CGAAGTAGAG CTGTGGCTCA TCACGGCCTT CCATGACAAG 780

GGCTCCCTCA CGGATTACCT CAAGGGGAAC ATCATCACAT GGAACGAACT GTGTCATGTA 840

GCAGAGACGA TGTCACGAGG CCTCTCATAC CTGCATGAGG ATGTGCCCTG GTGCCGTGGC 900

GAGGGCCACA AGCCGTCTAT TGCCCACAGG GACTTTAAAA GTAAGAATGT ATTGCTGAAG 960

AGCGACCTCA CAGCCGTGCT GGCTGACTTT GGCTTGGCTG TTCGATTTGA GCCAGGGAAA 1020

CCTCCAGGGG ACACCCACGG ACAGGTAGGC ACGAGACGGT ACATGGCTCC TGAGGTGCTC 1080

GAGGGAGCCA TCAACTTCCA GAGAGATGCC TTCCTGCGCA TTGACATGTA TGCCATGGGG 1140

TTGGTGCTGT GGGAGCTCGT GTCTCGCTGC AAGGCTGCAG ACGGACCCGT GGATGAGTAC 1200

ATGCTGCCCT TTGAGGAAGA GATTGGCCAG CACCCTTCGT TGGAGGAGCT GCAGGAGGTG 1260

GTGGTGCACA AGAAGATGAG GCCCACCATT AAAGATCACT GGTTGAAACA CCCGGGCCTG 1320

GCCCAGCTTT GTGTGACCAT CGAGGAGTGC TGGGACCATG ATGCAGAGGC TCGCTTGTCC 1380

GCGGGCTGTG TGGAGGAGCG GGTGTCCCTG ATTCGGAGGT CGGTCAACGG CACTACCTCG 1440

GACTGTCTCG TTTCCCTGGT GACCTCTGTC ACCAATGTGG ACCTGCCCCC TAAAGAGTCA 1500

AGCATCTAA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+++ vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 180   LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA  239

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 240   AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR  299

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +Kp+iaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 300   GeGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  357

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Pslee

Q: 358   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE  416

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP+i+++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 417   LQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  467

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDFVAVKIF PLQDKQSWQS EREIFSTPGM KHENLLQFIA 60

AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG QHPSLEELQE 240

VVVHKKMRPT IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013