EKS-GOG-00343

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00343

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	374.3	3.7E-112	116	377	262

Status

Unreviewed

Ensembl Protein

ENSGGOP00000001977

UniProt Accession

G3QHY9;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK1

Gene Synonyms/Alias

TNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000002000	ENSGGOP00000001977	ENSGGOT00000002019

Organism

Gorilla gorilla

Functional Description

Protein Length

662

Protein Sequence
(FASTA)

MLPEAGSLWL LKLLRDIQLA QFYWPILEEL NVTRPEHFDF VKPEDLDGIG MGRPAQRRLS 60

EALKRLRSGP KSKNWVYKIL GGFAPEHKEP TLPSDSPRHL PEPEGGLKCL IPEGAVCRGE 120

LLGSGCFGVV HRGLWTLPSG KSVPVAVKSL RVGPEGPMGT ELGDFLREVS VMMNLEHPHV 180

LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPTPPLLVA LLCLFLRQLA GAMAYLGARG 240

LVHRDLATRN LLLASPRTIK VADFGLVRPL GGARGRYVMG GPRPSSSFGR CAPESLRHGA 300

FSSASDVWMF GVTLWEMFSG GEEPWAGVPP YLILQRLEDR ARLPRPPLCS RALYSLALRC 360

WAPHPADRPS FSHLEGLLQE AGPSEGCCVR DVTEPGALRM ETGDPITVIE GSPDSTIWKG 420

QNGRTFKVGS FPASAVTLAD AGGLPATRPV HRGTPARGDQ HPGSIDGDRK KANLWDAPPA 480

RGQRRNMPLE RMKGISRSLE SVLSLGPRPT GGGSSPPEIR QARAVPQGPP GLPPRPPLSS 540

SSPQPSQPSR ERLPWPKRKP PHNHPMGMPG ASKAAALSGG LLPDPELQRK IMEVELSVHG 600

VTHQECQTAL GATGGDVVSA IRNLKVDQLF HLSSRSRADC RRILEHYQWD LSAASRYVLA 660

RP 662

Nucleotide Sequence
(FASTA)

ATGCTTCCTG AGGCCGGCTC CCTGTGGCTA CTGAAGCTGC TCCGGGACAT CCAGTTGGCC 60

CAGTTTTACT GGCCCATCCT TGAGGAGCTT AATGTCACTC GGCCAGAGCA CTTCGACTTT 120

GTAAAGCCTG AGGACCTGGA CGGCATTGGC ATGGGCCGGC CTGCCCAGCG CAGACTGTCC 180

GAAGCTCTGA AAAGGCTACG TTCTGGGCCT AAGTCTAAGA ACTGGGTCTA CAAGATCCTT 240

GGAGGTTTTG CCCCTGAGCA CAAGGAGCCC ACCCTACCCT CGGACAGCCC ACGGCACCTC 300

CCTGAGCCAG AGGGGGGCCT CAAGTGTCTG ATTCCAGAGG GTGCTGTTTG CAGAGGGGAG 360

CTGCTGGGTT CGGGCTGCTT CGGTGTGGTG CACCGAGGGC TGTGGACGCT GCCCAGTGGC 420

AAGAGTGTCC CAGTGGCTGT CAAGTCCCTC CGGGTAGGTC CCGAAGGCCC GATGGGCACA 480

GAACTGGGGG ACTTCCTGCG AGAGGTATCG GTCATGATGA ACTTGGAGCA CCCACACGTG 540

CTGCGTCTGC ACGGCCTTGT ACTGGGCCAG CCTCTGCAGA TGGTGATGGA GCTGGCGCCA 600

CTGGGCTCCC TGCACGCGCG CCTAACGGCC CCGGCCCCGA CACCCCCGCT GCTCGTGGCC 660

CTGCTCTGCC TCTTCCTGCG GCAGCTGGCG GGAGCCATGG CGTACCTGGG GGCCCGCGGG 720

CTGGTGCACC GAGACCTCGC TACGCGCAAC CTACTGCTGG CGTCGCCGCG CACCATCAAG 780

GTGGCTGACT TCGGGCTGGT GCGGCCTCTG GGCGGTGCCC GGGGCCGCTA CGTCATGGGC 840

GGGCCCCGCC CCTCCTCTTC CTTCGGCAGG TGTGCCCCAG AGAGCCTGCG CCACGGAGCC 900

TTCTCGTCTG CCTCGGACGT GTGGATGTTT GGGGTGACGC TGTGGGAGAT GTTCTCCGGG 960

GGCGAGGAAC CCTGGGCCGG GGTCCCACCG TACCTCATCC TGCAGCGGCT GGAGGACAGA 1020

GCCCGGCTGC CTAGGCCTCC CCTCTGCTCC AGGGCCCTCT ACTCCCTCGC CTTGCGCTGC 1080

TGGGCCCCCC ACCCTGCCGA CCGGCCTAGC TTTTCCCACC TGGAGGGGCT GCTGCAAGAG 1140

GCCGGGCCTT CGGAAGGATG TTGTGTGAGG GATGTCACAG AGCCAGGCGC CCTGAGGATG 1200

GAGACTGGTG ACCCCATCAC AGTCATCGAG GGCAGCCCCG ACTCCACAAT CTGGAAGGGC 1260

CAGAATGGTC GCACCTTCAA AGTGGGCAGC TTCCCAGCCT CGGCGGTGAC GCTGGCAGAT 1320

GCGGGGGGCT TGCCAGCCAC CCGTCCAGTC CACAGAGGCA CCCCTGCCCG GGGAGATCAA 1380

CACCCAGGAA GCATAGATGG AGACAGAAAG AAGGCAAATC TCTGGGATGC GCCCCCAGCA 1440

CGGGGCCAGA GGAGGAACAT GCCCCTGGAG AGGATGAAAG GCATTTCCAG GAGTCTGGAG 1500

TCAGTTCTAT CCCTCGGTCC TCGTCCCACA GGGGGTGGTT CAAGCCCCCC TGAAATTCGA 1560

CAAGCCAGAG CTGTGCCCCA GGGACCTCCA GGCCTGCCTC CACGCCCACC TTTATCCTCT 1620

AGCTCTCCTC AGCCCAGCCA GCCCTCTAGG GAGAGGCTTC CCTGGCCCAA AAGAAAACCC 1680

CCACACAATC ACCCCATGGG AATGCCTGGA GCCAGTAAAG CCGCTGCCCT CTCTGGAGGC 1740

CTCTTGCCCG ATCCTGAGTT GCAGAGGAAG ATTATGGAGG TGGAGCTGAG TGTGCATGGG 1800

GTCACCCACC AGGAGTGCCA GACAGCACTA GGAGCCACTG GGGGAGATGT GGTTTCTGCC 1860

ATCCGGAACC TCAAGGTAGA TCAGCTCTTC CACCTGAGTA GCCGGTCCAG AGCTGACTGC 1920

CGGCGCATCC TGGAGCATTA CCAGTGGGAC CTCTCAGCTG CCAGCCGCTA TGTCCTAGCC 1980

AGGCCCTGA 1989

Domain Profile

S: 1     iklleklGeGsfgvvkrgeWsapsgksvqvavkvlk..sdkllstelddflrevsvllkl  58

         ++++e+lG+G+fgvv+rg W+ psgksv+vavk+l+  ++  ++tel+dflrevsv+++l

Q: 116   VCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRvgPEGPMGTELGDFLREVSVMMNL  175

         56889******************************9999*********************

S: 59    ehenlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglay  118

         eh++++rl+G+vl+qpl++v+ela+lgsl++rl+++a +++llvall+ +++q+a ++ay

Q: 176   EHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAY  235

         ************************************************************

S: 119   leskrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkv.PfaWcaPes  177

         l+++ lvhrdla+rnlllas++++k++dfGlvr+lg ++++yv+  +++   f  caPes

Q: 236   LGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPSsSFGRCAPES  295

         *********************************************99975279*******

S: 178   lrtrkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediy  237

         lr+ +fssasdvW+fGvtlWemfs GeePW+g++++ il++++ +++rl++P++c++++y

Q: 296   LRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLE-DRARLPRPPLCSRALY  354

         *******************************************.9***************

S: 238   slllkcWakkpadrpkfsalkek  260

         sl+l+cWa +padrp+fs+l++

Q: 355   SLALRCWAPHPADRPSFSHLEGL  377

         ********************976

Domain Sequence
(FASTA)

VCRGELLGSG CFGVVHRGLW TLPSGKSVPV AVKSLRVGPE GPMGTELGDF LREVSVMMNL 60

EHPHVLRLHG LVLGQPLQMV MELAPLGSLH ARLTAPAPTP PLLVALLCLF LRQLAGAMAY 120

LGARGLVHRD LATRNLLLAS PRTIKVADFG LVRPLGGARG RYVMGGPRPS SSFGRCAPES 180

LRHGAFSSAS DVWMFGVTLW EMFSGGEEPW AGVPPYLILQ RLEDRARLPR PPLCSRALYS 240

LALRCWAPHP ADRPSFSHLE GL 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013