EKS-GOG-00360
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00360
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src442.26.6E-133261510250
StatusUnreviewed
Ensembl ProteinENSGGOP00000028067
UniProt AccessionG3QK47;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000002861ENSGGOP00000023319ENSGGOT00000023338
ENSGGOG00000002861ENSGGOP00000002815ENSGGOT00000002878
ENSGGOG00000002861ENSGGOP00000028067ENSGGOT00000030038
OrganismGorilla gorilla
Functional Description
Protein Length525
Protein Sequence
(FASTA)
SGSQPGSREP GMPASEDFPA MGCMKSKFLQ VGGNTFSKTE TSASPHCPVY VPDPTSTIKP 60
GPNSNNSNTP GIREAGSEDI IVVALYDYEA IHHEDLSFQK GDQMVVLEES GEWWKARSLA 120
TRKEGYIPSN YVARVDSLET EEWFFKGISR KDAERQLLAP GNMLGSFMIR DSETTKGSYS 180
LSVRDYDPRQ GDTVKHYKIR TLDNGGFYIS PRSTFSTLQE LVDHYRKGND GLCQKLSVPC 240
MSSKPQKPWE KDAWEIPRES LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA 300
FLAEANVMKT LQHDKLVKLH AVVTKEPIYI ITEFMAKGSL LDFLKSDEGS KQPLPKLIDF 360
SAQIAEGMAF IEQRNYIHRD LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI 420
KWTAPEAINF GSFTIKSDVW SFGILLMEIV TYGRIPYPGM SNPEVIRALE RGYRMPRPEN 480
CPEELYNIMM RCWKNRPEER PTFEYIQSVL DDFYTATESQ YQQQP 525
Nucleotide Sequence
(FASTA)
AGTGGGAGCC AGCCCGGGAG CAGGGAACCT GGAATGCCAG CATCAGAAGA CTTCCCCGCG 60
ATGGGATGCA TGAAGTCCAA GTTCCTCCAG GTCGGAGGCA ATACATTCTC AAAAACTGAA 120
ACCAGCGCCA GCCCACACTG TCCTGTGTAC GTGCCGGATC CCACATCCAC CATCAAGCCG 180
GGGCCTAATA GCAACAACAG CAACACACCA GGAATCAGGG AGGCAGGCTC TGAGGACATC 240
ATCGTGGTTG CCCTGTATGA TTACGAGGCC ATTCACCACG AAGACCTCAG CTTCCAGAAG 300
GGGGACCAGA TGGTGGTCCT AGAGGAATCC GGGGAGTGGT GGAAGGCTCG ATCCCTGGCC 360
ACCCGGAAGG AGGGCTACAT CCCAAGCAAC TATGTCGCCC GCGTGGACTC TCTGGAGACA 420
GAGGAGTGGT TTTTCAAGGG CATCAGCCGG AAGGACGCAG AGCGCCAACT GCTGGCTCCC 480
GGCAACATGC TGGGCTCCTT CATGATCCGG GATAGCGAGA CCACTAAAGG AAGCTACTCT 540
TTGTCCGTGC GAGACTACGA CCCTCGGCAG GGAGATACCG TGAAACATTA CAAGATCCGG 600
ACCCTGGACA ACGGGGGCTT CTACATATCC CCCCGAAGCA CCTTTAGCAC TCTGCAGGAG 660
CTGGTGGACC ACTACAGGAA GGGGAACGAT GGGCTCTGCC AGAAACTGTC GGTGCCCTGC 720
ATGTCTTCCA AGCCCCAGAA GCCTTGGGAG AAAGATGCCT GGGAGATCCC TCGGGAATCC 780
CTCAAGCTGG AGAAGAAACT TGGAGCTGGG CAGTTTGGGG AAGTCTGGAT GGCCACCTAC 840
AACAAGCACA CCAAGGTGGC AGTGAAGACG ATGAAGCCAG GGAGCATGTC GGTGGAGGCC 900
TTCCTGGCAG AGGCCAACGT GATGAAAACT CTGCAGCATG ACAAGCTGGT CAAACTTCAT 960
GCGGTGGTCA CCAAGGAGCC CATCTACATC ATCACGGAGT TCATGGCCAA AGGAAGCTTG 1020
CTGGACTTTC TGAAAAGTGA TGAGGGCAGC AAGCAGCCAT TGCCAAAACT CATTGACTTC 1080
TCAGCCCAGA TTGCAGAAGG CATGGCCTTC ATCGAGCAGA GGAACTACAT CCACCGAGAC 1140
CTCCGAGCTG CCAACATCTT GGTCTCTGCA TCCCTGGTGT GTAAGATTGC TGACTTTGGC 1200
CTGGCCCGGG TCATTGAGGA CAACGAGTAC ACGGCTCGGG AAGGGGCCAA GTTCCCCATC 1260
AAGTGGACAG CTCCTGAAGC CATCAACTTT GGCTCCTTCA CCATCAAGTC AGACGTCTGG 1320
TCCTTTGGTA TCCTGCTGAT GGAGATCGTC ACCTACGGCC GGATCCCTTA CCCAGGGATG 1380
TCAAACCCTG AAGTGATCCG AGCTCTGGAG CGTGGATACC GGATGCCTCG CCCAGAGAAC 1440
TGCCCAGAGG AGCTCTACAA CATCATGATG CGCTGCTGGA AAAACCGTCC GGAGGAGCGG 1500
CCGACCTTCG AATACATCCA GAGTGTGCTG GATGACTTCT ACACGGCCAC AGAGAGCCAG 1560
TACCAACAGC AGCCATGA 1578
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+
Q: 261   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH  320
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+makGslldflk++eg+k++lpkl+d++aq+aeGma++e++n+ihr
Q: 321   AVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR  379
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 380   DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  439
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+G++PypGm+n ev++++ergyr+prpe+cpeely+++++cwk++pee
Q: 440   WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEE  499
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 500   RPTFEYIQSVL  510
         *******9976
Domain Sequence
(FASTA)
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANVMKT LQHDKLVKLH 60
AVVTKEPIYI ITEFMAKGSL LDFLKSDEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 120
LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEIV TYGRIPYPGM SNPEVIRALE RGYRMPRPEN CPEELYNIMM RCWKNRPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-POA-00365
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013