EKS-GOG-00149
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00149
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR526.61.4E-158692968277
StatusUnreviewed
Ensembl ProteinENSGGOP00000027200
UniProt AccessionG3SGG4;
Protein Name
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000002917ENSGGOP00000018137ENSGGOT00000033207
ENSGGOG00000002917ENSGGOP00000027200ENSGGOT00000024164
ENSGGOG00000002917ENSGGOP00000017658ENSGGOT00000028123
OrganismGorilla gorilla
Functional Description
Protein Length1027
Protein Sequence
(FASTA)
PCMWHQQHVP CVCVCPCVCV CVCVCVCWPL SCALNAVCVT CPKSVAFALG VASAACGCAG 60
VKEWWLLQHA LRSACALHVR CVLCTQEAAS DGAAGSADLC PLPTEPCLAP SLEQQEQELT 120
VALGQPVRLC CGRAERGGHW YKEGSRLAPA GRVRGWRGRL EIASFLPEDA GRYLCLARGS 180
MIILQNLTLI TDGKPPATMM RTPSPIGTPR IGTFTPSKVS KSPRTCVPAA AHLITEKRRP 240
VWEHTVILGA FPCPPAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPMP TIRWLKDGQA 300
FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENAV GSIRYNYLLD VLERSPHRPI 360
LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP YVQVLKTADI 420
NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPGEHLKGQE MLRDAPLGQQ 480
WGLWPVGWSV SVGLWGLAWG AVCGFVGLSC MTAPLCLSTR GRPCDRLLRC GCLGLGITTA 540
SSVCVPTYVG SWEGLGCTGR PVSPLTSLSV CVCPCAREED PTWTAAAPEA RYTDIILYAS 600
GSLALAVLLL LAGLYRGQAL HGRHPRPPAT VQKLSRFPLA RQFSLESGSS GKSSSSLVRG 660
VRLSSSGPAL LAGLVSLDLP LDPLWEFPRD RLVLGKPLGE GCFGQVVRAE AFGMDPARPD 720
QASTVAVKML KDNASDKDLA DLVSEMEVMK LIGRHKNIIN LLGVCTQEGP LYVIVECAAK 780
GNLREFLRAR RPPGPDLSPD GPRSSEGPLS FPVLVSCAYQ VARGMQYLES RKCIHRDLAA 840
RNVLVTEDNV MKIADFGLAR GVHHIDYYKK TSNGRLPVKW MAPEALFDRV YTHQSDVWSF 900
GILLWEIFTL GGSPYPGIPV EELFSLLREG HRMDRPPHCP PELYGLMREC WHAAPSQRPT 960
FKQLVEALDK VLLAVSEEYL DLRLTFGPYS PSGGDASSTC SSSDSVFSHD PLPLGSSSFP 1020
FGSGVQT 1027
Nucleotide Sequence
(FASTA)
CCCTGTATGT GGCACCAACA GCATGTGCCT TGTGTGTGTG TGTGTCCGTG TGTGTGTGTA 60
TGCGTGTGTG TGTGTGTGTG TTGGCCACTG TCATGTGCAC TAAATGCTGT GTGTGTGACA 120
TGCCCCAAGA GTGTGGCATT TGCCCTGGGT GTGGCATCCG CAGCATGTGG CTGTGCTGGT 180
GTCAAGGAGT GGTGGCTCCT TCAGCATGCG TTGCGAAGTG CTTGTGCCCT GCATGTGCGG 240
TGTGTTCTCT GTACACAGGA GGCTGCCTCA GATGGGGCTG CGGGGTCTGC TGACCTCTGC 300
CCTCTGCCCA CAGAGCCCTG CCTGGCTCCC AGCCTGGAGC AGCAAGAGCA GGAACTGACA 360
GTAGCCCTTG GGCAGCCTGT GCGGCTGTGC TGTGGGCGGG CTGAGCGTGG TGGCCACTGG 420
TACAAGGAGG GCAGTCGCCT GGCACCTGCT GGCCGTGTAC GGGGCTGGAG GGGCCGCCTA 480
GAGATTGCCA GCTTCCTACC TGAGGATGCT GGCCGCTACC TCTGCCTGGC ACGAGGCTCC 540
ATGATCATCC TGCAGAATCT TACCTTGATT ACAGACGGTA AACCTCCAGC AACGATGATG 600
AGGACCCCAA GTCCCATAGG GACCCCTCGA ATAGGCACAT TTACCCCCAG CAAGGTCAGT 660
AAGTCTCCAA GGACTTGTGT CCCCGCTGCT GCTCATCTGA TCACTGAGAA GAGGAGGCCT 720
GTGTGGGAAC ACACAGTCAT TCTAGGGGCC TTCCCCTGCC CTCCAGCACC CTACTGGACA 780
CACCCCCAGC GCATGGAGAA GAAACTGCAT GCGGTACCTG CGGGGAACAC CGTCAAGTTC 840
CGCTGTCCAG CTGCAGGCAA CCCCATGCCC ACCATCCGCT GGCTTAAGGA TGGACAGGCC 900
TTTCATGGGG AGAACCGCAT TGGAGGCATT CGGCTGCGCC ATCAGCACTG GAGTCTCGTG 960
ATGGAGAGTG TGGTGCCCTC GGACCGCGGC ACATACACCT GCCTGGTAGA GAACGCTGTG 1020
GGCAGCATCC GCTATAACTA CCTGCTAGAT GTGCTGGAGC GGTCCCCGCA CCGGCCCATC 1080
CTGCAGGCCG GGCTCCCAGC CAACACCACA GCCGTGGTGG GCAGCGACGT GGAGCTGCTG 1140
TGCAAGGTGT ACAGCGATGC CCAGCCCCAC ATCCAGTGGC TGAAGCACAT CGTCATCAAC 1200
GGCAGCAGCT TCGGAGCCGA CGGTTTCCCC TATGTGCAAG TCCTAAAGAC TGCAGACATC 1260
AATAGCTCAG AGGTGGAGGT CCTGTACCTG CGGAACGTGT CAGCCGAGGA CGCAGGCGAG 1320
TACACCTGCC TCGCAGGCAA TTCCATCGGC CTCTCCTACC AGTCTGCCTG GCTCACAGTG 1380
CTGCCAGGTG AGCACCTGAA GGGCCAGGAG ATGCTGCGAG ATGCCCCTCT GGGCCAGCAG 1440
TGGGGGCTGT GGCCTGTTGG GTGGTCAGTC TCTGTTGGCC TGTGGGGTCT GGCCTGGGGG 1500
GCAGTGTGTG GATTTGTGGG TTTGAGCTGT ATGACAGCCC CTCTGTGCCT CTCCACACGT 1560
GGCCGTCCAT GTGACCGTCT GCTGAGGTGT GGGTGCCTGG GACTGGGCAT AACTACAGCT 1620
TCCTCCGTGT GTGTCCCCAC ATATGTTGGG AGCTGGGAGG GACTGGGGTG CACGGGGCGG 1680
CCAGTCTCAC CACTGACCAG TTTGTCTGTC TGTGTGTGTC CATGTGCGAG GGAGGAGGAC 1740
CCCACATGGA CCGCAGCAGC GCCTGAGGCC AGGTATACGG ACATCATCCT GTACGCGTCG 1800
GGCTCCCTGG CCTTGGCTGT GCTCCTGCTG CTGGCCGGGC TGTATCGAGG GCAGGCGCTC 1860
CACGGCCGGC ACCCCCGCCC ACCCGCCACT GTGCAGAAGC TCTCCCGCTT CCCTCTGGCC 1920
CGACAGTTCT CCCTGGAGTC AGGCTCTTCC GGCAAGTCAA GCTCATCCCT GGTACGAGGC 1980
GTGCGTCTCT CCTCCAGCGG CCCCGCCTTG CTCGCCGGCC TCGTGAGTCT AGATCTACCT 2040
CTCGACCCAC TATGGGAGTT CCCCCGGGAC AGGCTGGTGC TTGGGAAGCC CCTAGGCGAA 2100
GGCTGCTTTG GCCAGGTAGT ACGTGCAGAG GCCTTTGGCA TGGACCCTGC CCGGCCTGAC 2160
CAAGCCAGCA CTGTGGCCGT CAAGATGCTC AAAGACAACG CCTCTGACAA GGACCTGGCC 2220
GACCTGGTCT CGGAGATGGA GGTGATGAAG CTGATTGGCC GACACAAGAA CATCATCAAC 2280
CTGCTTGGTG TCTGCACCCA GGAAGGGCCC CTGTACGTGA TCGTGGAGTG CGCCGCCAAG 2340
GGAAACCTGC GGGAGTTCCT GCGGGCCCGG CGCCCCCCAG GCCCCGACCT CAGCCCCGAC 2400
GGTCCTCGGA GCAGTGAGGG GCCGCTCTCC TTCCCAGTCC TGGTCTCCTG CGCCTACCAG 2460
GTGGCCCGAG GCATGCAGTA TCTGGAGTCC CGGAAGTGTA TCCACCGGGA CCTGGCTGCC 2520
CGCAATGTGC TGGTGACCGA GGACAATGTG ATGAAGATTG CTGACTTTGG GCTGGCCCGC 2580
GGCGTCCACC ACATTGACTA CTATAAGAAA ACCAGCAACG GCCGCCTGCC TGTCAAGTGG 2640
ATGGCACCCG AGGCCTTGTT TGACCGGGTG TACACACACC AGAGTGACGT GTGGTCTTTT 2700
GGGATCCTGC TATGGGAGAT CTTCACCCTC GGGGGCTCCC CGTATCCTGG CATCCCGGTG 2760
GAGGAGCTGT TCTCGCTGCT GCGGGAGGGA CATCGGATGG ACCGACCCCC ACACTGCCCC 2820
CCAGAGCTGT ACGGACTGAT GCGTGAGTGC TGGCACGCGG CGCCCTCCCA GAGGCCTACC 2880
TTCAAGCAGC TGGTGGAGGC GCTGGACAAG GTCCTGCTGG CCGTCTCTGA GGAGTACCTC 2940
GACCTCCGCC TGACCTTCGG ACCCTATTCG CCCTCCGGTG GGGACGCCAG CAGCACCTGC 3000
TCCTCCAGTG ATTCTGTCTT CAGCCACGAC CCCCTGCCAT TGGGATCCAG CTCCTTCCCC 3060
TTCGGGTCTG GGGTGCAGAC A 3081
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv+aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl
Q: 692   LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL  751
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++
Q: 752   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF  811
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt
Q: 812   PVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT  871
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh
Q: 872   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  931
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p +c+ ely lmrecwha++s+rptfkqlve+l
Q: 932   RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL  968
         **********************************986
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVRAEA FGMDPARPDQ ASTVAVKMLK DNASDKDLAD LVSEMEVMKL 60
IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PRSSEGPLSF 120
PVLVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG VHHIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240
RMDRPPHCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Homo sapiens"; ?>Macaca mulatta"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>
EKS-HOS-00155
EKS-MAM-00146
EKS-OTG-00155
EKS-POA-00145
EKS-PTV-00140
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013