EKS-GOG-00161

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00161

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	495.2	5.0E-149	418	675	258

Status

Unreviewed

Ensembl Protein

ENSGGOP00000027839

UniProt Accession

G3QKB5;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000002930	ENSGGOP00000002886	ENSGGOT00000002951
ENSGGOG00000002930	ENSGGOP00000027839	ENSGGOT00000028881

Organism

Gorilla gorilla

Functional Description

Protein Length

735

Protein Sequence
(FASTA)

MPLAQLKEPW PLMELVPLDP ENGQTSGEEA GLQPSKDEGV LKEISITHHV KAGSEKADPS 60

HFELLKVLGQ GSFGKVFLVR KVTRPDSGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN 120

HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS 180

LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHS 240

HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN 300

PANRLGSGPD GAEEIKRHVF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP 360

KDSPGIPPSA GAHQLFRGFS FVATGLMEDD GKPRAPQAPL HSVVQQLHGK NLVFSDGYVV 420

KETIGVGSYS ECKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD 480

DGKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLHTIG KTVEYLHSQG VVHRDLKPSN 540

ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL 600

GILLYTMLAG YTPFANGPSD TPEEILTRIG SGKFTLSGGN WNTVSETAKD LVSKMLHVDP 660

HQRLTAKQVL QHPWVTQKDK LPQSQLSHQD LQLVKGAMAA TYSALNSSKP TPQLKPIESS 720

ILAQRRVRKL PSTTL 735

Nucleotide Sequence
(FASTA)

ATGCCGCTCG CCCAGCTCAA GGAGCCCTGG CCGCTCATGG AGCTAGTGCC GCTGGACCCG 60

GAGAATGGAC AGACCTCAGG GGAAGAAGCT GGACTTCAGC CGTCCAAGGA TGAGGGCGTC 120

CTCAAGGAGA TCTCCATCAC GCACCACGTC AAGGCTGGCT CTGAGAAGGC TGATCCATCC 180

CATTTCGAGC TCCTCAAGGT TCTGGGCCAG GGATCCTTTG GCAAAGTCTT CCTGGTGCGG 240

AAAGTCACCC GGCCTGACAG TGGGCACCTG TATGCTATGA AGGTGCTGAA GAAGGCAACG 300

CTGAAAGTAC GTGACCGCGT CCGGACCAAG ATGGAGAGAG ACATCCTGGC TGATGTAAAT 360

CACCCATTCG TGGTGAAGCT GCACTATGCC TTCCAGACCG AGGGCAAGCT CTATCTCATT 420

CTGGACTTCC TGCGTGGTGG GGACCTCTTC ACCCGGCTCT CAAAAGAGGT GATGTTCACG 480

GAGGAGGATG TGAAGTTTTA CCTGGCCGAG CTGGCTCTGG GCCTGGATCA CCTGCACAGC 540

CTGGGTATCA TTTACAGAGA CCTCAAGCCT GAGAACATCC TTCTGGATGA GGAGGGCCAC 600

ATCAAGCTCA CTGACTTTGG CCTGAGCAAA GAGGCCATTG ACCACGAGAA GAAGGCCTAT 660

TCTTTCTGCG GGACAGTGGA GTACATGGCC CCTGAGGTCG TCAACCGCCA GGGCCACTCC 720

CATAGTGCGG ACTGGTGGTC CTATGGGGTG TTGATGTTTG AGATGCTGAC GGGCTCCCTG 780

CCCTTCCAGG GGAAGGACCG GAAGGAGACC ATGACATTGA TTCTGAAGGC GAAGCTAGGC 840

ATGCCCCAGT TTCTGAGCAC TGAAGCCCAG AGCCTCTTGC GGGCCCTGTT CAAGCGGAAT 900

CCTGCCAACC GGCTCGGCTC CGGCCCTGAT GGGGCAGAGG AAATCAAGCG GCATGTCTTC 960

TACTCCACCA TTGACTGGAA TAAGCTATAC CGTCGTGAGA TCAAGCCACC CTTCAAGCCA 1020

GCAGTGGCTC AGCCTGATGA CACCTTCTAC TTTGACACCG AGTTCACGTC CCGCACACCC 1080

AAGGATTCCC CAGGCATCCC CCCCAGCGCT GGGGCCCATC AGCTGTTCCG GGGCTTCAGC 1140

TTCGTGGCCA CTGGCCTGAT GGAAGACGAC GGCAAGCCTC GTGCCCCACA AGCACCCCTG 1200

CACTCGGTGG TACAGCAACT CCATGGGAAG AACCTGGTTT TTAGTGACGG CTACGTGGTA 1260

AAGGAGACAA TTGGTGTGGG CTCCTACTCT GAGTGCAAGC GCTGTGTCCA CAAGGCCACC 1320

AACATGGAGT ATGCTGTCAA GGTCATTGAT AAGAGCAAGC GGGATCCTTC AGAAGAGATT 1380

GAGATTCTTC TGCGGTACGG CCAGCACCCC AACATCATCA CTCTGAAAGA TGTGTATGAT 1440

GATGGCAAAC ACGTGTACCT GGTGACAGAG CTGATGCGGG GTGGGGAGCT GCTGGACAAG 1500

ATCCTGCGGC AGAAGTTCTT CTCAGAGCGG GAGGCCAGCT TTGTCCTGCA CACCATTGGC 1560

AAAACTGTGG AGTATCTGCA CTCACAGGGG GTTGTGCACA GGGACCTGAA GCCCAGCAAC 1620

ATCCTGTATG TGGACGAGTC TGGGAATCCC GAGTGCCTGC GCATCTGTGA CTTTGGTTTT 1680

GCCAAACAGC TGCGGGCTGA GAATGGGCTC CTCATGACAC CTTGCTACAC AGCCAACTTT 1740

GTGGCGCCCG AGGTGCTGAA GCGCCAGGGC TACGATGAAG GCTGCGACAT CTGGAGCCTG 1800

GGCATTCTGC TCTACACCAT GCTGGCAGGA TACACTCCAT TTGCCAACGG TCCCAGTGAC 1860

ACACCAGAGG AAATCCTAAC CCGGATCGGC AGTGGGAAGT TTACCCTCAG TGGGGGAAAT 1920

TGGAACACAG TTTCAGAGAC AGCCAAGGAC CTGGTGTCCA AGATGCTACA CGTGGATCCC 1980

CACCAGCGCC TCACAGCTAA GCAGGTTCTG CAGCATCCAT GGGTCACCCA GAAAGACAAG 2040

CTTCCCCAAA GCCAGCTGTC CCACCAGGAC CTACAGCTTG TGAAGGGAGC CATGGCTGCC 2100

ACGTACTCTG CACTCAACAG CTCCAAGCCC ACCCCCCAGC TGAAGCCCAT CGAGTCATCC 2160

ATCCTGGCCC AGCGGCGAGT GAGGAAGTTG CCATCCACCA CCCTGTGA 2208

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y+vke++GvGsys ckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd

Q: 418   YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  477

         689*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgk+vylv+el++GGelld+i+++kffsereas +l+t+ k+veylh+qGvvhrdlk

Q: 478   VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK  537

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+

Q: 538   PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  597

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslG+llytmlaGy+pfangp+dt+eeil++i++Gkf+lsG++w++vse+akdlvsk+l+

Q: 598   WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH  657

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 658   VDPHQRLTAKQVLQHPWV  675

         *****************7

Domain Sequence
(FASTA)

YVVKETIGVG SYSECKRCVH KATNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60

VYDDGKHVYL VTELMRGGEL LDKILRQKFF SEREASFVLH TIGKTVEYLH SQGVVHRDLK 120

PSNILYVDES GNPECLRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180

WSLGILLYTM LAGYTPFANG PSDTPEEILT RIGSGKFTLS GGNWNTVSET AKDLVSKMLH 240

VDPHQRLTAK QVLQHPWV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013