EKS-GOG-00316
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00316
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20333.98.9E-10016272257
StatusUnreviewed
Ensembl ProteinENSGGOP00000002922
UniProt AccessionG3QKE8;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K2
Gene Synonyms/Alias MAP4K2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000002968ENSGGOP00000002922ENSGGOT00000002988
OrganismGorilla gorilla
Functional Description
Protein Length820
Protein Sequence
(FASTA)
MALLRDVSLQ DPRDRFELLQ RVGAGTYGDV YKARDTVTSE LAAVKIVKLD PGDDISSLQQ 60
EITILRECRH PNVVAYIGSY LRNDRLWICM EFCGGGSLQE IYHATGPLEE RQIAYVCREA 120
LKGLHHLHSQ GKIHRDIKGA NLLLTLQGDV KLADFGVSGE LTASVAKRRS FIGTPYWMAP 180
EVAAVERKGG YNELCDVWAL GITAIELGEL QPPLFHLHPM RALMLMSKSS FQPPKLRDKT 240
RWTQNFHHFL KLALTKNPKK RPTAEKLLQH PFTTQQLPRA LLTQLLDKAS DPHLGTPSPE 300
DCELETYDMF PDTIHSRGQH GPAERTPSEI QFHQVKFGAP RRKETDPLNE PWEEEWTLLG 360
KEELSGSLLQ SVQEALEERS LTIRSASEFQ ELDSPDDTMG TIKRAPFLGP LPPDPPAEEL 420
LSSPPGTLPP PPSGPNSSPL LPTAWATMKQ REDPERSSCH GLPPTPKVHM GACFSKVFNG 480
CPLRIHAAVT WIHPVTRDQF LVVGAEEGIY TLNLHELHED TLEKLISHRC SWLYCVNNVL 540
LSLSGKSTHI WAHDLPGLFE QRRLQQQVPL SIPTNRLTQR IIPRRFALST KIPDTKGCLQ 600
CRVVRNPYTG ATFLLAALPT SLLLLQWYEP LQKFLLLKNF SSPLPSPAGM LEPLVLDGKE 660
LPQVCVGAEG PEGPGCRVLF HVLPLEAGLT PDILIPPEGI PGSAQQVIQV DRDTILVSFE 720
RCVRIVNMQG EPTATLAPEL TFDFPIETVV CLQDSVLAFW SHGMQGRSLD TNEVTQEITD 780
ETRIFRVLGA HRDIILESIP TDNPEAHSNL YILTGHQSTY 820
Nucleotide Sequence
(FASTA)
ATGGCGCTGC TGCGGGATGT GTCGCTGCAG GACCCGCGGG ACCGCTTCGA GCTGCTGCAG 60
CGCGTGGGGG CCGGGACCTA TGGCGACGTC TACAAGGCCC GCGACACGGT CACGTCTGAA 120
CTGGCCGCCG TGAAGATAGT CAAGCTAGAC CCAGGGGACG ACATCAGCTC CCTCCAGCAG 180
GAAATCACCA TCCTGCGTGA GTGCCGCCAC CCCAATGTGG TGGCCTACAT TGGCAGCTAC 240
CTCAGGAATG ACCGCTTGTG GATCTGCATG GAGTTCTGCG GAGGGGGCTC CCTGCAGGAG 300
ATTTACCATG CCACTGGGCC CCTGGAGGAG CGGCAGATTG CCTACGTCTG CCGAGAGGCA 360
CTGAAGGGGC TCCACCACCT GCATTCTCAG GGGAAGATCC ACAGAGACAT CAAGGGAGCC 420
AACCTTCTCC TCACTCTCCA GGGAGATGTC AAACTGGCTG ACTTTGGGGT GTCAGGCGAG 480
CTGACAGCGT CTGTGGCCAA GAGGAGGTCT TTCATTGGGA CTCCCTACTG GATGGCTCCC 540
GAGGTGGCTG CTGTGGAGCG CAAAGGTGGC TACAATGAGC TATGTGACGT CTGGGCCCTG 600
GGCATCACTG CCATTGAGCT GGGAGAGCTG CAGCCCCCTC TGTTCCACCT GCACCCCATG 660
AGGGCCCTGA TGCTCATGTC GAAGAGCAGC TTCCAGCCGC CCAAACTGAG AGATAAGACT 720
CGCTGGACCC AGAATTTCCA CCACTTTCTC AAACTGGCCC TGACCAAGAA TCCTAAGAAG 780
AGGCCGACAG CAGAGAAGCT CCTGCAGCAC CCGTTCACAA CTCAGCAGCT CCCTCGGGCC 840
CTCCTCACAC AGCTGCTGGA CAAAGCCAGT GACCCTCATC TGGGGACCCC CTCCCCTGAG 900
GACTGTGAGC TGGAGACCTA TGACATGTTT CCAGACACCA TTCACTCCCG GGGGCAGCAC 960
GGCCCAGCCG AGAGGACCCC CTCGGAGATC CAGTTTCACC AGGTGAAATT TGGCGCCCCA 1020
CGCAGGAAGG AAACTGACCC ACTGAATGAG CCGTGGGAGG AAGAGTGGAC ACTACTGGGA 1080
AAGGAAGAGT TGAGTGGGAG CCTGTTGCAG TCGGTCCAGG AGGCCCTGGA GGAAAGGAGT 1140
CTGACTATTC GGTCAGCCTC AGAATTCCAG GAGCTGGACT CCCCAGACGA TACCATGGGA 1200
ACCATCAAGC GGGCCCCGTT CCTAGGGCCA CTCCCCCCTG ACCCTCCAGC AGAGGAGCTT 1260
CTGTCCAGTC CCCCAGGAAC CCTGCCCCCA CCTCCTTCAG GCCCCAACAG CTCCCCACTG 1320
CTGCCCACGG CCTGGGCCAC CATGAAGCAG CGGGAGGATC CTGAGAGGTC ATCCTGCCAC 1380
GGGCTCCCCC CAACTCCCAA GGTGCATATG GGCGCCTGCT TTTCCAAGGT CTTCAATGGC 1440
TGCCCCCTGC GGATCCACGC TGCTGTCACC TGGATTCACC CTGTTACTCG GGACCAGTTC 1500
CTGGTGGTAG GGGCCGAGGA AGGCATCTAC ACACTCAACC TGCATGAACT GCATGAGGAT 1560
ACGCTGGAGA AGCTGATTTC ACATCGCTGC TCCTGGCTCT ACTGCGTGAA CAACGTGCTG 1620
CTGTCACTCT CAGGGAAATC CACGCACATC TGGGCCCATG ACCTCCCAGG CCTGTTTGAG 1680
CAGCGGAGGC TACAGCAACA GGTTCCCCTC TCCATCCCCA CCAACCGCCT CACCCAGCGC 1740
ATCATCCCCA GGCGCTTTGC TCTGTCCACC AAGATTCCTG ACACCAAAGG CTGCTTGCAG 1800
TGTCGTGTGG TGCGGAACCC GTACACGGGT GCCACCTTCC TGCTGGCCGC CCTGCCCACC 1860
AGCCTGCTCC TGCTGCAGTG GTATGAGCCG CTGCAGAAGT TCCTGCTGCT GAAGAACTTC 1920
TCCAGCCCTC TGCCCAGCCC AGCTGGGATG CTGGAGCCGC TGGTGCTGGA TGGGAAGGAG 1980
CTGCCGCAGG TGTGTGTGGG GGCCGAGGGG CCTGAGGGGC CTGGCTGCCG CGTCCTGTTC 2040
CATGTCCTGC CCCTGGAGGC TGGCCTGACG CCCGACATCC TCATCCCACC TGAGGGGATC 2100
CCAGGCTCGG CCCAGCAGGT GATCCAGGTG GACAGGGACA CAATCCTAGT CAGCTTTGAA 2160
CGCTGTGTGA GGATTGTCAA CATGCAGGGC GAGCCCACGG CCACACTGGC ACCTGAGCTG 2220
ACCTTTGATT TCCCCATCGA GACTGTGGTG TGCCTGCAGG ACAGTGTGCT GGCCTTCTGG 2280
AGCCATGGGA TGCAAGGCCG AAGCCTGGAT ACCAATGAGG TGACCCAGGA GATCACAGAT 2340
GAAACAAGAA TCTTCCGAGT GCTTGGGGCC CACAGAGACA TCATCCTGGA GAGCATTCCC 2400
ACTGACAACC CAGAGGCGCA CAGCAACCTC TACATCCTCA CGGGCCACCA GAGCACCTAC 2460
TAA 2463
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         +ell+++g G++g+vy+ar++ t+el+a+k+++l+  +++++lq+ei++l++++hpn+v+
Q: 16    FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVA  75
         899*********************************************************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s+l++++lw++me++ gGsl+++++   + +l+E+qiay++re+lk+L++lHs+++i
Q: 76    YIGSYLRNDRLWICMEFCGGGSLQEIYH--ATGPLEERQIAYVCREALKGLHHLHSQGKI  133
         ****************************..9*****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179
         Hrdik++n+Llt +g+VkL+dfgv+ +l+++++kr++++gtpywmAPEv a+e + gY+e
Q: 134   HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVErKGGYNE  193
         ****************************************************98889***
S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237
          +D+w+lGItaiel e +pP+++l+p++al++++k++  ppkl++k++++++f++f++ +
Q: 194   LCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSfqPPKLRDKTRWTQNFHHFLKLA  253
         **********************************99988*********************
S: 238   lqknpekRpsasellkhkF  256
         l+knp+kRp+a++ll+h+F
Q: 254   LTKNPKKRPTAEKLLQHPF  272
         ******************9
Domain Sequence
(FASTA)
FELLQRVGAG TYGDVYKARD TVTSELAAVK IVKLDPGDDI SSLQQEITIL RECRHPNVVA 60
YIGSYLRNDR LWICMEFCGG GSLQEIYHAT GPLEERQIAY VCREALKGLH HLHSQGKIHR 120
DIKGANLLLT LQGDVKLADF GVSGELTASV AKRRSFIGTP YWMAPEVAAV ERKGGYNELC 180
DVWALGITAI ELGELQPPLF HLHPMRALML MSKSSFQPPK LRDKTRWTQN FHHFLKLALT 240
KNPKKRPTAE KLLQHPF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00310
EKS-BOT-00321
EKS-CAJ-00329
EKS-CAF-00324
EKS-CAP-00353
EKS-DAR-00674
EKS-DIO-00040
EKS-EQC-00329
EKS-FEC-00324
EKS-GAA-00396
EKS-HOS-00329
EKS-ICT-00315
EKS-MUM-00354
EKS-MUP-00327
EKS-MYL-00331
EKS-ORL-00381
EKS-OTG-00342
EKS-PAT-00304
EKS-POA-00311
EKS-PTV-00073
EKS-RAN-00352
EKS-SUS-00279
EKS-XIM-00410
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013