EPS-GOG-00046

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GOG-00046

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	546.8	1.8E-164	120	454	335

Status

Unreviewed

Ensembl Protein

ENSGGOP00000021162

UniProt Accession

G3RZB9;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF1

Gene Synonyms/Alias

PPEF1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000003393	ENSGGOP00000021162	ENSGGOT00000033406
ENSGGOG00000003393	ENSGGOP00000003343	ENSGGOT00000003418

Organism

Gorilla gorilla

Functional Description

Protein Length

652

Protein Sequence
(FASTA)

GCVSLSTCIL SMSAALRAAL IIQNWYRGYK ARLKARQHYA LTIFQSIEYA DEQGQMQLST 60

FFSFMLENYT HIHKEELELR NQSLESEQDL RDRWDYVDSI DVPDSYNGPR LQFPLTCTDI 120

DLLLEAFKEQ QMLLLEYIKN MALKSYIIAK SLRDWTEKVI EALDAVPTIG DLHGKLDDLF 180

LIFYKNGLPS ERNPYVFNGD FVDRGKNSIE ILMILCVSFL VYPNDLHLNR GNHEDFMMNL 240

RYGFTKEILR KYKLHGKRIL QILEELYAWL PIGTVVDNEI LVIHGGISET TDLNLLHRVE 300

RNKMKSVLIP PAETNRDHDT DSKHNKVGVT FNAHGRIKTN GSPTEHLTKH EWEQIIDILW 360

SDPRGKNGCF PNTCRGGGCY FGPDVTSKIL NKYQLKMLIR SHECKPEGYE ICHDGKVVTI 420

FSASNYYEEG SNRGAYIKLC SGTTPRFFQY QVTKATCFQP LRQRVDTMEN SAIKILRERV 480

ISRKSDLTRA FQLQDHRKSA KLDHRIINGS LRELLKLTKP WREREREKKN KYRNSLYEYM 540

SSFQNIRIEK PVQEAHSTLV ETLYRYRSDL EIIFNAIDTD HSGLISMEEF RAMWKLFSSH 600

YNVLIDDSQV NKLANIMDLN KDGSIDFNEF LKAFYVVHRY EDLMKPDVTN LG 652

Nucleotide Sequence
(FASTA)

GGGTGTGTTT CTTTATCCAC CTGCATTTTA TCAATGTCTG CAGCACTGAG AGCTGCGTTG 60

ATCATCCAGA ACTGGTACCG AGGTTACAAA GCTCGACTGA AGGCCAGACA ACACTATGCC 120

CTCACCATCT TCCAGTCCAT CGAATATGCT GATGAACAAG GCCAAATGCA GTTATCCACC 180

TTCTTTTCCT TCATGTTGGA AAACTACACA CATATACATA AGGAAGAGCT AGAATTAAGA 240

AATCAATCTC TTGAAAGCGA ACAGGACCTG AGGGATAGAT GGGATTATGT GGACTCGATA 300

GATGTCCCAG ACTCCTATAA TGGTCCTCGG CTACAATTTC CTCTCACTTG TACGGATATT 360

GATTTACTTC TTGAGGCCTT CAAGGAACAA CAGATGCTGC TACTGGAGTA TATTAAAAAC 420

ATGGCTTTAA AAAGCTATAT AATCGCTAAG AGCCTGAGGG ACTGGACTGA AAAGGTAATT 480

GAAGCACTAG ATGCTGTCCC CACTATAGGT GATTTGCATG GGAAACTGGA TGATCTTTTT 540

TTGATCTTCT ACAAGAATGG TCTCCCCTCA GAGAGGAACC CGTATGTTTT TAATGGTGAC 600

TTTGTAGATC GAGGAAAGAA TTCCATAGAG ATCCTCATGA TCCTGTGTGT GAGTTTTCTT 660

GTCTACCCCA ATGACCTGCA CTTGAACAGA GGGAACCATG AAGATTTTAT GATGAATCTG 720

AGGTATGGCT TCACGAAAGA AATTTTGCGT AAATATAAGC TACATGGAAA AAGAATCTTA 780

CAAATCTTGG AAGAACTCTA TGCCTGGCTC CCAATCGGTA CAGTCGTTGA CAATGAAATC 840

CTGGTCATCC ATGGTGGGAT ATCAGAGACC ACAGACTTGA ATTTACTCCA CCGTGTAGAG 900

AGGAACAAGA TGAAATCTGT GCTGATACCA CCAGCGGAAA CAAACAGAGA CCATGACACT 960

GACTCGAAGC ACAATAAAGT AGGTGTGACT TTTAATGCAC ATGGAAGAAT CAAAACCAAT 1020

GGATCTCCTA CTGAACACTT AACAAAGCAT GAATGGGAAC AGATTATTGA TATTCTGTGG 1080

AGTGATCCCA GAGGCAAAAA TGGCTGTTTT CCAAATACGT GCCGAGGAGG GGGCTGCTAT 1140

TTTGGACCAG ATGTTACTTC CAAGATTCTT AATAAATACC AGTTGAAGAT GCTCATCAGG 1200

TCTCATGAAT GTAAGCCCGA AGGGTATGAA ATCTGTCATG ATGGGAAGGT TGTGACTATA 1260

TTTTCTGCTT CTAATTATTA TGAAGAAGGC AGCAATCGAG GAGCTTACAT CAAACTATGT 1320

TCTGGTACAA CTCCTCGATT TTTCCAGTAC CAAGTAACTA AAGCAACGTG CTTTCAGCCT 1380

CTTCGCCAAA GAGTGGATAC TATGGAAAAC AGCGCCATCA AGATATTAAG AGAGAGAGTG 1440

ATTTCACGAA AAAGTGACCT TACTCGTGCT TTCCAACTTC AAGACCACAG AAAATCAGCA 1500

AAATTAGACC ATAGAATCAT AAATGGTTCT TTGAGGGAAC TGTTGAAGTT GACGAAACCA 1560

TGGCGAGAGA GAGAGAGAGA AAAAAAAAAC AAATATAGAA ACAGCCTATA TGAATACATG 1620

TCCAGCTTCC AGAATATCCG CATTGAAAAA CCTGTACAAG AGGCTCATTC TACTCTAGTT 1680

GAAACTCTGT ACAGATACAG ATCTGACCTG GAAATCATAT TTAATGCCAT TGACACTGAT 1740

CACTCAGGCC TGATCTCCAT GGAAGAATTT CGTGCCATGT GGAAACTTTT TAGTTCTCAC 1800

TACAATGTTC TTATTGATGA TTCCCAAGTC AATAAGCTTG CCAACATAAT GGACTTGAAC 1860

AAAGATGGAA GCATTGACTT TAATGAGTTT TTAAAGGCTT TCTATGTAGT GCATAGATAT 1920

GAGGACTTGA TGAAACCTGA TGTCACCAAC CTTGGCTAA 1959

Domain Profile

S: 1     idlllevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddl  60

         idllle+fk++++l  +y+ ++  ++  + k l + ++    + + v  +GdlhGklddl

Q: 120   IDLLLEAFKEQQMLLLEYIKNMALKSYIIAKSLRDWTEKVIEALDAVPTIGDLHGKLDDL  179

         8*************************************999999****************

S: 61    llvlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmn  120

         +l+++knGlPsernpyvfnGdfvdrGk+++e+l++l+++flv+Pn+++lnrGnhed++mn

Q: 180   FLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMN  239

         ************************************************************

S: 121   aryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksv  180

         +ryGf+ke+l kyk +gkril+ilee+y+wlP+g++vd+++lv+hGG+se+t+l+ll++v

Q: 240   LRYGFTKEILRKYKLHGKRILQILEELYAWLPIGTVVDNEILVIHGGISETTDLNLLHRV  299

         ************************************************************

S: 181   erkkrksvllpPeessrd................lgrldtdgepreslteteweqiidil  224

         er+k+ksvl+pP e++rd                +gr++t+g+p+e+lt++eweqiidil

Q: 300   ERNKMKSVLIPPAETNRDhdtdskhnkvgvtfnaHGRIKTNGSPTEHLTKHEWEQIIDIL  359

         ************************************************************

S: 225   wsdPratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvt  284

         wsdPr++nG++Pnt+rG+G+yfGPdvt+++l+ky+lk++irsheckpegyei+hdgkvvt

Q: 360   WSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVT  419

         ************************************************************

S: 285   ifsasnyyeegsnkgayiklnsqltprfvqyivak  319

         ifsasnyyeegsn+gayikl+s++tprf+qy+v+k

Q: 420   IFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTK  454

         ********************************996

Domain Sequence
(FASTA)

IDLLLEAFKE QQMLLLEYIK NMALKSYIIA KSLRDWTEKV IEALDAVPTI GDLHGKLDDL 60

FLIFYKNGLP SERNPYVFNG DFVDRGKNSI EILMILCVSF LVYPNDLHLN RGNHEDFMMN 120

LRYGFTKEIL RKYKLHGKRI LQILEELYAW LPIGTVVDNE ILVIHGGISE TTDLNLLHRV 180

ERNKMKSVLI PPAETNRDHD TDSKHNKVGV TFNAHGRIKT NGSPTEHLTK HEWEQIIDIL 240

WSDPRGKNGC FPNTCRGGGC YFGPDVTSKI LNKYQLKMLI RSHECKPEGY EICHDGKVVT 300

IFSASNYYEE GSNRGAYIKL CSGTTPRFFQ YQVTK 335

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00612	; IQ; 1.
PF00149	; Metallophos; 1.

SMARTs

SM00054	; EFh; 2.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 2.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013