EKS-GOG-00190

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00190

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	333.0	1.6E-99	310	582	273

Status

Unreviewed

Ensembl Protein

ENSGGOP00000003434

UniProt Accession

G3QLR9;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000003489	ENSGGOP00000003434	ENSGGOT00000003511

Organism

Gorilla gorilla

Functional Description

Protein Length

620

Protein Sequence
(FASTA)

MGSYLSVPAY FTSRDLFRCS ECQDSLTNWY YEKDGKLYCP KDYWGKFGEF CHGCSLLMTG 60

PFMVAGEFKY HPECFACMSC KVIIEDGDAY ALVQHATLYC GKCHNEVVLA PMFERLSTES 120

VQEQLPYSVT LISMPATTEG RRGFSVSVES ACSNYATTVQ VKEVNRMHIS PNNRNAIHPG 180

DRILEINGTP VRTLRVEEVE DAISQTSQTL QLLIEHDPVS QRLDQLRLEA RLAPHMQNAG 240

HPHALSTLDT KENLEGTLRR RSLRRSNSIS KSPGPSSPKE PLLFSRDISR SESLRCSSSY 300

SQQIFRPCDL IHGEVLGKGF FGQAIKVTHK ATGKVMVMKE LIRCDEETQK TFLTEVKVMR 360

SLDHPNVLKF IGVLYKDKKL NLLTEYIEGG TLKDFLRSMD PFPWQQKVRF AKGIASGMFG 420

STLGSLCFKF LGLESGKRFF KQDKTVVVAD FGLSRLIVEE RKRHPMEKAT TKKRTLRKND 480

RKKRYTVVGN PYWMAPEMLN GKSYDETVDI FSFGIVLCEV SSGTKAMPEA AGRARDCSCG 540

CLASSWAKCS PSQFPSKWFP DRETCCITSF PSRPAFSKLE DSFEALSLYL GELGIPLPAE 600

LEELDHTVSM QYGLTRDSPP 620

Nucleotide Sequence
(FASTA)

ATGGGGAGTT ACTTGTCAGT CCCGGCTTAC TTCACCTCCA GAGACTTATT TCGGTGTTCA 60

GAATGCCAGG ATTCCCTCAC CAACTGGTAC TATGAGAAGG ATGGGAAGCT CTACTGCCCC 120

AAGGACTACT GGGGGAAGTT TGGGGAGTTC TGTCATGGGT GCTCCCTGCT GATGACAGGG 180

CCTTTTATGG TGGCTGGGGA GTTCAAGTAC CACCCAGAGT GCTTTGCCTG TATGAGCTGC 240

AAGGTGATCA TTGAGGATGG GGATGCATAT GCACTGGTGC AGCATGCCAC CCTCTACTGT 300

GGGAAGTGCC ACAATGAGGT GGTGCTGGCA CCCATGTTTG AGAGACTCTC CACAGAGTCT 360

GTTCAGGAGC AGCTGCCTTA CTCTGTCACG CTCATCTCCA TGCCAGCCAC CACTGAAGGC 420

AGGCGGGGCT TCTCCGTGTC CGTGGAGAGT GCCTGCTCCA ACTACGCCAC CACTGTGCAA 480

GTGAAAGAGG TCAACCGGAT GCACATCAGT CCCAACAATC GCAATGCCAT CCACCCTGGG 540

GACCGCATCC TGGAGATCAA TGGGACCCCC GTCCGCACAC TTCGAGTGGA GGAGGTGGAG 600

GATGCAATTA GCCAGACGAG CCAGACACTT CAGCTGTTGA TTGAACATGA CCCTGTCTCC 660

CAACGCCTGG ACCAGCTGCG GCTGGAGGCC CGGCTTGCTC CTCACATGCA GAATGCTGGA 720

CACCCCCACG CCCTCAGCAC CCTGGACACC AAGGAGAATC TGGAGGGGAC ACTGAGGAGA 780

CGTTCCCTGA GGCGCAGTAA CAGTATCTCC AAGTCCCCTG GCCCCAGCTC CCCAAAGGAG 840

CCCCTGCTGT TCAGCCGTGA CATCAGCCGC TCAGAATCCC TTCGTTGTTC CAGCAGCTAT 900

TCACAGCAGA TCTTCCGGCC CTGTGACCTA ATCCATGGGG AGGTCCTGGG GAAGGGCTTC 960

TTTGGGCAGG CTATCAAGGT GACACACAAA GCCACGGGCA AAGTGATGGT CATGAAAGAG 1020

TTAATTCGAT GTGATGAGGA GACCCAGAAA ACTTTTCTGA CTGAGGTGAA AGTGATGCGC 1080

AGCCTGGACC ACCCCAATGT GCTCAAGTTC ATTGGTGTGC TGTACAAGGA TAAGAAGCTG 1140

AACCTGCTGA CAGAGTACAT TGAGGGGGGC ACACTGAAGG ACTTTCTGCG CAGTATGGAT 1200

CCGTTCCCCT GGCAGCAGAA GGTCAGGTTT GCCAAAGGAA TCGCCTCCGG AATGTTTGGG 1260

AGTACATTAG GGTCGCTGTG TTTTAAGTTT CTGGGGCTTG AATCAGGGAA AAGATTTTTT 1320

AAGCAAGACA AGACTGTGGT GGTGGCAGAC TTTGGGCTGT CACGGCTCAT AGTGGAAGAG 1380

AGGAAAAGGC ACCCCATGGA GAAGGCCACC ACCAAGAAAC GCACCTTGCG CAAGAACGAC 1440

CGCAAGAAGC GCTACACGGT GGTGGGAAAC CCCTACTGGA TGGCCCCTGA GATGCTGAAC 1500

GGAAAGAGCT ATGATGAGAC GGTGGATATC TTCTCCTTTG GGATCGTTCT CTGTGAGGTG 1560

AGCTCTGGCA CCAAGGCCAT GCCCGAGGCA GCAGGAAGGG CAAGAGACTG TTCATGTGGC 1620

TGTCTAGCTA GCTCTTGGGC CAAATGTAGC CCTTCTCAGT TCCCTTCAAA ATGGTTTCCG 1680

GACAGAGAAA CATGCTGCAT TACCTCTTTT CCTTCTAGAC CAGCATTCTC GAAACTGGAG 1740

GACTCCTTTG AGGCCCTCTC CCTATACCTG GGGGAGCTGG GCATCCCGCT GCCTGCAGAG 1800

CTGGAGGAGT TGGACCACAC TGTGAGCATG CAGTACGGCC TGACCCGGGA CTCACCTCCC 1860

TAG 1863

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r+l+hpnvlk

Q: 310   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK  369

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGl..sylhskgii  118

         fiGvl+kdkkl+llteyiegGtlk++l+s++++pw+q+vr+ak+iasG+  s l s +

Q: 370   FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMfgSTLGSLCFK  429

         *************************************************77789999999

S: 119   hrdlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvG  172

            l+s   + ++dk+vvvadfGl+rl+veerk+       +k+r+l+k+drkkr+tvvG

Q: 430   FLGLESGKRFFKQDKTVVVADFGLSRLIVEERKRHpmekatTKKRTLRKNDRKKRYTVVG  489

         9*******************************99889999999*****************

S: 173   sPywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvk.afrekl  231

         +PywmaPe+l+gksyde+vd+fsfGivlce+ +  +a P+   r+ d +     + + k

Q: 490   NPYWMAPEMLNGKSYDETVDIFSFGIVLCEVSSGTKAMPEAAGRARDCSCGCLaSSWAKC  549

         ***********************************************9998651568889

S: 232   vaedcPeaflklavvccdldpesrpsfeelekk  264

          +++ P+++++   +cc     srp+f++le++

Q: 550   SPSQFPSKWFPDRETCCITSFPSRPAFSKLEDS  582

         9*****************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFLRSM DPFPWQQKVR FAKGIASGMF GSTLGSLCFK 120

FLGLESGKRF FKQDKTVVVA DFGLSRLIVE ERKRHPMEKA TTKKRTLRKN DRKKRYTVVG 180

NPYWMAPEML NGKSYDETVD IFSFGIVLCE VSSGTKAMPE AAGRARDCSC GCLASSWAKC 240

SPSQFPSKWF PDRETCCITS FPSRPAFSKL EDS 273

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013