EKS-GOG-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	369.7	1.2E-110	117	401	285

Status

Unreviewed

Ensembl Protein

ENSGGOP00000003526

UniProt Accession

G3QM02;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK14

Gene Synonyms/Alias

CDK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000003585	ENSGGOP00000003526	ENSGGOT00000003606

Organism

Gorilla gorilla

Functional Description

Protein Length

451

Protein Sequence
(FASTA)

MHGYFGCNAA AEPDYSAFVG TPQICVTKMS TRNCQGMDSV IKPLDTIPED KKVRVQRTQS 60

TFDPFEKPAN QVKRVHSENN ACINFKTSST GKESPKVRRH SSPSSPTSPK FGKADSYEKL 120

EKLGEGSYAT VYKGKSKVNG KLVALKVIRL QEEEGTPFTA IREASLLKGL KHANIVLLHD 180

IIHTKETLTL VFEYVHTDLC QYMDKHPGGL HPDNVKLFLF QLLRGLSYIH QRYILHRDLK 240

PQNLLISDTG ELKLADFGLA RAKSVPSHTY SNEVVTLWYR PPDVLLGSTE YSTCLDMWGV 300

GCIFVEMIQG VAAFPGMKDI QDQLERIFLV LGTPNEDTWP GVHSLPHFKP ERFTLYSSKN 360

LRQAWNKLSY VNHAEDLASK LLQCSPKNRL SAQAALSHEY FSDLPPRLWE LTDMSSIFTV 420

PNVRLQPEAG ESMRAFGKNN SYGKSLSNSK H 451

Nucleotide Sequence
(FASTA)

ATGCACGGTT ACTTTGGCTG CAATGCTGCT GCAGAGCCCG ATTACTCTGC CTTCGTGGGA 60

ACTCCACAGA TATGTGTCAC AAAGATGTCT ACACGGAACT GCCAGGGAAT GGACTCAGTG 120

ATCAAACCCC TGGACACAAT TCCTGAGGAT AAAAAAGTCA GAGTTCAGAG GACACAGAGC 180

ACTTTTGACC CATTTGAGAA ACCAGCTAAT CAAGTAAAGA GGGTGCATTC TGAGAACAAT 240

GCTTGCATTA ACTTTAAGAC CTCCTCCACT GGCAAAGAGT CACCTAAAGT TAGGCGGCAC 300

TCCAGCCCCA GCTCGCCAAC AAGTCCCAAA TTTGGAAAAG CTGACTCATA TGAAAAGCTG 360

GAAAAACTAG GGGAAGGATC TTATGCTACA GTATACAAAG GGAAAAGCAA GGTAAATGGG 420

AAGTTGGTAG CTCTGAAGGT GATCAGGCTG CAGGAAGAAG AAGGGACACC TTTCACAGCT 480

ATCAGGGAAG CTTCTCTTTT AAAAGGACTA AAACATGCTA ACATAGTGCT ACTTCATGAC 540

ATCATCCATA CCAAGGAGAC GCTGACACTT GTGTTTGAAT ATGTGCACAC TGATTTATGT 600

CAGTACATGG ACAAGCACCC TGGGGGGCTG CATCCAGATA ATGTGAAGTT GTTTTTATTT 660

CAGTTGCTGC GAGGGCTGTC TTACATCCAC CAGCGTTATA TTTTGCACAG AGACCTGAAA 720

CCACAGAACC TTCTGATCAG TGACACGGGG GAGTTAAAGC TGGCAGATTT CGGTCTTGCA 780

AGAGCAAAAT CCGTCCCTAG CCACACATAC TCCAACGAAG TGGTTACCTT GTGGTACAGA 840

CCTCCAGATG TCCTTCTAGG CTCAACAGAA TATTCCACCT GCCTTGACAT GTGGGGAGTA 900

GGTTGCATCT TTGTTGAAAT GATCCAAGGA GTTGCTGCTT TTCCAGGAAT GAAAGACATT 960

CAGGATCAAC TTGAACGAAT ATTTCTGGTT CTTGGAACAC CAAATGAGGA CACATGGCCT 1020

GGAGTTCATT CTTTACCGCA TTTTAAGCCA GAACGCTTTA CCCTGTACAG CTCTAAAAAC 1080

CTTAGACAAG CGTGGAATAA GCTCAGCTAT GTGAACCATG CAGAGGACCT GGCCTCCAAG 1140

CTCCTACAAT GTTCCCCAAA GAACAGACTG TCGGCACAGG CTGCCTTGAG CCACGAGTAT 1200

TTTAGTGACC TGCCCCCACG GCTATGGGAA CTCACCGACA TGTCTTCTAT TTTTACTGTC 1260

CCAAATGTGA GATTGCAACC AGAAGCTGGA GAAAGCATGC GGGCCTTTGG GAAAAACAAT 1320

AGTTATGGCA AAAGTCTATC AAACAGCAAG CACTGA 1356

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklek+geG+y++vyk+k+k +g++vAlK irl++e eg p+ta+rE sllk lkh+ni

Q: 117   YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI  175

         99********************************998.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v L+++++ +k++l+Lvfe++++dL ++++k++  +l++++vk +l+qll+gl+y+H++

Q: 176   VLLHDIIH-TKETLTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRGLSYIHQRY  233

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis++g+lklaDfGlara s+p++ty++evvTlwYr+P++Llg++eYst

Q: 234   ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYST  293

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf  238

          +D+W+vgci++e+++  + f+g ++ +dqlerif +lgtp+e++wp+v++lp++k ++f

Q: 294   CLDMWGVGCIFVEMIQGVAAFPGMKDiQDQLERIFLVLGTPNEDTWPGVHSLPHFKpERF  353

         ************************99679***************************9999

S: 239   pkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf  284

         + +++k+l++ ++kl+  ++a dl +kll+++pk+R+sa++al+h+yf

Q: 354   TLYSSKNLRQAWNKLSyvNHAEDLASKLLQCSPKNRLSAQAALSHEYF  401

         99**********99997678***************************9

Domain Sequence
(FASTA)

YEKLEKLGEG SYATVYKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL LKGLKHANIV 60

LLHDIIHTKE TLTLVFEYVH TDLCQYMDKH PGGLHPDNVK LFLFQLLRGL SYIHQRYILH 120

RDLKPQNLLI SDTGELKLAD FGLARAKSVP SHTYSNEVVT LWYRPPDVLL GSTEYSTCLD 180

MWGVGCIFVE MIQGVAAFPG MKDIQDQLER IFLVLGTPNE DTWPGVHSLP HFKPERFTLY 240

SSKNLRQAWN KLSYVNHAED LASKLLQCSP KNRLSAQAAL SHEYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013