EKS-GOG-00111
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00111
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec475.15.9E-143363613251
StatusUnreviewed
Ensembl ProteinENSGGOP00000003555
UniProt AccessionG3QM29;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000003614ENSGGOP00000003555ENSGGOT00000003635
OrganismGorilla gorilla
Functional Description
Protein Length620
Protein Sequence
(FASTA)
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 60
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVPKY 120
HPNFWMDGKW RCCSQLEKLA AGCAQYDPTK NASKKPLPPT PEDNRRPLWE PEETVVIALY 180
DYQTNDPQEL ALRRNEEYCL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETHEWY 240
NKSISRDKAE KLLLDTGKEG AFMVRDSRTA GTYTVSVFTK AVVSENNPCI KHYHIKETND 300
NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCF GRQKAPVTAG LRYGKWVIDP 360
SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIREGAMSE EDFIEEAEVM MKLSHPKLVQ 420
LYGVCLEKAP ICLVFEFMEH GCLSDYLRTQ RGLFAAETLL GMCLDVCEGM AYLEEACVIH 480
RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540
VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASTHVYQI MNHCWKERPE 600
DRPAFSRLLR QLAEIAESGL 620
Nucleotide Sequence
(FASTA)
ATGAACAACT TTATCCTCCT GGAAGAACAG CTCATCAAGA AATCCCAACA AAAGAGAAGA 60
ACTTCTCCCT CGAACTTTAA AGTCCGCTTC TTTGTGTTAA CCAAAGCCAG CCTGGCATAC 120
TTTGAAGATC GTCATGGGAA GAAGCGCACG CTGAAGGGGT CCATTGAGCT CTCCCGAATC 180
AAATGTGTTG AGATTGTGAA AAGTGACATC AGCATCCCAT GCCACTATAA ATACCCATTT 240
CAGGTGGTGC ATGACAACTA CCTCCTATAT GTGTTTGCTC CAGATCGTGA GAGCAGGCAG 300
CGCTGGGTGC TGGCCCTTAA AGAAGAAACG AGGAATAATA ACAGTTTGGT GCCTAAATAT 360
CATCCTAATT TCTGGATGGA TGGGAAGTGG AGGTGCTGTT CTCAGCTGGA GAAGCTTGCA 420
GCAGGCTGTG CCCAATATGA TCCAACCAAG AATGCTTCAA AGAAGCCTCT TCCTCCTACT 480
CCTGAAGATA ACAGGCGACC ACTTTGGGAA CCTGAAGAAA CTGTGGTCAT TGCCTTATAT 540
GACTACCAAA CCAATGATCC TCAGGAACTC GCACTGCGGC GCAACGAAGA GTACTGCCTG 600
CTGGACAGTT CTGAGATTCA CTGGTGGAGA GTCCAGGACA GGAATGGGCA TGAAGGATAT 660
GTACCAAGCA GTTATCTGGT GGAAAAATCT CCAAATAATC TGGAAACCCA TGAGTGGTAC 720
AATAAGAGTA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT TGGACACAGG CAAAGAAGGA 780
GCCTTCATGG TAAGGGATTC CAGGACTGCA GGAACATACA CTGTGTCTGT TTTCACCAAG 840
GCTGTTGTAA GTGAGAACAA TCCCTGTATA AAGCATTATC ACATCAAGGA AACAAATGAC 900
AATCCTAAGC GATACTATGT GGCTGAAAAG TATGTGTTCG ATTCCATCCC TCTTCTCATC 960
AACTATCACC AACATAATGG AGGAGGCCTG GTGACTCGAC TCCGGTATCC AGTTTGTTTT 1020
GGGAGGCAGA AAGCCCCAGT TACAGCAGGG CTGAGATACG GGAAATGGGT GATCGATCCC 1080
TCAGAGCTCA CTTTTGTGCA AGAGATTGGC AGTGGGCAAT TTGGGTTGGT GCATCTGGGC 1140
TACTGGCTCA ACAAGGACAA GGTGGCTATC AAAACCATTC GGGAAGGGGC TATGTCAGAA 1200
GAGGACTTCA TAGAGGAGGC TGAAGTAATG ATGAAACTCT CTCATCCCAA ACTGGTGCAG 1260
CTGTATGGGG TGTGCCTGGA GAAGGCCCCC ATCTGCCTGG TGTTTGAGTT CATGGAGCAC 1320
GGCTGCCTGT CAGATTATCT ACGCACCCAG CGGGGACTTT TTGCTGCAGA GACCCTGCTG 1380
GGCATGTGTC TGGATGTGTG TGAGGGCATG GCCTACCTGG AAGAGGCATG TGTCATCCAC 1440
AGAGACTTGG CTGCCCGAAA TTGTTTGGTG GGAGAAAACC AAGTCATCAA GGTGTCTGAC 1500
TTTGGGATGA CAAGGTTCGT TCTGGATGAT CAGTACACCA GTTCCACAGG CACCAAATTC 1560
CCGGTGAAGT GGGCATCCCC AGAGGTTTTC TCTTTCAGTC GCTATAGCAG CAAGTCCGAT 1620
GTGTGGTCAT TTGGTGTGCT GATGTGGGAA GTTTTCAGTG AAGGCAAAAT CCCGTATGAA 1680
AACCGAAGCA ACTCAGAGGT GGTGGAAGAC ATCAGTACCG GATTTCGGTT GTACAAGCCC 1740
CGGCTGGCCT CCACACATGT CTACCAGATT ATGAATCACT GCTGGAAAGA GAGACCAGAA 1800
GATCGGCCAG CCTTCTCCAG ACTGCTGCGT CAACTGGCTG AAATTGCAGA ATCAGGGCTT 1860
TAG 1863
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly
Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLY  422
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+++pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle++++ihrd
Q: 423   GVCLEKAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRD  482
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw
Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye++snsevve++s+g+rly+p+las++vy++m++cwke+pe+r
Q: 543   SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDR  602
         ************************************************************
S: 241   ptfkellsale  251
         p+f++ll++l+
Q: 603   PAFSRLLRQLA  613
         ********996
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IREGAMSEED FIEEAEVMMK LSHPKLVQLY 60
GVCLEKAPIC LVFEFMEHGC LSDYLRTQRG LFAAETLLGM CLDVCEGMAY LEEACVIHRD 120
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180
SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASTHVYQIMN HCWKERPEDR 240
PAFSRLLRQL A 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-CIS-00119
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-PEM-00054
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013