EKS-GOG-00274

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00274

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.5	2.2E-140	173	460	288

Status

Unreviewed

Ensembl Protein

ENSGGOP00000003573

UniProt Accession

G3QM47;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000003634	ENSGGOP00000003573	ENSGGOT00000003653

Organism

Gorilla gorilla

Functional Description

Protein Length

471

Protein Sequence
(FASTA)

ALQCFCHLCT KDNFTCVTDG LCFVSVTETT DKVIHNSMCI AEIDLIPRDR PFVCAPSSKT 60

GSVTTTYCCN QDHCNKIELP TTVKSSPGLG PVELAAVIAG PVCFVCISLM LMVYICHNRT 120

VIHHRVPNEE DPSLDRPFIS EGTTLKDLIY DMTTSGSGSG LPLLVQRTIA RTIVLQESIG 180

KGRFGEVWRG KWRGEEVAVK IFSSREERSW FREAEIYQTV MLRHENILGF IAADNKDNGT 240

WTQLWLVSDY HEHGSLFDYL NRYTVTVEGM IKLALSTASG LAHLHMEIVG TQGKPAIAHR 300

DLKSKNILVK KNGTCCIADL GLAVRHDSAT DTIDIAPNHR VGTKRYMAPE VLDDSINMKH 360

FESFKRADIY AMGLVFWEIA RRCSIGGIHE DYQLPYYDLV PSDPSVEEMR KVVCEQKLRP 420

NIPNRWQSCE ALRVMAKIMR ECWYANGAAR LTALRIKKTL SQLSQQEGIK M 471

Nucleotide Sequence
(FASTA)

GCGTTACAGT GTTTCTGCCA CCTCTGTACA AAAGACAATT TTACTTGTGT GACAGATGGG 60

CTCTGCTTTG TCTCTGTCAC AGAGACCACA GACAAAGTTA TACACAACAG CATGTGTATA 120

GCTGAAATTG ACTTAATTCC TCGAGATAGG CCGTTTGTAT GTGCACCCTC TTCAAAAACT 180

GGATCTGTGA CTACAACATA TTGCTGCAAT CAGGACCATT GCAATAAAAT AGAACTTCCA 240

ACTACTGTAA AGTCATCACC TGGCCTTGGT CCTGTGGAAC TGGCAGCTGT CATTGCTGGA 300

CCAGTGTGCT TCGTCTGCAT CTCACTCATG TTGATGGTCT ATATCTGCCA CAACCGCACT 360

GTCATTCACC ATCGAGTGCC AAATGAAGAG GACCCTTCAT TAGATCGCCC TTTTATTTCA 420

GAGGGTACTA CGTTGAAAGA CTTAATTTAT GATATGACAA CGTCAGGTTC TGGCTCAGGT 480

TTACCATTGC TTGTTCAGAG AACAATTGCG AGAACTATTG TGTTACAAGA AAGCATTGGC 540

AAAGGTCGAT TTGGAGAAGT TTGGAGAGGA AAGTGGCGGG GAGAAGAAGT TGCTGTTAAG 600

ATATTCTCCT CTAGAGAAGA ACGTTCGTGG TTCCGTGAGG CAGAGATTTA TCAAACTGTA 660

ATGTTACGTC ATGAAAACAT CCTGGGATTT ATAGCAGCAG ACAATAAAGA CAATGGTACT 720

TGGACTCAGC TCTGGTTGGT GTCAGATTAT CATGAGCATG GATCCCTTTT TGATTACTTA 780

AACAGATACA CAGTTACTGT GGAAGGAATG ATAAAACTTG CTCTGTCCAC GGCGAGCGGT 840

CTTGCCCATC TTCACATGGA GATTGTTGGT ACCCAAGGAA AGCCAGCCAT TGCTCATAGA 900

GACTTGAAAT CAAAGAATAT CTTGGTAAAG AAGAATGGAA CTTGCTGTAT TGCAGACTTA 960

GGACTGGCAG TAAGACATGA TTCAGCCACA GATACCATTG ATATTGCTCC AAACCACAGA 1020

GTGGGAACAA AAAGGTACAT GGCCCCTGAA GTTCTCGATG ATTCCATAAA TATGAAACAT 1080

TTTGAATCCT TCAAACGTGC TGACATCTAT GCAATGGGCT TAGTATTCTG GGAAATTGCT 1140

CGACGATGTT CCATTGGTGG AATTCATGAA GATTACCAGC TGCCTTATTA TGATCTTGTA 1200

CCTTCTGACC CATCAGTTGA AGAAATGAGA AAAGTTGTTT GTGAACAGAA GTTAAGGCCA 1260

AATATCCCAA ACAGATGGCA GAGCTGTGAA GCCTTGAGAG TAATGGCTAA AATTATGAGA 1320

GAATGTTGGT ATGCCAATGG AGCAGCTAGG CTTACAGCAT TGCGGATTAA GAAAACATTA 1380

TCACAACTCA GTCAACAGGA AGGCATCAAA ATGTAA 1416

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 173   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  232

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 233   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  292

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 293   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  350

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 351   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  409

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 410   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  460

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013