EKS-GOG-00451

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00451

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	430.0	5.2E-129	34	316	283

Status

Unreviewed

Ensembl Protein

ENSGGOP00000003875

UniProt Accession

G3QMX6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK13

Gene Synonyms/Alias

MAPK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000003947	ENSGGOP00000003875	ENSGGOT00000003971

Organism

Gorilla gorilla

Functional Description

Protein Length

373

Protein Sequence
(FASTA)

GRRDRVPGMS LIRKKGFYKQ DVNKTAWELP KTYVSPTHVG SGAYGSVCSA IDKRSGEKVA 60

IKKLSRPFQS EIFAKRAYRE LLLLKHMQHE NVIGLLDVFT PASSLRNFHD FYLVMPFMQT 120

DLQKIMGMEF SEEKIQYLVY QMLKGLKYIH SAGVVHRDLK PGNLAVNEDC ELKILDFGLA 180

RHADAEMTGY VVTRWYRAPE VILSWMHYNQ TVDIWSVGCI MAEMLTGKTL FKGKDYLDQL 240

TQILKVTGVP GTEFVQKLND KAAKSYIQSL PQTPRKDFTQ LFPRASPQAA DLLEKMLELD 300

VDKRLTAAQA LTHPFFEPFR DPEEETEAQQ PFDDSLEHEK LTVDEWKQHI YKEIVNFSPI 360

ARKDSRRRSG MKL 373

Nucleotide Sequence
(FASTA)

GGCCGCCGAG ATCGGGTGCC CGGGATGAGC CTCATCCGGA AAAAGGGCTT CTACAAGCAG 60

GACGTCAACA AGACCGCCTG GGAGCTGCCC AAGACCTACG TGTCCCCGAC GCACGTCGGC 120

AGCGGGGCCT ATGGCTCCGT GTGCTCGGCC ATCGACAAGC GGTCAGGGGA GAAGGTGGCC 180

ATCAAGAAGC TGAGCCGACC CTTTCAGTCC GAGATCTTCG CCAAGCGCGC CTACCGGGAG 240

CTGCTGCTGC TGAAGCACAT GCAGCATGAG AACGTCATCG GGCTCCTGGA TGTCTTCACC 300

CCAGCCTCCT CCCTGCGCAA CTTCCATGAC TTCTACCTGG TGATGCCCTT CATGCAGACG 360

GATCTGCAGA AGATCATGGG GATGGAGTTC AGTGAGGAGA AGATCCAGTA CCTGGTGTAT 420

CAGATGCTCA AAGGCCTTAA GTACATCCAC TCTGCTGGGG TCGTGCACAG GGACCTGAAG 480

CCAGGCAACC TGGCTGTGAA TGAGGACTGT GAACTGAAGA TTCTGGATTT TGGGCTGGCA 540

CGACATGCAG ACGCCGAGAT GACTGGCTAC GTGGTGACCC GCTGGTACCG AGCCCCCGAG 600

GTGATCCTCA GCTGGATGCA CTACAACCAG ACAGTGGACA TCTGGTCTGT GGGCTGTATC 660

ATGGCAGAGA TGCTGACAGG GAAAACTCTG TTCAAGGGGA AAGATTACCT GGACCAGCTG 720

ACCCAGATCC TGAAAGTGAC CGGGGTGCCT GGCACGGAGT TTGTGCAGAA GCTGAACGAC 780

AAAGCGGCCA AATCCTACAT CCAGTCCCTG CCACAGACCC CCAGGAAGGA TTTCACTCAG 840

CTGTTCCCAC GGGCCAGCCC CCAGGCTGCG GACCTGCTGG AGAAGATGCT GGAGCTAGAC 900

GTGGACAAGC GCCTGACGGC CGCGCAGGCC CTCACCCATC CCTTCTTTGA ACCCTTCCGG 960

GACCCTGAGG AAGAGACGGA GGCCCAGCAG CCGTTTGATG ATTCCTTAGA ACACGAGAAA 1020

CTCACAGTGG ATGAATGGAA GCAGCACATC TACAAGGAGA TTGTGAACTT CAGCCCCATT 1080

GCCCGGAAGG ACTCACGGCG CCGGAGTGGC ATGAAGCTGT AG 1122

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNii  61

          s +++g+Gayg v+sa+dkr++e+vaikklsrpfq+e+ akr++REl llk+++heN+i

Q: 34    VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI  93

         566899******************************************************

S: 62    klldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsa  121

          lldvftp+++l++++d+Ylv+ +m+tdL+k++ ++ +s+e+i++l+yq+l+glky+Hsa

Q: 94    GLLDVFTPASSLRNFHDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHSA  152

         **********************************99.9**********************

S: 122   nviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkey  181

         +v+HrDlKP+Nl+vnedcelkildFGlar+ad+e    +t+yv+trwYraPe++ls+++y

Q: 153   GVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSWMHY  208

         **********************************....**********************

S: 182   tkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyik  241

         +++vDiWsvGCI+aE+ltgk+lf+gkd++dql++il+v+g p +ef++k++++ a++yi+

Q: 209   NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ  268

         ************************************************************

S: 242   slpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         slp++++kdf++lfp+as++a dLlek+L+ld dkR+++++aL+hp++

Q: 269   SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF  316

         **********************************************95

Domain Sequence
(FASTA)

VSPTHVGSGA YGSVCSAIDK RSGEKVAIKK LSRPFQSEIF AKRAYRELLL LKHMQHENVI 60

GLLDVFTPAS SLRNFHDFYL VMPFMQTDLQ KIMGMEFSEE KIQYLVYQML KGLKYIHSAG 120

VVHRDLKPGN LAVNEDCELK ILDFGLARHA DAEMTGYVVT RWYRAPEVIL SWMHYNQTVD 180

IWSVGCIMAE MLTGKTLFKG KDYLDQLTQI LKVTGVPGTE FVQKLNDKAA KSYIQSLPQT 240

PRKDFTQLFP RASPQAADLL EKMLELDVDK RLTAAQALTH PFF 283

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013