EKS-GOG-00163

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00163

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	448.6	8.3E-135	428	688	261

Status

Unreviewed

Ensembl Protein

ENSGGOP00000022959

UniProt Accession

G3S4F7;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA5

Gene Synonyms/Alias

RPS6KA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000004254	ENSGGOP00000022959	ENSGGOT00000022165
ENSGGOG00000004254	ENSGGOP00000004179	ENSGGOT00000004282

Organism

Gorilla gorilla

Functional Description

Protein Length

803

Protein Sequence
(FASTA)

MEEEGGSSGG AAGTSADGGD GGEQLLTVKH ELRTANLTGH AEKVGIENFE LLKVLGTGAY 60

GKVFLVRKIS GHDTGKLYAM KVLKKATIVQ KAKTTEHTRT ERQVLEHIRQ SPFLVTLHYA 120

FQTETKLHLI LDYINGGELF THLSQRERFT EHEVQIYVGE IVLALEHLHK LGIIYRDIKL 180

ENILLDSNGH VVLTDFGLSK EFVADETERA YSFCGTIEYM APDIVRGGDS GHDKKIKDWW 240

SLGVLMYELL TGASPFTVDG EKNSQAEISR RILKSEPPYP QEMSALAKDL IQRLLMKDPK 300

KRLGCGPRDA DEIKEHLFFQ KINWDDLAAK KVPAPFKPVI RDELDVSNFA EEFTEMDPTY 360

SPAALPQSSE KLFQGYSFVA PSILFKRNAA VIDPLQFHMG VERPGVTNVA RSAMMKDSPF 420

YQHYDLDLKD KPLGEGSFSI CRKCVHKKSN QAFAVKIISK RMEANTQKEI TALKLCEGHP 480

NIVKLHEVFH DQLHTFLVME LLNGGELFER IKKKKHFSET EASYIMRKLV SAVSHMHDVG 540

VVHRDLKPEN LLFTDENDNL EIKIIDFGFA RLKPPDNQPL KTPCFTLHYA APELLNQNGY 600

DESCDLWSLG VILYTMLSGQ VPFQSHDRSL TCTSAVEIMK KIKKGDFSFE GEAWKNVSQE 660

AKDLIQGLLT VDPNKRLKMS GLRYNEWLQD GSQLSSNPLM TPDILGSSGA AVHTCVKATF 720

HAFNKYKREG FCLQNVDKAP LAKRRKMKKT STSTETRSSS SESSHSSSSH SHGKTTPTKT 780

LQPSNPADSN NPETLFQFSD SVA 803

Nucleotide Sequence
(FASTA)

ATGGAGGAGG AGGGTGGCAG CAGCGGCGGC GCCGCGGGGA CCAGCGCGGA CGGCGGCGAC 60

GGAGGAGAGC AGCTCCTCAC TGTCAAGCAC GAGCTGCGGA CTGCTAATTT GACAGGACAT 120

GCTGAGAAGG TGGGAATAGA AAATTTTGAG CTCCTGAAGG TCCTAGGAAC TGGAGCTTAT 180

GGAAAAGTAT TTCTAGTTCG TAAAATAAGT GGCCATGATA CTGGAAAGCT GTATGCCATG 240

AAAGTTTTGA AAAAGGCAAC AATCGTTCAA AAGGCCAAAA CCACAGAGCA TACAAGGACA 300

GAACGACAAG TCCTGGAGCA CATTAGGCAG TCGCCATTTT TGGTGACATT ACATTATGCT 360

TTCCAGACAG AAACCAAACT TCATCTCATT TTAGATTATA TAAATGGTGG TGAACTTTTT 420

ACTCATCTTT CTCAAAGAGA GCGTTTCACA GAGCATGAGG TGCAGATTTA TGTTGGAGAG 480

ATTGTGCTTG CCCTCGAACA TCTCCACAAG TTGGGGATTA TATATCGTGA TATTAAGCTT 540

GAGAATATTC TACTTGATTC TAATGGCCAT GTGGTGCTGA CAGATTTTGG TCTGAGTAAG 600

GAGTTTGTGG CTGATGAAAC TGAAAGAGCA TATTCCTTTT GTGGAACTAT TGAATATATG 660

GCACCAGATA TTGTCAGAGG GGGAGATTCA GGACATGACA AGAAAATTAA GGACTGGTGG 720

AGTTTGGGTG TTCTAATGTA TGAATTACTA ACTGGAGCAT CTCCTTTCAC TGTTGATGGA 780

GAAAAAAATT CCCAAGCTGA GATATCTAGG AGAATATTAA AAAGTGAGCC TCCATATCCC 840

CAAGAAATGA GTGCTTTAGC TAAAGACCTA ATTCAGCGTC TTTTGATGAA AGATCCCAAG 900

AAGAGATTGG GATGTGGTCC ACGTGATGCA GATGAAATCA AAGAACATCT CTTCTTTCAG 960

AAAATAAATT GGGATGATTT AGCCGCCAAA AAAGTGCCTG CACCATTTAA GCCAGTCATT 1020

CGAGATGAAT TAGATGTGAG TAACTTTGCA GAAGAGTTCA CAGAAATGGA TCCCACTTAT 1080

TCTCCCGCAG CCCTGCCCCA GAGTTCTGAG AAGCTGTTTC AGGGCTATTC CTTTGTTGCT 1140

CCTTCCATCC TATTCAAGCG TAATGCAGCT GTCATAGACC CTCTTCAGTT TCACATGGGA 1200

GTTGAACGTC CTGGAGTGAC AAATGTTGCC AGGAGTGCAA TGATGAAGGA CTCTCCATTC 1260

TATCAACACT ATGACCTAGA TTTGAAGGAC AAACCCCTGG GAGAAGGTAG TTTTTCAATT 1320

TGTCGAAAGT GTGTGCATAA AAAAAGTAAC CAAGCTTTTG CAGTCAAAAT AATCAGCAAA 1380

AGGATGGAAG CCAATACTCA GAAGGAAATA ACAGCTCTGA AACTCTGTGA AGGACACCCC 1440

AATATTGTGA AGTTGCATGA AGTTTTTCAT GATCAGCTTC ACACGTTTCT AGTGATGGAA 1500

CTTCTGAATG GAGGAGAACT GTTTGAACGC ATTAAGAAAA AGAAGCACTT CAGTGAGACG 1560

GAAGCCAGCT ACATCATGAG GAAGCTTGTT TCAGCTGTAA GCCACATGCA TGATGTTGGA 1620

GTGGTGCACA GGGATCTGAA ACCTGAGAAT TTATTGTTCA CCGATGAAAA TGACAATTTG 1680

GAAATTAAAA TAATTGATTT TGGATTTGCA CGGCTAAAGC CACCGGATAA TCAGCCCCTG 1740

AAGACTCCAT GCTTCACCCT TCATTATGCG GCCCCAGAGC TCTTGAATCA GAACGGCTAC 1800

GATGAGTCCT GTGACCTGTG GAGCTTGGGC GTCATTTTGT ACACAATGTT GTCAGGACAG 1860

GTTCCCTTCC AATCTCATGA CCGAAGTTTG ACATGTACCA GCGCGGTGGA AATCATGAAG 1920

AAAATTAAAA AGGGAGATTT CTCCTTTGAA GGAGAAGCCT GGAAGAATGT ATCCCAAGAG 1980

GCTAAAGATT TGATCCAAGG ACTTCTCACA GTAGATCCAA ACAAAAGGCT TAAAATGTCT 2040

GGCTTGAGGT ACAATGAATG GCTACAAGAT GGCAGTCAGC TGTCCTCCAA TCCTCTGATG 2100

ACTCCGGATA TTCTAGGATC TTCCGGAGCT GCCGTGCATA CCTGTGTGAA AGCAACCTTC 2160

CACGCCTTTA ACAAATACAA GAGAGAGGGG TTTTGCCTTC AGAATGTCGA TAAGGCCCCT 2220

TTGGCTAAGA GAAGAAAAAT GAAAAAGACT AGCACCAGTA CCGAGACGCG CAGCAGTTCC 2280

AGTGAGAGTT CCCATTCTTC TTCCTCTCAT TCTCACGGTA AAACTACACC CACCAAGACA 2340

CTGCAGCCCA GCAACCCTGC CGACAGCAAT AACCCGGAGA CCCTCTTCCA GTTCTCGGAC 2400

TCAGTAGCTT AG 2412

Domain Profile

S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60

         +++++lG+Gs+s+c++cvhk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++

Q: 428   LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  487

         5789******************************9*************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk

Q: 488   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  547

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         pen+l++de+dn+e ikiidfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl

Q: 548   PENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL  606

         **************.*********************************************

S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236

         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++

Q: 607   WSLGVILYTMLSGQVPFqshdRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  666

         *****************9998899************************************

S: 237   klltvdpakrlkleqllkhswl  258

         +lltvdp+krlk+++l++++wl

Q: 667   GLLTVDPNKRLKMSGLRYNEWL  688

         *********************7

Domain Sequence
(FASTA)

LKDKPLGEGS FSICRKCVHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60

VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120

PENLLFTDEN DNLEIKIIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNQ NGYDESCDLW 180

SLGVILYTML SGQVPFQSHD RSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240

LLTVDPNKRL KMSGLRYNEW L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013