EKS-GOG-00304

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00304

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	391.6	2.3E-117	693	964	272

Status

Unreviewed

Ensembl Protein

ENSGGOP00000021483

UniProt Accession

G3QP17;

Protein Name

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000004378	ENSGGOP00000021483	ENSGGOT00000023218
ENSGGOG00000004378	ENSGGOP00000004300	ENSGGOT00000004407

Organism

Gorilla gorilla

Functional Description

Protein Length

1198

Protein Sequence
(FASTA)

MCSPGTSPGS KMALQSSFTC WNGTVLQLGQ ACDFHQDCAQ GEDESQMCRK LPVGFYCNFE 60

DGFCGWTQGT LSPHTPQWQV RTLKDARFQD HQDHALLLST TDVPASESAT VTSATFPAPI 120

KSSPCELRMS WLIRGVLRGN VSLVLVENKT GKEQGRMVWH VAAYEGLSLW QWTVLPLLDV 180

SDRFWLRMVA WWGQGSRAIV AFDNISISLD CYLTISGEDK IPQNTAPKSR NLFERNPNKE 240

LKPGENSPRQ TPIFDPTVHW LFTTCGASGP HGPTQAQCNN AYQNSNLSVE VGSEGPLKGI 300

QIWKVPATDT YSISGYGAAG GKGGKNTMMR SHGVSVLGIF NLEKDDMLYI LVGQQGEDAC 360

PSTNQLIQKV CIGENNVIEE EIRVNRSVHE WAGGGGGGGG ATYVFKMKDG VPVPLIIAAG 420

GGGRAYGAKT DTFHPERLEN NSSVLGLNGN SGAAGGGGGW NDNTSLLWAG KSLQEGATGG 480

HSCPQAMKKW GWETRGGFGG GGGGCSSGGG GGGYIGGNAA SNNDPEMDGE DGVSFISPLG 540

ILYTPALKVM EGHGEVNIKH YLNCSHCEVD ECHMDPESHK VICFCDHGTV LAEDGVSCIV 600

SPTPEPHLPL SLILSVVTSA LVAALVLAFS GIMIVYRRKH QELQAMQMEL QSPEYKLSKL 660

RTSTIMTDYN PNYCFAGKTS SISDLKEVPR KNITLIRGLG HGAFGEVYEG QVSGMPNDPS 720

PLQVAVKTLP EVCSEQDELD FLMEALIISK FNHQNIVRCI GVSLQALPRF ILLELMAGGD 780

LKSFLRETRP RPSQPSSLAM LDLLHVARDI ACGCQYLEEN HFIHRDGKLR NCISIIPGRA 840

SLIPKVQSFG LLSLLFRGSK ITKQKGIIYV PGNFNYPELL DYPIETMKSA GWTSFGVLLW 900

EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL 960

ERIGYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSSAA 1020

PPPLPTTSSG KAAKKPTAAE VSVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT 1080

SLWNPTYGSW FTEKPTKKNN PLAKKEPHER GGLEGSCTVP PNVATGRLPG ASLLLEPSSL 1140

TANMKEVPLF RLRHFPCGNV NYGYQQQGLP LEAATAPAAG HYEDTILKSK NSMNQPGP 1198

Nucleotide Sequence
(FASTA)

ATGTGCTCTC CAGGAACATC CCCAGGCTCC AAGATGGCCC TGCAGAGCTC CTTCACTTGT 60

TGGAATGGGA CAGTCCTCCA GCTTGGGCAG GCCTGTGACT TCCACCAGGA CTGTGCCCAG 120

GGAGAAGATG AGAGCCAGAT GTGCCGGAAA CTGCCAGTGG GTTTTTACTG CAACTTTGAA 180

GATGGCTTCT GTGGCTGGAC CCAAGGCACA CTGTCACCCC ACACTCCTCA GTGGCAGGTC 240

AGGACCCTAA AGGATGCCCG GTTCCAGGAC CACCAAGACC ATGCTCTATT GCTCAGTACC 300

ACTGATGTCC CCGCTTCTGA AAGTGCTACA GTGACCAGTG CTACGTTTCC TGCTCCGATC 360

AAGAGCTCTC CATGTGAGCT CCGAATGTCC TGGCTCATTC GTGGAGTCTT GAGGGGAAAC 420

GTGTCCTTGG TGCTAGTGGA GAACAAAACC GGGAAGGAGC AAGGCAGGAT GGTCTGGCAT 480

GTCGCCGCCT ATGAAGGCTT GAGCCTGTGG CAGTGGACGG TGTTGCCTCT CCTCGATGTG 540

TCTGACAGGT TCTGGCTGCG GATGGTCGCA TGGTGGGGAC AAGGATCCAG AGCCATCGTG 600

GCTTTTGACA ATATCTCCAT CAGCCTGGAC TGCTACCTCA CCATTAGTGG AGAGGACAAG 660

ATCCCGCAGA ATACAGCACC CAAATCAAGA AACCTGTTTG AGAGAAACCC AAACAAGGAG 720

CTGAAACCCG GGGAAAATTC ACCAAGACAG ACCCCCATCT TTGACCCTAC AGTTCATTGG 780

CTGTTCACCA CCTGTGGGGC CAGCGGGCCC CATGGCCCCA CCCAGGCACA GTGCAACAAC 840

GCCTACCAGA ACTCCAACCT GAGCGTGGAG GTGGGGAGCG AGGGCCCCCT GAAAGGCATC 900

CAGATCTGGA AGGTGCCAGC CACTGACACC TACAGCATCT CGGGCTACGG GGCTGCTGGC 960

GGGAAAGGCG GGAAGAACAC CATGATGCGG TCCCACGGCG TGTCTGTGCT GGGCATCTTC 1020

AACCTGGAGA AGGATGACAT GCTGTACATC CTGGTTGGGC AGCAGGGAGA GGACGCCTGC 1080

CCCAGTACAA ACCAGTTAAT CCAGAAAGTC TGCATTGGAG AGAACAATGT GATAGAAGAA 1140

GAAATCCGTG TGAACAGAAG CGTGCATGAG TGGGCAGGAG GCGGAGGAGG AGGGGGTGGA 1200

GCCACCTACG TATTTAAGAT GAAGGATGGA GTGCCGGTGC CCCTGATCAT TGCAGCCGGA 1260

GGTGGCGGCA GGGCCTACGG GGCCAAGACA GACACGTTCC ACCCAGAGAG ACTGGAGAAT 1320

AACTCCTCGG TTCTAGGGCT AAACGGCAAT TCCGGAGCCG CAGGTGGTGG AGGTGGCTGG 1380

AATGATAACA CTTCCTTGCT CTGGGCCGGA AAATCTTTGC AGGAGGGTGC CACCGGAGGA 1440

CATTCCTGCC CCCAGGCCAT GAAGAAGTGG GGGTGGGAGA CAAGAGGGGG TTTCGGAGGG 1500

GGTGGAGGGG GGTGCTCCTC AGGTGGAGGA GGCGGAGGAT ATATAGGCGG CAATGCAGCC 1560

TCAAACAATG ACCCCGAAAT GGATGGGGAA GATGGGGTTT CCTTCATCAG TCCACTGGGC 1620

ATCCTGTACA CCCCAGCTTT AAAAGTGATG GAAGGCCACG GGGAAGTGAA TATTAAGCAT 1680

TATCTAAACT GCAGTCACTG TGAGGTAGAC GAATGTCACA TGGACCCTGA AAGCCACAAG 1740

GTCATCTGCT TCTGTGACCA CGGGACGGTG CTGGCTGAGG ATGGCGTCTC CTGCATTGTG 1800

TCACCCACCC CGGAGCCACA CCTGCCACTC TCGCTGATCC TCTCTGTGGT GACCTCTGCC 1860

CTCGTGGCCG CCCTGGTCCT GGCTTTCTCC GGCATCATGA TTGTGTACCG CCGGAAGCAC 1920

CAGGAGCTGC AAGCCATGCA GATGGAGCTG CAGAGCCCTG AGTACAAGCT GAGCAAGCTC 1980

CGCACTTCGA CCATCATGAC CGACTACAAC CCCAACTACT GCTTTGCTGG CAAGACCTCC 2040

TCCATCAGCG ACCTGAAGGA GGTGCCACGG AAAAACATCA CCCTCATTCG GGGTCTGGGC 2100

CATGGCGCCT TTGGGGAGGT GTATGAAGGC CAGGTGTCCG GAATGCCCAA TGACCCAAGC 2160

CCCCTGCAAG TGGCTGTGAA GACGCTGCCT GAAGTGTGCT CTGAACAGGA CGAACTGGAT 2220

TTCCTCATGG AAGCCCTGAT CATCAGCAAA TTCAACCACC AGAACATCGT TCGCTGCATC 2280

GGGGTGAGCC TGCAAGCCCT GCCCCGGTTC ATCCTGCTGG AGCTCATGGC CGGGGGAGAC 2340

CTCAAGTCCT TCCTCCGAGA GACCCGCCCT CGCCCGAGCC AGCCCTCCTC CCTGGCCATG 2400

CTGGACCTCC TGCACGTGGC TCGGGACATT GCCTGCGGCT GTCAGTATTT GGAGGAAAAC 2460

CACTTCATCC ACCGAGATGG GAAGTTAAGG AATTGCATTT CAATCATTCC AGGCAGAGCA 2520

AGTTTAATAC CAAAAGTGCA AAGCTTTGGG CTTTTGTCGC TCCTGTTTAG GGGAAGTAAG 2580

ATCACGAAAC AGAAAGGAAT AATATATGTG CCAGGCAATT TTAATTACCC TGAATTACTA 2640

GATTATCCTA TCGAGACTAT GAAATCAGCT GGCTGGACGT CCTTTGGAGT GCTGCTATGG 2700

GAAATCTTTT CTCTCGGATA TATGCCATAC CCCAGCAAAA GCAACCAGGA AGTTCTGGAG 2760

TTTGTCACCA GTGGAGGCCG GATGGACCCA CCCAAGAACT GCCCTGGGCC TGTATACCGG 2820

ATAATGACTC AGTGCTGGCA ACATCAGCCT GAAGACAGGC CCAACTTTGC CATCATTTTG 2880

GAGAGGATTG GATACTGCAC CCAGGACCCG GATGTAATCA ACACCGCTTT GCCGATAGAA 2940

TATGGTCCAC TTGTGGAAGA GGAAGAGAAA GTGCCTGTGA GGCCCAAGGA CCCTGAGGGG 3000

GTTCCTCCTC TCCTGGTCTC TCAACAGGCG AAACGGGAGG AGGAGCGCAG CTCAGCTGCC 3060

CCACCACCTC TGCCTACCAC CTCCTCTGGC AAGGCTGCAA AGAAACCCAC AGCTGCAGAG 3120

GTCTCTGTTC GAGTCCCTAG AGGGCCGGCC GTGGAAGGGG GACACGTGAA TATGGCATTC 3180

TCTCAGTCCA ACCCCCCTTC GGAGTTGCAC AAGGTCCACG GATCCAGAAA CAAGCCCACC 3240

AGCTTGTGGA ACCCAACGTA CGGCTCCTGG TTTACAGAGA AACCCACCAA AAAGAATAAT 3300

CCTCTAGCAA AGAAGGAGCC ACACGAGAGG GGTGGGCTGG AGGGAAGCTG TACTGTCCCA 3360

CCTAACGTTG CAACTGGGAG ACTTCCGGGG GCCTCACTGC TCCTAGAGCC CTCTTCGCTG 3420

ACTGCCAATA TGAAGGAGGT ACCTCTGTTC AGGCTACGTC ACTTCCCTTG TGGGAATGTC 3480

AATTACGGCT ACCAGCAACA GGGCTTGCCC TTAGAAGCCG CTACTGCCCC TGCAGCTGGT 3540

CATTACGAGG ATACCATTCT GAAAAGCAAG AATAGCATGA ACCAGCCTGG GCCCTGA 3597

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfn

Q: 693   ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  752

         799*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+sslam dll+va+d+a+

Q: 753   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIAC  812

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskG.psrvakiadfGmardiyraey.yrkggrallpv  178

         Gc+yleen+fihrd   rn++   +G +s + k+  fG+   ++r +   ++ g   +p

Q: 813   GCQYLEENHFIHRDGKLRNCISIIPGrASLIPKVQSFGLLSLLFRGSKiTKQKGIIYVPG  872

         *********************99999456788*********9998765167789999***

S: 179   kwmppeafleGiftsktdvw.sfGvllwevfslGvvpypgksnqevlelvveGgrldspk  237

          +  pe +   i t k+  w sfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk

Q: 873   NFNYPELLDYPIETMKSAGWtSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPK  932

         ******9999**********88**************************************

S: 238   eipgsvyrimtdcwkhepedrpkfvsilerlq  269

         ++pg+vyrimt+cw+h+pedrp+f++iler+

Q: 933   NCPGPVYRIMTQCWQHQPEDRPNFAIILERIG  964

         ******************************96

Domain Sequence
(FASTA)

ITLIRGLGHG AFGEVYEGQV SGMPNDPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP SQPSSLAMLD LLHVARDIAC 120

GCQYLEENHF IHRDGKLRNC ISIIPGRASL IPKVQSFGLL SLLFRGSKIT KQKGIIYVPG 180

NFNYPELLDY PIETMKSAGW TSFGVLLWEI FSLGYMPYPS KSNQEVLEFV TSGGRMDPPK 240

NCPGPVYRIM TQCWQHQPED RPNFAIILER IG 272

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00629	; MAM; 2.
PF07714	; Pkinase_Tyr; 2.

SMARTs

SM00192

; LDLa; 1.

Prosites

PS50060	; MAM_2; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013