EKS-GOG-00060

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00060

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	381.7	2.6E-114	174	455	282

Status

Unreviewed

Ensembl Protein

ENSGGOP00000004386

UniProt Accession

G3QP97;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK18

Gene Synonyms/Alias

CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000004471	ENSGGOP00000004386	ENSGGOT00000004494

Organism

Gorilla gorilla

Functional Description

Protein Length

504

Protein Sequence
(FASTA)

MIMNKMKNFK RRFSLSVPRT ETIEESLAEF TEQFNQLHNR RNEDLQLGPL GREPPQECST 60

FSPTDSGEEP GQLSPGVQFQ RRQNQRRFSM EVRASGALPR QVAGCTHKGV HRRAAALQPD 120

FDVSKRLSLP MDIRLPQEFL QKLQMESPDL PKPLSRMSRR ASLSDIGFGK LETYVKLDKL 180

GEGTYATVFK GRSKLTENLV ALKEIRLEHE EGAPCTAIRE VSLLKNLKHA NIVTLHDLIH 240

TDRSLTLVFE YLDSDLKQYL DHCGNLMSMH NVKIFMFQLL RGLAYCHHRK ILHRDLKPQN 300

LLINERGELK LADFGLARAK SVPTKTYSNE VVTLWYRPPD VLLGSTEYST PIDMWGVGCI 360

HYEMATGRPL FPGSTVKEEL HLIFRLLGTP TEETWPGVTA FSEFRTYSFP CYLPQPLINH 420

APRLDTDGIH LLSSLLLYES KSRTSAEAAL SHPYFRSLGE RVHQLEDTAS IFSLKEIQLQ 480

KDPGYRGLAF QQPGRGKNRR QSIF 504

Nucleotide Sequence
(FASTA)

ATGATCATGA ACAAGATGAA GAACTTTAAG CGCCGTTTCT CCCTGTCAGT GCCCCGCACT 60

GAGACCATTG AAGAATCCTT GGCTGAATTC ACAGAGCAAT TCAACCAGCT TCACAACCGG 120

CGGAATGAGG ACTTGCAGCT CGGTCCTCTT GGCAGAGAAC CCCCGCAGGA GTGCAGCACC 180

TTCTCCCCAA CAGACAGCGG GGAGGAGCCG GGGCAGCTGT CCCCTGGCGT GCAGTTCCAG 240

CGGCGGCAGA ACCAGCGCCG CTTCTCCATG GAGGTGAGGG CCTCTGGAGC TCTGCCCCGG 300

CAGGTGGCAG GATGCACGCA CAAGGGTGTG CACAGGAGGG CAGCTGCCTT ACAGCCAGAC 360

TTTGACGTCA GCAAGAGGCT CTCTCTGCCC ATGGATATCC GCCTGCCCCA GGAATTCCTA 420

CAGAAGCTAC AGATGGAGAG CCCAGATCTG CCCAAGCCGC TCAGCCGCAT GTCCCGCCGG 480

GCCTCCCTGT CAGACATTGG CTTTGGGAAA CTGGAAACAT ACGTGAAACT GGACAAACTG 540

GGAGAGGGCA CCTATGCCAC AGTCTTCAAA GGGCGCAGCA AACTGACGGA GAACCTCGTG 600

GCCCTGAAAG AGATCCGGCT GGAGCACGAG GAGGGAGCGC CCTGCACTGC CATCCGAGAG 660

GTGTCTCTGC TGAAGAACCT GAAGCACGCC AATATTGTGA CCCTGCATGA CCTCATCCAC 720

ACAGATCGGT CCCTCACCCT GGTGTTTGAG TACCTGGACA GTGACCTGAA GCAGTATCTG 780

GACCACTGTG GGAACCTCAT GAGCATGCAC AACGTCAAGA TTTTCATGTT CCAGCTGCTC 840

CGGGGCCTCG CCTACTGTCA CCACCGCAAG ATCCTGCACC GGGACCTGAA GCCCCAGAAC 900

CTGCTCATCA ACGAGAGGGG GGAGCTGAAG CTGGCCGACT TTGGACTGGC CAGGGCCAAG 960

TCAGTGCCCA CAAAGACTTA CTCCAATGAG GTGGTGACCC TGTGGTACAG GCCCCCCGAT 1020

GTGCTGCTGG GATCCACAGA GTACTCCACC CCAATTGATA TGTGGGGCGT GGGCTGCATC 1080

CACTACGAGA TGGCCACAGG GAGGCCCCTC TTCCCGGGCT CCACAGTCAA GGAGGAGCTG 1140

CACCTCATCT TTCGCCTCCT CGGGACCCCC ACAGAAGAGA CGTGGCCCGG CGTGACCGCC 1200

TTCTCTGAGT TCCGCACCTA CAGCTTCCCC TGCTACCTCC CGCAGCCGCT CATCAACCAC 1260

GCGCCCAGGT TGGATACGGA TGGCATCCAC CTCCTGAGCA GCCTGCTGCT GTATGAATCC 1320

AAGAGTCGCA CGTCAGCAGA GGCTGCCCTG AGTCACCCCT ACTTCCGGTC TCTGGGAGAG 1380

CGTGTGCACC AGCTTGAAGA CACTGCCTCC ATCTTCTCCC TGAAGGAGAT CCAGCTCCAG 1440

AAGGACCCAG GCTACCGAGG CTTGGCCTTC CAGCAGCCAG GACGAGGGAA GAATAGGCGG 1500

CAGAGCATCT TCTGA 1515

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 174   YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANI  232

         7899********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++++l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+glay+H++k

Q: 233   VTLHDLIH-TDRSLTLVFEYLDSDLKQYLDHCGN-LMSMHNVKIFMFQLLRGLAYCHHRK  290

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 291   ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  350

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

          +D+W+vgci  e++t +plf+g++ +++l+ if+llgtp+e++wp+v+ ++e++ +sfp

Q: 351   PIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRtYSFP  410

         *******************************************************89***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

          + ++ l ++ ++l++++++ll++ll ++ k+R+sa++al+h+yf

Q: 411   CYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRTSAEAALSHPYF  455

         ********************************************9

Domain Sequence
(FASTA)

YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKNLKHANIV 60

TLHDLIHTDR SLTLVFEYLD SDLKQYLDHC GNLMSMHNVK IFMFQLLRGL AYCHHRKILH 120

RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180

MWGVGCIHYE MATGRPLFPG STVKEELHLI FRLLGTPTEE TWPGVTAFSE FRTYSFPCYL 240

PQPLINHAPR LDTDGIHLLS SLLLYESKSR TSAEAALSHP YF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013