EKS-GOG-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	493.9	1.2E-148	723	980	258

Status

Unreviewed

Ensembl Protein

ENSGGOP00000004424

UniProt Accession

G3QPD2;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB2

Gene Synonyms/Alias

ERBB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000004509	ENSGGOP00000004424	ENSGGOT00000004534

Organism

Gorilla gorilla

Functional Description

Protein Length

1258

Protein Sequence
(FASTA)

VSTMELAALC RWGLLLALLP PGAASTQVCT GTDMKLRLPA SPETHLDMLR HLYQGCQVVQ 60

GNLELTYLPT NASLSFLQDI QEVQGYVLIA HNQVRQVPLQ RLRIVRGTQL FEDNYALAVL 120

DNGDPLNNTT PVTGASPGGL RELQLRSLTE ILKGGVLIQR NPELCYQDTI LWKDIFHKNN 180

QLALTLIDTN RSRACHPCSP VCKGSRCWGE SSEDCQSLTR TVCAGGCARC KGPLPTDCCH 240

EQCAAGCTGP KHSDCLACLH FNHSGICELH CPALVTYNTD TFESMPNPEG RYTFGASCVT 300

ACPYNYLSTD VGSCTLVCPL HNQEVTAEDG TQRCEKCSKP CARVCYGLGM EHLREVRAVT 360

SANIQEFAGC KKIFGSLAFL PESFDGDPAS NTAPLQPEQL QVFETLEEIT GYLYISAWPD 420

SLPDLSIFQN LQVIRGRILH NGAYSLTLQG LGISWLGLRS LRELGSGLAL IHHNTHLCFV 480

HTVPWDQLFR NPHQALLHTA NRPEDECVGE GLACHQLCAR GHCWGPGPTQ CVNCSQFLRG 540

QECVEECRVL QGLPREYVNA RHCLPCHPEC QPQNGSVTCF GPEADQCVAC AHYKDPPFCV 600

ARCPSGVKPD LSYMPIWKFP DEEGACQPCP INCTHSCVDL DDKGCPAEQR ASPLTSIISA 660

VVGILLVVVL GVVFGILIKR RQQKIRKYTM RRLLQETELV EPLTPSGAMP NQAQMRILKE 720

TELRKVKVLG SGAFGTVYKG IWIPDGENVK IPVAIKVLRE NTSPKANKEI LDEAYVMAGV 780

GSPYVSRLLG ICLTSTVQLV TQLMPYGCLL DHVRENRGRL GSQDLLNWCM QIAKGMSYLE 840

DVRLVHRDLA ARNVLVKSPN HVKITDFGLA RLLDIDETEY HADGGKVPIK WMALESILRR 900

RFTHQSDVWS YGVTVWELMT FGAKPYDGIP AREIPDLLEK GERLPQPPIC TIDVYMIMVK 960

CWMIDSECRP RFRELVSEFS RMARDPQRFV VIQNEDLGPA SPLDSTFYRS LLEDDDMGDL 1020

VDAEEYLVPQ QGFFCPDPAP GAGGMVHHRH RSSSTRSGGG DLTLGLEPSE EEAPRSPLAP 1080

SEGAGSDVFD GDLGMGAAKG LQSLPTHDPS PLQRYSEDPT VPLPSETDGY VAPLTCSPQP 1140

EYVNQPDVRP QPPSPREGPL PAARPAGATL ERPKTLSPGK NGVVKDVFAF GGAVENPEYL 1200

TPQGGAAPQP HPPPAFSPAF DNLYYWDQDP PERGAPPSTF KGTPTAENPE YLGLDVPV 1258

Nucleotide Sequence
(FASTA)

GTGAGCACCA TGGAGCTGGC GGCCTTGTGC CGCTGGGGGC TCCTCCTCGC CCTCTTGCCC 60

CCCGGAGCCG CGAGCACCCA AGTGTGCACC GGCACAGACA TGAAGCTGCG GCTCCCTGCC 120

AGTCCCGAGA CCCATCTGGA CATGCTCCGC CACCTCTACC AGGGCTGCCA GGTGGTGCAG 180

GGAAACCTGG AACTCACCTA CCTGCCCACC AATGCCAGCC TGTCCTTCCT GCAGGATATC 240

CAGGAGGTGC AGGGCTACGT GCTCATCGCT CACAACCAAG TGAGGCAGGT CCCACTACAG 300

AGGCTGCGGA TTGTGCGAGG CACCCAGCTC TTTGAGGACA ACTATGCCCT GGCCGTGCTA 360

GACAATGGAG ACCCGCTGAA CAATACCACC CCTGTCACAG GGGCCTCCCC AGGAGGCCTG 420

CGGGAGCTGC AGCTTCGAAG CCTCACAGAG ATCTTGAAAG GAGGGGTCTT GATCCAGCGG 480

AACCCCGAGC TCTGCTACCA GGACACGATT TTGTGGAAGG ACATCTTCCA CAAGAACAAT 540

CAGCTGGCTC TCACACTGAT AGACACCAAC CGCTCTCGGG CCTGCCACCC CTGTTCTCCG 600

GTGTGTAAGG GCTCCCGCTG CTGGGGAGAG AGTTCTGAGG ATTGTCAGAG CCTGACACGC 660

ACTGTCTGTG CCGGTGGCTG TGCCCGCTGC AAGGGGCCAC TGCCCACTGA CTGCTGCCAT 720

GAGCAGTGTG CTGCCGGCTG CACGGGCCCC AAGCACTCTG ACTGCCTGGC CTGCCTCCAC 780

TTCAACCACA GTGGCATCTG TGAGCTGCAC TGCCCAGCCC TGGTCACCTA CAACACAGAC 840

ACGTTTGAGT CCATGCCCAA TCCCGAGGGC CGGTATACAT TCGGCGCCAG CTGTGTGACT 900

GCCTGTCCCT ACAACTACCT TTCTACGGAC GTGGGATCCT GCACCCTTGT CTGCCCCCTG 960

CACAACCAAG AGGTGACAGC AGAGGATGGA ACACAGCGGT GTGAGAAGTG CAGCAAGCCC 1020

TGTGCCCGAG TGTGCTATGG TCTGGGCATG GAGCACTTGC GAGAGGTGAG GGCAGTTACC 1080

AGTGCCAATA TCCAGGAGTT TGCTGGCTGC AAGAAGATCT TTGGGAGCCT GGCATTTCTG 1140

CCGGAGAGCT TTGATGGGGA CCCAGCCTCC AACACCGCCC CGCTCCAGCC AGAGCAGCTC 1200

CAAGTGTTTG AGACTCTGGA AGAGATCACA GGTTACCTAT ACATCTCAGC ATGGCCAGAC 1260

AGCCTGCCTG ACCTCAGCAT CTTCCAGAAC CTGCAAGTAA TCCGGGGACG AATTCTGCAC 1320

AATGGCGCCT ACTCGCTGAC CCTGCAAGGG CTGGGCATCA GCTGGCTGGG GCTGCGCTCG 1380

CTGAGGGAAC TGGGCAGTGG ACTGGCCCTC ATCCACCATA ACACCCACCT CTGCTTCGTG 1440

CACACGGTGC CCTGGGACCA GCTCTTTCGG AACCCGCACC AAGCTCTGCT CCACACTGCC 1500

AACCGGCCAG AGGACGAGTG TGTGGGCGAG GGCCTGGCCT GCCACCAGCT GTGCGCCCGA 1560

GGGCACTGCT GGGGTCCAGG GCCCACCCAG TGTGTCAACT GCAGCCAGTT CCTTCGGGGC 1620

CAGGAGTGCG TGGAGGAATG CCGAGTACTG CAGGGGCTCC CCAGGGAGTA TGTGAATGCC 1680

AGGCACTGTT TGCCGTGCCA CCCTGAGTGT CAGCCCCAGA ATGGCTCAGT GACCTGTTTT 1740

GGACCGGAGG CTGACCAGTG TGTGGCCTGT GCCCACTATA AGGATCCTCC CTTCTGCGTG 1800

GCCCGCTGCC CCAGCGGTGT GAAACCTGAC CTCTCCTACA TGCCCATCTG GAAGTTTCCA 1860

GATGAGGAGG GCGCATGCCA GCCTTGCCCC ATCAACTGCA CCCACTCCTG TGTGGACCTG 1920

GATGACAAGG GCTGCCCCGC CGAGCAGAGA GCCAGCCCTC TGACGTCCAT CATCTCTGCG 1980

GTGGTTGGCA TTCTGCTGGT CGTGGTCTTG GGGGTGGTCT TTGGGATCCT CATCAAGCGA 2040

CGGCAGCAGA AGATCCGGAA GTACACGATG CGGAGACTGC TGCAGGAAAC GGAGCTGGTG 2100

GAGCCGCTGA CACCTAGCGG AGCGATGCCC AACCAGGCGC AGATGCGGAT CCTGAAAGAG 2160

ACGGAGCTGA GGAAGGTGAA GGTGCTTGGA TCTGGCGCTT TTGGCACAGT CTACAAGGGC 2220

ATCTGGATCC CTGATGGGGA GAATGTGAAA ATTCCAGTGG CCATCAAAGT GTTGAGGGAA 2280

AACACATCCC CCAAAGCCAA TAAAGAAATC TTAGACGAAG CATACGTGAT GGCTGGTGTG 2340

GGCTCCCCAT ATGTCTCCCG CCTTCTGGGC ATCTGCCTGA CATCCACGGT GCAGCTGGTG 2400

ACACAGCTTA TGCCCTATGG CTGCCTCTTA GACCATGTCC GGGAAAACCG CGGACGCCTG 2460

GGCTCCCAGG ACCTGCTGAA CTGGTGTATG CAGATTGCCA AGGGGATGAG CTACCTGGAG 2520

GATGTGCGGC TTGTACACAG GGACTTGGCT GCTCGGAACG TGCTGGTCAA GAGTCCCAAC 2580

CATGTCAAAA TTACAGACTT CGGGCTGGCT CGGCTGCTGG ACATTGACGA GACAGAGTAC 2640

CATGCAGATG GGGGCAAGGT GCCCATCAAG TGGATGGCGC TGGAGTCCAT TCTCCGCCGG 2700

CGGTTCACCC ACCAGAGTGA TGTGTGGAGT TATGGTGTGA CTGTGTGGGA GCTGATGACT 2760

TTTGGGGCCA AACCTTACGA TGGGATCCCA GCCCGGGAGA TCCCTGACCT GCTGGAAAAG 2820

GGGGAGCGGC TGCCCCAGCC CCCCATCTGC ACCATTGATG TCTACATGAT CATGGTCAAA 2880

TGTTGGATGA TTGACTCTGA ATGTCGGCCG AGATTCCGGG AGTTGGTGTC TGAATTCTCC 2940

CGCATGGCCA GGGACCCCCA GCGCTTTGTG GTCATCCAGA ATGAGGACTT GGGCCCAGCC 3000

AGTCCCTTGG ACAGCACCTT CTACCGCTCA CTGCTGGAGG ACGATGACAT GGGGGACCTG 3060

GTGGATGCTG AGGAGTATCT GGTACCCCAG CAGGGCTTCT TCTGTCCAGA CCCTGCCCCG 3120

GGCGCTGGGG GCATGGTCCA CCACAGGCAC CGCAGCTCAT CTACCAGGAG TGGCGGTGGG 3180

GACCTGACAC TAGGGCTGGA GCCCTCTGAA GAGGAGGCCC CCAGGTCTCC ACTGGCACCC 3240

TCCGAAGGGG CTGGCTCCGA TGTATTTGAT GGTGACCTGG GAATGGGGGC AGCCAAGGGG 3300

CTGCAAAGCC TCCCCACACA TGACCCCAGC CCTCTACAGC GGTACAGTGA GGACCCCACA 3360

GTACCCCTGC CCTCTGAGAC TGATGGCTAC GTTGCCCCCC TGACCTGCAG CCCCCAGCCC 3420

GAATATGTGA ACCAGCCAGA TGTTCGGCCC CAGCCCCCTT CGCCCCGAGA GGGCCCTCTG 3480

CCTGCTGCCC GACCTGCTGG TGCCACTCTG GAAAGGCCCA AGACTCTCTC CCCAGGGAAG 3540

AATGGGGTCG TCAAAGACGT TTTTGCCTTT GGGGGTGCCG TGGAGAACCC CGAGTACTTG 3600

ACACCCCAGG GAGGAGCTGC CCCTCAGCCC CACCCTCCTC CTGCCTTCAG CCCAGCCTTC 3660

GACAACCTCT ATTACTGGGA CCAGGACCCA CCAGAGCGGG GGGCTCCACC CAGCACCTTC 3720

AAAGGGACAC CTACGGCAGA GAACCCAGAG TACCTGGGTC TGGACGTGCC AGTGTGA 3777

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +

Q: 723   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  782

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+qlvtql+p+Gclld+vre++++lGsq+llnwc+qiakGmsyle+

Q: 783   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDV  842

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++

Q: 843   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  902

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw

Q: 903   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  962

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mid+e+rp+f+el++efs

Q: 963   MIDSECRPRFRELVSEFS  980

         ****************96

Domain Sequence
(FASTA)

LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60

PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VRENRGRLGS QDLLNWCMQI AKGMSYLEDV 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180

THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240

MIDSECRPRF RELVSEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013