EPS-GOG-00014

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GOG-00014

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	151.8	1.6E-44	133	278	146

Status

Unreviewed

Ensembl Protein

ENSGGOP00000025901

UniProt Accession

G3QPE2;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000004523	ENSGGOP00000025901	ENSGGOT00000030303
ENSGGOG00000004523	ENSGGOP00000004434	ENSGGOT00000004544

Organism

Gorilla gorilla

Functional Description

Protein Length

1151

Protein Sequence
(FASTA)

MATRKDTEEE QVVPSEEDEA NVRAVQAHYL RSPSPSQYSM VSDAETESIF MEPIHLSSAI 60

AAKQIINEEL KPRGVRADAE CPGMLESAEQ LLVEDLYNRV REKMDDTSLY NTPCVLDLQR 120

ALVQDRQEAP WNEVDEVWPS VFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPEFYT 180

GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL 240

MIFHNMAILE ALMTVRKKRA IYPNDGFLKQ LRELNEKLME EREEDYGREG GSAEAEEGEG 300

TGSMLGARVH ALTVEEEDDS ASHLSGSSLG KATQASKPLT LIDEEEEEKL YEQWKKGQGL 360

LSDKVPQDGG GWRSASSGQG GEELEDEDVE RIIQEWQSRN ERYQAEGYRR WGSDAGSSVG 420

RRRRTLSESS AWESVSSHDI WVLKQQLELN RPDHGRRRRA DSMSSESTWD AWNERLLEIE 480

KEASRRYHAK SKKEEAADRS SEAGSRVRED DEDSVGSEAS SFYNFCSRNK DKLTALERWK 540

IKRIQFGFHK KDLGAGDSSS EPGAEEAVGE KKNPSDVSLT AYQAWKLTHQ KKVGSENKQE 600

VVELSKGEDS ALAKKRQRRL ELLERSRQTL EESQSMASWE ADSSTASGSI PLSAFWSAAP 660

SVSADGDTTS VLSTQSHRSH LSQAASNIAG CSTSNPTTPL PNLPVGPGDT ISIASIQNWI 720

ANVVSETLAQ KQNEMLLLSR SPSVASMKAV PAASCLGDDQ VSMLSGQSSS SLGGCLLPQS 780

QARPSSAMQS VLSCNTTLSS PAESCRSKVR GTSKPIFSLF VDNVDLKELG RKEKEMQMEL 840

REKMSEYKME KLASDNKRSS LFKKKKVKED EDDGVGDGDE DTDSAIGSFR YSSRSNSQKP 900

ETDTCSSLAV CDHYASGSRV GKEMDSSINK WLSGLRTEEK PPFQSDWSGS SRGKYTRSSL 960

LRETESKSSS YKFSKSQSEE QDTSSYHEVN GNSVRSTSRF SSSSTREGRE MHKFSRSTYN 1020

ETSSSREESP EPYFFRRTPE SSEREESPEP QRPNWARSRD WEDVEESSKS DFSEFGAKRK 1080

FTQSFMRSEE EGEKERTENR EEGRFASGRR SQYRRSTDRE EEEEMDDEAI IAAWRCRQEE 1140

TRTKLQKRRE D 1151

Nucleotide Sequence
(FASTA)

ATGGCGACCA GAAAGGACAC AGAGGAGGAG CAGGTAGTCC CAAGCGAGGA GGACGAAGCC 60

AACGTGAGGG CGGTGCAGGC CCACTACCTC CGAAGCCCCT CCCCTAGCCA GTATTCGATG 120

GTCTCAGATG CAGAAACAGA AAGCATTTTC ATGGAACCCA TTCACCTCTC CTCAGCCATT 180

GCAGCCAAAC AAATCATCAA TGAAGAACTC AAGCCACGGG GAGTCAGAGC AGACGCAGAG 240

TGTCCAGGCA TGCTGGAGTC TGCTGAACAG CTGCTGGTGG AGGACCTGTA CAACCGCGTC 300

AGGGAGAAGA TGGATGACAC CAGCCTCTAT AATACGCCCT GCGTCCTGGA CCTACAGCGG 360

GCCCTGGTTC AGGATCGCCA AGAGGCGCCC TGGAATGAGG TGGATGAGGT CTGGCCCAGT 420

GTCTTCATAG CTGAGAAGAG TGTGGCTGTG AACAAGGGGA GGCTGAAGAG GCTGGGAATC 480

ACCCACATTC TGAATGCTGC GCATGGCACC GGCGTTTACA CTGGCCCCGA ATTCTACACT 540

GGCCTGGAGA TCCAGTACCT GGGTGTAGAG GTGGATGACT TTCCTGAGGT GGACATTTCC 600

CAGCATTTCC GGAAGGCGGC TGAGTTCCTG GATGAGGCAC TGCTGACTTA CAGAGGGAAA 660

GTCCTGGTCA GCAGCGAAAT GGGCATCAGC CGGTCAGCAG TGCTGGTGGT CGCCTACCTG 720

ATGATCTTCC ACAACATGGC CATCCTGGAG GCTTTGATGA CCGTGCGTAA GAAGCGGGCC 780

ATCTACCCCA ATGACGGCTT CCTGAAGCAG CTGCGGGAGC TCAATGAGAA GTTGATGGAG 840

GAGAGAGAGG AGGACTATGG CCGGGAGGGG GGATCAGCTG AGGCTGAGGA GGGCGAGGGC 900

ACTGGGAGCA TGCTCGGGGC CAGAGTGCAC GCCCTGACGG TGGAAGAGGA GGACGACAGC 960

GCCAGCCACC TGAGTGGCTC CTCCCTGGGG AAGGCCACCC AGGCCTCCAA GCCCCTCACC 1020

CTCATAGACG AGGAGGAGGA GGAGAAACTG TACGAGCAGT GGAAGAAGGG GCAGGGCCTC 1080

CTCTCGGACA AGGTCCCCCA GGATGGAGGT GGCTGGCGCT CGGCCTCCTC TGGCCAGGGT 1140

GGGGAGGAGC TCGAGGATGA GGACGTGGAG AGGATCATCC AGGAGTGGCA GAGCCGAAAC 1200

GAGAGGTACC AAGCAGAAGG GTACCGGAGG TGGGGAAGCG ACGCTGGCTC CTCGGTGGGG 1260

AGGCGGCGGC GCACCCTGAG CGAGAGCAGC GCCTGGGAGA GCGTGAGCAG CCACGACATC 1320

TGGGTCCTGA AGCAGCAGCT GGAGCTGAAC CGCCCGGACC ACGGCAGGAG GCGCCGCGCA 1380

GACTCGATGT CCTCGGAGAG CACCTGGGAC GCATGGAACG AGAGGCTGCT GGAGATTGAG 1440

AAGGAGGCTT CCCGGAGGTA CCACGCCAAG AGCAAGAAAG AGGAGGCGGC GGACAGGAGC 1500

TCAGAAGCAG GGAGCAGGGT GCGGGAGGAT GATGAGGACA GCGTGGGCTC TGAGGCCAGT 1560

TCCTTCTACA ACTTCTGCAG CAGGAACAAG GACAAGCTTA CTGCCCTGGA AAGATGGAAG 1620

ATCAAGAGAA TCCAATTTGG ATTTCACAAG AAAGACTTGG GAGCGGGAGA CAGCAGCAGT 1680

GAGCCCGGTG CAGAGGAGGC AGTAGGGGAG AAGAAGAACC CCTCCGACGT CAGCCTGACA 1740

GCCTACCAGG CCTGGAAGCT GACACACCAG AAGAAGGTGG GCAGTGAGAA CAAGCAGGAG 1800

GTGGTGGAGC TCAGCAAGGG GGAGGACTCG GCCTTGGCTA AGAAGAGACA ACGGAGGCTG 1860

GAGCTGCTGG AGAGAAGCCG GCAGACGCTG GAGGAGAGCC AGTCTATGGC AAGCTGGGAG 1920

GCGGACAGCT CCACGGCCAG CGGGAGCATT CCCCTCTCTG CGTTCTGGTC TGCAGCCCCC 1980

TCAGTCAGTG CTGATGGGGA CACGACGTCA GTACTGAGCA CCCAGAGCCA CCGCTCCCAC 2040

CTGTCTCAGG CTGCAAGCAA CATAGCGGGG TGTTCAACCT CCAACCCCAC CACACCCCTG 2100

CCTAACCTGC CAGTGGGGCC TGGAGACACC ATTTCCATTG CTAGTATCCA GAACTGGATT 2160

GCCAACGTAG TCAGCGAGAC CCTTGCTCAG AAGCAAAATG AAATGCTGCT GTTGTCCCGC 2220

TCACCGTCTG TTGCAAGCAT GAAGGCAGTA CCAGCGGCCA GCTGCCTGGG GGATGACCAA 2280

GTCTCCATGC TTAGTGGACA GAGCAGCTCC TCCTTGGGTG GCTGCCTGTT GCCTCAGAGC 2340

CAGGCAAGAC CCAGCTCTGC CATGCAGTCT GTGCTATCCT GCAACACCAC ACTGAGCTCA 2400

CCCGCGGAAA GTTGCAGGAG CAAAGTGAGG GGGACCAGCA AGCCCATCTT CAGCCTCTTT 2460

GTTGACAATG TGGACCTAAA GGAACTTGGC CGGAAGGAGA AGGAGATGCA GATGGAGCTT 2520

AGGGAGAAGA TGTCTGAGTA CAAAATGGAA AAGCTGGCCT CAGACAACAA ACGCAGCTCC 2580

CTCTTCAAGA AGAAGAAGGT CAAGGAAGAT GAGGATGATG GTGTGGGTGA TGGGGATGAG 2640

GACACTGACA GTGCCATAGG GAGCTTCCGA TATTCTTCCC GCAGTAATTC CCAGAAACCT 2700

GAAACGGACA CATGCTCCTC CCTGGCTGTC TGTGATCACT ATGCAAGTGG CAGCAGAGTT 2760

GGCAAAGAGA TGGATAGCAG TATTAATAAG TGGCTCAGTG GCCTCAGGAC AGAGGAAAAA 2820

CCTCCTTTCC AAAGTGACTG GTCTGGAAGT TCCAGAGGGA AGTACACCAG ATCGTCCTTG 2880

CTCAGGGAGA CAGAGTCTAA ATCCTCCAGT TACAAGTTTT CCAAATCCCA GTCAGAGGAA 2940

CAGGACACCT CCTCCTACCA CGAGGTAAAT GGCAACTCTG TAAGAAGCAC TTCACGGTTC 3000

TCATCTTCCT CCACCAGGGA GGGCAGAGAG ATGCACAAGT TCTCCAGGTC CACGTACAAC 3060

GAGACCTCAA GTTCCCGAGA GGAGAGCCCA GAGCCCTACT TCTTCCGCCG GACCCCAGAG 3120

TCCTCAGAAA GGGAAGAGTC CCCAGAGCCA CAGCGCCCAA ATTGGGCCAG GTCCAGGGAC 3180

TGGGAAGATG TGGAAGAGTC ATCCAAGTCA GATTTCTCTG AATTTGGAGC CAAGAGGAAG 3240

TTCACCCAGA GCTTTATGAG GTCTGAAGAA GAGGGAGAGA AAGAGAGGAC AGAAAACAGA 3300

GAAGAAGGGA GGTTTGCATC TGGACGGCGG TCCCAGTATC GGAGAAGCAC TGACAGGGAG 3360

GAAGAGGAAG AAATGGACGA TGAAGCCATA ATTGCTGCTT GGAGATGCCG GCAAGAAGAA 3420

ACCAGGACCA AGCTGCAGAA AAGGAGGGAG GACTGA 3456

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 133   EVDEVWPSVFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++G+sRSa+lv+aYLm+++++++ +A

Q: 192   DDFPEVDISQHFRKAAEFLDEAlLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v++kr +i+pn+gfl+QL+el++kl

Q: 252   LMTVRKKR-AIYPNDGFLKQLRELNEKL  278

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPSVF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKVL VSSEMGISRS AVLVVAYLMI FHNMAILEAL 120

MTVRKKRAIY PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013