EPS-GOG-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GOG-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	120.1	8.8E-35	29	169	141

Status

Unreviewed

Ensembl Protein

ENSGGOP00000004503

UniProt Accession

G3QPK6;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP12

Gene Synonyms/Alias

DUSP12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000004596	ENSGGOP00000004503	ENSGGOT00000004618

Organism

Gorilla gorilla

Functional Description

Protein Length

340

Protein Sequence
(FASTA)

MLEAPGPSDG CELSNPSASR VSCAGQMLEV QPGLYFGGAA AVAEPDHLRE AGITAVLTVD 60

SEEPSFKAGP GVEDLSRLFV PALDKPETDL LSHLDRCVAF IGQARAEGRA VLVHCHAGVS 120

RSVAIITAFL MKTDQLPFEK AYEKLQILKP EAKMNEGFEW QLKLYQAMGY EVDTSSAIYK 180

QYRLQKVTEK YPELQNLPQE LFAVDPTTVS QGLKDEVLYK CRKCRRSLFR SSSILDHHEG 240

SGPIAFAHKR MTPSSMLTTG RQAQCTSYFI EPVQWMESAL LGVMDGQLLC PKCSAKLGSF 300

NWYGEQCSCG RWITPAFQIH KNRVDEMKIL PVLGSQTRKI 340

Nucleotide Sequence
(FASTA)

ATGTTGGAGG CTCCGGGCCC GAGTGATGGC TGCGAGCTCA GCAACCCCAG CGCCAGCAGA 60

GTCAGCTGCG CCGGGCAGAT GCTGGAAGTG CAGCCAGGAT TGTATTTCGG TGGGGCCGCG 120

GCCGTCGCGG AGCCAGATCA CCTGAGGGAA GCGGGCATCA CGGCCGTGCT AACAGTGGAC 180

TCGGAGGAGC CCAGCTTCAA GGCGGGGCCT GGGGTCGAGG ATCTATCGCG CCTCTTCGTG 240

CCAGCGCTGG ACAAACCCGA GACGGACCTA CTCAGCCATC TGGACCGGTG CGTGGCCTTC 300

ATCGGTCAGG CCCGCGCTGA GGGCCGTGCG GTGTTGGTGC ACTGTCATGC AGGAGTCAGT 360

CGAAGTGTGG CCATAATAAC TGCTTTTCTC ATGAAGACTG ACCAACTTCC CTTTGAAAAA 420

GCCTATGAAA AGCTCCAGAT TCTCAAACCA GAGGCTAAGA TGAATGAGGG GTTTGAGTGG 480

CAACTGAAAT TATACCAGGC AATGGGATAC GAAGTGGATA CCTCTAGTGC AATTTATAAG 540

CAATATCGTT TACAAAAGGT TACAGAGAAG TATCCAGAAT TGCAGAATTT ACCTCAAGAA 600

CTCTTTGCTG TTGACCCAAC TACCGTTTCA CAAGGATTGA AAGATGAGGT TCTCTACAAG 660

TGTAGAAAGT GCAGGCGATC ATTATTTCGA AGTTCTAGTA TTCTGGATCA CCATGAAGGA 720

AGTGGACCTA TAGCCTTTGC CCACAAGAGA ATGACACCAT CTTCCATGCT TACCACAGGG 780

AGGCAAGCTC AATGTACATC TTATTTCATT GAACCTGTAC AGTGGATGGA ATCTGCTTTG 840

TTGGGAGTGA TGGATGGACA GCTTCTTTGC CCAAAATGCA GTGCCAAGTT GGGTTCCTTC 900

AACTGGTATG GTGAACAGTG CTCTTGTGGT AGGTGGATAA CACCTGCTTT TCAAATACAT 960

AAGAATAGAG TGGATGAAAT GAAAATATTG CCTGTTTTGG GATCACAAAC AAGAAAAATA 1020

TGA 1023

Domain Profile

S: 4     eilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdDs  63

         e+ pgly g++a + +  +L+++git v+++  +   ++++P +    + + + +p+ D+

Q: 29    EVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVE---DLSRLFVPALDK  85

         799***************************************986...888899******

S: 64    dvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieav  123

         ++tdll+++d++++fi +a+ +g++vlvHC+aGvsRS+++++a+Lmk+ +l +++A+e++

Q: 86    PETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKL  145

         ************************************************************

S: 124   krkrpsiepnegfleQLlelekkl  147

         +  +p++++negf +QL +++ ++

Q: 146   QILKPEAKMNEGFEWQLKLYQAMG  169

         ********************9886

Domain Sequence
(FASTA)

EVQPGLYFGG AAAVAEPDHL REAGITAVLT VDSEEPSFKA GPGVEDLSRL FVPALDKPET 60

DLLSHLDRCV AFIGQARAEG RAVLVHCHAG VSRSVAIITA FLMKTDQLPF EKAYEKLQIL 120

KPEAKMNEGF EWQLKLYQAM G 141

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0008270	; F:zinc ion binding
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR007087	; Znf_C2H2.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.
PS50157	; ZINC_FINGER_C2H2_2; 1.

Prints

Created Date

20-Feb-2013