EKS-GOG-00079

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00079

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	448.3	1.5E-134	109	392	284

Status

Unreviewed

Ensembl Protein

ENSGGOP00000027152

UniProt Accession

G3QPQ5;

Protein Name

Protein Synonyms/Alias

Gene Name

GSK3A

Gene Synonyms/Alias

GSK3A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000004649	ENSGGOP00000004554	ENSGGOT00000004673
ENSGGOG00000004649	ENSGGOP00000027152	ENSGGOT00000030255

Organism

Gorilla gorilla

Functional Description

Protein Length

472

Protein Sequence
(FASTA)

MSGGGPSGGG PGGSGRARTS SFAEPGGSAS GPGGTGGGKA SVGAMGGGVG ASSSGGGPGG 60

SGGGGSGGPG AGTSFPPPGV KLGRDSGKVT TVVATLGQGP ERSQEVAYTD IKVIGNGSFG 120

VVYQARLAET RELVAIKKVL QDKRFKNREL QIMRKLDHCN IVRLRYFFYS SGEKKDELYL 180

NLVLEYVPET VYRVARHFTK AKLTIPILYV KVYMYQLFRS LAYIHSQGVC HRDIKPQNLL 240

VDPDTAVLKL CDFGSAKQLV RGEPNVSYIC SRYYRAPELI FGATDYTSSI DVWSAGCVLA 300

ELLLGQPIFP GDSGVDQLVE IIKVLGTPTR EQIREMNPNY TEFKFPQIKA HPWTKVFKSR 360

TPPEAIALCS SLLEYTPSSR LSPLEACAHS FFDELRCLGT QLPNNRPLPP LFNFSAGELS 420

IQPSLNAILI PPHLRSPAGT TTLTQSSQAL TETPTSSDWQ STDATPTLTN SS 472

Nucleotide Sequence
(FASTA)

ATGAGCGGCG GCGGGCCTTC GGGAGGCGGC CCTGGGGGCT CGGGCAGGGC GCGGACCAGC 60

TCGTTCGCGG AGCCCGGAGG CTCGGCCTCC GGCCCAGGCG GCACCGGCGG CGGAAAGGCA 120

TCTGTCGGGG CCATGGGTGG GGGCGTCGGG GCCTCGAGCT CCGGGGGTGG ACCCGGCGGC 180

AGCGGCGGAG GAGGCAGCGG AGGCCCCGGC GCAGGCACTA GCTTCCCGCC GCCCGGGGTG 240

AAGCTGGGCC GTGACAGCGG GAAGGTGACC ACAGTCGTAG CCACTCTAGG CCAAGGCCCA 300

GAGCGCTCCC AAGAAGTGGC TTACACGGAC ATCAAAGTGA TTGGCAATGG CTCATTTGGG 360

GTCGTGTACC AGGCACGGCT GGCAGAGACC AGGGAACTAG TCGCCATTAA GAAGGTTCTC 420

CAGGACAAGA GGTTCAAGAA CCGAGAGCTG CAGATCATGC GTAAGCTGGA CCACTGCAAT 480

ATTGTGAGGC TGAGATACTT TTTCTACTCC AGTGGCGAGA AGAAAGACGA GCTTTACCTA 540

AATCTGGTGC TGGAATATGT GCCCGAGACA GTGTACCGGG TGGCCCGCCA CTTCACCAAG 600

GCCAAGTTGA CCATCCCTAT TCTCTATGTC AAGGTGTACA TGTACCAGCT CTTCCGCAGC 660

TTGGCCTACA TCCACTCCCA GGGCGTGTGT CACCGTGACA TCAAGCCCCA GAACCTGCTG 720

GTGGACCCTG ACACTGCTGT CCTCAAGCTC TGCGATTTTG GCAGTGCAAA GCAGTTGGTC 780

CGAGGGGAGC CCAATGTCTC CTACATCTGT TCTCGCTACT ACCGGGCCCC AGAGCTCATC 840

TTTGGAGCCA CTGATTACAC CTCATCCATC GATGTTTGGT CAGCTGGCTG TGTACTGGCG 900

GAGCTCCTCT TGGGCCAGCC CATCTTCCCT GGGGACAGTG GGGTGGACCA GCTGGTGGAG 960

ATCATCAAGG TGCTGGGAAC ACCAACCCGG GAACAAATCC GAGAGATGAA CCCCAACTAC 1020

ACGGAGTTCA AGTTCCCTCA GATTAAAGCT CACCCCTGGA CAAAGGTGTT CAAATCTCGA 1080

ACGCCGCCAG AGGCCATCGC GCTCTGCTCT AGCCTGCTGG AGTACACCCC ATCCTCAAGG 1140

CTCTCCCCAC TAGAGGCCTG TGCGCATAGC TTCTTTGATG AACTGCGATG TCTGGGAACC 1200

CAGCTGCCTA ACAACCGCCC ACTTCCTCCT CTCTTCAACT TCAGTGCTGG TGAACTCTCC 1260

ATCCAACCGT CTCTCAACGC CATTCTCATC CCTCCTCACT TGAGGTCCCC AGCGGGCACT 1320

ACCACCCTCA CCCAGTCCTC ACAAGCTTTA ACTGAGACTC CGACCAGCTC AGACTGGCAG 1380

TCGACCGATG CCACACCTAC CCTCACTAAC TCCTCCTGA 1419

Domain Profile

S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61

         +++k+ig+GsFg+Vyqa+l+e++e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+yf

Q: 109   TDIKVIGNGSFGVVYQARLAETREL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF  167

         789**********************.**********************************

S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121

         f++s ekkd++ylnlvley+Pet+++v+r+++++k ++++l+vk+y+yQlfr+lay+hs+

Q: 168   FYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQ  227

         ************************************************************

S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181

         +++HrDiKPqNllvd++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++yt

Q: 228   GVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT  287

         ************************************************************

S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241

         ++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf++

Q: 288   SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ  347

         ************************************************************

S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         ik+++++kv+k+++++ea++l++++l+y+p++Rls+le++ah+ff

Q: 348   IKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF  392

         ********************************************9

Domain Sequence
(FASTA)

TDIKVIGNGS FGVVYQARLA ETRELVAIKK VLQDKRFKNR ELQIMRKLDH CNIVRLRYFF 60

YSSGEKKDEL YLNLVLEYVP ETVYRVARHF TKAKLTIPIL YVKVYMYQLF RSLAYIHSQG 120

VCHRDIKPQN LLVDPDTAVL KLCDFGSAKQ LVRGEPNVSY ICSRYYRAPE LIFGATDYTS 180

SIDVWSAGCV LAELLLGQPI FPGDSGVDQL VEIIKVLGTP TREQIREMNP NYTEFKFPQI 240

KAHPWTKVFK SRTPPEAIAL CSSLLEYTPS SRLSPLEACA HSFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013