EKS-GOG-00229

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00229

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	336.2	1.9E-100	168	419	252

Status

Unreviewed

Ensembl Protein

ENSGGOP00000004643

UniProt Accession

G3QPY6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K5

Gene Synonyms/Alias

MAP2K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000004734	ENSGGOP00000004643	ENSGGOT00000004763

Organism

Gorilla gorilla

Functional Description

Protein Length

448

Protein Sequence
(FASTA)

MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60

EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120

KVNTRAGPSQ HSSPAVSDSL PSNSLKKSSA ELKKILANGQ MNEQDIRYRD TLGHGNGGTV 180

YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 240

TEFMDGGSLD VYRKMPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC 300

DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 360

KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 420

QFNDGNAAVV SMWVCRALEE RRSQQGPP 448

Nucleotide Sequence
(FASTA)

ATGCTGTGGC TAGCCCTTGG CCCCTTTCCT GCCATGGAGA ACCAGGTGCT GGTAATTCGC 60

ATCAAGATCC CAAATAGTGG CGCGGTGGAC TGGACAGTGC ACTCCGGGCC GCAGTTACTC 120

TTCAGGGATG TGCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCAACAAC TACAGCATTT 180

GAATATGAAG ATGAAGATGG TGATCGAATT ACAGTGAGAA GTGATGAGGA AATGAAGGCA 240

ATGCTGTCAT ATTATTATTC CACAGTAATG GAACAGCAAG TAAATGGACA GTTAATAGAG 300

CCTCTGCAGA TATTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 360

AAGGTGAATA CTCGGGCCGG ACCCTCTCAA CACAGCAGCC CAGCAGTCTC AGATTCACTT 420

CCAAGCAATA GCTTAAAGAA GTCTTCTGCT GAACTGAAAA AAATACTAGC CAATGGCCAG 480

ATGAATGAAC AAGACATACG ATATCGGGAC ACTCTTGGTC ATGGTAACGG AGGCACAGTC 540

TACAAAGCAT ATCATGTCCC GAGTGGGAAA ATATTAGCTG TAAAGGTCAT ACTACTAGAT 600

ATTACACTGG AACTTCAGAA GCAAATTATG TCTGAATTGG AAATTCTTTA TAAGTGTGAT 660

TCATCATATA TCATTGGATT TTATGGAGCA TTTTTTGTAG AAAACAGGAT TTCAATATGT 720

ACAGAATTCA TGGATGGGGG ATCTTTGGAT GTATATAGGA AAATGCCAGA ACATGTCCTT 780

GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACTTATT TGTGGAGTTT AAAGATTTTA 840

CATAGAGACG TGAAGCCCTC CAATATGCTA GTAAACACAA GAGGACAGGT TAAGCTGTGT 900

GATTTTGGAG TTAGCACTCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 960

GCTTATATGG CGCCTGAAAG GATTTCAGGG GAGCAGTATG GAATTCATTC TGATGTCTGG 1020

AGCTTAGGAA TCTCTTTTAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGATTCAG 1080

AAAAACCAGG GATCTTTAAT GCCTCTCCAG CTTCTGCAGT GCATTGTTGA TGAGGATTCG 1140

CCCGTCCTTC CAGTTGGAGA GTTCTCGGAG CCATTTGTAC ATTTCATCAC TCAGTGTATG 1200

CGAAAACAGC CAAAAGAAAG GCCAGCACCT GAAGAATTGA TGGGCCACCC GTTCATCGTG 1260

CAGTTCAATG ACGGAAATGC CGCCGTGGTG TCCATGTGGG TGTGCCGGGC GCTGGAGGAG 1320

AGGCGGAGCC AGCAGGGGCC CCCGTGA 1347

Domain Profile

S: 3     kleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivk  62

           ++lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++

Q: 168   YRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIG  226

         5679************************************************.*******

S: 63    fyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkekl  122

         fyGaf+ e+++sic+e+mdg+sld v++k       +pe+vlg+iavavvk+l+yl+ +l

Q: 227   FYGAFFVENRISICTEFMDGGSLD-VYRK-------MPEHVLGRIAVAVVKGLTYLW-SL  277

         ************************.6886.......8********************.78

S: 123   kiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvk  182

         ki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++

Q: 278   KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIH  336

         *****************************************************.******

S: 183   sdvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqefv  236

         sdvWslG++++ela gr+py++ ++      +l+ll++iv+e++p+lp  efse f++f+

Q: 337   SDVWSLGISFMELALGRFPYPQIQKnqgslmPLQLLQCIVDEDSPVLPVGEFSEPFVHFI  396

         ***********************9999*********************************

S: 237   skClkkdekeRpklkellkhafi  259

         ++C++k++keRp  +el+ h+fi

Q: 397   TQCMRKQPKERPAPEELMGHPFI  419

         **********************7

Domain Sequence
(FASTA)

YRDTLGHGNG GTVYKAYHVP SGKILAVKVI LLDITLELQK QIMSELEILY KCDSSYIIGF 60

YGAFFVENRI SICTEFMDGG SLDVYRKMPE HVLGRIAVAV VKGLTYLWSL KILHRDVKPS 120

NMLVNTRGQV KLCDFGVSTQ LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM 180

ELALGRFPYP QIQKNQGSLM PLQLLQCIVD EDSPVLPVGE FSEPFVHFIT QCMRKQPKER 240

PAPEELMGHP FI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013