EKS-GOG-00418

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00418

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	376.8	6.7E-113	243	513	271

Status

Unreviewed

Ensembl Protein

ENSGGOP00000024715

UniProt Accession

G3QQ98;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE1

Gene Synonyms/Alias

WEE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000004855	ENSGGOP00000024715	ENSGGOT00000029814
ENSGGOG00000004855	ENSGGOP00000004760	ENSGGOT00000004882

Organism

Gorilla gorilla

Functional Description

Protein Length

590

Protein Sequence
(FASTA)

LSFAPPRRPS PVRAVCTLRQ KLIFSPCSDG SGHSTGEDSA FQEPDSPLPP AELEEDLLLP 60

GACPGADEAG GGAEGDSWEE EGFGSSSPVK SPAAPYFLGS SFSPVRCGGP GDASPRGDHP 120

GTPPHKTFRK LRLFDTPHTP KSLLSKARGI DSSSVKLRGS SLFMDTEKSG KREFDVRQTP 180

QVNINPFTPD SLLLHSSGQC RRRKRTYWND SYLMAWMYLS DISIEKRITI TESNMKSRYT 240

TEFHELEKIG SGEFGSVFKC VKRLDGCIYA IKRSKKPLAG SVDEQNALRE VYAHAVLGQH 300

SHVVRYFSAW AEDDHMLIQN EYCNGGSLAD AISENYRIMS YFKEAELKDL LLQVGRGLRY 360

IHSMSLVHMD IKPSNIFISR TSIPNAASEE GDEDDWASNK VIFKIGDLGH VTRISSPQVE 420

EGDSRFLANE VLQENYTHLP KADIFALALT VVCAAGAEPL PRNGDQWHEI RQGRLPRIPQ 480

VLSQEFTELL KVMIHPDPER RPSAMALVKH SVLLSASRKS AEQLRIELNA EKFKNSLLQK 540

ELKKAQMAKA AAEERALFTD RMATRSTTQS NRTSRLIGKK MNRSVSLTIY 590

Nucleotide Sequence
(FASTA)

CTCTCTTTTG CCCCTCCCAG AAGGCCCAGC CCCGTCCGGG CGGTGTGCAC CTTGCGGCAG 60

AAGCTGATCT TCTCGCCCTG CAGCGACGGC AGCGGCCACA GCACCGGGGA GGACTCGGCC 120

TTTCAAGAGC CCGACTCGCC GCTGCCGCCC GCGGAGCTGG AGGAGGACCT GTTGCTGCCC 180

GGCGCCTGCC CGGGCGCGGA CGAGGCGGGC GGTGGGGCGG AGGGCGACTC GTGGGAGGAG 240

GAGGGATTCG GCTCCTCGTC GCCGGTCAAG TCGCCGGCGG CCCCCTACTT CCTGGGTAGC 300

TCCTTCTCGC CGGTGCGCTG CGGCGGCCCA GGAGATGCGT CGCCGCGGGG TGACCACCCG 360

GGCACCCCGC CACACAAGAC CTTCCGCAAG CTGCGACTCT TCGACACCCC GCACACGCCC 420

AAGAGTTTGC TCTCCAAAGC TCGAGGAATT GATTCCAGCT CTGTTAAACT CCGGGGTAGT 480

TCTCTCTTCA TGGATACAGA AAAATCAGGA AAAAGGGAAT TTGATGTGCG ACAGACTCCT 540

CAAGTGAATA TTAATCCTTT TACTCCGGAT TCTTTGTTGC TTCATTCCTC AGGACAGTGT 600

CGTCGTAGAA AGAGAACGTA TTGGAATGAT TCCTATTTAA TGGCATGGAT GTATCTGTCA 660

GATATATCGA TAGAAAAAAG AATTACAATT ACTGAAAGCA ATATGAAGTC CCGGTATACA 720

ACAGAATTTC ATGAGCTAGA GAAAATTGGC TCTGGAGAAT TTGGTTCGGT GTTTAAGTGT 780

GTGAAGAGGC TGGATGGATG CATTTATGCC ATTAAGCGAT CAAAAAAGCC ATTGGCCGGC 840

TCTGTTGATG AGCAGAACGC TTTGAGAGAA GTATATGCTC ATGCAGTGCT TGGACAGCAT 900

TCTCATGTAG TTCGATATTT CTCTGCGTGG GCAGAAGATG ATCATATGCT TATACAGAAT 960

GAATATTGTA ATGGTGGAAG TTTAGCTGAT GCTATAAGTG AAAACTACAG AATCATGAGT 1020

TACTTTAAAG AAGCAGAGTT GAAGGATCTC CTTTTGCAAG TTGGCCGAGG CTTGAGGTAT 1080

ATTCATTCAA TGTCTTTGGT TCACATGGAT ATAAAACCTA GTAATATTTT CATATCTCGA 1140

ACCTCAATCC CAAATGCTGC CTCCGAAGAA GGAGACGAAG ATGATTGGGC ATCCAACAAA 1200

GTTATATTTA AAATAGGTGA TCTTGGGCAT GTAACAAGGA TCTCCAGTCC ACAAGTTGAA 1260

GAGGGCGATA GTCGTTTTCT TGCAAATGAA GTTTTACAGG AGAACTATAC CCATCTACCA 1320

AAAGCAGATA TTTTTGCGCT TGCCCTCACA GTGGTATGTG CTGCTGGTGC TGAACCTCTT 1380

CCGAGAAATG GAGATCAATG GCATGAAATC AGACAGGGTA GATTACCTCG GATACCACAA 1440

GTGCTTTCCC AAGAATTTAC AGAGTTGCTG AAAGTTATGA TTCATCCAGA TCCAGAGAGA 1500

AGACCTTCAG CAATGGCACT GGTAAAGCAT TCAGTACTGC TGTCCGCTTC TAGAAAGAGT 1560

GCAGAACAAT TACGAATAGA ATTGAATGCC GAAAAGTTCA AAAATTCACT TTTACAAAAA 1620

GAACTCAAGA AAGCACAGAT GGCAAAAGCT GCAGCTGAGG AAAGAGCACT CTTCACTGAC 1680

CGGATGGCCA CTAGGTCCAC CACCCAGAGT AATAGAACAT CTCGACTTAT TGGAAAGAAA 1740

ATGAACCGCT CTGTCAGCCT TACTATATAC TGA 1773

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F+e+ekiG+Gefg+vfk+vkr+dg++yAik+skkpl+g+++e++alrEv+ahavlgqh++

Q: 243   FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH  302

         99**********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+ggsL++a++e+++++++++eaelk++ll++ +glry+H

Q: 303   VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIH  362

         ************************************************************

S: 121   ssslvHlDikpenifi...................tkevtlklgDlGlvtelnsedkskv  161

         s+slvH+Dikp+nifi                   +++v++k+gDlG+vt++   ++++v

Q: 363   SMSLVHMDIKPSNIFIsrtsipnaaseegdeddwaSNKVIFKIGDLGHVTRI---SSPQV  419

         ****************************************************...9****

S: 162   eEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpdei  220

         eEGDsr+la+E+lqe+y++l kaDiF+l+lt++++a++++lP+nG++Wh++R+g+lp +i

Q: 420   EEGDSRFLANEVLQENYTHLpKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLP-RI  478

         *********************************************************.**

S: 221   lkelsedlrellklmlepdperRptaeellkhevl  255

          ++ls++++ellk+m++pdperRp+a++l+kh+vl

Q: 479   PQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL  513

         ********************************986

Domain Sequence
(FASTA)

FHELEKIGSG EFGSVFKCVK RLDGCIYAIK RSKKPLAGSV DEQNALREVY AHAVLGQHSH 60

VVRYFSAWAE DDHMLIQNEY CNGGSLADAI SENYRIMSYF KEAELKDLLL QVGRGLRYIH 120

SMSLVHMDIK PSNIFISRTS IPNAASEEGD EDDWASNKVI FKIGDLGHVT RISSPQVEEG 180

DSRFLANEVL QENYTHLPKA DIFALALTVV CAAGAEPLPR NGDQWHEIRQ GRLPRIPQVL 240

SQEFTELLKV MIHPDPERRP SAMALVKHSV L 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007067	; P:mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013