EKS-GOG-00162
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00162
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb493.81.4E-148411668258
StatusUnreviewed
Ensembl ProteinENSGGOP00000027596
UniProt AccessionG3QQH4;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000004934ENSGGOP00000027596ENSGGOT00000022704
ENSGGOG00000004934ENSGGOP00000004840ENSGGOT00000004963
OrganismGorilla gorilla
Functional Description
Protein Length729
Protein Sequence
(FASTA)
MKKFAVRRFF SVYLRRKSRS KSSSLSRLEE EGVVKEIDIS HHVKEGFEKA DPSQFELLKV 60
LGQGSYGKVF LVRKVKGSDA GQLYAMKVLK KATLKVRDRV RSKMERDILA EVNHPFIVKL 120
HYAFQTEGKL YLILDFLRGG DLFTRLSKEV MFTEEDVKFY LAELALALDH LHSLGIIYRD 180
LKPENILLDE EGHIKITDFG LSKEAIDHDK RAYSFCGTIE YMAPEVVNRR GHTQSADWWS 240
FGVLMFEMLT GSLPFQGKDR KETMALILKA KLGMPQFLSG EAQSLLRALF KRNPCNRLGA 300
GIDGVEEIKR HPFFVTIDWN ALYRKEIKPP FKPAVGRPED TFHFDPEFTA RTPTDSPGVP 360
PSANAHHLFR GFSFVASSLI QEPSQQDLHK VPVHPIVQQL HGNNIHFTDG YEIKEDIGVG 420
SYSVCKRCVH KATDTEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD VYDDGKFVYL 480
VMELMRGGEL LDRILRQRYF SEREASDVLC TITKTMDYLH SQGVVHRDLK PSNILYRDES 540
GSPESIRVCD FGFAKQLRAG NGLLMTPCYT ANFVAPEVLK RQGYDAACDI WSLGILLYTM 600
LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH VDPHQRLTAM 660
QVLKHPWVVN REYLSPNQLS RQDVHLVKGA MAATYFALNR TPQAPRLEPV LSSNLAQRRG 720
MKRLTSTRL 729
Nucleotide Sequence
(FASTA)
ATGAAGAAGT TCGCCGTGCG CAGGTTCTTC TCCGTGTACC TGCGCAGGAA GTCGCGCTCC 60
AAGAGCTCCA GCCTGAGCCG GCTCGAGGAA GAAGGTGTCG TGAAGGAGAT AGACATCAGC 120
CATCATGTGA AGGAGGGCTT TGAGAAGGCA GACCCTTCCC AGTTTGAGCT GCTGAAGGTT 180
TTAGGACAAG GATCCTATGG AAAGGTGTTC CTGGTGAGGA AGGTGAAGGG GTCCGACGCT 240
GGGCAGCTCT ATGCCATGAA GGTCCTTAAG AAAGCCACCC TAAAAGTTCG GGACCGAGTG 300
AGATCGAAGA TGGAGAGAGA CATCTTGGCA GAAGTGAATC ACCCCTTCAT TGTGAAGCTT 360
CATTATGCCT TTCAGACGGA AGGAAAGCTC TACCTGATCC TGGACTTCCT GCGGGGAGGG 420
GACCTCTTCA CCCGGCTCTC CAAAGAGGTC ATGTTCACGG AGGAGGATGT CAAGTTCTAC 480
CTGGCTGAGC TGGCCTTGGC TTTAGACCAT CTCCACAGCC TGGGGATCAT CTACAGAGAT 540
CTGAAGCCTG AGAACATCCT CCTGGATGAA GAGGGACATA TTAAGATCAC AGATTTCGGC 600
CTGAGTAAGG AGGCCATTGA CCACGACAAG AGAGCGTACT CCTTCTGCGG GACGATCGAA 660
TACATGGCGC CCGAGGTGGT GAACCGGCGA GGACACACGC AGAGTGCCGA CTGGTGGTCC 720
TTCGGCGTGC TCATGTTCGA GATGCTCACG GGGTCCCTGC CGTTCCAGGG GAAGGACAGG 780
AAGGAGACCA TGGCTCTCAT CCTGAAAGCC AAGCTGGGGA TGCCGCAGTT CCTCAGTGGG 840
GAGGCACAAA GTTTGCTGCG AGCTCTCTTC AAACGGAACC CCTGCAACCG ACTGGGTGCT 900
GGCATTGACG GAGTGGAGGA AATTAAGCGC CATCCCTTCT TTGTGACCAT AGACTGGAAC 960
GCGCTGTACC GGAAGGAGAT CAAGCCGCCT TTCAAACCAG CAGTGGGCAG GCCTGAGGAC 1020
ACCTTCCACT TTGACCCCGA GTTCACAGCG CGGACGCCCA CAGACTCTCC TGGCGTCCCC 1080
CCGAGTGCAA ACGCTCATCA CCTGTTTAGA GGATTCAGCT TTGTGGCCTC AAGCCTGATC 1140
CAGGAGCCCT CACAGCAAGA TCTGCACAAA GTCCCAGTTC ACCCAATCGT GCAGCAGTTA 1200
CACGGGAACA ACATCCACTT CACCGATGGC TACGAGATCA AGGAGGACAT CGGGGTGGGC 1260
TCCTACTCAG TGTGCAAGCG ATGTGTGCAT AAAGCCACCG ACACCGAGTA TGCCGTGAAG 1320
ATCATTGATA AGAGCAAGAG AGACCCCTCG GAAGAGATCG AGATCCTCCT GCGGTACGGC 1380
CAGCACCCGA ACATCATCAC CCTCAAGGAT GTCTATGATG ATGGCAAGTT TGTGTACCTG 1440
GTAATGGAGC TGATGCGTGG TGGGGAGCTC CTGGACCGCA TCCTCCGGCA GAGATACTTC 1500
TCGGAGCGCG AAGCCAGTGA CGTCCTGTGC ACCATCACCA AGACCATGGA CTACCTCCAT 1560
TCCCAGGGGG TTGTTCATCG AGACCTGAAG CCGAGTAACA TCCTGTACAG GGATGAGTCG 1620
GGGAGCCCAG AATCCATCCG AGTCTGCGAC TTCGGCTTTG CCAAGCAGCT GCGCGCGGGG 1680
AACGGGCTGC TCATGACACC CTGCTACACA GCCAATTTCG TGGCCCCGGA GGTCCTGAAG 1740
CGTCAAGGCT ATGATGCGGC GTGTGACATC TGGAGTTTGG GGATCCTGTT GTACACCATG 1800
CTGGCAGGAT TTACCCCTTT TGCAAATGGG CCAGACGATA CCCCTGAGGA GATTCTGGCG 1860
CGGATCGGCA GTGGGAAGTA TGCCCTTTCT GGGGGAAACT GGGACTCGAT ATCTGACGCA 1920
GCTAAAGACG TCGTGTCCAA GATGCTCCAC GTGGACCCTC ATCAGCGCCT GACGGCGATG 1980
CAAGTGCTCA AACACCCGTG GGTGGTCAAC AGAGAGTACC TGTCCCCAAA CCAGCTCAGC 2040
CGACAGGACG TGCACCTGGT GAAGGGCGCG ATGGCCGCCA CCTACTTTGC TCTAAACAGA 2100
ACACCTCAGG CCCCGCGGCT GGAGCCCGTG CTGTCGTCCA ACCTGGCTCA GCGCAGAGGC 2160
ATGAAGAGAC TCACGTCCAC GCGGTTGTAG 2190
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat++e+avkiidkskrd+seeieillry+qhpni+tlkd
Q: 411   YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  470
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelldri+++++fsereas++l+t++k+++ylh+qGvvhrdlk
Q: 471   VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK  530
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des+++esi+++dfGfak++ra ngll+tpcyt+nfvapevlkrqGyd+acd+
Q: 531   PSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDI  590
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaG++pfangp+dt+eeila+i++Gk++lsG++wds+s++akd+vsk+l+
Q: 591   WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH  650
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl+++q+lkh+w+
Q: 651   VDPHQRLTAMQVLKHPWV  668
         *****************7
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATDTEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKFVYL VMELMRGGEL LDRILRQRYF SEREASDVLC TITKTMDYLH SQGVVHRDLK 120
PSNILYRDES GSPESIRVCD FGFAKQLRAG NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180
WSLGILLYTM LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH 240
VDPHQRLTAM QVLKHPWV 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-EQC-00163
EKS-GAG-00139
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-ORC-00150
EKS-OTG-00167
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-XET-00150
EKS-XIM-00198
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013