EKS-GOG-00363

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00363

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	423.2	4.1E-127	188	437	250

Status

Unreviewed

Ensembl Protein

ENSGGOP00000017853

UniProt Accession

G3QQZ5;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000005127	ENSGGOP00000005025	ENSGGOT00000005154
ENSGGOG00000005127	ENSGGOP00000017853	ENSGGOT00000022100

Organism

Gorilla gorilla

Functional Description

Protein Length

452

Protein Sequence
(FASTA)

PLSILDKHFV VALYDYTAMN DRDLQMLKGE KLQVLKGTGD WWLARSLVTG REGYVPSNFV 60

ARVESLEMER WFFRSLGRKE AERQLLAPIN KAGSFLIRES ETNKGAFSLS VKDVTTQGEL 120

IKHYKIRSLD EGGYYISPRI TFPSLQALVQ HYSKKGDGLC QRLTLPCVSP ALQNPWAQDE 180

WEIPRQSLRL VRKLGSGQFG EVWMGYYKNN MKVAIKTLKE GTMSPEAFLG EANVMKALQH 240

ERLVRLYAVV TKEPIYIVTE YMARGCLLDF LKTDEGSRLS LPRLIDMSAQ IAEGMAYIER 300

MNSIHRDLRA ANILVSEALC CKIADFGLAR IIDSEYTAQE GAKFPIKWTA PEAIHFGVFT 360

IKADVWSFGV LLMEVVTYGR VPYPGMSNPE VIRSLERGYR MPRPDTCPPE LYRGVIAECW 420

RSRPEERPTF EFLQSVLEDF YTATERQYEL QP 452

Nucleotide Sequence
(FASTA)

CCCTTGTCCA TTTTAGACAA GCATTTCGTG GTGGCTCTGT ATGACTACAC CGCTATGAAT 60

GATCGGGACC TGCAGATGCT GAAGGGGGAG AAGCTACAGG TCCTGAAGGG AACTGGAGAC 120

TGGTGGCTGG CCAGGTCACT CGTCACAGGA AGAGAAGGCT ATGTGCCCAG CAACTTTGTG 180

GCCCGAGTGG AGAGCCTGGA AATGGAAAGG TGGTTCTTTA GATCACTGGG TCGGAAGGAG 240

GCTGAGAGGC AGCTTCTTGC TCCAATCAAC AAGGCCGGCT CCTTTCTTAT CAGAGAGAGT 300

GAAACCAACA AAGGTGCCTT CTCCCTGTCT GTGAAGGACG TCACCACCCA AGGGGAGCTG 360

ATCAAGCACT ATAAGATCCG CTCCCTGGAT GAAGGGGGCT ACTACATCTC CCCCCGGATC 420

ACCTTCCCCT CGCTCCAGGC CCTGGTGCAG CACTATTCTA AGAAGGGGGA TGGTCTATGC 480

CAGAGGCTGA CCCTGCCCTG TGTGAGCCCG GCCCTGCAGA ACCCCTGGGC CCAGGATGAA 540

TGGGAGATCC CCCGGCAGTC TCTCAGGCTG GTCAGGAAAC TCGGGTCTGG ACAATTTGGC 600

GAAGTGTGGA TGGGTTACTA CAAAAACAAC ATGAAGGTGG CCATTAAGAC GCTGAAGGAG 660

GGAACCATGT CTCCAGAAGC CTTCCTGGGC GAGGCCAACG TGATGAAGGC TCTGCAGCAC 720

GAGCGGCTGG TCCGACTTTA CGCAGTGGTC ACCAAGGAGC CCATCTACAT TGTCACCGAG 780

TACATGGCCA GAGGATGCCT GCTGGATTTC CTGAAGACAG ATGAAGGGAG CAGATTGTCA 840

CTCCCAAGGC TGATTGATAT GTCGGCGCAG ATTGCTGAAG GGATGGCGTA CATTGAGCGC 900

ATGAATTCCA TCCACCGCGA CCTGCGGGCG GCCAACATCC TGGTGTCTGA GGCCTTGTGC 960

TGCAAAATTG CTGATTTTGG CTTGGCTCGA ATCATCGACA GTGAATACAC GGCCCAAGAG 1020

GGGGCCAAGT TCCCCATCAA GTGGACAGCC CCGGAAGCCA TCCACTTCGG GGTCTTTACC 1080

ATCAAAGCAG ACGTGTGGTC GTTTGGAGTC CTCCTGATGG AAGTTGTCAC TTATGGGCGG 1140

GTGCCATACC CAGGGATGAG CAACCCGGAG GTCATCCGCA GCCTGGAGCG CGGCTACCGC 1200

ATGCCGCGCC CCGACACCTG CCCGCCGGAG CTGTACCGCG GCGTCATCGC CGAGTGCTGG 1260

CGCAGCCGGC CCGAGGAGCG GCCCACCTTC GAGTTCCTGC AGTCGGTGCT GGAGGACTTC 1320

TACACGGCCA CCGAGAGGCA GTACGAGCTG CAGCCCTAG 1359

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+lv+klG+GqfGevw+g++k+++kva+ktlkegt+speafl ea+++k l+he+lv+ly

Q: 188   LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY  247

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+ma+G+lldflk++eg++l+lp+l+d++aq+aeGmay+e++n ihr

Q: 248   AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHR  306

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e l++k+adfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv

Q: 307   DLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  365

         **************************.899******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239

         WsfG+ll+e+vt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+++pe

Q: 366   WSFGVLLMEVVTYGRVPYPGMSNPEVIRSLERGYRMPRPDTCPPELYRgVIAECWRSRPE  425

         ************************************************9***********

S: 240   erPtfetlqevl  251

         erPtfe+lq+vl

Q: 426   ERPTFEFLQSVL  437

         *********986

Domain Sequence
(FASTA)

LRLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 60

AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD 120

LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180

FGVLLMEVVT YGRVPYPGMS NPEVIRSLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER 240

PTFEFLQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013