EPS-GOG-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GOG-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	211.0	3.3E-62	594	839	246

Status

Unreviewed

Ensembl Protein

ENSGGOP00000016854

UniProt Accession

G3QR38;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1

Gene Synonyms/Alias

PHLPP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000005176	ENSGGOP00000005073	ENSGGOT00000005204
ENSGGOG00000005176	ENSGGOP00000016854	ENSGGOT00000024142

Organism

Gorilla gorilla

Functional Description

Protein Length

1124

Protein Sequence
(FASTA)

MHVLPLIGGK VEEVKKHQHC LAFSSSGPQS QTYYICFDTF TEYLRWLRQV SKVASQRISS 60

VDLSCCSLEH LPANLFYSQD LTHLNLKQNF LRQNPSLPAA RGLNELQRFT KLKSLNLSNN 120

HLGDFPLAVC SIPTLAELNV SCNALRSVPA AVGVMHNLQT FLLDGNFLQS LPAELENMKQ 180

LSYLGLSFNE FTDIPEVLEK LTAVDKLCMS GNCVETLRLQ ALRKMPHIKH VDLRLNVIRK 240

LIADEVDFLQ HVTQLDLRDN KLGDLDAMIF NNIEVLHCER NQLVTLDICG YFLKGLYASS 300

NELVQLDVYP VPNYLSYMDV SRNRLENVPE WVCESRKLEV LDIGHNQICE LPARLFCNSS 360

LRKLLAGHNQ LARLPERLER TSVEVLDVQH NQLLELPPNL LMKADSLRFL NASANKLESL 420

PPATLSEETN SILQELYLTN NSLTDKCVPL LTGHPHLKIL HMAYNRLQSF PASKMAKLEE 480

LEEIDLSGNK LKAIPTTIMN CRRMHTVIAH SNCIEVFPEV MQLPEIKCVD LSCNELSEVT 540

LPENLPPKLQ ELDLTGNPRL VLDHKTLELL NNIRCFKIDQ PSTGDPSGAP AVWSHGYTEA 600

SGVKNKLCVA ALSVNNFCDN REALYGVFDG DRNVEVPYLL QCTMSDILAE ELQKTKNEEE 660

YMVNTFIVMQ RKLGTAGQKL GGAAVLCHIK HDPVDPGGSF TLTSANVGKC QTVLCRNGKP 720

LPLSRSYIMS CEEELKRIKQ HKAIITEDGK VNGVTESTRI LGYTFLHPSV VPRPHVQSVL 780

LTPQDEFFIL GSKGLWDSLS VEEAVEAVRN VPDALAAAKK LCTLAQSYGC HDSISAVVVQ 840

LSVTEDSFCC CELSAGGAVP PPSPGIFPPS VNMVIKDRPS DGLGVPSSSS GMASEISSEL 900

STSEMSSEVG STASDEPPPG ALSENSPAYP SEQRCMLHPI CLSNSFQRQL SSATFSSAFS 960

DNGLDSDDEE PIEGVFTNGS RVEVEVDIHC SRAKEKEKQQ HLLQVPAEAS DEGIVISANE 1020

DEPGLPRKAD FSAVGTIGRR RANGSVAPQE RSHNVIEVAT DAPLRKPGGY FAAPAQPDPD 1080

DQFIIPPELE EEVKEIMPPP PQLQPQLPRH YQLDQLPDYY DTPL 1124

Nucleotide Sequence
(FASTA)

ATGCATGTTC TGCCACTAAT TGGTGGAAAA GTAGAAGAAG TGAAAAAGCA CCAACACTGT 60

TTAGCATTTA GCTCCTCTGG ACCCCAAAGC CAGACTTACT ACATTTGCTT TGATACTTTC 120

ACAGAATACT TAAGGTGGCT GCGACAAGTC TCCAAGGTTG CATCCCAGCG CATTAGCTCA 180

GTGGACCTCT CGTGTTGTAG CCTGGAACAT CTGCCTGCCA ACCTCTTCTA CAGCCAAGAC 240

CTCACTCATC TCAATTTAAA ACAAAACTTC CTAAGGCAGA ACCCTAGCCT TCCAGCTGCC 300

AGGGGGCTTA ATGAACTGCA AAGGTTCACC AAGTTGAAGA GTCTTAACCT TTCCAATAAT 360

CATTTAGGGG ACTTCCCACT GGCAGTCTGC AGTATTCCAA CCCTGGCAGA GCTGAACGTG 420

TCCTGCAATG CCCTGCGATC AGTCCCGGCA GCCGTTGGAG TGATGCACAA CTTACAGACA 480

TTTTTGTTGG ATGGAAACTT TCTCCAATCC CTTCCTGCTG AGTTGGAGAA CATGAAGCAG 540

CTTAGTTATC TGGGTCTTTC TTTCAATGAA TTTACTGACA TTCCCGAAGT ATTGGAGAAA 600

TTGACTGCTG TGGATAAACT TTGTATGTCT GGAAACTGTG TGGAGACCCT TAGGCTACAG 660

GCTTTAAGAA AAATGCCTCA CATTAAACAT GTGGATCTAA GGTTGAACGT AATTAGGAAG 720

CTGATAGCAG ATGAAGTGGA CTTTCTACAG CATGTTACTC AGCTTGACCT ACGAGACAAT 780

AAGCTTGGTG ATCTAGATGC TATGATTTTC AACAACATTG AAGTTTTACA CTGTGAAAGG 840

AATCAACTGG TCACATTAGA CATCTGTGGC TATTTCCTAA AAGGACTCTA TGCCTCTTCT 900

AATGAACTTG TTCAACTTGA TGTTTACCCA GTTCCAAATT ATCTGTCCTA CATGGATGTT 960

TCAAGGAACC GCTTAGAAAA TGTGCCTGAG TGGGTATGTG AAAGCCGAAA GCTAGAAGTT 1020

TTGGATATTG GTCATAATCA AATATGTGAA CTTCCTGCCC GCTTATTTTG TAATAGCAGT 1080

CTCCGGAAAC TACTGGCAGG ACACAACCAG TTGGCAAGGC TGCCTGAAAG GCTAGAAAGA 1140

ACCTCGGTGG AGGTCTTGGA TGTGCAACAC AACCAGCTCC TTGAGCTCCC GCCTAACCTT 1200

CTGATGAAGG CTGACAGCCT GAGATTCCTG AACGCCTCTG CGAACAAACT GGAAAGCCTT 1260

CCTCCAGCCA CGCTTTCCGA AGAGACAAAC AGTATCTTAC AAGAGTTGTA TTTGACCAAT 1320

AACAGCCTCA CCGACAAATG TGTGCCCTTG TTAACGGGAC ACCCCCATTT GAAGATCCTT 1380

CACATGGCTT ATAACCGACT TCAGAGTTTT CCAGCAAGTA AAATGGCGAA ACTGGAGGAA 1440

CTTGAAGAAA TTGATCTCAG TGGGAATAAG CTGAAAGCCA TCCCAACAAC GATCATGAAT 1500

TGCAGGCGCA TGCACACCGT GATTGCTCAC TCCAACTGCA TCGAGGTCTT TCCCGAAGTT 1560

ATGCAGCTCC CAGAGATCAA GTGTGTGGAC CTGAGCTGTA ATGAGCTAAG TGAAGTCACA 1620

TTACCAGAAA ACCTGCCTCC CAAACTGCAG GAGCTAGACC TGACTGGAAA CCCTCGCCTT 1680

GTCCTTGATC ACAAAACCCT GGAACTACTG AATAATATCC GCTGTTTCAA GATTGATCAG 1740

CCTTCTACAG GAGACCCTTC CGGAGCCCCA GCTGTATGGA GTCATGGTTA CACTGAAGCT 1800

TCGGGGGTAA AAAACAAGTT GTGTGTCGCA GCCCTGTCGG TGAATAACTT CTGTGACAAC 1860

CGCGAAGCCC TGTATGGTGT GTTTGACGGA GACCGGAATG TGGAGGTGCC CTACCTTCTC 1920

CAGTGCACTA TGAGTGACAT TTTGGCTGAA GAGCTGCAAA AAACAAAAAA CGAAGAAGAA 1980

TACATGGTCA ATACATTCAT TGTCATGCAA AGGAAACTTG GAACTGCTGG GCAGAAGCTT 2040

GGTGGTGCCG CTGTCCTTTG TCATATCAAG CATGACCCTG TGGATCCAGG AGGATCCTTC 2100

ACCTTGACCT CTGCTAATGT GGGCAAGTGC CAAACAGTTC TCTGTCGAAA TGGAAAGCCG 2160

CTGCCTCTGT CCAGATCTTA CATCATGAGC TGTGAAGAAG AGCTGAAGAG GATTAAACAG 2220

CACAAGGCCA TTATCACTGA GGATGGCAAG GTGAACGGAG TGACTGAGTC CACGCGCATC 2280

CTGGGCTACA CCTTCCTCCA TCCCAGTGTG GTGCCTCGCC CCCACGTGCA GTCCGTGCTC 2340

CTGACCCCCC AGGATGAGTT CTTCATCCTA GGCAGTAAGG GGTTGTGGGA CAGCCTGTCC 2400

GTTGAGGAGG CCGTGGAGGC CGTGCGCAAC GTGCCCGACG CCCTGGCTGC TGCCAAGAAG 2460

CTGTGTACCC TGGCCCAGAG CTACGGCTGC CACGACAGCA TCAGCGCTGT GGTGGTGCAG 2520

CTCAGTGTCA CTGAGGACAG CTTCTGCTGC TGCGAGCTCA GCGCCGGTGG GGCTGTGCCA 2580

CCACCCAGTC CTGGCATCTT TCCTCCCTCA GTGAACATGG TGATCAAGGA TCGGCCCTCA 2640

GATGGGCTGG GCGTGCCGTC CTCCAGCAGC GGCATGGCTT CCGAGATTAG CAGTGAGCTC 2700

TCCACTTCTG AGATGAGCAG CGAGGTGGGG TCAACAGCCT CCGATGAGCC CCCGCCCGGA 2760

GCCCTAAGCG AGAACAGCCC TGCCTACCCC AGTGAGCAGC GCTGCATGCT CCACCCCATC 2820

TGTCTGTCCA ACTCCTTCCA GCGCCAGCTA TCCAGCGCCA CGTTCTCTAG CGCCTTCTCC 2880

GACAACGGCC TTGACAGTGA CGATGAGGAG CCCATCGAGG GCGTCTTCAC CAACGGCAGC 2940

CGGGTGGAGG TGGAGGTGGA CATCCACTGT AGCCGGGCCA AGGAGAAGGA GAAACAGCAG 3000

CACCTGCTTC AGGTGCCAGC AGAGGCCAGC GATGAGGGCA TTGTCATCAG CGCCAATGAG 3060

GATGAGCCAG GTCTGCCCAG GAAGGCAGAC TTCTCTGCCG TTGGGACCAT TGGGCGCCGG 3120

AGGGCCAATG GCTCTGTTGC GCCCCAGGAA AGGAGCCACA ATGTGATAGA GGTGGCCACA 3180

GACGCACCTC TTCGAAAGCC TGGAGGCTAT TTTGCTGCCC CAGCTCAGCC GGATCCCGAT 3240

GATCAGTTTA TCATACCCCC GGAGCTGGAA GAGGAGGTCA AAGAAATCAT GCCACCACCC 3300

CCTCAGCTCC AGCCGCAGCT GCCGCGGCAC TACCAGCTGG ACCAGCTGCC AGATTATTAT 3360

GACACGCCAC TATGA 3375

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s++nf++++e+     ++gv+DG+++ ev + +++++++il

Q: 594   SHGYTEASGVKNKLCVAALSVNNFCDNREA-----LYGVFDGDRNVEVPYLLQCTMSDIL  648

         689***********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aeel+    ++++ ++++ ++F+ ++++l       ++ +k G +av+++ik++

Q: 649   AEELQ----KTKNEEEYMVNTFIVMQRKL------GTAGQKLGGAAVLCHIKHDpvdpgg  698

         ***99....999*****************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG++++vLcrngk+++ls+ + +s+e+El+Ri+++++ ++++   +v+Gv++

Q: 699   sfTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDG--KVNGVTE  756

         *99*****************************************9999998..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R lG ++l+p v+p+P+v+s+ lt++def+iL+s+Glwd +s eeav++vr+v +

Q: 757   STRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPD---  813

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          + +aakkL++la+++g++d++sa+vv

Q: 814   -ALAAAKKLCTLAQSYGCHDSISAVVV  839

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNNFCDNREA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ 60

KTKNEEEYMV NTFIVMQRKL GTAGQKLGGA AVLCHIKHDP VDPGGSFTLT SANVGKCQTV 120

LCRNGKPLPL SRSYIMSCEE ELKRIKQHKA IITEDGKVNG VTESTRILGY TFLHPSVVPR 180

PHVQSVLLTP QDEFFILGSK GLWDSLSVEE AVEAVRNVPD ALAAAKKLCT LAQSYGCHDS 240

ISAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>