EKS-GOG-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	343.9	9.4E-103	820	1094	275

Status

Unreviewed

Ensembl Protein

ENSGGOP00000005613

UniProt Accession

G3QSH5;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK3

Gene Synonyms/Alias

JAK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000005727	ENSGGOP00000015419	ENSGGOT00000015862
ENSGGOG00000005727	ENSGGOP00000005613	ENSGGOT00000005758

Organism

Gorilla gorilla

Functional Description

Protein Length

1107

Protein Sequence
(FASTA)

MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA EDLCVQAAKA 60

SGILPVYHSL FALATEDLSC WFPPSHIFSV EDASTQVLLY RIRFYFPNWF GLEKCHRFGL 120

RKDLASAILD LPVLEHLFAQ HRSDLVSGRL PVGLSLKEQG ECLSLAVLDL ARMAREQAQR 180

PGELLKTVSY KACLPPSLRD LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM 240

DLERLDPAGA AETFHVGLPG ALGGHDGLGL LRVAGDGGIA WTQGEQEVLQ PFCDFPEIVD 300

ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR LTTDSQHFFC 360

KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV LRRSPQDFDS FLLTVCVQTP 420

LGPDYKGCLI RRSPTGTFLL VGLSRPHSSL RELLATCWDG GLHVDGVAVT LTSCCIPRPK 480

EKSNLIVVQR GHSPPTSSLV QPQSQYQLSQ MTFHKIPADS LHENLGHGSF TKIYRGCRHE 540

VVDGEARKTE VLLKVMDAKH KNCMESFLEA ASLMSQVSYR HLVLLHGVCM AGDSTMVQEF 600

VHLGAIDMYL RKRGHLVPAS WKLQVVKQLA YALNYLEDKG LPHGNVSARK VLLAREGADG 660

SPPFIKLSDP GVSPAVLSLE MLTDRIPWVA PECLREAQTL SLEADKWGFG ATVWEVFSGV 720

TMPISALDPA KKLQFYEDRQ QLPAPKWTEL ALLIQQCMAY EPVQRPSFRA VIRDLNSLIS 780

SDYELLSDPT PGALAPRDGL WNGAQLYACQ DPTIFEERHL KYISQLGKGN FGSVELCRYD 840

PLGDNTGALV AVKQLQHSGP DQQRDFQREI QILKALHSDF IVKYRGVSYG PGRQSLRLVM 900

EYLPSGCLRD FLQRHRARLD ASRLLLYSSQ ICKGMEYLGS RRCVHRDLAA RNILVESEAH 960

VKIADFGLAK LLPLDKDYYV VREPGQSPIF WWYAPESLSD NIFSRQSDVW SFGVVLYELF 1020

TYCDKSCSPS AEFLRMMGCE RDVPALCRLL ELLEEGQRLP APPACPAEVH ELMKLCWAPS 1080

PQDRPSFSAL GPQLDMLWSG RRGCETH 1107

Nucleotide Sequence
(FASTA)

ATGGCACCTC CAAGTGAAGA GACGCCCCTG ATCCCTCAGC GTTCATGCAG CCTCTTGTCC 60

ACGGAGGCTG GTGCCCTGCA TGTGCTGCTG CCCGCTCGGG GCCCCGGGCC CCCCCAGCGC 120

CTATCTTTCT CCTTTGGGGA CCACTTGGCT GAGGACCTGT GCGTGCAGGC TGCCAAGGCC 180

AGCGGCATCC TGCCTGTGTA CCACTCCCTT TTTGCTCTGG CCACGGAGGA CCTGTCCTGC 240

TGGTTCCCCC CGAGCCACAT CTTCTCCGTG GAGGATGCCA GCACCCAAGT CCTGCTCTAC 300

AGGATTCGCT TTTACTTCCC CAATTGGTTT GGGCTGGAGA AGTGCCACCG CTTCGGGCTA 360

CGCAAGGATT TGGCCAGCGC TATCCTTGAC CTGCCAGTCC TGGAGCACCT CTTTGCCCAG 420

CACCGCAGTG ACCTGGTGAG TGGGCGCCTC CCCGTGGGCC TCAGTCTCAA GGAGCAGGGT 480

GAGTGTCTCA GCCTGGCCGT GTTGGACCTG GCCCGGATGG CGCGAGAGCA GGCCCAGCGG 540

CCGGGAGAGC TGCTGAAGAC TGTCAGCTAC AAGGCCTGCC TACCCCCAAG CCTGCGCGAC 600

CTGATCCAGG GCCTGAGCTT CGTGACGCGG AGGCGTATTC GGAGGACGGT GCGCAGAGCC 660

CTGCGCCGCG TGGCCGCCTG CCAGGCAGAC AGGCACTCGC TCATGGCCAA GTACATCATG 720

GACCTGGAGC GGCTGGATCC AGCCGGGGCC GCCGAGACCT TCCACGTGGG CCTCCCTGGG 780

GCCCTTGGTG GCCACGACGG GCTGGGGCTG CTCCGCGTGG CTGGTGACGG CGGCATCGCC 840

TGGACCCAGG GAGAACAGGA GGTCCTCCAG CCCTTCTGCG ACTTTCCAGA AATCGTAGAC 900

ATTAGCATCA AGCAGGCCCC GCGCGTTGGC CCGGCCGGGG AGCACCGCCT GGTCACTGTT 960

ACCAGGACAG ACAACCAGAT TTTAGAGGCC GAGTTCCCAG GGCTGCCCGA GGCTCTGTCG 1020

TTCGTGGCGC TCGTGGACGG CTACTTCCGG CTGACCACGG ACTCCCAGCA CTTCTTCTGC 1080

AAGGAGGTGG CACCGCCGAG GCTGCTGGAG GAAGTGGCCG AGCAGTGCCA CGGCCCCATC 1140

ACTCTGGACT TTGCCATCAA CAAGCTCAAG ACTGGGGGCT CACGTCCTGG CTCCTATGTT 1200

CTCCGCCGCA GCCCCCAGGA CTTTGACAGC TTCCTCCTCA CTGTCTGTGT CCAGACACCC 1260

CTTGGTCCTG ATTATAAGGG CTGCCTCATC CGGCGCAGCC CCACAGGAAC CTTCCTTCTG 1320

GTTGGCCTCA GCCGACCCCA CAGCAGTCTT CGAGAGCTCC TGGCAACCTG CTGGGATGGG 1380

GGGCTGCACG TAGATGGGGT GGCAGTGACC CTCACTTCCT GCTGTATCCC CAGACCCAAA 1440

GAAAAGTCCA ACCTGATCGT GGTCCAGAGA GGTCACAGCC CACCCACATC ATCCTTGGTT 1500

CAGCCCCAAT CCCAATACCA GCTGAGTCAG ATGACATTTC ACAAGATCCC TGCTGACAGC 1560

CTGCATGAGA ACCTGGGCCA TGGGTCCTTC ACCAAGATTT ACCGGGGCTG TCGCCATGAG 1620

GTGGTGGATG GGGAGGCCCG AAAGACAGAG GTGCTGCTGA AGGTGATGGA TGCCAAGCAC 1680

AAGAACTGCA TGGAGTCATT CCTGGAAGCA GCGAGCTTGA TGAGCCAAGT GTCATACCGG 1740

CATCTCGTGC TGCTCCACGG CGTGTGCATG GCTGGAGACA GCACCATGGT GCAGGAATTT 1800

GTACACCTGG GGGCCATAGA CATGTATCTG CGAAAACGTG GCCACCTGGT GCCAGCCAGC 1860

TGGAAACTGC AGGTGGTCAA ACAGCTGGCC TACGCCCTCA ACTATCTGGA GGACAAAGGC 1920

CTCCCCCATG GCAATGTCTC TGCCCGGAAG GTGCTCCTGG CTCGGGAGGG GGCTGATGGG 1980

AGCCCGCCCT TCATCAAGCT GAGTGACCCT GGGGTCAGCC CCGCTGTGTT AAGCCTGGAG 2040

ATGCTCACCG ACAGGATCCC CTGGGTGGCC CCCGAGTGTC TCCGGGAGGC CCAGACACTT 2100

AGCTTGGAAG CTGACAAGTG GGGCTTCGGC GCCACGGTCT GGGAAGTGTT TAGTGGCGTC 2160

ACCATGCCCA TCAGTGCCCT GGATCCTGCT AAGAAACTCC AATTTTATGA GGACCGGCAG 2220

CAGCTGCCGG CCCCCAAGTG GACAGAGCTG GCCCTGCTGA TTCAACAGTG CATGGCCTAT 2280

GAGCCGGTCC AGAGGCCCTC CTTCCGAGCC GTCATTCGTG ACCTCAATAG CCTCATCTCT 2340

TCAGACTATG AGCTCCTCTC AGACCCCACA CCTGGTGCCC TGGCACCTCG TGATGGGCTG 2400

TGGAATGGTG CCCAGCTCTA TGCCTGCCAA GACCCCACGA TCTTCGAGGA GAGACACCTC 2460

AAGTACATCT CACAGCTGGG CAAGGGCAAC TTTGGCAGCG TGGAGCTGTG CCGCTATGAC 2520

CCGCTAGGCG ACAATACAGG TGCCCTGGTG GCCGTGAAAC AGCTGCAGCA CAGCGGGCCA 2580

GACCAGCAGA GGGACTTTCA GCGGGAGATT CAGATCCTCA AAGCACTGCA CAGTGATTTC 2640

ATTGTCAAGT ATCGTGGTGT CAGCTATGGC CCGGGCCGCC AGAGCCTGCG GCTGGTCATG 2700

GAGTACCTGC CCAGCGGCTG CTTGCGCGAC TTCCTGCAGC GGCACCGCGC GCGCCTCGAT 2760

GCCAGCCGCC TCCTTCTCTA TTCCTCGCAG ATCTGCAAGG GCATGGAGTA CCTGGGCTCC 2820

CGCCGCTGCG TGCACCGCGA CCTGGCCGCC CGAAACATCC TCGTGGAGAG CGAGGCACAC 2880

GTCAAGATCG CTGACTTCGG CCTAGCTAAG CTGCTGCCGC TTGACAAAGA CTACTACGTG 2940

GTTCGCGAGC CGGGCCAGAG CCCCATTTTC TGGTGGTATG CCCCCGAATC CCTCTCGGAC 3000

AACATCTTCT CTCGCCAGTC GGACGTCTGG AGCTTCGGGG TCGTCCTGTA CGAGCTCTTC 3060

ACCTACTGCG ACAAAAGCTG CAGCCCCTCG GCCGAGTTCC TGCGGATGAT GGGATGTGAG 3120

CGGGATGTCC CCGCCCTCTG CCGCCTCCTG GAACTGCTGG AGGAGGGCCA GAGGCTGCCG 3180

GCGCCTCCTG CCTGCCCTGC TGAGGTTCAC GAGCTCATGA AGCTGTGCTG GGCCCCTAGC 3240

CCACAGGACC GGCCATCATT CAGTGCCCTG GGCCCCCAGC TGGACATGCT GTGGAGCGGA 3300

AGACGGGGGT GTGAGACTCA T 3321

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk+i++Lgkg+f++v+++r+d+ gd+t++ va+k+L++sg+d++rdf+re++il++l+++

Q: 820   LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSD  879

         799*********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk++gv++ +g++  rlVmey++sG+L+++L++++++l++s+ll +++q++k+meYL+

Q: 880   FIVKYRGVSYGPGRQslRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLG  939

         ************************************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsrip.wl  176

         ++++vhrd+aarn+Lve+e++      vk++d+glak+++ d +Yy+vre+++s+i+ w+

Q: 940   SRRCVHRDLAARNILVESEAH------VKIADFGLAKLLPLDkDYYVVREPGQSPIFwWY  993

         *********************......*****************************9459

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         ape+ls++  +s++sdvWsFgv+lyel+t c+k++sp    lr++++e       r+lel

Q: 994   APESLSDNI-FSRQSDVWSFGVVLYELFTyCDKSCSPsaefLRMMGCErdvpalcRLLEL  1052

         *********.**************************************************

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265

         lee++rlp+p+ cpae++elm+ c++ +p++rpsF+a+  +l

Q: 1053  LEEGQRLPAPPaCPAEVHELMKLCWAPSPQDRPSFSALGPQL  1094

         ************************************998776

Domain Sequence
(FASTA)

LKYISQLGKG NFGSVELCRY DPLGDNTGAL VAVKQLQHSG PDQQRDFQRE IQILKALHSD 60

FIVKYRGVSY GPGRQSLRLV MEYLPSGCLR DFLQRHRARL DASRLLLYSS QICKGMEYLG 120

SRRCVHRDLA ARNILVESEA HVKIADFGLA KLLPLDKDYY VVREPGQSPI FWWYAPESLS 180

DNIFSRQSDV WSFGVVLYEL FTYCDKSCSP SAEFLRMMGC ERDVPALCRL LELLEEGQRL 240

PAPPACPAEV HELMKLCWAP SPQDRPSFSA LGPQL 275

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775	; Tyr_kinase_non-rcpt_Jak3.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01826	; JANUSKINASE3.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013