EKS-GOG-00275

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00275

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.4	4.9E-137	206	493	288

Status

Unreviewed

Ensembl Protein

ENSGGOP00000006266

UniProt Accession

G3QU70;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000006405	ENSGGOP00000006266	ENSGGOT00000006435

Organism

Gorilla gorilla

Functional Description

Protein Length

504

Protein Sequence
(FASTA)

MLRDYILSLE KDLQKISPSM SMSAPQFPAA LLCACTSCLQ ANYTCETDGA CMVSIFNLDG 60

MEHHVRTCIP KVELVPAGKP FYCLSSEDLR NTHCCYTDYC NRIDLRVPSG HLKEPEHPSM 120

WGPVELVGII AGPVFLLFLI IIIVFLVINY HQRVYHNRQR LDMEDPSCEM CLSKDKTLQD 180

LVYDLSTSGS GSGLPLFVQR TVARTIVLQE IIGKGRFGEV WRGRWRGGDV AVKIFSSREE 240

RSWFREAEIY QTVMLRHENI LGFIAADNKD NGTWTQLWLV SDYHEHGSLF DYLNRYTVTI 300

EGMIKLALSA ASGLAHLHME IVGTQGKPGI AHRDLKSKNI LVKKNGMCAI ADLGLAVRHD 360

AVTDTIDIAP NQRVGTKRYM APEVLDETIN MKHFDSFKCA DIYALGLVYW EIARRCNSGG 420

VHEEYQLPYY DLVPSDPSIE EMRKVVCDQK LRPNIPNWWQ SYEALRVMGK MMRECWYANG 480

AARLTALRIK KTLSQLSVQE DVKI 504

Nucleotide Sequence
(FASTA)

ATGCTAAGGG ATTATATTCT AAGTTTGGAA AAGGACCTGC AAAAGATCTC ACCATCGATG 60

TCAATGTCTG CTCCCCAATT TCCTGCAGCT CTGCTGTGTG CGTGCACCAG CTGCCTCCAG 120

GCCAACTACA CGTGTGAGAC AGATGGGGCC TGCATGGTTT CCATTTTCAA TCTGGATGGG 180

ATGGAGCACC ATGTGCGCAC CTGCATCCCC AAAGTGGAGC TGGTCCCTGC CGGGAAGCCC 240

TTCTACTGCC TGAGCTCGGA GGACCTGCGC AACACCCACT GTTGCTACAC TGACTACTGC 300

AACAGGATCG ACTTGAGGGT GCCCAGTGGT CACCTCAAGG AGCCTGAGCA CCCATCCATG 360

TGGGGCCCGG TGGAGCTGGT AGGCATCATC GCCGGCCCGG TGTTCCTCCT GTTCCTCATC 420

ATCATCATTG TTTTCCTTGT CATTAACTAT CATCAGCGTG TCTATCACAA CCGCCAGAGA 480

CTGGACATGG AAGATCCCTC ATGTGAGATG TGTCTCTCCA AAGACAAGAC GCTCCAGGAT 540

CTTGTCTACG ATCTCTCCAC CTCAGGGTCT GGCTCAGGGT TACCCCTCTT TGTCCAGCGC 600

ACAGTGGCCC GAACCATCGT TTTACAAGAG ATTATTGGCA AGGGTCGGTT TGGGGAAGTA 660

TGGCGGGGCC GCTGGAGGGG TGGTGATGTG GCTGTGAAAA TATTCTCTTC TCGTGAAGAA 720

CGGTCTTGGT TCAGGGAAGC AGAGATATAC CAGACGGTCA TGCTGCGCCA TGAAAACATC 780

CTTGGATTTA TTGCCGCTGA CAATAAAGAT AATGGCACCT GGACACAGCT GTGGCTTGTT 840

TCTGACTATC ATGAGCACGG GTCCCTGTTT GATTATCTGA ACCGGTACAC AGTGACAATT 900

GAGGGGATGA TTAAGCTGGC CTTGTCTGCT GCTAGTGGGC TGGCACACCT GCACATGGAG 960

ATCGTGGGCA CCCAAGGGAA GCCTGGAATT GCTCATCGAG ACTTAAAGTC AAAGAACATT 1020

CTGGTGAAGA AAAATGGCAT GTGTGCCATA GCAGACCTGG GCCTGGCTGT CCGTCACGAT 1080

GCAGTCACTG ACACCATTGA CATTGCCCCG AATCAGAGGG TGGGGACCAA ACGATACATG 1140

GCCCCTGAAG TACTTGATGA AACCATTAAT ATGAAACACT TTGACTCCTT TAAATGTGCT 1200

GATATTTATG CCCTCGGGCT TGTATATTGG GAGATTGCTC GAAGATGCAA TTCTGGAGGA 1260

GTCCATGAAG AATATCAGCT GCCATATTAC GACTTAGTGC CCTCTGACCC TTCCATTGAG 1320

GAAATGCGAA AGGTTGTATG TGATCAGAAG CTGCGTCCCA ACATCCCCAA TTGGTGGCAG 1380

AGTTATGAGG CGCTGCGGGT GATGGGGAAG ATGATGCGAG AGTGTTGGTA TGCCAACGGC 1440

GCGGCCCGCC TGACGGCCCT GCGCATCAAG AAGACCCTCT CCCAGCTCAG CGTGCAGGAA 1500

GACGTGAAGA TCTAA 1515

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 206   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  265

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 266   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  325

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 326   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  383

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 384   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  442

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 443   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  493

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013