EKS-GOG-00003

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00003

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	516.1	1.7E-155	636	892	257

Status

Unreviewed

Ensembl Protein

ENSGGOP00000006364

UniProt Accession

G3QUG2;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA7

Gene Synonyms/Alias

EPHA7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000006503	ENSGGOP00000006364	ENSGGOT00000006534

Organism

Gorilla gorilla

Functional Description

Protein Length

1001

Protein Sequence
(FASTA)

MVFQTRYPSW IILCYIWLLR FAHTGEAQAA KEVLLLDSKA QQTELEWISS PPNGWEEISG 60

LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTLRDCN SLPGVLGTCK 120

ETFNLYYYET DYDTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK 180

GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAIFPDTVT GSEFSSLVEV RGTCVSSAEE 240

EAENSPRMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPYP ACGRGFYKSS SQDLQCSRCP 300

THSFSDKEGS SRCECEDGYY RAPSDPPYVA CTRPPSAPQN LIFNINQTTV SLEWSPPADN 360

GGRNDVTYRI LCKRCSWEQG ECVPCGSNIG YMPQQTGLED NYVTVMDLLA HANYTFEVEA 420

VNGVSDLSRS QRLFAAVSIT TGQTAPSQVS GVMKERVLQR SVELSWQEPE HPNGVITEYE 480

IKYYEKDQRE RTYSTVKTKS TSASINNLKP GTVYVFQIRA FTAAGYGNYS PRLDVATLEE 540

ATGKMFEATA VSSEQNPVII IAVVAVAGTI ILVFMVFGFI IGRRHCGYSK ADQEGDEELY 600

FHFKFPGTKT YIDPETYEDP NRAVHQFAKE LDASCIKIER VIGAGEFGEV CSGRLKLPGK 660

RDVAVAIKTL KVGYTEKQRR DFLCEASIMG QFDHPNVVHL EGVVTRGKPV MIVIEFMENG 720

ALDAFLRKHD GQFTVIQLVG MLRGIAAGMR YLADMGYVHR DLAARNILVN SNLVCKVSDF 780

GLSRVIEDDP EAVYTTTGGK IPVRWTAPEA IQYRKFTSAS DVWSYGIVMW EVMSYGERPY 840

WDMSNQDVIK AIEEGYRLPA PMDCPAGLHQ LMLDCWQKER AERPKFEQIV GILDKMIRNP 900

NSLKTPLGTC SRPISPLLDQ NTPDFTTFCS VGEWLQAIKM ERYKDNFTAA GYNSLESVAR 960

MTIEDVMSLG ITLVGHQKKI MSSIQTMRAQ MLHLHGTGIQ V 1001

Nucleotide Sequence
(FASTA)

ATGGTTTTTC AAACTCGGTA CCCTTCATGG ATTATTTTAT GCTACATCTG GCTGCTCCGC 60

TTTGCACACA CAGGGGAGGC GCAGGCTGCG AAGGAAGTAC TACTGCTGGA TTCTAAAGCA 120

CAACAAACAG AGTTGGAGTG GATTTCCTCT CCACCCAATG GGTGGGAAGA AATTAGTGGT 180

TTGGATGAGA ACTATACCCC GATACGAACA TACCAGGTGT GCCAAGTCAT GGAGCCCAAC 240

CAAAACAACT GGCTGCGGAC TAACTGGATT TCCAAAGGCA ATGCACAAAG GATTTTTGTA 300

GAATTGAAAT TCACCCTGAG GGATTGTAAC AGTCTTCCTG GAGTACTGGG AACTTGCAAG 360

GAAACATTTA ATTTGTACTA TTATGAAACA GACTATGACA CTGGCAGGAA TATAAGAGAA 420

AACCTCTATG TAAAGATAGA CACCATTGCT GCAGATGAAA GTTTTACCCA AGGTGACCTT 480

GGTGAAAGAA AGATGAAGCT TAACACTGAG GTGAGAGAGA TTGGACCTTT GTCCAAAAAG 540

GGATTCTATC TTGCCTTTCA GGATGTAGGG GCTTGCATAG CTTTGGTTTC TGTCAAAGTG 600

TACTACAAGA AGTGCTGGTC CATTATTGAG AACTTAGCTA TCTTTCCAGA TACAGTGACT 660

GGTTCAGAAT TTTCCTCTTT AGTCGAGGTT CGAGGGACAT GTGTCAGCAG TGCAGAGGAA 720

GAAGCGGAAA ACTCCCCCAG GATGCACTGC AGTGCAGAAG GAGAATGGTT AGTGCCCATT 780

GGAAAATGTA TCTGCAAAGC AGGCTACCAG CAAAAAGGAG ACACTTGTGA ACCATACCCA 840

GCCTGTGGCC GTGGGTTCTA CAAGTCTTCC TCTCAAGATC TTCAGTGCTC TCGTTGTCCA 900

ACTCACAGTT TTTCTGATAA AGAAGGCTCC TCCAGATGTG AATGTGAAGA TGGGTATTAC 960

AGGGCTCCAT CTGACCCACC GTACGTTGCA TGCACAAGGC CTCCATCTGC ACCACAGAAC 1020

CTCATTTTCA ACATCAACCA AACCACAGTA AGTTTGGAAT GGAGTCCTCC TGCAGACAAT 1080

GGGGGAAGAA ACGATGTGAC CTACAGAATA TTGTGTAAGC GGTGCAGTTG GGAGCAGGGC 1140

GAATGTGTTC CCTGTGGGAG TAACATTGGA TACATGCCCC AGCAGACTGG ATTAGAGGAT 1200

AACTATGTCA CTGTCATGGA CCTGCTAGCC CACGCTAATT ATACTTTTGA AGTTGAAGCT 1260

GTAAATGGAG TTTCTGACTT AAGCCGATCC CAGAGGCTCT TTGCTGCTGT CAGTATCACC 1320

ACTGGTCAAA CAGCTCCCTC GCAAGTGAGC GGAGTAATGA AGGAGAGAGT ACTGCAGCGG 1380

AGTGTCGAGC TTTCCTGGCA GGAACCAGAG CATCCCAATG GAGTCATCAC AGAATATGAA 1440

ATCAAGTATT ACGAGAAAGA TCAAAGGGAA CGGACCTACT CAACAGTAAA AACCAAGTCT 1500

ACTTCAGCCT CCATTAATAA TCTGAAACCA GGAACAGTGT ATGTTTTCCA GATTCGGGCT 1560

TTTACTGCTG CTGGTTATGG AAATTACAGT CCCAGACTTG ATGTTGCTAC ACTAGAGGAA 1620

GCTACAGGTA AAATGTTTGA AGCTACAGCT GTCTCCAGTG AACAGAATCC TGTTATTATC 1680

ATTGCTGTGG TTGCTGTGGC TGGGACCATC ATTTTGGTGT TCATGGTCTT TGGCTTCATC 1740

ATTGGGAGAA GGCACTGTGG TTATAGCAAA GCTGACCAAG AAGGCGATGA AGAGCTTTAC 1800

TTTCATTTTA AATTTCCAGG CACCAAAACC TACATTGACC CTGAAACCTA TGAGGACCCA 1860

AATAGAGCTG TCCATCAATT CGCCAAGGAG CTAGATGCCT CCTGTATTAA AATTGAGCGT 1920

GTGATTGGTG CAGGAGAATT TGGTGAAGTC TGCAGTGGCC GTTTGAAACT TCCAGGGAAA 1980

AGAGATGTTG CAGTAGCCAT AAAAACCCTG AAAGTTGGTT ACACAGAAAA ACAAAGGAGA 2040

GACTTTTTGT GTGAAGCAAG CATCATGGGG CAGTTTGACC ACCCAAATGT TGTCCATTTG 2100

GAAGGGGTTG TTACAAGAGG GAAACCAGTC ATGATAGTAA TAGAGTTCAT GGAAAATGGA 2160

GCCCTAGATG CATTTCTCAG GAAACATGAT GGGCAATTTA CAGTCATTCA GTTAGTAGGA 2220

ATGCTGAGAG GAATTGCTGC TGGAATGAGA TATTTGGCTG ATATGGGATA TGTTCACAGG 2280

GACCTTGCAG CTCGCAATAT TCTTGTCAAC AGCAATCTCG TTTGTAAAGT GTCAGATTTT 2340

GGCCTGTCCC GAGTTATAGA GGATGATCCA GAAGCTGTCT ATACAACTAC TGGTGGAAAA 2400

ATTCCAGTAA GGTGGACAGC ACCCGAAGCC ATCCAGTACC GGAAATTCAC ATCAGCCAGT 2460

GATGTATGGA GCTATGGAAT AGTCATGTGG GAAGTTATGT CTTATGGAGA AAGACCTTAT 2520

TGGGACATGT CAAATCAAGA TGTTATAAAA GCAATAGAAG AAGGTTATCG TTTACCAGCA 2580

CCCATGGACT GCCCAGCTGG CCTTCACCAG CTAATGTTGG ATTGTTGGCA AAAGGAGCGT 2640

GCTGAAAGGC CAAAATTTGA ACAGATAGTT GGAATTCTAG ACAAAATGAT TCGAAACCCA 2700

AATAGTCTGA AAACTCCCCT GGGAACTTGT AGTAGGCCAA TAAGCCCTCT TCTGGATCAA 2760

AACACTCCTG ATTTCACTAC CTTTTGTTCA GTTGGAGAAT GGCTACAAGC TATTAAGATG 2820

GAAAGATATA AAGATAACTT CACGGCAGCT GGCTACAATT CCCTTGAATC AGTAGCCAGG 2880

ATGACTATTG AGGATGTGAT GAGTTTAGGG ATCACACTGG TTGGTCATCA AAAGAAAATC 2940

ATGAGCAGCA TTCAGACTAT GAGAGCACAA ATGCTACATT TACATGGAAC TGGCATTCAA 3000

GTGTGA 3006

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         +kie+viGaGefGevcsGrlklpgkr++avaiktlk g+tekqrrdfl+easi+Gqfdhp

Q: 636   IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHP  695

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         n+++leGvvt++kpvmiv+e+mengald+flrk+dgqftviqlvgmlrGia+gm+yl+dm

Q: 696   NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM  755

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         gyvhrdlaarnilvnsnlvckvsdfGlsrv+edd+ea+ytt+ggkip+rwtapeai+yrk

Q: 756   GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK  815

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlp+pmdcpa+l+qlmldc

Q: 816   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDC  875

         ************************************************************

S: 241   wqkdraerpkfeqivsi  257

         wqk+raerpkfeqiv i

Q: 876   WQKERAERPKFEQIVGI  892

         **************987

Domain Sequence
(FASTA)

IKIERVIGAG EFGEVCSGRL KLPGKRDVAV AIKTLKVGYT EKQRRDFLCE ASIMGQFDHP 60

NVVHLEGVVT RGKPVMIVIE FMENGALDAF LRKHDGQFTV IQLVGMLRGI AAGMRYLADM 120

GYVHRDLAAR NILVNSNLVC KVSDFGLSRV IEDDPEAVYT TTGGKIPVRW TAPEAIQYRK 180

FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPAPMDCP AGLHQLMLDC 240

WQKERAERPK FEQIVGI 257

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013