EKS-GOG-00286

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00286

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	485.1	6.9E-146	571	832	262

Status

Unreviewed

Ensembl Protein

ENSGGOP00000006398

UniProt Accession

G3QUJ4;

Protein Name

Protein Synonyms/Alias

Gene Name

ERN1

Gene Synonyms/Alias

ERN1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000006532	ENSGGOP00000006398	ENSGGOT00000006568

Organism

Gorilla gorilla

Functional Description

Protein Length

977

Protein Sequence
(FASTA)

MPARRLLLLL TLLLPGLGIF GSTSTVTLPE TLLFVSTLDG SLHAVSKRTG SIKWTLKEDP 60

VLQVPTHVEE PAFLPDPNDG SLYTLGSKNN EGLTKLPFTI PELVQASPCR SSDGILYMGK 120

KQDIWYVIDL LTGEKQQTLS SAFADSLCPS TSLLYLGRTE YTITMYDTKT RELRWNATYF 180

DYAASLPEDD VDYKMSHFVS NGDGLVVTVD SESGDVLWIQ NYASPVVAFY VWQREGLRKV 240

MHINVAVETL RYLTFMSGEV GRITKWKYPF PKETEAKSKL TPTLYVGKYS TSLYASPSMV 300

HEGVAVVPRG STLPLLEGPQ TDGVTIGDKG ECVITPSTDV KFDPGLKSKN KFNYLRNYWL 360

LIGHHETPLS ASTKMLERFP NNLPKHRENV IPADSEKKSF EEVINLVDQT SENAPTTVSR 420

DVEEKPAHAP ARPEAPVDSM LKDMATIILS TFLLIGWVAF IITYPLSMHQ QQQLQHQQFQ 480

KELEKIQLLQ QQQQQLPFHP PGDMAQDGEL LDTSGPYSES SGTSSPSTSP RASNHSLCSG 540

SSASKAGSSP SLEQDDGDEE TSMVIVGKIS FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR 600

ILPECFSFAD REVQLLRESD EHPNVIRYFC TEKDRQFQYI AIELCAATLQ EYVEQKDFAH 660

LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK PHNILISMPN AHGKIKAMIS DFGLCKKLAV 720

GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ 780

RQANILLGAC SLDCLHPEKH EDVIARELIE KMIAMDPQKR PSAKHVLKHP FFWSLEKQLQ 840

FFQDVSDRIE KESLDGPIVK QLERGGRAVV KMDWRENITV PLQTDLRKFR TYKGGSVRDL 900

LRAMRNKKHH YRELPAEVRE TLGSLPDDFM CYFTSRFPHL LAHTYRAMEL CSHERLFQPY 960

YFHEPPEPQP PVTPDAL 977

Nucleotide Sequence
(FASTA)

ATGCCGGCCC GGCGGCTGCT GCTGCTGCTG ACGCTGCTGC TGCCCGGCCT CGGGATTTTT 60

GGAAGTACCA GCACAGTGAC GCTTCCTGAA ACCTTGTTGT TTGTGTCAAC GCTGGATGGA 120

AGTTTGCATG CTGTCAGCAA GAGGACAGGC TCAATCAAAT GGACTTTAAA AGAAGATCCA 180

GTCCTGCAGG TCCCAACACA TGTGGAAGAG CCTGCCTTTC TCCCAGATCC TAATGATGGC 240

AGCCTGTATA CGCTTGGAAG CAAGAATAAT GAAGGCCTGA CGAAACTTCC TTTTACCATC 300

CCAGAATTGG TGCAGGCATC CCCATGCCGA AGTTCAGATG GGATCCTCTA CATGGGTAAA 360

AAGCAGGACA TCTGGTATGT TATTGACCTC CTGACTGGGG AGAAGCAGCA GACTTTGTCA 420

TCGGCCTTTG CAGATAGTCT CTGCCCATCA ACCTCTCTTC TGTATCTTGG GCGAACAGAA 480

TACACCATCA CCATGTACGA CACCAAAACC CGAGAGCTCC GGTGGAATGC CACCTACTTT 540

GACTATGCGG CCTCACTGCC TGAGGACGAC GTGGACTACA AGATGTCCCA CTTTGTGTCC 600

AATGGTGATG GGCTGGTGGT GACTGTGGAC AGTGAATCTG GGGACGTCCT GTGGATCCAA 660

AACTACGCCT CCCCTGTGGT GGCCTTTTAT GTCTGGCAGC GGGAGGGTCT GAGGAAGGTG 720

ATGCACATCA ATGTCGCTGT GGAGACCCTG CGCTATCTGA CCTTCATGTC TGGGGAGGTG 780

GGGCGCATCA CAAAGTGGAA GTACCCGTTC CCCAAGGAGA CAGAGGCCAA GAGCAAGCTG 840

ACGCCCACTC TGTATGTTGG GAAATACTCT ACCAGCCTCT ATGCCTCTCC CTCAATGGTA 900

CACGAGGGGG TTGCTGTCGT GCCCCGCGGC AGCACACTTC CTTTGCTGGA AGGGCCCCAG 960

ACTGATGGCG TCACCATCGG GGACAAGGGG GAGTGTGTGA TCACGCCCAG CACGGACGTC 1020

AAGTTTGACC CCGGACTCAA AAGCAAGAAC AAGTTCAACT ACTTGAGGAA TTACTGGCTT 1080

CTGATAGGAC ACCATGAAAC CCCACTGTCT GCGTCTACCA AGATGCTGGA GAGATTTCCC 1140

AACAATCTAC CCAAACATCG GGAAAATGTG ATTCCTGCTG ATTCAGAGAA AAAGAGCTTT 1200

GAGGAAGTTA TCAACCTGGT TGACCAGACT TCAGAAAACG CACCTACCAC CGTGTCTCGG 1260

GATGTGGAGG AGAAGCCCGC CCATGCCCCT GCCCGGCCCG AGGCCCCCGT GGACTCCATG 1320

CTTAAGGACA TGGCTACCAT CATCCTGAGC ACCTTCCTGC TGATTGGCTG GGTGGCCTTC 1380

ATCATCACCT ATCCCCTGAG CATGCATCAG CAGCAGCAGC TCCAGCACCA GCAGTTCCAG 1440

AAGGAACTGG AGAAGATCCA GCTCCTGCAG CAGCAGCAGC AGCAGCTGCC CTTCCACCCA 1500

CCTGGAGACA TGGCTCAGGA CGGCGAGCTC CTGGACACGT CTGGCCCATA CTCAGAGAGC 1560

TCGGGCACCA GCAGCCCCAG CACGTCCCCC AGGGCCTCCA ACCACTCGCT CTGCTCCGGC 1620

AGCTCTGCCT CCAAGGCTGG CAGCAGCCCC TCCCTGGAAC AAGACGATGG AGATGAGGAA 1680

ACCAGCATGG TGATAGTTGG GAAAATTTCC TTCTGTCCCA AGGATGTCCT GGGCCATGGA 1740

GCTGAGGGCA CAATTGTGTA CCGGGGCATG TTTGACAACC GCGACGTGGC CGTGAAGAGG 1800

ATCCTCCCCG AATGTTTTAG CTTCGCAGAC CGTGAGGTCC AGCTGTTGCG AGAATCGGAT 1860

GAGCACCCGA ACGTGATCCG CTACTTCTGC ACGGAGAAGG ACCGGCAATT CCAGTACATT 1920

GCCATCGAGC TGTGTGCAGC CACCCTGCAA GAGTATGTGG AGCAGAAGGA CTTTGCGCAT 1980

CTCGGCCTGG AGCCCATCAC CTTGCTGCAG CAGACCACCT CGGGCCTGGC CCACCTCCAC 2040

TCCCTCAACA TCGTTCACAG AGACCTAAAG CCACACAACA TTCTCATATC CATGCCCAAT 2100

GCACACGGCA AGATCAAGGC CATGATCTCC GACTTTGGCC TCTGCAAGAA GCTGGCAGTG 2160

GGCAGACACA GTTTCAGCCG CCGATCTGGG GTGCCTGGCA CAGAAGGCTG GATTGCTCCG 2220

GAGATGCTGA GCGAAGACTG TAAGGAGAAC CCTACCTACA CGGTGGACAT CTTTTCTGCA 2280

GGCTGCGTCT TTTACTACGT AATCTCTGAG GGCAGCCACC CTTTTGGCAA GTCCCTGCAG 2340

CGGCAGGCCA ACATCCTCCT GGGTGCCTGC AGCCTTGACT GCTTGCACCC GGAGAAGCAC 2400

GAAGACGTCA TTGCACGTGA ATTGATAGAG AAGATGATTG CGATGGATCC TCAGAAACGC 2460

CCCTCAGCGA AGCACGTGCT CAAACACCCG TTCTTCTGGA GCCTAGAGAA GCAGCTCCAG 2520

TTCTTCCAGG ACGTGAGCGA CAGAATAGAA AAGGAATCCC TGGATGGCCC GATCGTGAAG 2580

CAGTTAGAGA GAGGCGGGAG AGCCGTGGTG AAGATGGACT GGCGGGAGAA CATCACTGTC 2640

CCCCTCCAGA CAGACCTGCG TAAATTCAGG ACCTATAAAG GTGGTTCTGT CAGAGATCTC 2700

CTCCGAGCCA TGAGAAATAA GAAGCACCAC TACCGGGAGC TGCCTGCAGA GGTGCGGGAG 2760

ACGCTGGGGT CCCTCCCCGA CGACTTCATG TGCTACTTCA CATCTCGCTT CCCCCACCTC 2820

CTCGCACACA CCTACCGGGC CATGGAGCTG TGCAGCCACG AGAGACTCTT CCAGCCCTAC 2880

TACTTCCACG AGCCCCCAGA GCCCCAGCCC CCAGTGACTC CAGACGCCCT CTGA 2934

Domain Profile

S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60

         f+pkdvlG+GaeGt+v+rG+f++r+vavkr+l+e++++a+rev+llresdehpnviryfc

Q: 571   FCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC  630

         79**********************************************************

S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120

         tekdrqf+yia+elcaa+lq+yve+kd++ + +lepi+ll+q++sGlahlhsl+ivhrdl

Q: 631   TEKDRQFQYIAIELCAATLQEYVEQKDFA-HLGLEPITLLQQTTSGLAHLHSLNIVHRDL  689

         *****************************.******************************

S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180

         kp+nilis+p+a+gk++++isdfGlckkl+vG++sfsrrsgv+GteGwiape+l+e++ke

Q: 690   KPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE  749

         ************************************************************

S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240

         ++t++vdifs+Gcvfyyv+s+G+hpfG+sl+rqanil g++sld+l++ek+e+via++li

Q: 750   NPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELI  809

         ************************************************************

S: 241   skmidkdplkrpsakkvlkhplf  263

         +kmi++dp+krpsak+vlkhp+f

Q: 810   EKMIAMDPQKRPSAKHVLKHPFF  832

         **********************9

Domain Sequence
(FASTA)

FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR ILPECFSFAD REVQLLRESD EHPNVIRYFC 60

TEKDRQFQYI AIELCAATLQ EYVEQKDFAH LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK 120

PHNILISMPN AHGKIKAMIS DFGLCKKLAV GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN 180

PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ RQANILLGAC SLDCLHPEKH EDVIARELIE 240

KMIAMDPQKR PSAKHVLKHP FF 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006397	; P:mRNA processing

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 5.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013