EKS-GOG-00069

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00069

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	325.8	2.8E-97	26	337	312

Status

Unreviewed

Ensembl Protein

ENSGGOP00000006433

UniProt Accession

G3QUM8;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK8

Gene Synonyms/Alias

CDK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000006569	ENSGGOP00000006433	ENSGGOT00000006603

Organism

Gorilla gorilla

Functional Description

Protein Length

469

Protein Sequence
(FASTA)

MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 60

MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 120

VQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IAADMGFARL 180

FNSPLKPLAD LDPVVVTFWY RAPELLLGAR HYTKAIEDIW AIGCIFAELL TSEPIFHCRQ 240

EDIKTSNPYH HDQLDRIFNV MGFPADKDWE DIKKMPEHST LMKDFRRNTY TNCSLIKYME 300

KHKVKPDSKA FHLLQKLLTM DPIKRITSEQ AMQDPYFLED PLPTSDVFAG CQIPYPKREF 360

LTEEEPDDKG DKPIEKNQQQ QQGNNHTNGT GHPGNQDSSH TQGPPLKKVR VVPPTTTSGG 420

LIMTSDYQRS NPHAAYPNPG PSTSQPQSSM GYSATSQQPP QYSHQTHRY 469

Nucleotide Sequence
(FASTA)

ATGGACTATG ACTTTAAAGT GAAGCTGAGC AGCGAGCGGG AGCGGGTCGA GGACCTGTTT 60

GAATACGAGG GCTGCAAAGT TGGCCGAGGC ACTTATGGTC ACGTCTACAA AGCCAAGAGG 120

AAAGATGGGA AGGATGATAA AGACTATGCT TTAAAACAAA TAGAAGGAAC TGGGATCTCT 180

ATGTCGGCAT GTAGAGAAAT AGCATTACTT CGAGAGCTTA AGCATCCAAA CGTCATTTCT 240

CTTCAAAAGG TGTTTCTGTC TCATGCTGAT AGGAAGGTGT GGCTTCTGTT TGACTATGCT 300

GAACATGACC TCTGGCATAT AATCAAGTTT CACAGAGCTT CTAAAGCAAA CAAGAAGCCA 360

GTTCAGTTAC CTCGGGGAAT GGTGAAGTCA CTATTATATC AGATCCTAGA TGGTATTCAC 420

TACCTGCATG CTAACTGGGT GTTGCACAGA GATTTGAAAC CTGCTAATAT TTTAGTTATG 480

GGTGAAGGTC CTGAGCGAGG AAGAGTAAAA ATTGCAGCTG ACATGGGCTT TGCCCGATTA 540

TTTAATTCAC CTTTGAAGCC TTTAGCAGAT TTGGATCCAG TGGTTGTTAC ATTCTGGTAC 600

CGAGCCCCTG AACTACTTCT TGGAGCAAGG CATTATACCA AAGCTATTGA AGATATTTGG 660

GCTATAGGGT GTATATTTGC AGAACTACTA ACGTCAGAAC CAATATTTCA CTGTCGACAA 720

GAGGACATCA AAACTAGTAA TCCTTATCAC CATGACCAGC TGGACAGAAT ATTCAATGTA 780

ATGGGATTTC CTGCAGATAA AGATTGGGAA GATATAAAAA AGATGCCTGA ACATTCAACA 840

TTAATGAAAG ATTTCAGAAG AAATACGTAT ACCAACTGCA GCCTTATCAA GTATATGGAA 900

AAACATAAAG TTAAACCAGA TAGTAAAGCA TTCCACTTGC TTCAGAAGTT GCTTACCATG 960

GACCCAATAA AGCGAATTAC CTCAGAACAG GCTATGCAGG ATCCCTATTT CCTAGAAGAC 1020

CCACTTCCTA CATCAGACGT TTTTGCCGGT TGTCAAATCC CTTACCCAAA ACGAGAATTT 1080

TTAACGGAAG AAGAACCTGA TGACAAAGGA GACAAACCAA TTGAGAAGAA CCAGCAGCAG 1140

CAGCAGGGCA ATAACCACAC TAATGGAACT GGCCACCCAG GGAATCAAGA CAGCAGTCAC 1200

ACACAGGGAC CCCCGTTGAA GAAAGTGAGA GTTGTTCCTC CTACCACTAC CTCAGGTGGA 1260

CTTATCATGA CCTCAGACTA TCAGCGTTCC AATCCACATG CTGCCTATCC CAACCCTGGA 1320

CCAAGCACAT CACAGCCGCA GAGCAGCATG GGATACTCAG CTACCTCCCA GCAGCCTCCA 1380

CAGTACTCAC ATCAGACACA TCGGTACTGA 1410

Domain Profile

S: 6     kigeGtygkvykakdke..tgevvAlKkirlekekegvpitalrEisllkelkhknivkL  63

         k+g+Gtyg+vykak+k+  +++ +AlK+i    e +g++++a+rEi+ll+elkh+n+++L

Q: 26    KVGRGTYGHVYKAKRKDgkDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL  81

         79************986447778******....999************************

S: 64    levva.kdkkklyLvfefleqdLkkllkkkkkk.......klsleevkslllqlleglay  115

         ++v+  ++++k++L+f+++e+dL++++k ++++       +l++ +vksll+q+l+g++y

Q: 82    QKVFLsHADRKVWLLFDYAEHDLWHIIKFHRASkankkpvQLPRGMVKSLLYQILDGIHY  141

         ****94555*********************9999999999********************

S: 116   lHsnkilHRDlKpqNlLiske....gklkl.aDfGlarafssplk...tytkevvTlwYr  167

         lH+n++lHRDlKp+N+L++ e    g++k+ aD+G+ar f+splk   +++++vvT+wYr

Q: 142   LHANWVLHRDLKPANILVMGEgperGRVKIaADMGFARLFNSPLKplaDLDPVVVTFWYR  201

         *******************9988889***955********99999665699*********

S: 168   aPelLlgakeYstav.DiWsvgcilaelltrkplfqgkse.........idqlerifkll  217

         aPelLlga++Y++a+ DiW++gci+aellt++p+f++++e         +dql+rif+++

Q: 202   APELLLGARHYTKAIeDIWAIGCIFAELLTSEPIFHCRQEdiktsnpyhHDQLDRIFNVM  261

         ***************99*******************************************

S: 218   gtpsekvwpevsklpeyk...ksfpkkkkk..klkekvkklk....ekaldllekllald  268

         g p +k+w++++k+pe++   k+f++++++  +l ++++k k    +ka++ll+kll++d

Q: 262   GFPADKDWEDIKKMPEHStlmKDFRRNTYTncSLIKYMEKHKvkpdSKAFHLLQKLLTMD  321

         *****************96644777777764455666644333354679***********

S: 269   pkkRisakealqhkyf  284

         p kRi++++a+q++yf

Q: 322   PIKRITSEQAMQDPYF  337

         ***************9

Domain Sequence
(FASTA)

KVGRGTYGHV YKAKRKDGKD DKDYALKQIE GTGISMSACR EIALLRELKH PNVISLQKVF 60

LSHADRKVWL LFDYAEHDLW HIIKFHRASK ANKKPVQLPR GMVKSLLYQI LDGIHYLHAN 120

WVLHRDLKPA NILVMGEGPE RGRVKIAADM GFARLFNSPL KPLADLDPVV VTFWYRAPEL 180

LLGARHYTKA IEDIWAIGCI FAELLTSEPI FHCRQEDIKT SNPYHHDQLD RIFNVMGFPA 240

DKDWEDIKKM PEHSTLMKDF RRNTYTNCSL IKYMEKHKVK PDSKAFHLLQ KLLTMDPIKR 300

ITSEQAMQDP YF 312

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013