EKS-GOG-00165

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00165

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	393.9	3.8E-118	453	709	257

Status

Unreviewed

Ensembl Protein

ENSGGOP00000007258

UniProt Accession

G3QWT9;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000006600	ENSGGOP00000007258	ENSGGOT00000007449
ENSGGOG00000006600	ENSGGOP00000006462	ENSGGOT00000006633

Organism

Gorilla gorilla

Functional Description

Protein Length

765

Protein Sequence
(FASTA)

MGNGSVKPKH SKHPDGHSGN LTTDALRNKV TELERELRRK DAEIQEREYH LKELREQLSK 60

QTVAIAELTE ELQNKCIQLN KLQDVVHMQG GSPLQASPDK VPLEVHRKTS GLVSLHSRRG 120

AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC 240

TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 360

ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 420

MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 540

ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNMIP FSHDIVSHTV 660

NLLVITIQED VSPKSTVKKY SITIDNLHKN LFTEEIGAHQ HGMKIKKTHF LRWLNGFNWE 720

GLKARSLPSP LQRELKGPID HSYFDKYPPE KGMPPDELSG WDKDF 765

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA ACCTAAACAT TCCAAGCACC CAGATGGACA CTCTGGAAAC 60

CTCACCACTG ATGCTCTGCG GAACAAGGTG ACAGAGCTGG AGAGAGAGTT GAGGAGGAAG 120

GATGCTGAGA TCCAGGAGCG GGAGTACCAT TTGAAGGAGC TGCGGGAGCA GCTGTCGAAG 180

CAGACTGTGG CCATTGCTGA ACTCACAGAG GAGCTCCAGA ACAAGTGCAT CCAGCTGAAC 240

AAGCTGCAGG ATGTGGTGCA TATGCAGGGA GGAAGCCCGC TTCAGGCCTC TCCAGATAAA 300

GTGCCTCTTG AGGTCCACCG GAAGACCTCT GGATTGGTCT CTCTCCATAG CAGGAGGGGA 360

GCAAAGGCTG GCGTGTCTGC TGAGCCAACA ACCCGGACCT ATGACCTGAA CAAACCCCCT 420

GAATTTTCCT TTGAGAAAGC AAGAGTCAGA AAAGACTCCA GTGAGAAGAA GCTCATTACA 480

GATGCCCTTA ATAAAAATCA GTTTCTGAAA AGACTGGATC CTCAGCAGAT CAAAGACATG 540

GTGGAATGCA TGTATGGGAG AAACTATCAG CAAGGGAGTT ACATTATTAA GCAAGGAGAA 600

CCAGGAAACC ATATCTTTGT GCTGGCAGAG GGTCGACTAG AGGTGTTCCA AGGGGAGAAA 660

TTGCTGTCCT CCATCCCTAT GTGGACCACA TTTGGGGAGC TTGCCATTTT ATACAACTGT 720

ACAAGGACTG CCTCTGTGAA AGCTATTACC AATGTTAAAA CATGGGCACT AGATCGAGAG 780

GTATTCCAGA ATATAATGAG GAGAACAGCC CAAGCTAGAG ATGAACAATA CAGAAACTTC 840

CTCAGAAGTG TATCCTTGCT GAAGAATTTA CCTGAAGATA AATTAACCAA GATCATTGAC 900

TGCTTGGAAG TGGAATACTA TGACAAAGGA GATTACATCA TTAGAGAGGG CGAGGAAGGA 960

AGTACCTTTT TCATTTTGGC AAAAGGAAAG GTAAAAGTAA CACAGAGCAC AGAAGGCCAT 1020

GATCAACCAC AGCTGATAAA AACACTGCAG AAAGGAGAAT ACTTTGGAGA AAAAGCTCTT 1080

ATCAGTGATG ATGTCAGGTC AGCTAACATT ATTGCTGAAG AAAATGATGT TGCATGCCTG 1140

GTTATAGATC GAGAAACATT CAACCAAACT GTCGGTACAT TTGAAGAGCT GCAAAAATAC 1200

CTTGAAGGAT ATGTGGCAAA CCTGAACCGT GATGATGAAA AAAGACATGC GAAGCGGTCC 1260

ATGTCTAACT GGAAGCTGTC CAAAGCACTC TCTCTGGAAA TGATTCAGCT GAAGGAGAAG 1320

GTGGCCAGAT TTTCCTCATC ATCCCCATTC CAGAACCTTG AGATTATTGC AACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT TGAGCTTGTT AAAGTAAAAA ATGAGAATGT CGCTTTTGCT 1440

ATGAAGTGTA TAAGGAAGAA GCACATAGTT GACACTAAGC AGCAGGAGCA TGTCTACTCA 1500

GAGAAGAGGA TCCTAGAGGA GCTGTGCTCT CCATTCATTG TGAAATTATA TCGTACTTTC 1560

AAGGACAATA AGTATGTATA CATGCTTCTG GAGGCCTGCT TAGGTGGGGA GCTCTGGAGT 1620

ATATTAAGGG ACAGAGGCAG CTTTGATGAA CCCACCTCCA AATTCTGCGT TGCTTGTGTG 1680

ACAGAAGCAT TTGATTACCT GCATCGACTA GGTATTATCT ACAGAGACTT GAAACCAGAA 1740

AACTTAATTC TAGATGCTGA GGGTTACCTT AAATTGGTTG ACTTTGGATT TGCGAAGAAA 1800

ATAGGGTCTG GACAGAAAAC ATGGACATTC TGTGGGACTC CAGAATATGT AGCTCCTGAA 1860

GTCATTCTCA ACAAGGGACA TGACTTCAGT GTGGATTTCT GGTCACTGGG AATTCTAGTG 1920

TATGAGCTCC TAACGGGCAA TATGATACCT TTTTCTCATG ACATTGTTTC ACATACAGTG 1980

AACTTGCTGG TTATAACTAT TCAAGAGGAT GTTTCACCTA AATCAACTGT GAAAAAGTAT 2040

TCTATAACCA TTGATAACCT TCATAAGAAT CTTTTCACTG AAGAAATAGG GGCACATCAA 2100

CATGGTATGA AAATAAAAAA GACACATTTT CTCAGGTGGT TAAATGGTTT TAATTGGGAG 2160

GGACTGAAAG CACGGAGCCT TCCATCACCT TTGCAAAGAG AGCTCAAGGG ACCCATAGAT 2220

CACAGCTACT TTGACAAATA TCCTCCTGAA AAGGGAATGC CTCCAGATGA ACTATCAGGC 2280

TGGGATAAAG ACTTCTGA 2298

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+

Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 512   FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkp.pfsgvdplktynlilkgidklelprkitkeaedlikklcrdn  239

         d+w+lgilvyelltg+  pfs     +t nl++  i+    p++  k+ +  i +l ++

Q: 632   DFWSLGILVYELLTGNMiPFSHDIVSHTVNLLVITIQEDVSPKSTVKKYSITIDNLHKNL  691

         ***************854999999999*********************************

S: 240   paerlgylkggikdikkh  257

          +e +g +++g+k  k h

Q: 692   FTEEIGAHQHGMKIKKTH  709

         **********99755555

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60

IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNMIPFS HDIVSHTVNL LVITIQEDVS PKSTVKKYSI TIDNLHKNLF 240

TEEIGAHQHG MKIKKTH 257

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013