EKS-GOG-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	388.3	2.3E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSGGOP00000021751

UniProt Accession

G3S106;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000006621	ENSGGOP00000021751	ENSGGOT00000032257
ENSGGOG00000006621	ENSGGOP00000006483	ENSGGOT00000006654

Organism

Gorilla gorilla

Functional Description

Protein Length

968

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY LKNRVKPFSE NEARHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLSIEAKD 240

LIHQLLRRNP ADRLSLSSVL DHPFMSRNSS TKSKDLRTVE DSIDSGHATI STAITASSST 300

SISGSLFDKR RLLIGQPLPN KMTVFPKNKS SSDFSSSGDG NSFYTQWGNQ ETSNSGRGRV 360

IQDAEERPHS RYLRRAYSSD RSGTSNSQSQ AKTYTMERCH SAEMLSMSKR SGGGENEERY 420

SPTDNNANIF NFFKEKTSSS SGSFERPDNN QALSNHLCPG KTPFPFADPT PQTETVQQWF 480

GNLQINAHLR KTTKYDSISP NRDFQGHPDL QKDTSKNAWT DTKVKKNSDA SDNAHSVKQQ 540

NTIEYMTALH SKPEIIQQEC VFGSDPLSEQ SKTRGMEPPL GYQNRTLRSI TSPLVAHRLK 600

PIRQKTKKAV VCILDSEEVC VELVKEYASQ EYVKEVLQIS SDGNTITIYY PNGGRGFPLA 660

DRPPSPTDNI SRYSFDNLPE KYWRKYQYAS RFVQLVRSKS PKITYFTRYA KCILMENSPG 720

ADFEVWFYDG VKIHKTEDFI QVIEKTGKSY TLKSESEVNS LKEEIKMYMD HANEGHRICL 780

ALESIISEEE RKTRSAPFFP IIIGRKPGST SSPKALSPPP SVDSNYPTRD RASFNRMVMH 840

SAVFETESPR LDKSQVKSES LNLFLLRNTK YFLWGKNQQP KNLEILMEIN GKQDSLSNNL 900

TSGAVWVQFN DGSQLLVQAG VSSISYTSPN GQTTRYGENE KLPDYIKQKL QCLSSILLMF 960

SNPTPNFH 968

Nucleotide Sequence
(FASTA)

ATGGCGACCT GCATCGGGGA GAAGATCGAG GATTTTAAAG TTGGAAATCT GCTTGGTAAA 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CTGGTTTGGA AGTTGCAATC 120

AAAATGATAG ATAAGAAAGC CATGTACAAA GCAGGAATGG TACAGAGAGT CCAAAATGAG 180

GTGAAAATAC ATTGCCAATT GAAACATCCT TCTATCTTGG AGCTTTATAA CTATTTTGAA 240

GATAGCAATT ATGTGTATCT GGTATTAGAA ATGTGCCATA ATGGAGAAAT GAACAGGTAT 300

CTAAAGAATA GAGTGAAACC CTTCTCAGAA AATGAAGCTC GACACTTCAT GCACCAGATC 360

ATCACAGGGA TGTTGTATCT TCATTCTCAT GGTATACTAC ACCGGGACCT CACACTTTCT 420

AACCTCCTAC TGACTCGTAA TATGAACATC AAGATTGCTG ATTTTGGGCT GGCAACTCAA 480

CTGAAAATGC CACATGAAAA GCACTATACA TTATGTGGAA CTCCTAACTA CATTTCACCA 540

GAAATTGCCA CTCGAAGTGC ACATGGCCTT GAATCTGATG TTTGGTCCCT GGGCTGTATG 600

TTTTATACAT TACTTATCGG GAGACCACCC TTCGACACTG ACACAGTCAA GAACACATTA 660

AATAAAGTAG TATTGGCAGA TTATGAAATG CCAACTTTTT TGTCAATAGA GGCCAAGGAC 720

CTTATTCACC AGTTACTTCG TAGAAATCCA GCAGATCGTT TAAGCCTGTC TTCAGTATTG 780

GACCATCCTT TTATGTCCCG AAATTCTTCA ACAAAAAGTA AAGATTTAAG AACTGTGGAA 840

GACTCAATTG ATAGTGGGCA TGCCACAATT TCTACTGCAA TTACAGCTTC TTCCAGTACC 900

AGTATAAGTG GTAGTTTATT TGACAAAAGA AGACTTTTGA TTGGTCAGCC ACTCCCAAAT 960

AAAATGACTG TATTTCCAAA GAATAAAAGT TCAAGTGATT TTTCTTCTTC AGGAGATGGA 1020

AACAGTTTTT ATACTCAGTG GGGAAATCAA GAAACCAGTA ATAGTGGAAG GGGAAGAGTA 1080

ATTCAAGATG CAGAAGAAAG GCCACATTCT CGATACCTTC GTAGAGCTTA TTCCTCTGAT 1140

AGATCTGGCA CTTCTAATAG TCAGTCTCAA GCAAAAACAT ATACAATGGA ACGATGTCAC 1200

TCAGCAGAAA TGCTTTCAAT GTCCAAAAGA TCAGGAGGAG GTGAAAATGA AGAGAGGTAC 1260

TCACCCACAG ACAACAATGC CAACATTTTT AACTTCTTTA AAGAAAAGAC ATCCAGTAGT 1320

TCTGGATCTT TTGAAAGACC TGATAACAAT CAAGCGCTCT CCAATCATCT TTGTCCAGGA 1380

AAAACTCCTT TTCCATTTGC AGACCCGACA CCTCAGACTG AAACGGTACA ACAGTGGTTT 1440

GGGAATCTGC AAATAAATGC TCATTTAAGA AAAACTACTA AATATGACAG CATCAGCCCA 1500

AACCGGGACT TCCAGGGCCA TCCAGATTTG CAGAAGGACA CATCAAAAAA TGCCTGGACT 1560

GATACAAAAG TCAAAAAGAA CTCTGATGCT TCTGATAATG CACATTCTGT AAAACAGCAG 1620

AATACCATAG AATATATGAC CGCACTTCAC AGTAAACCTG AGATAATCCA ACAAGAATGT 1680

GTTTTTGGCT CAGATCCTCT TTCTGAACAG AGCAAGACTA GGGGTATGGA GCCACCATTG 1740

GGTTATCAGA ATCGTACATT AAGAAGCATT ACATCTCCGT TGGTTGCTCA CAGGTTAAAA 1800

CCAATCAGAC AGAAAACCAA AAAGGCTGTG GTATGCATAC TTGATTCAGA GGAGGTGTGT 1860

GTGGAGCTTG TAAAGGAGTA TGCATCTCAA GAATATGTGA AAGAAGTTCT TCAGATATCT 1920

AGTGATGGAA ATACGATCAC TATTTATTAT CCAAATGGTG GAAGAGGTTT TCCTCTTGCT 1980

GATAGACCAC CCTCACCTAC TGACAACATC AGTAGGTACA GCTTTGACAA TTTACCAGAA 2040

AAATACTGGC GAAAATATCA ATATGCTTCC AGGTTTGTAC AGCTTGTAAG ATCTAAATCT 2100

CCGAAAATCA CTTATTTTAC AAGATACGCT AAATGCATTT TGATGGAGAA TTCTCCTGGT 2160

GCTGATTTTG AGGTTTGGTT TTATGATGGG GTAAAAATAC ACAAAACAGA AGATTTCATT 2220

CAGGTGATTG AAAAGACAGG GAAGTCTTAC ACTTTAAAAA GTGAAAGTGA AGTTAATAGC 2280

TTGAAAGAGG AGATAAAAAT GTATATGGAC CATGCTAATG AGGGTCATCG TATTTGTTTA 2340

GCACTGGAAT CCATAATTTC AGAAGAGGAA AGGAAAACTA GGAGTGCTCC CTTTTTCCCA 2400

ATAATCATAG GAAGAAAACC TGGTAGTACT AGTTCACCTA AGGCCTTATC ACCTCCTCCT 2460

TCTGTGGATT CAAATTACCC AACGAGAGAT AGAGCATCTT TCAACAGAAT GGTCATGCAT 2520

AGTGCTGTTT TTGAGACAGA GTCGCCCAGG CTGGATAAAA GTCAAGTGAA AAGTGAATCC 2580

CTAAATCTCT TCTTGTTAAG AAATACTAAA TATTTCTTGT GGGGGAAAAA CCAACAACCA 2640

AAAAACTTGG AAATCCTAAT GGAAATTAAT GGGAAACAGG ATTCACTTTC TAATAATTTA 2700

ACTAGTGGAG CTGTGTGGGT TCAGTTTAAT GATGGGTCCC AGTTGCTTGT GCAGGCAGGA 2760

GTGTCTTCTA TCAGTTATAC CTCACCAAAT GGTCAAACAA CTAGGTATGG AGAAAATGAA 2820

AAATTACCAG ACTACATCAA ACAGAAATTA CAGTGTCTGT CTTCCATCCT TTTGATGTTT 2880

TCTAATCCGA CTCCTAATTT TCATTGA 2907

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++

Q: 72    ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRvKPFSENEARHFMHQIITGMLYLHSHG  131

         *********************************9**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSIEAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED SNYVYLVLEM CHNGEMNRYL KNRVKPFSEN EARHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLSIEAKDL IHQLLRRNPA 240

DRLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013