EKS-GOG-00315

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00315

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	335.6	2.7E-100	257	498	242

Status

Unreviewed

Ensembl Protein

ENSGGOP00000007089

UniProt Accession

G3QWD3;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK2

Gene Synonyms/Alias

PAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000007239	ENSGGOP00000007089	ENSGGOT00000007275

Organism

Gorilla gorilla

Functional Description

Protein Length

522

Protein Sequence
(FASTA)

MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR HKIISIFSGT 60

EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP 120

QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GTEAPAVVTE EEDDDEETAP 180

PVIAPRPDHT KSIYTRSVID PVPAPVGDAH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV 240

SIGDPKTKFN CSTGFVASGT VFTATDVALG QEVAIKQINL QKQPKKELII NEILVMKELK 300

NPNIVNFLDS YLVGDELFVV MEYLAGGSLT DVVTETCMDE AQIAAVCREC LQALEFLHAN 360

QVIHRDIKSD NVLLGMEGSV KLTDFGFCAQ ITPEQSKRST MVGTPYWMAP EVVTRKAYGP 420

KVDIWSLGIM AIEMVEGEPP YLNENPLRAL YLIATNGTPE LQNPEKLSPI FRDFLNRCLE 480

MDVEKRGSAK ELLQHPFLKL AKPLSSLTPL IMAAKEAMKS NR 522

Nucleotide Sequence
(FASTA)

ATGTCTGATA ACGGAGAACT GGAAGACAAG CCTCCAGCAC CTCCTGTGCG AATGAGCAGC 60

ACCATCTTTA GCACTGGAGG CAAAGACCCT TTGTCAGCCA ATCACAGTTT GAAACCTTTG 120

CCCTCTGTTC CAGAAGAGAA AAAGCCCAGG CATAAAATCA TCTCCATATT CTCAGGCACA 180

GAGAAAGGAA GTAAAAAGAA AGAAAAGGAA CGGCCAGAAA TTTCTCCTCC ATCTGATTTT 240

GAGCACACCA TCCATGTTGG CTTTGATGCT GTTACTGGAG AATTCACTGG CATGCCAGAA 300

CAGTGGGCTC GATTACTACA GACCTCCAAT ATCACCAAAC TAGAGCAAAA GAAGAATCCT 360

CAGGCTGTGC TGGATGTCCT AAAGTTCTAC GACTCCAACA CAGTGAAGCA GAAATACCTG 420

AGCTTTACTC CTCCCGAGAA AGATGGCTTT CCTTCTGGAA CACCAGCACT GAATGCCAAG 480

GGAACAGAAG CACCCGCAGT AGTGACAGAG GAGGAGGATG ATGATGAAGA GACTGCTCCT 540

CCCGTTATTG CCCCGCGACC GGATCATACG AAATCAATTT ACACACGGTC TGTAATTGAC 600

CCTGTTCCTG CACCAGTTGG TGATGCACAT GTTGATGGTG CTGCCAAGTC TTTAGACAAA 660

CAGAAAAAGA AGACTAAGAT GACAGATGAA GAGATTATGG AGAAATTAAG AACTATCGTG 720

AGCATAGGTG ACCCTAAGAC TAAATTCAAT TGCAGCACTG GTTTTGTGGC TTCTGGTACA 780

GTTTTCACTG CTACTGACGT TGCATTGGGA CAGGAGGTTG CTATCAAACA AATTAATTTA 840

CAGAAACAGC CAAAGAAGGA ACTGATCATT AACGAGATTC TGGTGATGAA AGAATTGAAA 900

AATCCCAACA TCGTTAACTT CTTGGACAGT TACCTGGTAG GAGATGAATT GTTTGTGGTC 960

ATGGAATACC TTGCTGGGGG GTCACTCACT GATGTGGTAA CAGAAACCTG CATGGATGAA 1020

GCACAGATTG CCGCTGTATG CAGAGAGTGT TTACAGGCAT TGGAGTTTTT ACATGCTAAT 1080

CAAGTGATCC ACAGAGACAT CAAAAGTGAC AATGTACTTT TGGGAATGGA AGGATCGGTT 1140

AAGCTCACTG ACTTTGGTTT CTGTGCCCAG ATCACCCCTG AGCAGAGCAA ACGCAGTACC 1200

ATGGTCGGAA CACCATACTG GATGGCACCA GAGGTGGTTA CACGGAAAGC TTATGGCCCT 1260

AAAGTCGACA TATGGTCTCT GGGTATCATG GCTATTGAGA TGGTAGAAGG AGAGCCTCCA 1320

TACCTCAATG AAAATCCCTT GAGGGCCTTG TACCTAATAG CAACTAATGG AACCCCAGAA 1380

CTTCAGAATC CAGAGAAACT TTCCCCAATA TTTCGGGATT TCTTAAATCG ATGTTTGGAA 1440

ATGGATGTGG AAAAAAGGGG TTCAGCCAAA GAATTATTAC AGCATCCTTT CCTGAAACTG 1500

GCCAAACCGT TATCTAGCTT GACACCACTG ATCATGGCAG CTAAAGAAGC AATGAAGAGT 1560

AACCGTTAA 1569

Domain Profile

S: 11    algkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveylesflkeee  70

         a+g+v++a+++  g+ vaik+inl+kq+k+e++++ei v+k+lk+pniv++l+s+l+ +e

Q: 257   ASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDE  316

         789*********************************************************

S: 71    lwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdikakniL  130

         l++vmeylagGsl+d+v+   ++ ++E qia+++re+l+aLe+lH+++viHrdik++n+L

Q: 317   LFVVMEYLAGGSLTDVVT---ETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVL  373

         ******************...9**************************************

S: 131   lteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiwslGIta  190

         l +eg+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k+DiwslGI+a

Q: 374   LGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPKVDIWSLGIMA  431

         *****************************************..9****************

S: 191   ielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpekRpsase  250

         ie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f+++cl+ ++ekR sa+e

Q: 432   IEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKE  491

         ************************************************************

S: 251   llkhkFl  257

         ll+h+Fl

Q: 492   LLQHPFL  498

         ******7

Domain Sequence
(FASTA)

ASGTVFTATD VALGQEVAIK QINLQKQPKK ELIINEILVM KELKNPNIVN FLDSYLVGDE 60

LFVVMEYLAG GSLTDVVTET CMDEAQIAAV CRECLQALEF LHANQVIHRD IKSDNVLLGM 120

EGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS LGIMAIEMVE 180

GEPPYLNENP LRALYLIATN GTPELQNPEK LSPIFRDFLN RCLEMDVEKR GSAKELLQHP 240

FL 242

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013