EKS-GOG-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	342.0	3.6E-102	849	1121	273

Status

Unreviewed

Ensembl Protein

ENSGGOP00000007096

UniProt Accession

G3QWD9;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000007243	ENSGGOP00000007096	ENSGGOT00000007282

Organism

Gorilla gorilla

Functional Description

Protein Length

1133

Protein Sequence
(FASTA)

MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLQ VYLYHSLGKS EADYLTFPSG 60

EYVAEEICIA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NVLYRIRFYF 120

PRWYCSGSNR AYRHGISRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 180

MAVLDMMRIA KENDQTPLAI YNSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIQQF 240

SQCKATARNL KLKYLINLET LQSAFYTEKF EVKEPGSGPS GEEIFATIII TGNGGIQWSR 300

GKHKESETLT EQDLQLYCDF PNIIDVSIKQ ANQEGSNESR VVTIHKQDGK NLEIELSSLR 360

EALSFVSLID GYYRLTADAH HYLCKEVAPP TVLENIQSNC HGPISMDFAI SKLKKAGNQT 420

GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENE EYNLSGTKKN FSSLKDLLNC 480

YQMETVRSDN IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI 540

RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM 600

MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK LEVAKQLAWA 660

MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 720

PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL 780

ANLINNCMDY EPDFRPSFRA IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 840

PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 900

ILKSLQHDNI VKYKGVCYSA EGRRNLKLIM EYLPYGSLRD YLQKHKERID HIKLLQYTSQ 960

ICKGMEYLGT KRYIHRDLAT RNILVENENR VKIGDFGLTK VLPQDKEYYK VKEPGESPIF 1020

WYAPESLTES KFSVASDVWS FGVVLYELFT YIEKSKSPPA EFMRMIGNDK QGQMIVFHLI 1080

ELLKNNGRLP RPDGCPDEIY MIMTECWNNN VNQRPSFRDL ALRVDQIRDN MAG 1133

Nucleotide Sequence
(FASTA)

ATGGGAATGG CCTGCCTTAC GATGACAGAA ATGGAGGGAA CATCCACCTC TTCTATATAT 60

CAGAATGGTG ATATTTCTGG AAATGCCAAT TCTATGAAGC AAATAGATCC AGTTCTTCAG 120

GTGTATCTTT ACCATTCCCT TGGGAAATCT GAGGCAGATT ATCTGACCTT TCCATCCGGG 180

GAGTATGTTG CAGAAGAAAT CTGTATTGCT GCTTCTAAAG CTTGTGGTAT CACACCTGTG 240

TATCATAATA TGTTTGCTTT AATGAGTGAA ACAGAAAGGA TCTGGTATCC ACCCAACCAT 300

GTCTTCCATA TAGATGAGTC AACCAGGCAT AATGTACTCT ACAGAATAAG ATTTTACTTT 360

CCTCGTTGGT ACTGCAGTGG CAGCAACAGA GCCTATCGGC ATGGAATATC TCGAGGTGCT 420

GAAGCTCCTC TTCTTGATGA CTTTGTCATG TCTTACCTCT TTGCTCAGTG GCGGCATGAT 480

TTTGTGCATG GATGGATAAA AGTACCTGTG ACTCATGAAA CACAGGAAGA ATGTCTTGGG 540

ATGGCAGTGT TAGATATGAT GAGAATAGCC AAAGAAAACG ATCAAACCCC ACTGGCCATC 600

TATAACTCTA TCAGCTACAA GACATTCTTA CCAAAATGTA TTCGAGCAAA GATCCAAGAC 660

TATCATATTT TGACAAGGAA GCGAATAAGG TACAGATTTC GCAGATTTAT TCAGCAATTC 720

AGCCAATGCA AAGCCACTGC CAGAAACTTG AAACTTAAGT ATCTTATAAA TCTGGAAACT 780

CTGCAGTCTG CCTTCTACAC AGAGAAATTT GAAGTAAAAG AACCTGGAAG TGGTCCTTCA 840

GGTGAGGAGA TTTTTGCAAC CATTATAATA ACTGGAAACG GTGGAATTCA GTGGTCAAGA 900

GGGAAACATA AAGAAAGTGA GACACTGACA GAACAGGATT TACAGTTATA TTGCGATTTT 960

CCTAATATTA TTGATGTCAG TATTAAGCAA GCAAACCAAG AGGGTTCAAA TGAAAGCCGA 1020

GTTGTAACTA TCCATAAGCA AGATGGTAAA AATCTGGAAA TTGAACTTAG CTCATTAAGG 1080

GAAGCTTTGT CTTTCGTGTC ATTAATTGAT GGATATTATA GATTAACTGC AGATGCACAT 1140

CATTACCTCT GTAAAGAAGT AGCACCTCCA ACAGTGCTTG AAAATATACA AAGCAACTGT 1200

CATGGCCCAA TTTCGATGGA TTTTGCCATT AGTAAACTGA AGAAAGCAGG TAATCAGACT 1260

GGACTGTATG TACTTCGATG CAGTCCTAAG GACTTTAATA AATATTTTTT GACTTTTGCT 1320

GTCGAGCGAG AAAATGTCAT TGAATATAAA CACTGTTTGA TTACAAAAAA TGAGAATGAA 1380

GAGTACAACC TCAGTGGGAC AAAGAAGAAC TTCAGCAGTC TTAAAGATCT TTTGAATTGT 1440

TACCAGATGG AAACGGTTCG CTCAGACAAT ATAATTTTCC AGTTTACTAA ATGCTGTCCC 1500

CCAAAGCCAA AAGATAAATC AAACCTTCTA GTCTTCAGAA CGAATGGTGT TTCTGATGTA 1560

CCAACCTCAC CAACATTACA GAGGCCTACT CATATGAACC AAATGGTGTT TCACAAAATC 1620

AGAAATGAAG ATTTGATATT TAATGAAAGC CTTGGCCAAG GCACTTTTAC AAAGATTTTT 1680

AAAGGCGTAC GAAGAGAAGT AGGAGACTAC GGTCAACTGC ATGAAACAGA AGTTCTTTTA 1740

AAAGTTCTGG ATAAAGCACA CAGAAACTAT TCAGAGTCTT TCTTTGAAGC AGCAAGTATG 1800

ATGAGCAAGC TTTCTCACAA GCATTTGGTT TTAAATTATG GAGTATGTGT CTGTGGAGAC 1860

GAGAATATTC TGGTTCAGGA GTTTGTAAAA TTTGGATCAC TAGATACATA TCTGAAAAAG 1920

AATAAAAATT GTATAAATAT ATTATGGAAA CTTGAAGTTG CTAAACAGTT GGCATGGGCC 1980

ATGCATTTTC TAGAAGAAAA CACCCTTATT CATGGGAATG TATGTGCCAA AAATATTCTG 2040

CTTATCAGAG AAGAAGACAG GAAGACAGGA AATCCTCCTT TCATCAAACT TAGTGATCCT 2100

GGCATTAGTA TTACAGTTTT GCCAAAGGAC ATTCTTCAGG AGAGAATACC ATGGGTACCA 2160

CCTGAATGCA TTGAAAATCC TAAAAATTTA AATTTGGCAA CAGACAAATG GAGTTTTGGT 2220

ACCACTTTGT GGGAAATCTG CAGTGGAGGA GATAAACCTC TAAGTGCTCT GGATTCTCAA 2280

AGAAAGCTAC AATTTTATGA AGATAGGCAT CAGCTTCCTG CACCAAAGTG GGCAGAATTA 2340

GCAAACCTTA TAAATAATTG TATGGATTAT GAACCAGATT TCAGGCCTTC TTTCAGAGCC 2400

ATCATACGAG ATCTTAACAG TTTGTTTACT CCAGATTATG AACTATTAAC AGAAAATGAC 2460

ATGTTACCAA ATATGAGGAT AGGTGCCCTA GGGTTTTCTG GTGCCTTTGA AGACCGGGAT 2520

CCTACACAGT TTGAAGAGAG ACATTTGAAA TTTCTACAGC AACTTGGCAA GGGTAATTTT 2580

GGGAGTGTGG AGATGTGCCG GTATGACCCT CTACAGGACA ACACTGGGGA GGTGGTCGCT 2640

GTAAAAAAGC TTCAGCATAG TACTGAAGAG CACCTAAGAG ACTTTGAAAG GGAAATTGAA 2700

ATCCTGAAAT CCCTACAGCA TGACAACATT GTAAAGTACA AGGGAGTGTG CTACAGTGCT 2760

GAAGGTCGGC GTAATCTAAA ATTAATTATG GAATATTTAC CATATGGAAG TTTACGAGAC 2820

TATCTTCAAA AACATAAAGA ACGGATAGAT CACATAAAAC TTCTGCAGTA CACATCTCAG 2880

ATATGCAAGG GTATGGAGTA TCTTGGTACA AAAAGGTATA TCCACAGGGA TCTGGCAACG 2940

AGAAATATAT TGGTGGAGAA TGAGAACAGA GTTAAAATTG GAGATTTTGG GTTAACCAAA 3000

GTCTTGCCAC AAGACAAAGA ATACTATAAA GTAAAAGAAC CTGGTGAAAG TCCCATATTC 3060

TGGTATGCTC CGGAATCACT GACAGAGAGC AAGTTTTCTG TGGCCTCAGA TGTTTGGAGC 3120

TTTGGAGTGG TTCTGTATGA ACTTTTCACA TACATTGAGA AGAGTAAAAG TCCACCAGCG 3180

GAATTTATGC GTATGATTGG CAACGACAAA CAAGGACAGA TGATCGTGTT CCATTTGATA 3240

GAACTTTTGA AGAATAATGG AAGATTACCA AGACCAGATG GATGCCCAGA TGAGATCTAT 3300

ATGATCATGA CAGAATGCTG GAACAATAAT GTAAATCAAC GCCCCTCCTT TAGGGATCTA 3360

GCTCTTCGAG TGGATCAAAT AAGGGATAAC ATGGCTGGAT GA 3402

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 849   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  908

         6899********************************************************

S: 61    hivklkgvcvaegen...rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         +ivk+kgvc++ + +   +l+mey+++GsL++yL+k+ke++++ +ll++++q++k+meYL

Q: 909   NIVKYKGVCYSAEGRrnlKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYL  968

         *********98765557*******************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+

Q: 969   GTKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWY  1022

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rkle  223

         ape+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++e

Q: 1023  APESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIE  1081

         *********.*******************************999999999**********

S: 224   lleekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         ll+++ rlp+p+ cp+e++++mt+c++++ +qrpsFr+++

Q: 1082  LLKNNGRLPRPDgCPDEIYMIMTECWNNNVNQRPSFRDLA  1121

         *************************************995

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAEGRRNLKL IMEYLPYGSL RDYLQKHKER IDHIKLLQYT SQICKGMEYL 120

GTKRYIHRDL ATRNILVENE NRVKIGDFGL TKVLPQDKEY YKVKEPGESP IFWYAPESLT 180

ESKFSVASDV WSFGVVLYEL FTYIEKSKSP PAEFMRMIGN DKQGQMIVFH LIELLKNNGR 240

LPRPDGCPDE IYMIMTECWN NNVNQRPSFR DLA 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013