EKS-GOG-00395
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00395
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR603.91.3E-181600958359
StatusUnreviewed
Ensembl ProteinENSGGOP00000007098
UniProt AccessionG3QWE1;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000007244ENSGGOP00000007098ENSGGOT00000007284
OrganismGorilla gorilla
Functional Description
Protein Length1110
Protein Sequence
(FASTA)
MRLPGVMPAL ALKGELLLLP LLLLLEPQIS QGLVVTPPGP ELVLNVSSTF VLTCLGSAPV 60
VWERMSQEPP QEMAKAQDGT FSSVLTLTNL TGLDTGEYFC THNDSRGLET DERKRLYIFV 120
PDPTVGFLPN DAEELFIFLT EITEITIPCR VTDPQLVVTL HEKKGDIALP VPYDHQRGFS 180
GIFEDRSYIC KTTIGDREVD SDAYYVYRLQ VSSINVSVNA VQTVVRQGEN ITLMCIVIGN 240
EVVNFEWTYP RKESGRLVEP VTDFLLDMPY HIRSILHIPS AELEDSGTYT CNVTESVNDH 300
QDEKAINITV VESGYVRLLG EVGTLQFAEL HRSRTLQVVF EAYPPPTVLW FKDNRTLGDS 360
SAGEIALSTR NVSETRYVSE LTLVRVKVAE AGHYTMRAFH EDAEVQLSFQ LQINVPVRVL 420
ELSESHPDSG EQTVRCRGRG MPQPNIIWSA CRDLKRCPRE LPPTLLGNSS EEESQLETNV 480
TYWEEEQEFE VVSTLRLQHV DRPLSVRCTL RNAVGQDTQE VIVVPHSLPF KVVVISAILA 540
LVVLTVISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWELPRDQL 600
VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP 660
HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQHHSDKRRP PSAELYSNAL 720
PVGLPLPSHV SLTGESDGGY MDMSKDESVD YVPMLDMKGD VKYADIESSN YMAPYDNYVP 780
SAPERTCRAT LINESPLLSY MDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV 840
KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG 900
GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER 960
LLGEGYKKPR EQKYQQVDEE FLRSDHPAIL RSQARLPGFH GLRSPLDTSS VLYTAVQPNE 1020
GDNDYIIPLP DPKPEVADEG PLEGSPSLAS STLNEVNTSS TISCDSPLEP QDEPEPEPQL 1080
ELQVEPGPEL EQLPDSGCPA PRAEAEDSFL 1110
Nucleotide Sequence
(FASTA)
ATGCGGCTTC CGGGTGTGAT GCCAGCTCTG GCCCTCAAAG GCGAGCTGCT GTTGCTGCCC 60
CTCCTGTTAC TGCTGGAACC ACAGATCTCT CAGGGCCTGG TCGTCACACC CCCGGGGCCA 120
GAGCTTGTCC TCAATGTCTC CAGCACCTTC GTTCTGACCT GCTTGGGTTC AGCTCCGGTG 180
GTATGGGAAC GGATGTCCCA GGAGCCCCCA CAGGAAATGG CCAAGGCCCA GGACGGCACC 240
TTCTCCAGCG TGCTCACACT GACCAACCTC ACTGGGCTAG ACACGGGAGA ATACTTTTGC 300
ACCCACAATG ACTCCCGTGG ACTGGAGACC GATGAGCGGA AACGGCTCTA CATCTTTGTG 360
CCAGATCCCA CCGTGGGCTT CCTCCCTAAT GATGCCGAGG AACTATTCAT CTTTCTCACG 420
GAAATAACTG AGATCACCAT TCCATGCCGA GTAACAGACC CACAGCTGGT GGTGACACTG 480
CACGAGAAGA AAGGGGACAT TGCACTGCCT GTCCCCTATG ATCACCAACG TGGCTTTTCT 540
GGTATCTTTG AGGACAGAAG CTACATCTGC AAAACCACCA TTGGGGACAG GGAGGTGGAT 600
TCCGATGCCT ACTATGTCTA CAGACTCCAG GTGTCATCCA TCAACGTCTC TGTGAACGCA 660
GTGCAGACTG TGGTCCGCCA GGGTGAGAAC ATCACCCTCA TGTGCATTGT GATCGGGAAT 720
GAGGTGGTCA ACTTCGAGTG GACATACCCC CGCAAAGAAA GTGGACGGCT GGTGGAGCCG 780
GTGACCGACT TCCTCTTGGA TATGCCTTAC CACATCCGCT CCATCCTGCA CATCCCCAGT 840
GCCGAGTTAG AAGACTCGGG GACCTACACC TGCAATGTGA CGGAGAGTGT GAATGACCAT 900
CAGGATGAAA AGGCCATCAA CATCACCGTG GTTGAGAGCG GCTACGTGCG GCTCCTGGGA 960
GAGGTGGGCA CACTACAATT TGCTGAGCTG CATCGGAGCC GGACACTGCA GGTAGTGTTC 1020
GAGGCCTACC CACCGCCCAC TGTCCTGTGG TTCAAAGACA ACCGCACCCT GGGCGACTCC 1080
AGCGCTGGCG AAATCGCCCT GTCCACGCGC AACGTGTCGG AGACCCGGTA TGTGTCAGAG 1140
CTGACGCTCG TTCGCGTGAA GGTGGCAGAG GCTGGCCACT ACACCATGCG GGCCTTCCAT 1200
GAGGATGCTG AGGTCCAGCT CTCCTTCCAG CTACAGATCA ATGTCCCTGT CCGAGTGCTG 1260
GAGCTAAGTG AGAGCCACCC TGACAGTGGG GAACAGACAG TCCGCTGTCG TGGCCGGGGC 1320
ATGCCCCAGC CGAACATCAT CTGGTCTGCC TGCAGAGACC TCAAAAGGTG TCCACGCGAG 1380
CTGCCACCCA CGCTGCTGGG GAACAGTTCC GAAGAGGAGA GCCAGCTGGA GACTAACGTG 1440
ACGTACTGGG AGGAGGAGCA GGAGTTTGAG GTGGTGAGCA CACTGCGTCT GCAGCACGTG 1500
GATCGGCCAC TGTCGGTGCG CTGCACGCTG CGCAACGCTG TGGGCCAGGA CACGCAGGAG 1560
GTCATCGTGG TGCCACACTC CTTGCCCTTT AAGGTGGTGG TGATCTCAGC CATCCTGGCC 1620
CTGGTGGTGC TCACCGTCAT CTCCCTTATC ATCCTCATCA TGCTTTGGCA GAAGAAGCCA 1680
CGTTACGAGA TCCGATGGAA GGTGATTGAG TCTGTGAGCT CTGACGGCCA TGAGTACATC 1740
TACGTGGACC CCATGCAGCT GCCCTATGAC TCCACGTGGG AGCTGCCGCG GGACCAGCTT 1800
GTGCTGGGAC GCACCCTCGG CTCTGGGGCC TTTGGGCAGG TGGTGGAGGC CACGGCTCAT 1860
GGCCTGAGCC ATTCTCAGGC CACGATGAAA GTGGCCGTCA AGATGCTTAA ATCCACAGCC 1920
CGCAGCAGTG AGAAGCAAGC CCTTATGTCG GAGCTGAAGA TCATGAGTCA CCTTGGGCCC 1980
CACCTGAACG TGGTCAACCT GTTGGGGGCC TGCACCAAAG GAGGACCCAT CTATATCATC 2040
ACTGAGTACT GCCGCTACGG AGACCTGGTG GACTACCTGC ACCGCAACAA ACACACCTTC 2100
CTGCAGCACC ACTCCGACAA GCGCCGCCCG CCCAGCGCAG AGCTCTACAG CAATGCACTG 2160
CCCGTTGGGC TCCCCCTGCC CAGCCATGTG TCCTTGACCG GGGAGAGCGA CGGTGGCTAC 2220
ATGGACATGA GCAAGGATGA GTCGGTGGAC TATGTGCCCA TGCTGGACAT GAAAGGAGAC 2280
GTCAAATATG CAGACATCGA GTCCTCCAAC TACATGGCCC CTTACGATAA CTACGTTCCC 2340
TCTGCCCCGG AGAGGACCTG TCGGGCAACT TTGATCAACG AGTCTCCATT GCTAAGCTAC 2400
ATGGACCTCG TGGGCTTCAG CTACCAGGTG GCCAATGGCA TGGAGTTTCT GGCCTCCAAG 2460
AACTGCGTCC ACAGAGACCT GGCAGCTAGG AACGTGCTCA TCTGTGAAGG CAAGCTGGTC 2520
AAGATCTGTG ACTTTGGCCT GGCTCGAGAC ATCATGCGGG ACTCGAATTA CATCTCCAAA 2580
GGCAGCACCT TTTTGCCTTT GAAGTGGATG GCTCCGGAGA GCATCTTCAA CAGCCTCTAC 2640
ACCACCCTGA GTGACGTGTG GTCCTTCGGG ATCCTGCTCT GGGAGATCTT CACCTTGGGT 2700
GGCACCCCTT ACCCAGAGCT GCCCATGAAC GAGCAGTTCT ACAATGCCAT CAAACGGGGT 2760
TACCGCATGG CCCAGCCTGC CCATGCCTCC GACGAGATCT ATGAGATCAT GCAGAAGTGC 2820
TGGGAAGAGA AGTTTGAGAT TCGGCCCCCC TTCTCCCAGC TGGTGCTGCT TCTCGAGAGA 2880
CTGTTGGGCG AAGGTTACAA AAAGCCCCGG GAGCAGAAGT ACCAGCAGGT GGATGAGGAG 2940
TTTCTGAGGA GTGACCACCC AGCCATCCTT CGGTCCCAGG CCCGCTTGCC TGGGTTCCAT 3000
GGCCTCCGAT CTCCCCTGGA CACCAGCTCC GTCCTCTATA CTGCCGTGCA GCCCAATGAG 3060
GGTGACAACG ACTATATCAT CCCCCTGCCT GACCCCAAAC CCGAGGTTGC TGACGAGGGC 3120
CCACTGGAGG GTTCCCCCAG CCTAGCCAGC TCCACCCTGA ATGAAGTCAA CACCTCCTCA 3180
ACCATCTCCT GTGACAGCCC CCTGGAGCCC CAGGACGAAC CAGAGCCAGA GCCCCAGCTT 3240
GAGCTCCAGG TGGAGCCGGG GCCGGAGCTG GAACAGTTGC CGGATTCGGG GTGCCCTGCG 3300
CCTCGGGCGG AAGCAGAGGA TAGCTTCCTG TAG 3333
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG
Q: 600   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  659
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+++++k++++++el+s+a
Q: 660   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNA  719
         ************************************************************
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
         l+++  l s++sl+ es++ y+d++kd                ++d++ss++++++++++
Q: 720   LPVGLPLPSHVSLTGESDGGYMDMSKDesvdyvpmldmkgdvkYADIESSNYMAPYDNYV  779
         ************************************************************
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          sa er+++a+l++e s  l+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk
Q: 780   PSAPERTCRATLINE-SPLLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  838
         **************9.99******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+
Q: 839   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  898
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll
Q: 899   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  958
         ********************************************************9986
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQHHSDKRR PPSAELYSNA 120
LPVGLPLPSH VSLTGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIESS NYMAPYDNYV 180
PSAPERTCRA TLINESPLLS YMDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240
VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300
GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013