EKS-GOG-00080

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00080

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	438.4	1.5E-131	56	353	298

Status

Unreviewed

Ensembl Protein

ENSGGOP00000007214

UniProt Accession

G3QWP9;

Protein Name

Protein Synonyms/Alias

Gene Name

GSK3B

Gene Synonyms/Alias

GSK3B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000007367	ENSGGOP00000007214	ENSGGOT00000007405

Organism

Gorilla gorilla

Functional Description

Protein Length

400

Protein Sequence
(FASTA)

MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60

VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 120

EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 180

DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 240

WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300

WTKDSSGTGH FTSGVRVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH SFFDELRDPN 360

VKLPNGRDTP ALFNFTTQDA NTGDRGQTNN AASASASNST 400

Nucleotide Sequence
(FASTA)

ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCGGT GCAGCAGCCT 60

TCAGCTTTTG GCAGCATGAA AGTTAGCAGA GACAAGGACG GCAGCAAGGT GACAACAGTG 120

GTGGCAACTC CTGGGCAGGG TCCAGACAGG CCACAAGAAG TCAGCTATAC AGACACTAAA 180

GTGATTGGAA ATGGATCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA TTCAGGAGAA 240

CTGGTCGCCA TCAAGAAAGT ATTGCAGGAC AAGAGATTTA AGAATCGAGA GCTCCAGATC 300

ATGAGAAAGC TAGATCACTG TAACATAGTC AGATTGCGTT ATTTCTTCTA CTCCAGTGGT 360

GAGAAGAAAG ATGAGGTCTA TCTTAATCTG GTGCTGGACT ATGTTCCGGA AACAGTATAC 420

AGAGTTGCCA GACACTATAG TCGAGCCAAA CAGACGCTCC CTGTGATTTA TGTCAAGTTG 480

TATATGTATC AGCTGTTCCG AAGTTTAGCC TATATCCATT CCTTTGGAAT CTGCCATCGG 540

GATATTAAAC CGCAGAACCT CTTGTTGGAT CCTGATACTG CTGTATTAAA ACTCTGTGAC 600

TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAACCCAATG TTTCGTATAT CTGTTCTCGG 660

TACTATAGGG CACCAGAGTT GATCTTTGGA GCCACTGATT ATACCTCTAG TATAGATGTA 720

TGGTCTGCTG GCTGTGTGTT GGCTGAGCTG TTACTAGGAC AACCAATATT TCCAGGGGAT 780

AGTGGTGTGG ATCAGTTGGT AGAAATAATC AAGGTCCTGG GAACTCCAAC AAGGGAGCAA 840

ATCAGAGAAA TGAACCCAAA CTACACAGAA TTTAAATTCC CTCAAATTAA GGCACATCCT 900

TGGACTAAGG ATTCGTCAGG AACAGGACAT TTCACCTCAG GAGTGCGGGT CTTCCGACCC 960

CGAACTCCAC CGGAGGCAAT TGCACTGTGT AGCCGTCTGC TGGAGTATAC CCCAACTGCC 1020

CGACTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTTG ATGAATTACG GGACCCAAAT 1080

GTCAAACTAC CAAATGGGCG AGACACACCT GCACTCTTCA ACTTCACCAC TCAAGATGCT 1140

AATACTGGAG ACCGTGGACA GACCAATAAT GCTGCTTCTG CATCAGCTTC CAACTCCACC 1200

TGA 1203

Domain Profile

S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLly  60

         ++++k+ig+GsFg+Vyqa+l+++ e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+y

Q: 56    YTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY  114

         5789**********************.*********************************

S: 61    ffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhs  120

         ff++s ekkd+vylnlvl+y+Pet+++v+r+++++k++l+v++vkly+yQlfr+lay+hs

Q: 115   FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS  174

         ************************************************************

S: 121   leivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakey  180

         ++i+HrDiKPqNll+d++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++y

Q: 175   FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY  234

         ************************************************************

S: 181   ttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfk  240

         t++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf+

Q: 235   TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP  294

         ************************************************************

S: 241   kikkvslakvlkkk.............edkeavdllkkilkyepkkRlsalellahpff  286

         +ik+++++k  + +             +++ea++l++++l+y+p++Rl++le++ah+ff

Q: 295   QIKAHPWTKDSSGTghftsgvrvfrprTPPEAIALCSRLLEYTPTARLTPLEACAHSFF  353

         *********999556899****************************************9

Domain Sequence
(FASTA)

YTDTKVIGNG SFGVVYQAKL CDSGELVAIK KVLQDKRFKN RELQIMRKLD HCNIVRLRYF 60

FYSSGEKKDE VYLNLVLDYV PETVYRVARH YSRAKQTLPV IYVKLYMYQL FRSLAYIHSF 120

GICHRDIKPQ NLLLDPDTAV LKLCDFGSAK QLVRGEPNVS YICSRYYRAP ELIFGATDYT 180

SSIDVWSAGC VLAELLLGQP IFPGDSGVDQ LVEIIKVLGT PTREQIREMN PNYTEFKFPQ 240

IKAHPWTKDS SGTGHFTSGV RVFRPRTPPE AIALCSRLLE YTPTARLTPL EACAHSFF 298

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013